AR053413A1 - Antagonistas dipiperidinicos sustituidos del ccr2, composicion farmaceutica, su preparacion y uso del compuesto para preparar medicamentos - Google Patents

Antagonistas dipiperidinicos sustituidos del ccr2, composicion farmaceutica, su preparacion y uso del compuesto para preparar medicamentos

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Publication number
AR053413A1
AR053413A1 ARP050104063A ARP050104063A AR053413A1 AR 053413 A1 AR053413 A1 AR 053413A1 AR P050104063 A ARP050104063 A AR P050104063A AR P050104063 A ARP050104063 A AR P050104063A AR 053413 A1 AR053413 A1 AR 053413A1
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Argentina
Prior art keywords
alkyl
carbonylalkoxy
acyl
alkoxy
aryl
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ARP050104063A
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English (en)
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Janssen Pharmaceutica Nv
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Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of AR053413A1 publication Critical patent/AR053413A1/es

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    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
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    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Cardiology (AREA)
  • Epidemiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Diabetes (AREA)
  • Ophthalmology & Optometry (AREA)
  • Dermatology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Rheumatology (AREA)
  • Neurosurgery (AREA)
  • Otolaryngology (AREA)
  • Pain & Pain Management (AREA)
  • Hospice & Palliative Care (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Obesity (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Transplantation (AREA)
  • Orthopedic Medicine & Surgery (AREA)

Abstract

Compuestos de dipiperidina sustituidos de formula (1) o sus sales, isomeros, profármacos, metabolitos o polimorfos, los cuales son antagonistas del CCR2 y son utiles en la prevencion, tratamiento o alivio de síndromes, trastornos o enfermedades inflamatorias mediados por CCR2 en un sujeto que lo necesita Reivindicacion 1: Un compuesto de la formula (1) o sus sales, isomeros, profármacos, metabolitos o polimorfos, donde X1 está ausente, es alquilo, carbonilo, alquilcarbamoílo o alquilcarbamoilalquilo, R1 es arilo o heteociclilo, donde heterociclilo tiene un átomo de nitrogeno opcionalmente presente y donde el átomo de nitrogeno está opcionalmente oxidado, y donde arilo y heterociclilo están cada uno opcionalmente sustituido con uno o más de alquilo, alcoxi, ciano, halogeno, hidroxi, hidroxialquilo, nitro, amino (opcionalmente sustituido con uno o más de alquilo, acilo, carbonilalcoxi, sulfonilalquilo, alquilcarboxi o alquilcabonilalcoxi), alquilcarboxi, alquilcarbonilalcoxi, alcoxicarboxi, alcoxicarbonilalcoxi, alquilamino, alquilaminoalquilo, sulfonilamino, sulfonilaminoalquilo, alquilsulfonilamino, alquilsulfonilaminoalquilo, carboxi, acilo, carbonilalcoxi, carbamoílo o carbamoilalquilo. X2 está ausente o es alquilo, R2 es hidroxi, halogeno, amino (opcionalmente sustituido con uno o más de alquilo, formilo, acilo, sulfonilalquilo o carboniloxi), ciano, nitro, alcoxi, carboxi, carbonilalcoxi, oxiacilo, oxiacilarilo, oxiacrililo, oxiacrilarilo (opcionalmente sustituido en arilo con uno o más de alquilo, alcoxi, ciano, halogeno, hidroxi, nitro, amino o aminoalquilo), oxicarbonilalcoxi, aminoacilamino, aminoacilaminoalquilo, carbamoílo, carbamoilalquilo, urea o ureaalquilo. X3 es carbonilo, carboxilo, acilo, acilos, acrililo, carbonilalquinilo, carbonilalcoxi, carbamoílo, carbamoilalquilo, alquilcarbamoílo, tiocabamilo o iminometilaminocarbonilo, donde cuando X3 es carbonilalcoxi, entonces R3 está opcionalmente presente, y R3 es cicloalquilo, arilo, o heterocililo cada uno opcionalmente sustituido con uno o más de alquilo, alcoxi, ciano, halogeno, alquiltrihalo, alcoxitrihalo, hidroxi, nitro, amino, aminoalquilo, alquilamino, alquilaminoalquilo, tioalquilo, tioalquiltrihalo, carboxi, acilo, carbonilalcoxi, carbamoílo, carbamoilalquilo o arilo (opcionalmente sustituido en arilo con uno o más de alquilo, alcoxi, halogeno, hidroxi, nitro amino aminoalquilo)
ARP050104063A 2004-09-28 2005-09-27 Antagonistas dipiperidinicos sustituidos del ccr2, composicion farmaceutica, su preparacion y uso del compuesto para preparar medicamentos AR053413A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US61392204P 2004-09-28 2004-09-28

