MX170706B - Procedimiento para la preparacion de (-) -n"ciano-n-3- piridil -n'- 1, 2, 2-trimetilpropilguanidina - Google Patents

Procedimiento para la preparacion de (-) -n"ciano-n-3- piridil -n'- 1, 2, 2-trimetilpropilguanidina

Info

Publication number
MX170706B
MX170706B MX019348A MX1934890A MX170706B MX 170706 B MX170706 B MX 170706B MX 019348 A MX019348 A MX 019348A MX 1934890 A MX1934890 A MX 1934890A MX 170706 B MX170706 B MX 170706B
Authority
MX
Mexico
Prior art keywords
procedure
preparation
trimetilpropilguanidina
piridil
ciano
Prior art date
Application number
MX019348A
Other languages
English (en)
Inventor
David Wayne Robertson
Mitchell Irvin Steinberg
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of MX170706B publication Critical patent/MX170706B/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
    • C07C279/04—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to acyclic carbon atoms of a carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/75—Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Epidemiology (AREA)
  • Pyridine Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

La presente invención se refiere a un procedimiento para la preparación de (-) N"-ciano-N-3-piridil-N'-1,2,2-trimetilpropilguanidina o una sal de adición de ácido farmaceuticamente aceptable de la misma, el procedimiento está caracterizado porque consiste en: a) la resolución de la N"-ciano-N-3-piridil-N'-1,2,2-trimetilpropilguanidina racemica o b) hacer reaccionar (-)-N-3-piridinil-N'-(1,2,2-trimetilpropil)tiourea con una carbodiimida reactiva y cianamida y c) opcionalmente convertir el producto resultante en una sal de adición de ácido farmaceuticamente aceptable del mismo. El uso descrito de los compuestos es como agentes antihipertensores.
MX019348A 1989-02-03 1990-02-01 Procedimiento para la preparacion de (-) -n"ciano-n-3- piridil -n'- 1, 2, 2-trimetilpropilguanidina MX170706B (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US30671489A 1989-02-03 1989-02-03

Publications (1)

Publication Number Publication Date
MX170706B true MX170706B (es) 1993-09-08

Family

ID=23186533

Family Applications (1)

Application Number Title Priority Date Filing Date
MX019348A MX170706B (es) 1989-02-03 1990-02-01 Procedimiento para la preparacion de (-) -n"ciano-n-3- piridil -n'- 1, 2, 2-trimetilpropilguanidina

Country Status (13)

Country Link
EP (1) EP0381504A3 (es)
JP (1) JP2823631B2 (es)
KR (1) KR100220989B1 (es)
CN (1) CN1043527C (es)
AU (1) AU623217B2 (es)
CA (1) CA2009074C (es)
HU (1) HU208959B (es)
IE (1) IE900391L (es)
IL (1) IL93252A0 (es)
MX (1) MX170706B (es)
NZ (1) NZ232336A (es)
PT (1) PT93033B (es)
ZA (1) ZA90772B (es)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ229828A (en) * 1988-08-09 1992-03-26 Squibb & Sons Inc Aryl cyanoguanidine derivatives and pharmaceutical compositions
JPH05294935A (ja) * 1991-03-15 1993-11-09 Green Cross Corp:The アミノピリジン系化合物
US5371086A (en) * 1991-03-15 1994-12-06 The Green Cross Corporation Aminopyridine compounds
WO1994004499A1 (en) * 1992-08-13 1994-03-03 The Upjohn Company Cyanoguanidines as potassium channel blockers
AU673785B2 (en) * 1993-06-11 1996-11-21 Upjohn Company, The Pyrimidine cyanoguanidines as K-channel blockers
AU7888798A (en) * 1996-12-26 1998-07-31 Kirin Beer Kabushiki Kaisha Drugs for ameliorating ophthalmic circulatory disturbance
FR2760838B1 (fr) * 1997-03-13 1999-05-21 Corning Inc Circuit fluidique integre d'execution d'un processus de preparation ou d'analyse d'un echantillon de matiere fluide, son procede de fabrication et appareil d'exploitation de ce circuit
EP1198456B1 (en) * 1999-08-03 2007-09-19 Abbott Laboratories Potassium channel openers
US6645968B2 (en) 1999-08-03 2003-11-11 Abbott Laboratories Potassium channel openers
US9590554B2 (en) * 2013-09-27 2017-03-07 Mitsubishi Electric Corporation Electric power converter

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1489879A (en) * 1974-12-20 1977-10-26 Leo Pharm Prod Ltd N'-cyano-n'-3-pyridylguanidines
FR2624699B1 (fr) * 1987-12-18 1990-04-13 Bernard Lyon I Universite Clau Derives heterocycliques de n-carbamoyl-, n-thiocarbamoyl- ou n-amidino-glycine ou beta-alanine utiles comme agents edulcorants

Also Published As

Publication number Publication date
KR900012897A (ko) 1990-09-03
NZ232336A (en) 1991-07-26
CN1043527C (zh) 1999-06-02
CA2009074C (en) 1999-07-27
CN1044654A (zh) 1990-08-15
JPH02235868A (ja) 1990-09-18
IE900391L (en) 1990-08-03
AU4897790A (en) 1990-08-09
IL93252A0 (en) 1990-11-29
EP0381504A3 (en) 1991-09-04
ZA90772B (en) 1991-10-30
KR100220989B1 (ko) 1999-09-15
HUT53876A (en) 1990-12-28
HU900641D0 (en) 1990-04-28
AU623217B2 (en) 1992-05-07
CA2009074A1 (en) 1990-08-03
EP0381504A2 (en) 1990-08-08
JP2823631B2 (ja) 1998-11-11
HU208959B (en) 1994-02-28
PT93033B (pt) 1996-03-29
PT93033A (pt) 1990-11-07

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