MX2007003793A - Antagonistas del receptor 2 de citocina quimioatrayente de dipiperidina sustituida. - Google Patents
Antagonistas del receptor 2 de citocina quimioatrayente de dipiperidina sustituida.Info
- Publication number
- MX2007003793A MX2007003793A MX2007003793A MX2007003793A MX2007003793A MX 2007003793 A MX2007003793 A MX 2007003793A MX 2007003793 A MX2007003793 A MX 2007003793A MX 2007003793 A MX2007003793 A MX 2007003793A MX 2007003793 A MX2007003793 A MX 2007003793A
- Authority
- MX
- Mexico
- Prior art keywords
- substituted
- dipiperdine
- ccr2 antagonists
- ccr2
- antagonists
- Prior art date
Links
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
Abstract
Los compuestos de dipiperidina sustituida de formula (1) o su sal, isomero, profarmaco, metabolito o polimorfo, que son antagonistas de CCR2 y son utiles en la prevencion, tratamiento o mejora de sindromes inflamatorios, trastornos o enfermedades mediados por CCR2 en un sujeto en necesidad del mismo. (ver formula).
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US61392204P | 2004-09-28 | 2004-09-28 | |
PCT/US2005/032500 WO2006036527A1 (en) | 2004-09-28 | 2005-09-12 | Substituted dipiperdine ccr2 antagonists |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2007003793A true MX2007003793A (es) | 2007-07-11 |
Family
ID=35788241
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2007003793A MX2007003793A (es) | 2004-09-28 | 2005-09-12 | Antagonistas del receptor 2 de citocina quimioatrayente de dipiperidina sustituida. |
Country Status (18)
Country | Link |
---|---|
US (1) | US20060069123A1 (es) |
EP (1) | EP1802602A1 (es) |
JP (1) | JP2008514700A (es) |
KR (1) | KR20070063562A (es) |
CN (1) | CN101065374A (es) |
AR (1) | AR053413A1 (es) |
AU (1) | AU2005290028A1 (es) |
BR (1) | BRPI0516166A (es) |
CA (1) | CA2582225A1 (es) |
CR (1) | CR9088A (es) |
EA (1) | EA200700757A1 (es) |
EC (1) | ECSP077358A (es) |
IL (1) | IL182254A0 (es) |
MX (1) | MX2007003793A (es) |
NO (1) | NO20072065L (es) |
TW (1) | TW200621707A (es) |
WO (1) | WO2006036527A1 (es) |
ZA (1) | ZA200702544B (es) |
Families Citing this family (48)
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WO2007130712A1 (en) * | 2006-01-31 | 2007-11-15 | Janssen Pharmaceutica, Nv | Substituted dipiperidine as ccr2 antagonists for the treatment of inflammatory diseases |
US20070219245A1 (en) * | 2006-03-14 | 2007-09-20 | Cuifen Hou | Method of use for substituted dipiperidine ccr2 antagonists |
US7629351B2 (en) * | 2006-07-28 | 2009-12-08 | Bristol-Myers Squibb Company | N-((1R,2S,5R)-5-(tert-butylamino)-2-((S)-2-oxo-3-(6-(trifluoromethyl)quinazolin-4-ylamino) pyrrolidin-1-yl)cyclohexyl)acetamide and other modulators of chemokine receptor activity, crystalline forms and process |
US7687508B2 (en) * | 2006-07-28 | 2010-03-30 | Bristol-Myers Squibb Company | Cyclic derivatives as modulators of chemokine receptor activity |
US7671062B2 (en) * | 2006-07-28 | 2010-03-02 | Bristol-Myers Squibb Company | Modulators of chemokine receptor activity, crystalline forms and process |
US20080076120A1 (en) * | 2006-09-14 | 2008-03-27 | Millennium Pharmaceuticals, Inc. | Methods for the identification, evaluation and treatment of patients having CC-Chemokine receptor 2 (CCR-2) mediated disorders |
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TW201033204A (en) * | 2008-12-10 | 2010-09-16 | Janssen Pharmaceutica Nv | 4-azetidinyl-1-heteroaryl-cyclohexanol antagonists of CCR2 |
JP5685580B2 (ja) * | 2009-04-16 | 2015-03-18 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプJanssen Pharmaceutica Naamloze Vennootschap | Ccr2の4−アゼチジニル−1−ヘテロアリール−シクロヘキサンアンタゴニスト |
US20100267689A1 (en) * | 2009-04-17 | 2010-10-21 | Xuqing Zhang | 4-azetidinyl-1-phenyl-cyclohexane antagonists of ccr2 |
