MEP24408A - Derivatives of 5-(pyridin-3-yl)-1-azabicyclo[3.2.1]octane, the preparation thereof and the application of same in therapeutics - Google Patents

Derivatives of 5-(pyridin-3-yl)-1-azabicyclo[3.2.1]octane, the preparation thereof and the application of same in therapeutics

Info

Publication number
MEP24408A
MEP24408A MEP-244/08A MEP24408A MEP24408A ME P24408 A MEP24408 A ME P24408A ME P24408 A MEP24408 A ME P24408A ME P24408 A MEP24408 A ME P24408A
Authority
ME
Montenegro
Prior art keywords
group
azabicyclo
pyridin
therapeutics
octane
Prior art date
Application number
MEP-244/08A
Other languages
English (en)
Croatian (hr)
Inventor
Frederic Galli
Odile Leclerc
Alistair Lochead
Alain Nedelec
Original Assignee
Sanofi Aventis
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Aventis filed Critical Sanofi Aventis
Publication of MEP24408A publication Critical patent/MEP24408A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/08—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Psychiatry (AREA)
  • Psychology (AREA)
  • Pain & Pain Management (AREA)
  • Addiction (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Jedinjenja opšte formule (I) u kojoj R predstavlja atom halogena ili fenilnu grupu supstituisanu sa jednom ili više grupa izabranih od atoma halogena, i –(C1-C6) alkila, (C1-C6)alkoksi, nitro, amino, trifl uorometi l, cijano, hidroksi, aceti l ili meti lendioksi grupe, ili predstavlja piperidinil grupu, ili ti enil grupu, ili indolil grupu, ili pirimidinil grupu po izboru supstituisanu sa jednom ili više (C1-C6) alkoksi grupa, gdje, jedna od dva ugljenik-ugljenik veze predstavlja ---- je prosta veza, a druga može biti prosta ili dvostruka. Terapetska primjena.
MEP-244/08A 2002-01-07 2003-01-03 Derivatives of 5-(pyridin-3-yl)-1-azabicyclo[3.2.1]octane, the preparation thereof and the application of same in therapeutics MEP24408A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR0200109A FR2834511B1 (fr) 2002-01-07 2002-01-07 Derives de 5-(pyridin-3-yl)-1-azabicyclo[3.2.1]octane, leur preparation et leur application en therapeutique
PCT/FR2003/000004 WO2003057697A1 (fr) 2002-01-07 2003-01-03 Derives de 5-(pyridin-3-yl)-1-azabicyclo [3.2.1] octane, leur preparation et leur application en therapeutique

Publications (1)

Publication Number Publication Date
MEP24408A true MEP24408A (en) 2010-10-10

Family

ID=8871176

Family Applications (2)

Application Number Title Priority Date Filing Date
MEP-244/08A MEP24408A (en) 2002-01-07 2003-01-03 Derivatives of 5-(pyridin-3-yl)-1-azabicyclo[3.2.1]octane, the preparation thereof and the application of same in therapeutics
MEP-2008-244A ME00213B (me) 2002-01-07 2003-01-03 Derivati 5-(piridin-3-il)-1-azabiciklo (3.2.1.) oktana, njihova priprema i terapeutska primjena

Family Applications After (1)

Application Number Title Priority Date Filing Date
MEP-2008-244A ME00213B (me) 2002-01-07 2003-01-03 Derivati 5-(piridin-3-il)-1-azabiciklo (3.2.1.) oktana, njihova priprema i terapeutska primjena

Country Status (35)