Publications (1)

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AR053413A1 true AR053413A1 (es) 2007-05-09

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ID=35788241

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ARP050104063A AR053413A1 (es) 2004-09-28 2005-09-27 Antagonistas dipiperidinicos sustituidos del ccr2, composicion farmaceutica, su preparacion y uso del compuesto para preparar medicamentos

Country Status (18)

Country Link
US (1) US20060069123A1 (es)
EP (1) EP1802602A1 (es)
JP (1) JP2008514700A (es)
KR (1) KR20070063562A (es)
CN (1) CN101065374A (es)
AR (1) AR053413A1 (es)
AU (1) AU2005290028A1 (es)
BR (1) BRPI0516166A (es)
CA (1) CA2582225A1 (es)
CR (1) CR9088A (es)
EA (1) EA200700757A1 (es)
EC (1) ECSP077358A (es)
IL (1) IL182254A0 (es)
MX (1) MX2007003793A (es)
NO (1) NO20072065L (es)
TW (1) TW200621707A (es)
WO (1) WO2006036527A1 (es)
ZA (1) ZA200702544B (es)

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US7671062B2 (en) * 2006-07-28 2010-03-02 Bristol-Myers Squibb Company Modulators of chemokine receptor activity, crystalline forms and process
US20080076120A1 (en) * 2006-09-14 2008-03-27 Millennium Pharmaceuticals, Inc. Methods for the identification, evaluation and treatment of patients having CC-Chemokine receptor 2 (CCR-2) mediated disorders
SI2530083T1 (sl) 2006-09-22 2016-09-30 Pharmacyclics Llc Inhibitorji Bruton tirozin kinaze
WO2008109238A1 (en) * 2007-03-02 2008-09-12 Janssen Pharmaceutica N.V. Substituted cyclopentyl piperidine ccr2 antagonists
US8809273B2 (en) 2007-03-28 2014-08-19 Pharmacyclics, Inc. Inhibitors of Bruton's tyrosine kinase
AU2008232762B2 (en) * 2007-03-28 2013-09-19 Pharmacyclics Llc Inhibitors of Bruton's tyrosine kinase
CL2008001810A1 (es) * 2007-06-20 2008-12-26 Glaxo Group Ltd Compuestos derivados de espiroindolinas, moduladores de receptores de quimiocinas; composicion farmaceutica que comprende a dichos compuestos; y su uso para tratar aterosclerosis, dolor inflamatorio, influenza, sindrome metabolico, entre otras enfermedades.
WO2009061881A1 (en) * 2007-11-07 2009-05-14 Glaxo Group Limited Spirodihydrobenzofurans as modulators of chemokine receptors
WO2009076404A1 (en) * 2007-12-10 2009-06-18 Epix Delaware, Inc. Carboxamide compounds and their use as antagonists of the chemokine ccr2 receptor
WO2009076512A1 (en) 2007-12-11 2009-06-18 Epix Delaware, Inc. Carboxamidξ compounds and their use as chemokine receptor agonists
WO2010008761A1 (en) * 2008-06-23 2010-01-21 Janssen Pharmaceutica Nv Piperidyl acrylamide antogonists of ccr2
CN102159214A (zh) 2008-07-16 2011-08-17 药品循环公司 用于实体肿瘤的治疗的布鲁顿酪氨酸激酶的抑制剂
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