MX2007014892A - Formas polimorficas del ester etilico del acido 3-[(2-{[4-(hexiloxicarbonilamino-imino-metil)-fenilamino]-metil}- 1-metil-h-bencimidazol-5-carbonil)-piridin-2-il--amino]propionico . - Google Patents
Formas polimorficas del ester etilico del acido 3-[(2-{[4-(hexiloxicarbonilamino-imino-metil)-fenilamino]-metil}- 1-metil-h-bencimidazol-5-carbonil)-piridin-2-il--amino]propionico .Info
- Publication number
- MX2007014892A MX2007014892A MX2007014892A MX2007014892A MX2007014892A MX 2007014892 A MX2007014892 A MX 2007014892A MX 2007014892 A MX2007014892 A MX 2007014892A MX 2007014892 A MX2007014892 A MX 2007014892A MX 2007014892 A MX2007014892 A MX 2007014892A
- Authority
- MX
- Mexico
- Prior art keywords
- methyl
- hexyloxycarbonylamino
- iminomethyl
- phenylamino
- benzimidazole
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyridine Compounds (AREA)
Abstract
La invencion se refiere a nuevas formas polimorfas del principio activo ester etilico del acido 3-[(2-{[4-(hexiloxicarbonilamino-im ino-metil)-fenilamino]-metil}-1-metil-h-bencimidazol-5-carbonil)- piridin-2- ilamino]propionico, a su preparacion y su utilizacion como medicamentos.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE102005025728A DE102005025728A1 (de) | 2005-06-04 | 2005-06-04 | Polymorphe von 3-[(2-{[4-(Hexyloxycarbonylamino-imino-methyl)-phenylamino]-methyl}-1-methyl-1H-benzimidazol-5-carbonyl)-pyridin-2-yl-amino]-Propionsäure-ethylester |
PCT/EP2006/062847 WO2006131491A1 (de) | 2005-06-04 | 2006-06-01 | Polymorphe von 3-[(2-{[4-(hexyloxycarbonylamino-imino-methyl)-phenylamino]-methyl}-1-methyl-1h-benzimidazol-5-carbonyl)-pyridin-2-yl-amino]-propionsäure-ethylester |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2007014892A true MX2007014892A (es) | 2008-04-17 |
Family
ID=36812978
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2007014892A MX2007014892A (es) | 2005-06-04 | 2006-06-01 | Formas polimorficas del ester etilico del acido 3-[(2-{[4-(hexiloxicarbonilamino-imino-metil)-fenilamino]-metil}- 1-metil-h-bencimidazol-5-carbonil)-piridin-2-il--amino]propionico . |
Country Status (22)
Country | Link |
---|---|
US (1) | US20060276513A1 (es) |
EP (3) | EP2088146A3 (es) |
JP (1) | JP2008545734A (es) |
KR (1) | KR20080021763A (es) |
CN (1) | CN101189224B (es) |
AR (1) | AR054278A1 (es) |
AU (1) | AU2006256778A1 (es) |
BR (1) | BRPI0611099A2 (es) |
CA (1) | CA2609583A1 (es) |
DE (1) | DE102005025728A1 (es) |
EA (1) | EA014082B1 (es) |
EC (1) | ECSP077981A (es) |
IL (1) | IL187845A0 (es) |
MX (1) | MX2007014892A (es) |
NO (1) | NO20075862L (es) |
NZ (1) | NZ564621A (es) |
PE (1) | PE20070082A1 (es) |
TW (1) | TW200716107A (es) |
UA (1) | UA92349C2 (es) |
UY (1) | UY29575A1 (es) |
WO (1) | WO2006131491A1 (es) |
ZA (1) | ZA200709715B (es) |
Families Citing this family (34)
Publication number | Priority date | Publication date | Assignee | Title |
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US20030181488A1 (en) * | 2002-03-07 | 2003-09-25 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Administration form for the oral application of 3-[(2-{[4-(hexyloxycarbonylamino-imino-methyl)-phenylamino]-methyl}-1-methyl-1H-benzimidazol-5-carbonyl)-pyridin-2-yl-amino]-propionic acid ethyl ester and the salts thereof |
