MX2007001505A - Fragmentos de arnt sintetasa. - Google Patents
Fragmentos de arnt sintetasa.Info
- Publication number
- MX2007001505A MX2007001505A MX2007001505A MX2007001505A MX2007001505A MX 2007001505 A MX2007001505 A MX 2007001505A MX 2007001505 A MX2007001505 A MX 2007001505A MX 2007001505 A MX2007001505 A MX 2007001505A MX 2007001505 A MX2007001505 A MX 2007001505A
- Authority
- MX
- Mexico
- Prior art keywords
- trna synthetase
- synthetase fragments
- methods
- angiogenesis
- fragments
- Prior art date
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/53—Ligases (6)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/93—Ligases (6)
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Genetics & Genomics (AREA)
- Dermatology (AREA)
- Immunology (AREA)
- Rheumatology (AREA)
- Molecular Biology (AREA)
- General Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Epidemiology (AREA)
- Biotechnology (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Ophthalmology & Optometry (AREA)
- Endocrinology (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Physical Education & Sports Medicine (AREA)
- Reproductive Health (AREA)
- Cardiology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Pain & Pain Management (AREA)
Abstract
La presente invencion se refiere a composiciones y procedimientos para tratar afecciones asociadas con la angiogenesis. En particular, la presente invencion se refiere a complejos multi-unidad de fragmentos de ARNt sintetasa y a usos de los mismos; a diversos complejos multi-unidad que incluyen un fragmento de ARNt sintetasa; a composiciones y procedimientos para modular la angiogenesis; a polinucleotidos que codifican fragmentos de ARNt sintetasa y a usos de los mismos; a anticuerpos y epitopes especificos para fragmentos de ARNt sintetasa; a variantes de fragmentos de ARNt sintetasa y a usos de los mismos; a procedimientos para el tratamiento de la angiogenesis; a procedimientos para seleccionar agentes anti-angiogenicos; a procedimientos para modular la angiogenesis; a kits para modular la angiogenesis; y a procedimientos comerciales para modular la angiogenesis. Preferiblemente, los fragmentos de ARNTt sintetasa son fragmentos de triptofanil ARNt sintetasa, y mas preferiblemente fragmentos de triptofanil ARNt sintetasa humana.
Applications Claiming Priority (15)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US59801904P | 2004-08-02 | 2004-08-02 | |
US10/962,217 US20060079673A1 (en) | 2004-08-02 | 2004-10-07 | Polynucleotides encoding tRNA synthetase fragments and uses thereof |
US10/961,526 US20060079672A1 (en) | 2004-10-07 | 2004-10-07 | Kits for modulating angiogenesis |
US10/962,171 US20060079473A1 (en) | 2004-10-07 | 2004-10-07 | Multi-unit complexes and uses thereof |
US10/962,375 US20060078553A1 (en) | 2004-10-07 | 2004-10-07 | Diverse multi-unit complexes including a tRNA synthetase fragment |
US10/961,486 US20060078886A1 (en) | 2004-10-07 | 2004-10-07 | Business methods for modulating angiogenesis |
US10/962,062 US20060078556A1 (en) | 2004-10-07 | 2004-10-07 | Antibodies and epitopes specific to tRNA synthetase fragments |