JP5685581B2 (ja) * | 2009-04-17 | 2015-03-18 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプJanssen Pharmaceutica Naamloze Vennootschap | Ccr2の4−アゼチジニル−1−ヘテロ原子結合シクロヘキサンアンタゴニスト |
KR101151415B1 (ko) | 2009-07-10 | 2012-06-01 | 양지화학 주식회사 | Ccr2 길항제로서의 피페라지닐에틸 3-아미노피롤리딘 유도체 |
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US9962251B2 (en) | 2013-10-17 | 2018-05-08 | Boston Scientific Scimed, Inc. | Devices and methods for delivering implants |
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AU2015296215A1 (en) | 2014-08-01 | 2017-03-23 | Pharmacyclics Llc | Inhibitors of bruton's tyrosine kinase |
CN106573002A (zh) | 2014-08-07 | 2017-04-19 | 药品循环有限责任公司 | 布鲁顿氏酪氨酸激酶抑制剂的新型制剂 |
DK3050574T3 (da) | 2015-01-28 | 2020-01-20 | Univ Bordeaux | Anvendelse af plerixafor til behandling og/eller forebyggelse af akutte forværringer af kronisk obstruktiv lungesygdom |
TW202315634A (zh) | 2015-03-03 | 2023-04-16 | 美商製藥公司 | 布魯東氏(bruton’s)酪胺酸激酶抑制劑之醫藥調配物 |
WO2019200181A1 (en) | 2018-04-11 | 2019-10-17 | Ohio State Innovation Foundation | Methods and compositions for sustained release microparticles for ocular drug delivery |
WO2020048830A1 (en) | 2018-09-03 | 2020-03-12 | Bayer Aktiengesellschaft | 5-aryl-3,9-diazaspiro[5.5]undecan-2-one compounds |
WO2020048831A1 (en) | 2018-09-03 | 2020-03-12 | Bayer Aktiengesellschaft | 5-aryl-3,9-diazaspiro[5.5]undecan-2-one compounds |
WO2020048828A1 (en) | 2018-09-03 | 2020-03-12 | Bayer Pharma Aktiengesellschaft | 5-heteroaryl-3,9-diazaspiro[5.5]undecane compounds |
Family Cites Families (2)
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GB9803228D0 (en) * | 1998-02-17 | 1998-04-08 | Zeneca Ltd | Chemical compounds |
GB0107907D0 (en) * | 2001-03-29 | 2001-05-23 | Smithkline Beecham Plc | Novel compounds |
-
2005
- 2005-09-12 KR KR1020077009314A patent/KR20070063562A/ko not_active Application Discontinuation
- 2005-09-12 EP EP05797411A patent/EP1802602A1/en not_active Withdrawn
- 2005-09-12 MX MX2007003793A patent/MX2007003793A/es unknown
- 2005-09-12 CA CA002582225A patent/CA2582225A1/en not_active Abandoned
- 2005-09-12 BR BRPI0516166-5A patent/BRPI0516166A/pt not_active IP Right Cessation
- 2005-09-12 AU AU2005290028A patent/AU2005290028A1/en not_active Abandoned
- 2005-09-12 JP JP2007534623A patent/JP2008514700A/ja active Pending
- 2005-09-12 US US11/224,215 patent/US20060069123A1/en not_active Abandoned
- 2005-09-12 EA EA200700757A patent/EA200700757A1/ru unknown
- 2005-09-12 CN CNA2005800403016A patent/CN101065374A/zh active Pending
- 2005-09-12 WO PCT/US2005/032500 patent/WO2006036527A1/en active Application Filing
- 2005-09-27 TW TW094133431A patent/TW200621707A/zh unknown
- 2005-09-27 AR ARP050104063A patent/AR053413A1/es not_active Application Discontinuation
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2007
- 2007-03-27 IL IL182254A patent/IL182254A0/en unknown
- 2007-03-27 ZA ZA200702544A patent/ZA200702544B/xx unknown
- 2007-03-28 EC EC2007007358A patent/ECSP077358A/es unknown
- 2007-04-23 NO NO20072065A patent/NO20072065L/no not_active Application Discontinuation
- 2007-04-27 CR CR9088A patent/CR9088A/es unknown
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JP2008514700A (ja) | 2008-05-08 |
CA2582225A1 (en) | 2006-04-06 |
AR053413A1 (es) | 2007-05-09 |
EA200700757A1 (ru) | 2007-10-26 |
CN101065374A (zh) | 2007-10-31 |
ECSP077358A (es) | 2007-04-26 |
AU2005290028A1 (en) | 2006-04-06 |
BRPI0516166A (pt) | 2008-08-26 |
CR9088A (es) | 2008-09-09 |
US20060069123A1 (en) | 2006-03-30 |
EP1802602A1 (en) | 2007-07-04 |
IL182254A0 (en) | 2007-09-20 |
WO2006036527A1 (en) | 2006-04-06 |
KR20070063562A (ko) | 2007-06-19 |
NO20072065L (no) | 2007-06-15 |
TW200621707A (en) | 2006-07-01 |
ZA200702544B (en) | 2008-09-25 |
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