DE10339862A1 (de) * | 2003-08-29 | 2005-03-24 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | 3-[(2-{[4-(Hexyloxycarbonylamino-imino-methyl)- phenylamino]-methyl}-1-methyl-1H-benzimidazol-5-carbonyl)-pyridin-2-yl-amino]-propionsäure-ethylester-Methansulfonat und dessen Verwendung als Arzneimittel |
DE102006054005A1 (de) * | 2006-11-16 | 2008-05-21 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Neue Polymorphe von 3-[(2-{[4-(Hexyloxycarbonylamino-imino-methyl)-phenylamino]-methyl}-1-methyl-1H-benzimidazol-5-carbonyl)-pyridin-2-yl-amino]-propionsäure-ethylester |
CN101980697A (zh) * | 2008-03-28 | 2011-02-23 | 贝林格尔.英格海姆国际有限公司 | 制备口服给药的达比加群制剂的方法 |
NZ589746A (en) | 2008-07-14 | 2012-10-26 | Boehringer Ingelheim Int | Method for manufacturing medicinal compounds containing dabigatran |
CN103356614A (zh) | 2008-11-11 | 2013-10-23 | 贝林格尔.英格海姆国际有限公司 | 使用达比加群酯或其盐治疗或预防血栓形成且与常规华法林疗法相比具有改良安全性的方法 |
HUP1000069A2 (en) | 2010-02-02 | 2012-05-02 | Egis Gyogyszergyar Nyilvanosan M Kod Ruszvunytarsasag | New salts for the preparation of pharmaceutical composition |
JP2013521318A (ja) | 2010-03-08 | 2013-06-10 | ラティオファルム ゲー・エム・ベー・ハー | ダビガトランエテキシラートを含有する医薬組成物 |
WO2012027543A1 (en) | 2010-08-25 | 2012-03-01 | Teva Pharmaceuticals Usa, Inc. | Solid state forms of dabigatran etexilate, dabigatran etexilate mesylate and processes for preparation thereof |
US9174609B2 (en) | 2011-04-21 | 2015-11-03 | Pylon Manufacturing Corp. | Wiper blade with cover |
HUP1100244A2 (hu) | 2011-05-11 | 2012-11-28 | Egis Gyogyszergyar Nyilvanosan Muekoedoe Reszvenytarsasag | Gyógyszeripari intermedierek és eljárás elõállításukra |
WO2012162492A1 (en) | 2011-05-24 | 2012-11-29 | Teva Pharmaceutical Industries Ltd. | Compressed core comprising organic acids for a pharmaceutical composition |
EP2610251A1 (en) * | 2011-12-29 | 2013-07-03 | Zaklady Farmaceutyczne Polpharma SA | Novel polymorphic forms of dabigatran etexilate and process for the preparation thereof |
WO2013111163A2 (en) | 2012-01-20 | 2013-08-01 | Cadila Healthcare Limited | Process for the preparation of dabigatran etexilate mesylate and polymorphs of intermediates thereof |
WO2013124749A1 (en) * | 2012-02-20 | 2013-08-29 | Alembic Pharmaceuticals Limited | Novel polymorph of dabigatran etexilate |
US20130219649A1 (en) | 2012-02-24 | 2013-08-29 | Pylon Manufacturing Corp. | Wiper blade |
EP2872499A1 (en) * | 2012-07-16 | 2015-05-20 | Interquim, S.A. | Process for the preparation of intermediates for the synthesis of dabigatran etexilate, and crystalline forms of said intermediates |
WO2014020546A2 (en) | 2012-07-31 | 2014-02-06 | Ranbaxy Laboratories Limited | Crystalline forms of dabigatran etexilate and process for their preparation |
US9150542B2 (en) | 2012-08-31 | 2015-10-06 | Ranbaxy Laboratories Limited | Process for the preparation of crystalline form I of methanesulfonate salt of dabigatran etexilate |
CN103664881A (zh) * | 2012-09-20 | 2014-03-26 | 天津药物研究院 | 结晶变体形态b的达比加群酯及其制备方法和用途 |