US10/961,529 US20060079441A1 (en) | 2004-10-07 | 2004-10-07 | Methods of modulating angiogenesis |
US10/961,528 US20060078887A1 (en) | 2004-10-07 | 2004-10-07 | Methods for screening for anti-angiogenic agents |
US10/962,218 US20060079474A1 (en) | 2004-10-07 | 2004-10-07 | Analogs of tRNA synthetase fragments and uses thereof |
US10/962,058 US20060079472A1 (en) | 2004-10-07 | 2004-10-07 | Methods for treating angiogenesis |
US62465604P | 2004-11-02 | 2004-11-02 | |
US10/980,866 US20060024286A1 (en) | 2004-08-02 | 2004-11-02 | Variants of tRNA synthetase fragments and uses thereof |
US11/019,969 US20060024287A1 (en) | 2004-08-02 | 2004-12-20 | Compositions and methods for modulating angiogenesis |
PCT/IB2005/002180 WO2006016217A1 (en) | 2004-08-02 | 2005-07-21 | tRNA SYNTHETASE FRAGMENTS |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2007001505A true MX2007001505A (es) | 2007-06-11 |
Family
ID=35839163
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2007001505A MX2007001505A (es) | 2004-08-02 | 2005-07-21 | Fragmentos de arnt sintetasa. |
Country Status (8)
Country | Link |
---|---|
US (1) | US20060079673A1 (es) |
EP (1) | EP1776138B1 (es) |
JP (1) | JP4938661B2 (es) |
AT (1) | ATE446105T1 (es) |
CA (1) | CA2575694C (es) |
ES (1) | ES2332799T3 (es) |
MX (1) | MX2007001505A (es) |
WO (1) | WO2006016217A1 (es) |
Families Citing this family (40)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8282921B2 (en) * | 2004-08-02 | 2012-10-09 | Paul Glidden | tRNA synthetase fragments |
JP4777225B2 (ja) * | 2006-12-04 | 2011-09-21 | キヤノン株式会社 | 吐出用液体及び吐出方法 |
MX2010013632A (es) | 2008-06-11 | 2011-06-16 | Atyr Pharma Inc | Actividad trombopoyetica de polipeptidos de tirosil-arnt sintetasa. |
JP5756751B2 (ja) | 2008-06-26 | 2015-07-29 | エータイアー ファーマ, インコーポレイテッド | 非正準的な生物学的活性を有するグリシル−tRNA合成酵素を含む組成物および方法 |
ES2552773T3 (es) | 2009-02-27 | 2015-12-02 | Atyr Pharma, Inc. | Motivos estructurales de polipéptidos asociados con la actividad de señalización celular |
AU2010226726B8 (en) | 2009-03-16 | 2014-08-14 | Pangu Biopharma Limited | Compositions and methods comprising histidyl-tRNA synthetase splice variants having non-canonical biological activities |
CN102449143B (zh) * | 2009-03-31 | 2017-11-14 | Atyr医药公司 | 包含具有非常规生物活性的天冬氨酰‑tRNA合成酶的组合物和方法 |
US20120252718A1 (en) * | 2009-10-06 | 2012-10-04 | The Trustees Of The University Of Pennsylvania | Compositions and Methods for Regulating Cytochrome c-Mediated Apoptosis by tRNA |
US8828395B2 (en) | 2009-12-11 | 2014-09-09 | Atyr Pharma, Inc. | Antibodies that bind tyrosyl-tRNA synthetases |
EP2939689B1 (en) | 2009-12-11 | 2017-09-13 | aTyr Pharma, Inc. | Glutaminyl tRNA synthetases for use in the treatment of inflammatory disorders |
CN103118692A (zh) | 2010-04-26 | 2013-05-22 | Atyr医药公司 | 与半胱氨酰-tRNA合成酶的蛋白片段相关的治疗、诊断和抗体组合物的创新发现 |
US8986681B2 (en) | 2010-04-27 | 2015-03-24 | Atyr Pharma, Inc. | Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of threonyl-tRNA synthetases |
