MX2007004191A - Metodo para depurar derivados de 3-hidroxi-amidino-fenilalanina mediante la precipitacion y recristalizacion de una sal con un acido sulfonico aromatico. - Google Patents
Metodo para depurar derivados de 3-hidroxi-amidino-fenilalanina mediante la precipitacion y recristalizacion de una sal con un acido sulfonico aromatico.Info
- Publication number
- MX2007004191A MX2007004191A MX2007004191A MX2007004191A MX2007004191A MX 2007004191 A MX2007004191 A MX 2007004191A MX 2007004191 A MX2007004191 A MX 2007004191A MX 2007004191 A MX2007004191 A MX 2007004191A MX 2007004191 A MX2007004191 A MX 2007004191A
- Authority
- MX
- Mexico
- Prior art keywords
- hydroxyamidinophenylalanine
- derivatives
- cleaning
- sulphonic acid
- recrystallisation
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
- C07D295/20—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carbonic acid, or sulfur or nitrogen analogues thereof
- C07D295/205—Radicals derived from carbonic acid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
- C07D295/20—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carbonic acid, or sulfur or nitrogen analogues thereof
Abstract
La invencion se refiere a un metodo para purificar derivados de 3-hidroxiamidinofenilalanina que comprende las etapas de: (a) adicionar un acido sulfonico aromatico a una solucion de un derivado de 3-hidroxiamidinofenilalanina eventualmente contaminado para formar un precipitado, (b) separar el precipitado que se forma en la etapa (a), y ( c ) recuperar del precipitado el derivado de 3-hidroxiamidinofenilalanina libre. Los derivados de 3-hidroxiamidinofenilalanina se pueden usar, por ejemplo, como inhibidores de la urocinasa. La presente invencion se refiere ademas al uso de derivados de 3- hidroxiamidinofenilalanina con alto grado de pureza para la produccion de derivados de 3-amidinofenilalanina.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP04024553 | 2004-10-14 | ||
PCT/EP2005/010970 WO2006042678A1 (de) | 2004-10-14 | 2005-10-14 | Verfahren zur reinigung von 3-hydroxy-amidino-phenylalanin-derivaten durch ausfällung und umkristallisation eines salzes mit einer aromatischen sulfonsäure |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2007004191A true MX2007004191A (es) | 2007-06-11 |
Family
ID=35462142
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2007004191A MX2007004191A (es) | 2004-10-14 | 2005-10-14 | Metodo para depurar derivados de 3-hidroxi-amidino-fenilalanina mediante la precipitacion y recristalizacion de una sal con un acido sulfonico aromatico. |
Country Status (16)
Country | Link |
---|---|
US (1) | US7951943B2 (es) |
EP (1) | EP1799665B1 (es) |
JP (1) | JP5096157B2 (es) |
KR (1) | KR101106652B1 (es) |
CN (1) | CN101039928B (es) |
AT (1) | ATE440092T1 (es) |
AU (1) | AU2005297610B2 (es) |
BR (1) | BRPI0516106B1 (es) |
CA (1) | CA2583771C (es) |
DE (1) | DE502005007959D1 (es) |
ES (1) | ES2328052T3 (es) |
HK (1) | HK1101170A1 (es) |
MX (1) | MX2007004191A (es) |
RU (1) | RU2391336C2 (es) |
SG (1) | SG156645A1 (es) |
WO (1) | WO2006042678A1 (es) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR20220151613A (ko) | 2020-03-10 | 2022-11-15 | 레드힐 바이오파마 엘티디 | 코로나바이러스 감염의 치료 |
US11471448B2 (en) | 2020-12-15 | 2022-10-18 | Redhill Biopharma Ltd. | Sphingosine kinase 2 inhibitor for treating coronavirus infection in moderately severe patients with pneumonia |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4375430A (en) * | 1981-09-08 | 1983-03-01 | Pfizer Inc. | Processes for preparation, isolation and purification of dipeptide sweeteners |
JPH10237030A (ja) * | 1997-02-26 | 1998-09-08 | Ajinomoto Co Inc | 分岐鎖アミノ酸の精製法 |
JP4414652B2 (ja) * | 2001-03-21 | 2010-02-10 | ヴィレックス アクチェンゲゼルシャフト | ウロキナーゼ阻害剤 |
SI21137A (sl) | 2002-01-24 | 2003-08-31 | LEK, tovarna farmacevtskih in kemičnih izdelkov, d.d. | Derivati azafenilalanina |
CH695999A5 (de) * | 2002-02-28 | 2006-11-15 | Wilex Ag | Verfahren zur Herstellung von 3- Amidinophenylalanin-Derivaten. |
-
2005
- 2005-10-14 WO PCT/EP2005/010970 patent/WO2006042678A1/de active Application Filing
- 2005-10-14 ES ES05790930T patent/ES2328052T3/es active Active
- 2005-10-14 RU RU2007117751/04A patent/RU2391336C2/ru active
- 2005-10-14 KR KR1020077010741A patent/KR101106652B1/ko active IP Right Grant
- 2005-10-14 SG SG200906861-0A patent/SG156645A1/en unknown
- 2005-10-14 DE DE502005007959T patent/DE502005007959D1/de active Active
- 2005-10-14 MX MX2007004191A patent/MX2007004191A/es active IP Right Grant
- 2005-10-14 AU AU2005297610A patent/AU2005297610B2/en not_active Ceased
- 2005-10-14 CA CA2583771A patent/CA2583771C/en active Active
- 2005-10-14 BR BRPI0516106-1A patent/BRPI0516106B1/pt not_active IP Right Cessation
- 2005-10-14 CN CN2005800350199A patent/CN101039928B/zh active Active
- 2005-10-14 US US11/576,978 patent/US7951943B2/en not_active Expired - Fee Related
- 2005-10-14 JP JP2007536080A patent/JP5096157B2/ja not_active Expired - Fee Related
- 2005-10-14 EP EP05790930A patent/EP1799665B1/de not_active Not-in-force
- 2005-10-14 AT AT05790930T patent/ATE440092T1/de active
-
2007
- 2007-08-22 HK HK07109145.8A patent/HK1101170A1/xx unknown
Also Published As
Publication number | Publication date |
---|---|
CN101039928A (zh) | 2007-09-19 |
BRPI0516106A (pt) | 2008-08-26 |
ES2328052T3 (es) | 2009-11-06 |
US20090099360A9 (en) | 2009-04-16 |
US7951943B2 (en) | 2011-05-31 |
RU2007117751A (ru) | 2008-11-20 |
JP2008516908A (ja) | 2008-05-22 |
EP1799665B1 (de) | 2009-08-19 |
KR20070063591A (ko) | 2007-06-19 |
RU2391336C2 (ru) | 2010-06-10 |
WO2006042678A1 (de) | 2006-04-27 |
EP1799665A1 (de) | 2007-06-27 |
JP5096157B2 (ja) | 2012-12-12 |
BRPI0516106B1 (pt) | 2021-08-24 |
CA2583771C (en) | 2013-08-27 |
AU2005297610A1 (en) | 2006-04-27 |
CA2583771A1 (en) | 2006-04-27 |
ATE440092T1 (de) | 2009-09-15 |
KR101106652B1 (ko) | 2012-01-18 |
US20080039626A1 (en) | 2008-02-14 |
SG156645A1 (en) | 2009-11-26 |
CN101039928B (zh) | 2010-12-08 |
AU2005297610B2 (en) | 2011-05-19 |
HK1101170A1 (en) | 2007-10-12 |
DE502005007959D1 (de) | 2009-10-01 |
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Legal Events
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FG | Grant or registration |