WO2014049586A2 (en) | 2012-09-28 | 2014-04-03 | Ranbaxy Laboratories Limited | Process for the preparation of dabigatran etexilate or pharmaceutically acceptable salt thereof |
CA2885994A1 (en) | 2012-09-28 | 2014-04-03 | Ranbaxy Laboratories Limited | Process for the preparation of dabigatran etexilate or pharmaceutically acceptable salt thereof |
CN103788063B (zh) * | 2012-10-29 | 2016-01-20 | 天津药物研究院 | 四水合达比加群酯晶体及其制备方法和药物用途 |
CN103864756B (zh) * | 2012-12-11 | 2018-06-15 | 四川海思科制药有限公司 | 丁二磺酸达比加群酯及其制备方法和用途 |
WO2014178017A1 (en) | 2013-04-30 | 2014-11-06 | Ranbaxy Laboratories Limited | Dabigatran etexilate impurity, process of its preparation, and its use as a reference standard |
WO2015124764A1 (en) | 2014-02-24 | 2015-08-27 | Erregierre S.P.A. | Synthesis process of dabigatran etexilate mesylate, intermediates of the process and novel polymorph of dabigatran etexilate |
WO2015128875A2 (en) | 2014-02-26 | 2015-09-03 | Megafine Pharma (P) Ltd. | A process for preparation of dabigatran etexilate mesylate and intermediates thereof |
CN104892574A (zh) * | 2014-03-04 | 2015-09-09 | 浙江海正药业股份有限公司 | 达比加群酯甲磺酸盐的晶型及其制备方法和用途 |
CN104974137A (zh) * | 2014-04-04 | 2015-10-14 | 江苏天士力帝益药业有限公司 | 达比加群酯甲磺酸盐新晶型及其制备方法 |
WO2017037743A2 (en) * | 2015-09-03 | 2017-03-09 | Sun Pharmaceutical Industries Limited | Dabigatran etexilate 1,4-butanedisulfonate salt and its crystal form |
CN105859686B (zh) | 2016-05-24 | 2021-10-08 | 浙江华海药业股份有限公司 | 一种达比加群酯游离碱的精制方法 |
CN106349221A (zh) * | 2016-08-29 | 2017-01-25 | 常州市阳光药业有限公司 | 高纯度达比加群酯的制备方法 |
CN107778291A (zh) * | 2016-08-31 | 2018-03-09 | 亚宝药业集团股份有限公司 | 一种甲磺酸达比加群酯晶型ⅱ的制备方法 |
JP2020193184A (ja) * | 2019-05-30 | 2020-12-03 | ダイト株式会社 | ダビガトランエテキシラートメタンスルホン酸塩の形態iの製造方法 |
Family Cites Families (9)
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US4675405A (en) * | 1984-09-21 | 1987-06-23 | American Home Products Corporation | Quinoline compounds as antiallergic and antithrombotic agents |
US5416099A (en) * | 1991-10-29 | 1995-05-16 | Merck & Co., Inc. | Fibrinogen receptor antagonists |
DE4421052A1 (de) * | 1994-06-17 | 1995-12-21 | Basf Ag | Neue Thrombininhibitoren, ihre Herstellung und Verwendung |
PE121699A1 (es) * | 1997-02-18 | 1999-12-08 | Boehringer Ingelheim Pharma | Heterociclos biciclicos disustituidos como inhibidores de la trombina |
US6414008B1 (en) * | 1997-04-29 | 2002-07-02 | Boehringer Ingelheim Pharma Kg | Disubstituted bicyclic heterocycles, the preparation thereof, and their use as pharmaceutical compositions |
US6627646B2 (en) * | 2001-07-17 | 2003-09-30 | Sepracor Inc. | Norastemizole polymorphs |
PT1870100E (pt) | 2002-03-07 | 2012-04-17 | Boehringer Ingelheim Int | Metanossulfonato de 3-[(2-{[4-(hexiloxicarbonilamino-iminometil)- fenilamino]-metil}-1-metil-1h-benzimidazol-5-carbonil)- piridin-2-il-amino]-propionato de etilo |
DE10235639A1 (de) * | 2002-08-02 | 2004-02-19 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Neue Prodrugs von 1-Methyl-2-(4-amidinophenylaminomethyl)-benzimidazol-5-yl-carbonsäure-(N-2-pyridyl-N-2-hydroxycarbonylethyl)-amid, ihre Herstellung und ihre Verwendung als Arzneimittel |
