JP5527739B2 - 好中球エラスターゼ活性の阻害が有益である疾患または状態の処置のための２−ピリドン誘導体 - Google Patents
好中球エラスターゼ活性の阻害が有益である疾患または状態の処置のための２−ピリドン誘導体 Download PDFInfo
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- JP5527739B2 JP5527739B2 JP2009509486A JP2009509486A JP5527739B2 JP 5527739 B2 JP5527739 B2 JP 5527739B2 JP 2009509486 A JP2009509486 A JP 2009509486A JP 2009509486 A JP2009509486 A JP 2009509486A JP 5527739 B2 JP5527739 B2 JP 5527739B2
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- phenyl
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- trifluoromethyl
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Classifications
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- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
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- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
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Landscapes
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- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US79878406P | 2006-05-08 | 2006-05-08 | |
| US60/798,784 | 2006-05-08 | ||
| PCT/SE2007/000442 WO2007129963A1 (en) | 2006-05-08 | 2007-05-07 | 2-pyrazinone derivatives for the treatment of disease or condition in which inhibition of neutrophil elastase activity is beneficial. |
Publications (3)
| Publication Number | Publication Date |
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| JP2009536197A JP2009536197A (ja) | 2009-10-08 |
| JP2009536197A5 JP2009536197A5 (enExample) | 2010-06-03 |
| JP5527739B2 true JP5527739B2 (ja) | 2014-06-25 |
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| JP2009509486A Expired - Fee Related JP5527739B2 (ja) | 2006-05-08 | 2007-05-07 | 好中球エラスターゼ活性の阻害が有益である疾患または状態の処置のための２−ピリドン誘導体 |
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| JP (1) | JP5527739B2 (enExample) |
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| AR (1) | AR060874A1 (enExample) |
| AU (2) | AU2007248951B2 (enExample) |
| BR (1) | BRPI0711362A2 (enExample) |
| CA (1) | CA2650553C (enExample) |
| CL (1) | CL2007001283A1 (enExample) |
| CO (1) | CO6140058A2 (enExample) |
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| TW200808771A (en) | 2006-05-08 | 2008-02-16 | Astrazeneca Ab | Novel compounds II |
| HRP20141174T1 (hr) | 2007-06-27 | 2015-02-13 | Astrazeneca Ab | Derivati pirazinona i njihova uporaba za lijeäśenje bolesti pluä†a |
| WO2009058076A1 (en) * | 2007-11-02 | 2009-05-07 | Astrazeneca Ab | 2-pyrazinone derivatives and their use as inhibitors of neutrophile elastase |
| AU2008325288B2 (en) | 2007-11-06 | 2011-12-22 | Astrazeneca Ab | Some 2-pyrazinone derivatives and their use as inhibitors of neutrophile elastase |
| AR073711A1 (es) | 2008-10-01 | 2010-11-24 | Astrazeneca Ab | Derivados de isoquinolina |
| TW201036957A (en) * | 2009-02-20 | 2010-10-16 | Astrazeneca Ab | Novel salt 628 |
| GB0913345D0 (en) | 2009-07-31 | 2009-09-16 | Astrazeneca Ab | New combination 802 |
| CA2773618A1 (en) * | 2009-10-02 | 2011-04-07 | Astrazeneca Ab | 2-pyridone compounds used as inhibitors of neutrophil elastase |
| WO2011061527A1 (en) | 2009-11-17 | 2011-05-26 | Astrazeneca Ab | Combinations comprising a glucocorticoid receptor modulator for the treatment of respiratory diseases |
| US20110224229A1 (en) | 2010-03-10 | 2011-09-15 | Astrazeneca Ab | Novel Crystalline Form |
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| GB201021979D0 (en) | 2010-12-23 | 2011-02-02 | Astrazeneca Ab | New compound |
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| US20190008867A1 (en) * | 2015-11-13 | 2019-01-10 | Ph Pharma Co., Ltd. | 4-(4-cyano-2-thioaryl)dihydropyrimidinones for treating chronic wounds |
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| CN108440508B (zh) * | 2018-04-04 | 2020-03-20 | 河南科技大学第一附属医院 | 吡嗪药物及其制备方法、组合物及在胃肠病人护理的应用 |
| CA3154761A1 (en) | 2019-09-17 | 2021-03-25 | Mereo Biopharma 4 Limited | Alvelestat for use in the treatment of graft rejection, bronchiolitis obliterans syndrome and graft versus host disease |
| SI4106757T1 (sl) | 2020-04-16 | 2023-11-30 | Mereo Biopharma 4 Limited | Postopki, ki vključujejo zaviralec nevtrofilne elastaze alvelestat, za zdravljenje bolezni dihal, ki jo sproži pomanjkanje antitripsina alfa-1 |
| WO2023067103A1 (en) | 2021-10-20 | 2023-04-27 | Mereo Biopharma 4 Limited | Neutrophil elastase inhibitors for use in the treatment of fibrosis |
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| CN118724801B (zh) * | 2024-09-03 | 2024-12-03 | 中节能万润股份有限公司 | 一种甲苯磺酸艾多沙班中间体的制备方法 |
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- 2007-05-07 EP EP07748106A patent/EP2018377A4/en not_active Withdrawn
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| KR20090009956A (ko) | 2009-01-23 |
| EP2018377A4 (en) | 2011-03-30 |
| AU2007248951B2 (en) | 2011-05-19 |
| IL194949A0 (en) | 2009-08-03 |
| AU2007248951A1 (en) | 2007-11-15 |
| CO6140058A2 (es) | 2010-03-19 |
| RU2011131170A (ru) | 2013-02-10 |
| AU2010236027A1 (en) | 2010-11-18 |
| SG170101A1 (en) | 2011-04-29 |
| ECSP088869A (es) | 2008-12-30 |
| US20090209555A1 (en) | 2009-08-20 |
| US20120108610A1 (en) | 2012-05-03 |
| CN101490040A (zh) | 2009-07-22 |
| AR060874A1 (es) | 2008-07-16 |
| AU2010236027B2 (en) | 2011-08-18 |
| EP2018377A1 (en) | 2009-01-28 |
| CN101490040B (zh) | 2013-06-12 |
| TW200808771A (en) | 2008-02-16 |
| CL2007001283A1 (es) | 2008-01-18 |
| MX2008013837A (es) | 2008-11-10 |
| JP2009536197A (ja) | 2009-10-08 |
| CA2650553A1 (en) | 2007-11-15 |
| KR101429303B1 (ko) | 2014-08-12 |
| CA2650553C (en) | 2014-07-08 |
| UY30327A1 (es) | 2008-01-02 |
| RU2448098C2 (ru) | 2012-04-20 |
| WO2007129963A1 (en) | 2007-11-15 |
| US8114881B2 (en) | 2012-02-14 |
| RU2008143457A (ru) | 2010-06-20 |
| US8410114B2 (en) | 2013-04-02 |
| BRPI0711362A2 (pt) | 2011-12-06 |
| NO20084845L (no) | 2009-02-03 |
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