JP6294074B2 (ja) | 2010-04-27 | 2018-03-14 | エータイアー ファーマ, インコーポレイテッド | イソロイシルtRNA合成酵素のタンパク質フラグメントに関連した治療用、診断用および抗体組成物の革新的発見 |
US8993723B2 (en) | 2010-04-28 | 2015-03-31 | Atyr Pharma, Inc. | Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of alanyl-tRNA synthetases |
CN103118693B (zh) | 2010-04-29 | 2017-05-03 | Atyr 医药公司 | 与缬氨酰‑tRNA合成酶的蛋白片段相关的治疗、诊断和抗体组合物的创新发现 |
WO2011150279A2 (en) | 2010-05-27 | 2011-12-01 | Atyr Pharma, Inc. | Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of glutaminyl-trna synthetases |
US8986680B2 (en) | 2010-04-29 | 2015-03-24 | Atyr Pharma, Inc. | Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of Asparaginyl tRNA synthetases |
US8961961B2 (en) | 2010-05-03 | 2015-02-24 | a Tyr Pharma, Inc. | Innovative discovery of therapeutic, diagnostic, and antibody compositions related protein fragments of arginyl-tRNA synthetases |
WO2011139988A2 (en) | 2010-05-03 | 2011-11-10 | Atyr Pharma, Inc. | Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of seryl-trna synthetases |
AU2011248227B2 (en) | 2010-05-03 | 2016-12-01 | Pangu Biopharma Limited | Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of phenylalanyl-alpha-tRNA synthetases |
EP2566496B1 (en) | 2010-05-03 | 2018-02-28 | aTyr Pharma, Inc. | Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of methionyl-trna synthetases |
US9062301B2 (en) | 2010-05-04 | 2015-06-23 | Atyr Pharma, Inc. | Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of glutamyl-prolyl-tRNA synthetases |
WO2011140267A2 (en) | 2010-05-04 | 2011-11-10 | Atyr Pharma, Inc. | Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of p38 multi-trna synthetase complex |
CN103200953B (zh) | 2010-05-14 | 2017-02-15 | Atyr 医药公司 | 与苯丙氨酰‑β‑tRNA合成酶的蛋白片段相关的治疗、诊断和抗体组合物的创新发现 |
AU2011256366C1 (en) | 2010-05-17 | 2017-06-15 | Pangu Biopharma Limited | Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of leucyl-tRNA synthetases |
EP2575857B1 (en) | 2010-06-01 | 2018-01-24 | aTyr Pharma, Inc. | Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of lysyl-trna synthetases |
CA2804278C (en) | 2010-07-12 | 2021-07-13 | Atyr Pharma, Inc. | Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of aspartyl-trna synthetases |
AU2011289831C1 (en) | 2010-07-12 | 2017-06-15 | Pangu Biopharma Limited | Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of glycyl-tRNA synthetases |
US8999321B2 (en) | 2010-07-12 | 2015-04-07 | Atyr Pharma, Inc. | Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of glycyl-tRNA synthetases |
WO2012021249A2 (en) | 2010-07-12 | 2012-02-16 | Atyr Pharma, Inc. | Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of histidyl-trna synthetases |
WO2012027611A2 (en) | 2010-08-25 | 2012-03-01 | Atyr Pharma, Inc. | INNOVATIVE DISCOVERY OF THERAPEUTIC, DIAGNOSTIC, AND ANTIBODY COMPOSITIONS RELATED TO PROTEIN FRAGMENTS OF TYROSYL-tRNA SYNTHETASES |
EP2624857B1 (en) * | 2010-10-06 | 2017-08-02 | aTyr Pharma, Inc. | Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of tryptophanyl trna synthetases |
WO2013022982A2 (en) | 2011-08-09 | 2013-02-14 | Atyr Pharma, Inc. | Pegylated tyrosyl-trna synthetase polypeptides |