DE10339862A1 (de) * | 2003-08-29 | 2005-03-24 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | 3-[(2-{[4-(Hexyloxycarbonylamino-imino-methyl)- phenylamino]-methyl}-1-methyl-1H-benzimidazol-5-carbonyl)-pyridin-2-yl-amino]-propionsäure-ethylester-Methansulfonat und dessen Verwendung als Arzneimittel |
-
2005
- 2005-06-04 DE DE102005025728A patent/DE102005025728A1/de not_active Withdrawn
-
2006
- 2006-05-31 US US11/421,153 patent/US20060276513A1/en not_active Abandoned
- 2006-06-01 UA UAA200714329A patent/UA92349C2/ru unknown
- 2006-06-01 AU AU2006256778A patent/AU2006256778A1/en not_active Abandoned
- 2006-06-01 BR BRPI0611099-1A patent/BRPI0611099A2/pt not_active IP Right Cessation
- 2006-06-01 EP EP09157302A patent/EP2088146A3/de not_active Withdrawn
- 2006-06-01 UY UY29575A patent/UY29575A1/es not_active Application Discontinuation
- 2006-06-01 CA CA002609583A patent/CA2609583A1/en not_active Abandoned
- 2006-06-01 EP EP06763468A patent/EP1891046A1/de not_active Ceased
- 2006-06-01 EP EP10180840A patent/EP2305665A1/de not_active Withdrawn
- 2006-06-01 WO PCT/EP2006/062847 patent/WO2006131491A1/de active Application Filing
- 2006-06-01 NZ NZ564621A patent/NZ564621A/en not_active IP Right Cessation
- 2006-06-01 MX MX2007014892A patent/MX2007014892A/es not_active Application Discontinuation
- 2006-06-01 EA EA200702541A patent/EA014082B1/ru not_active IP Right Cessation
- 2006-06-01 CN CN2006800197579A patent/CN101189224B/zh not_active Expired - Fee Related
- 2006-06-01 JP JP2008514111A patent/JP2008545734A/ja active Pending
- 2006-06-01 KR KR1020087000286A patent/KR20080021763A/ko not_active Application Discontinuation
- 2006-06-02 PE PE2006000604A patent/PE20070082A1/es not_active Application Discontinuation
- 2006-06-02 AR AR20060102306A patent/AR054278A1/es unknown
- 2006-06-02 TW TW095119674A patent/TW200716107A/zh unknown
-
2007
- 2007-11-12 ZA ZA200709715A patent/ZA200709715B/xx unknown
- 2007-11-15 NO NO20075862A patent/NO20075862L/no not_active Application Discontinuation
- 2007-12-03 IL IL187845A patent/IL187845A0/en unknown
- 2007-12-05 EC EC2007007981A patent/ECSP077981A/es unknown
Also Published As
Publication number | Publication date |
---|---|
EA014082B1 (ru) | 2010-08-30 |
UY29575A1 (es) | 2006-12-29 |
NO20075862L (no) | 2008-02-26 |
EP2088146A2 (de) | 2009-08-12 |
EA200702541A1 (ru) | 2008-06-30 |
DE102005025728A1 (de) | 2006-12-07 |
EP1891046A1 (de) | 2008-02-27 |
IL187845A0 (en) | 2008-03-20 |
UA92349C2 (ru) | 2010-10-25 |
JP2008545734A (ja) | 2008-12-18 |
WO2006131491A8 (de) | 2007-12-27 |
AU2006256778A8 (en) | 2008-03-13 |
US20060276513A1 (en) | 2006-12-07 |
KR20080021763A (ko) | 2008-03-07 |
TW200716107A (en) | 2007-05-01 |
BRPI0611099A2 (pt) | 2010-08-10 |
CN101189224B (zh) | 2012-03-28 |
EP2305665A1 (de) | 2011-04-06 |
WO2006131491A1 (de) | 2006-12-14 |
AR054278A1 (es) | 2007-06-13 |
CA2609583A1 (en) | 2006-12-14 |
ECSP077981A (es) | 2008-01-23 |
ZA200709715B (en) | 2008-10-29 |
PE20070082A1 (es) | 2007-01-16 |
EP2088146A3 (de) | 2009-10-28 |
CN101189224A (zh) | 2008-05-28 |
NZ564621A (en) | 2011-03-31 |
AU2006256778A1 (en) | 2006-12-14 |
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Legal Events
Date | Code | Title | Description |
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FA | Abandonment or withdrawal |