MEP33108A - Derivati bengamida, postupak za njihovu proizvodnju i njihova primjena za liječenje bolesti raka - Google Patents

Derivati bengamida, postupak za njihovu proizvodnju i njihova primjena za liječenje bolesti raka

Info

Publication number
MEP33108A
MEP33108A MEP-331/08A MEP33108A MEP33108A ME P33108 A MEP33108 A ME P33108A ME P33108 A MEP33108 A ME P33108A ME P33108 A MEP33108 A ME P33108A
Authority
ME
Montenegro
Prior art keywords
cancer
treatment
production
bengamide derivatives
bengamide
Prior art date
Application number
MEP-331/08A
Other languages
English (en)
Inventor
Holger Hoffmann
Sabine Haag-Richter
Michael Kurz
Heiko Tietgen
Original Assignee
Sanofi Aventis Deutschland
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Aventis Deutschland filed Critical Sanofi Aventis Deutschland
Publication of MEP33108A publication Critical patent/MEP33108A/bs

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/02—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D223/06—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom not condensed with other rings with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D223/08—Oxygen atoms
    • C07D223/10—Oxygen atoms attached in position 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/02—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D223/06—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom not condensed with other rings with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D223/12—Nitrogen atoms not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C12N1/205—Bacterial isolates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/10—Nitrogen as only ring hetero atom
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Medicinal Chemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Microbiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Virology (AREA)
  • Epidemiology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

Ovaj pronalazak obuhvata derivate bengamida, koji nastaju u toku fermentacije mikroorganizma Myxococcus virescens ST200611 (DSM 15898), njihovu primjenu za liječenje bolesti raka, ljekovi koji sadrže derivate bengamida, jedan postupak za proizvodnju bengamida formule (V), kao mikrooorganizam Myxococcus virescens ST200611 (DSM 15898).
MEP-331/08A 2003-10-24 2004-10-08 Derivati bengamida, postupak za njihovu proizvodnju i njihova primjena za liječenje bolesti raka MEP33108A (bs)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10349669A DE10349669B3 (de) 2003-10-24 2003-10-24 Bengamide-Derivate, Verfahren zu ihrer Herstellung und ihre Verwendung
PCT/EP2004/011244 WO2005044803A1 (de) 2003-10-24 2004-10-08 Bengamide-derivate, verfahren zu ihrer herstellung und ihre verwendung zur behandlung von krebserkrankungen

Publications (1)

Publication Number Publication Date
MEP33108A true MEP33108A (bs) 2010-10-10

Family

ID=34484998

Family Applications (1)

Application Number Title Priority Date Filing Date
MEP-331/08A MEP33108A (bs) 2003-10-24 2004-10-08 Derivati bengamida, postupak za njihovu proizvodnju i njihova primjena za liječenje bolesti raka

Country Status (29)

Country Link
EP (2) EP1680405B1 (bs)
JP (1) JP4769190B2 (bs)
KR (1) KR20060120044A (bs)
CN (2) CN101294173A (bs)
AR (1) AR046553A1 (bs)
AT (2) ATE420074T1 (bs)
AU (1) AU2004287561B2 (bs)
BR (1) BRPI0415529A (bs)
CA (1) CA2543003A1 (bs)
CL (1) CL2009000674A1 (bs)
CY (1) CY1110458T1 (bs)
DE (3) DE10349669B3 (bs)
DK (1) DK1680405T3 (bs)
ES (1) ES2320894T3 (bs)
HR (1) HRP20090187T1 (bs)
IL (1) IL174524A (bs)
MA (1) MA28213A1 (bs)
ME (1) MEP33108A (bs)
MX (1) MXPA06004084A (bs)
NO (1) NO20062149L (bs)
NZ (1) NZ546744A (bs)
PL (1) PL1680405T3 (bs)
PT (1) PT1680405E (bs)
RS (1) RS20060263A (bs)
RU (1) RU2357956C2 (bs)
SI (1) SI1680405T1 (bs)
UY (1) UY28574A1 (bs)
WO (1) WO2005044803A1 (bs)
ZA (1) ZA200602231B (bs)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2878528B1 (fr) 2004-11-29 2008-05-16 Aventis Pharma Sa 2-alcoxy-3,4,5-trihydroxy-alkylamides, leur preparation, compositions les contenant et utilisation
FR2878525B1 (fr) * 2004-11-29 2007-02-23 Aventis Pharma Sa Bengamides possedant un cycle caprolactame substitue, procede de preparation, compositions les contenant et utilisation
FR2901556A1 (fr) 2006-05-24 2007-11-30 Sanofi Aventis Sa Derives de 2-alcoxy-3,4,5-trihydroxy-alkylamide, leur preparation, compositions les contenant et utilisation
FR2901554B1 (fr) 2006-05-24 2011-04-01 Sanofi Aventis 2-alcoxy-3,4,5-trihydroxy-alkylamide-benzazepine, leur preparation, compositions les contenant et utilisation
FR2901555A1 (fr) 2006-05-24 2007-11-30 Sanofi Aventis Sa 2-alcoxy-3,4,5-trihydroxy-alkylamide-benzothiazepine, leur preparation, compositions les contenant et utilisation