US9822353B2 (en) | 2011-12-06 | 2017-11-21 | Atyr Pharma, Inc. | PEGylated aspartyl-tRNA synthetase polypeptides |
WO2013086216A1 (en) | 2011-12-06 | 2013-06-13 | Atyr Pharma, Inc. | Improved aspartyl-trna synthetases |
CA2858613A1 (en) | 2011-12-29 | 2013-08-08 | Atyr Pharma, Inc. | Aspartyl-trna synthetase-fc conjugates |
WO2013123432A2 (en) | 2012-02-16 | 2013-08-22 | Atyr Pharma, Inc. | Histidyl-trna synthetases for treating autoimmune and inflammatory diseases |
CN105378075B (zh) | 2013-03-15 | 2022-04-05 | Atyr 医药公司 | 组氨酰-trna合成酶-fc缀合物 |
JP2020517638A (ja) | 2017-04-20 | 2020-06-18 | エータイアー ファーマ, インコーポレイテッド | 肺の炎症を治療するための組成物および方法 |
WO2021010800A1 (ko) * | 2019-07-18 | 2021-01-21 | 제이더블유바이오사이언스 주식회사 | Wrs 단백질에 특이적으로 결합하는 항체 및 이의 용도 |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR890002068B1 (ko) * | 1987-01-13 | 1989-06-16 | 제일제당 주식회사 | 겔여과 컬럼에 의한 엔도톡신의 제거방법 |
JPH01196295A (ja) * | 1988-01-30 | 1989-08-08 | Tosoh Corp | プロウロキナーゼからの発熱性物質除去方法 |
JPH01196294A (ja) * | 1988-01-30 | 1989-08-08 | Tosoh Corp | スーパーオキサイド・ジムスターゼから発熱性物質を除去する方法 |
JPH01242105A (ja) * | 1988-03-18 | 1989-09-27 | Toray Ind Inc | エンドトキシン除去材 |
JPH04197436A (ja) * | 1990-11-29 | 1992-07-17 | Terumo Corp | エンドトキシン吸着フィルター |
GB9601068D0 (en) * | 1996-01-19 | 1996-03-20 | Smithkline Beecham Plc | Novel compounds |
GB2327945A (en) * | 1997-07-31 | 1999-02-10 | Medeva Europ Ltd | Removal of endotoxin from vaccines |
EP1272506B1 (en) * | 2000-03-31 | 2015-07-29 | The Scripps Research Institute | Human aminoacyl-trna synthetase polypeptides useful for the regulation of angiogenesis |
ATE420653T1 (de) * | 2001-02-23 | 2009-01-15 | Scripps Research Inst | Von tryptophanyl-trna-synthetase stammende polypeptide zur regulierung der angiogenese |
US6903189B2 (en) * | 2001-03-21 | 2005-06-07 | The Scripps Research Institute | Human aminoacyl-tRNA synthetase polypeptides useful for the regulation of angiogenesis |
AU2002332430A1 (en) * | 2001-07-26 | 2003-02-17 | Novartis Ag | Methods of treating neuropilin-mediated diseases |
-
2004
- 2004-10-07 US US10/962,217 patent/US20060079673A1/en not_active Abandoned
-
2005
- 2005-07-21 WO PCT/IB2005/002180 patent/WO2006016217A1/en active Application Filing
- 2005-07-21 MX MX2007001505A patent/MX2007001505A/es active IP Right Grant
- 2005-07-21 ES ES05759912T patent/ES2332799T3/es active Active
- 2005-07-21 JP JP2007524410A patent/JP4938661B2/ja not_active Expired - Fee Related
- 2005-07-21 EP EP05759912A patent/EP1776138B1/en not_active Not-in-force
- 2005-07-21 CA CA2575694A patent/CA2575694C/en not_active Expired - Fee Related
- 2005-07-21 AT AT05759912T patent/ATE446105T1/de not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
CA2575694C (en) | 2012-07-10 |
US20060079673A1 (en) | 2006-04-13 |
ES2332799T3 (es) | 2010-02-12 |
EP1776138A1 (en) | 2007-04-25 |
ATE446105T1 (de) | 2009-11-15 |
WO2006016217A1 (en) | 2006-02-16 |
JP2008508349A (ja) | 2008-03-21 |
CA2575694A1 (en) | 2006-02-16 |
JP4938661B2 (ja) | 2012-05-23 |
EP1776138B1 (en) | 2009-10-21 |
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