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SU1598876A3 (ru) * 1986-04-04 1990-10-07 Санкио Компани Лимитед (Фирма) Способ получени производных пергидротиазепина, или пергидроазепина, или их дигидрохлоридов, или сложных эфиров
CO5140099A1 (es) * 1998-11-17 2002-03-22 Novartis Ag Ciertas caprolactamas sustituidas, composiciones farmaceuticas que las contienen, y su uso en el tratamiento de tumores
JP2003532711A (ja) * 2000-05-11 2003-11-05 ノバルティス アクチエンゲゼルシャフト 置換カプロラクタム炭酸エステルおよびカプロラクタムエーテル、およびそれらの抗腫瘍薬としての使用
JP2004262793A (ja) * 2003-02-28 2004-09-24 Noyaku Bio Technology Kaihatsu Gijutsu Kenkyu Kumiai 化合物ｎ−９０１１、その製造法及び用途
AU2004263287B2 (en) * 2003-07-25 2009-02-12 Novartis Ag Substituted lactams and their use as anti-cancer agents

Also Published As

Publication number Publication date
ES2320894T3 (es) 2009-05-29
CN100398520C (zh) 2008-07-02
CN1871217A (zh) 2006-11-29
EP1680405B1 (de) 2009-01-07
UY28574A1 (es) 2005-05-31
JP2007509084A (ja) 2007-04-12
CA2543003A1 (en) 2005-05-19
DE502004008837D1 (de) 2009-02-26
MXPA06004084A (es) 2006-06-27
ZA200602231B (en) 2007-06-27
CN101294173A (zh) 2008-10-29
ATE477244T1 (de) 2010-08-15
RS20060263A (sr) 2008-09-29
EP1873146A2 (de) 2008-01-02
DK1680405T3 (da) 2009-05-04
EP1680405A1 (de) 2006-07-19
ATE420074T1 (de) 2009-01-15
CY1110458T1 (el) 2015-04-29
NO20062149L (no) 2006-07-11
IL174524A (en) 2012-08-30
SI1680405T1 (sl) 2009-06-30
DE10349669B3 (de) 2005-05-25
AU2004287561A1 (en) 2005-05-19
CL2009000674A1 (es) 2009-08-07
EP1873146B1 (de) 2010-08-11
EP1873146A3 (de) 2008-05-21
BRPI0415529A (pt) 2006-12-26
RU2006117769A (ru) 2007-11-27
HRP20090187T1 (en) 2009-05-31
WO2005044803A1 (de) 2005-05-19
IL174524A0 (en) 2006-08-01
NZ546744A (en) 2009-03-31
PL1680405T3 (pl) 2009-06-30
AU2004287561B2 (en) 2011-06-02
JP4769190B2 (ja) 2011-09-07
AR046553A1 (es) 2005-12-14
MA28213A1 (fr) 2006-10-02
KR20060120044A (ko) 2006-11-24
PT1680405E (pt) 2009-03-31
DE502004011536D1 (de) 2010-09-23
HK1098131A1 (zh) 2007-07-13
RU2357956C2 (ru) 2009-06-10

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