Country Link
US (2) US7223750B2 (bs)
EP (1) EP1465893B1 (bs)
JP (1) JP4402957B2 (bs)
KR (1) KR100977332B1 (bs)
CN (2) CN1276921C (bs)
AR (2) AR038098A1 (bs)
AT (1) ATE355290T1 (bs)
AU (1) AU2003216777B2 (bs)
BR (1) BR0306707A (bs)
CA (1) CA2471628C (bs)
CO (1) CO5590914A2 (bs)
CY (1) CY1106580T1 (bs)
DE (1) DE60312123T2 (bs)
DK (1) DK1465893T3 (bs)
EA (1) EA007793B1 (bs)
EC (1) ECSP045176A (bs)
ES (1) ES2281631T3 (bs)
FR (1) FR2834511B1 (bs)
HR (1) HRP20040617B1 (bs)
IL (2) IL162524A0 (bs)
IS (1) IS2470B (bs)
MA (1) MA27165A1 (bs)
ME (2) MEP24408A (bs)
MX (1) MXPA04006630A (bs)
NO (1) NO329309B1 (bs)
NZ (1) NZ533793A (bs)
PL (1) PL216665B1 (bs)
PT (1) PT1465893E (bs)
RS (1) RS50921B (bs)
SI (1) SI1465893T1 (bs)
TN (1) TNSN04120A1 (bs)
TW (1) TWI336703B (bs)
UA (1) UA77229C2 (bs)
WO (1) WO2003057697A1 (bs)
ZA (1) ZA200405002B (bs)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9902007D0 (en) * 1999-01-30 1999-03-17 Thomas Carpentry Services Limi Improvements relating to door frames
FR2834511B1 (fr) * 2002-01-07 2004-02-13 Sanofi Synthelabo Derives de 5-(pyridin-3-yl)-1-azabicyclo[3.2.1]octane, leur preparation et leur application en therapeutique
FR2889701B1 (fr) * 2005-08-12 2007-10-05 Sanofi Aventis Sa Derives de 5-pyridinyl-1-azabicyclo[3.2.1]octane, leur preparation en therapeutique.
FR2889847B1 (fr) * 2005-08-18 2007-10-05 Sanofi Aventis Sa Derives de 5-pyridazinyl-1-azabicyclo[3.2.1]octave, leur preparation en therapeutique.
FR2912404B1 (fr) * 2007-02-09 2009-04-10 Sanofi Aventis Sa Derives d'azabicycloalkane,leur preparation et leur application en therapeutique.
KR101928505B1 (ko) * 2011-01-28 2018-12-12 에스케이바이오팜 주식회사 피리돈 유도체 및 이를 포함하는 약학적 조성물
KR101925971B1 (ko) * 2011-01-28 2018-12-06 에스케이바이오팜 주식회사 피리돈 유도체 및 이를 포함하는 약학적 조성물
EP3704117A1 (en) 2017-11-03 2020-09-09 Alcon Inc. Azabicyclo and diazepine derivatives for treating ocular disorders

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5817679A (en) * 1993-04-01 1998-10-06 University Of Virginia 7-Azabicyclo 2.2.1!-heptane and -heptene derivatives as cholinergic receptor ligands
WO1995003306A1 (en) 1993-07-22 1995-02-02 E.I. Du Pont De Nemours And Company Arthropodicidal azacyclic heterocycles
FR2786770B1 (fr) * 1998-12-04 2001-01-19 Synthelabo Derives de 1,4-diazabicyclo[3.2.2.]nonane, leur preparation et leur application en therapeutique
FR2786769B1 (fr) * 1998-12-04 2002-10-25 Synthelabo Derives de 2,5-diazabicyclo[2.2.1]heptane, leur preparation et leur application en therapeutique
FR2834511B1 (fr) * 2002-01-07 2004-02-13 Sanofi Synthelabo Derives de 5-(pyridin-3-yl)-1-azabicyclo[3.2.1]octane, leur preparation et leur application en therapeutique

Also Published As

Publication number Publication date
ECSP045176A (es) 2004-08-27
CN1612876A (zh) 2005-05-04
DE60312123T2 (de) 2007-09-13
DE60312123D1 (de) 2007-04-12
JP4402957B2 (ja) 2010-01-20
PL216665B1 (pl) 2014-04-30
MA27165A1 (fr) 2005-01-03
DK1465893T3 (da) 2007-06-04
PL370065A1 (en) 2005-05-16
US20050020568A1 (en) 2005-01-27
ES2281631T3 (es) 2007-10-01
US7585974B2 (en) 2009-09-08
IL162524A0 (en) 2005-11-20
KR20040077705A (ko) 2004-09-06
KR100977332B1 (ko) 2010-08-20
CA2471628A1 (en) 2003-07-17
CN1911928A (zh) 2007-02-14
CN1276921C (zh) 2006-09-27
HK1066547A1 (en) 2005-03-24
IS7322A (is) 2004-06-16
FR2834511A1 (fr) 2003-07-11
SI1465893T1 (sl) 2007-08-31
RS50921B (sr) 2010-08-31
NZ533793A (en) 2007-01-26
PT1465893E (pt) 2007-05-31
ZA200405002B (en) 2006-05-31
ATE355290T1 (de) 2006-03-15
CO5590914A2 (es) 2005-12-30
EP1465893A1 (fr) 2004-10-13
TNSN04120A1 (fr) 2006-06-01
AU2003216777B2 (en) 2008-10-02
HRP20040617B1 (hr) 2012-10-31
IL162524A (en) 2010-05-17
TW200305413A (en) 2003-11-01
ME00213B (me) 2011-02-10
AR038098A1 (es) 2004-12-29
NO20042846L (no) 2004-09-21
EP1465893B1 (fr) 2007-02-28
RS59904A (sr) 2006-10-27
US7223750B2 (en) 2007-05-29
WO2003057697A1 (fr) 2003-07-17
US20070185137A1 (en) 2007-08-09
NO329309B1 (no) 2010-09-27
AR086573A2 (es) 2014-01-08
EA007793B1 (ru) 2007-02-27
HRP20040617A2 (en) 2004-10-31
MXPA04006630A (es) 2004-11-10
AU2003216777A1 (en) 2003-07-24
CY1106580T1 (el) 2012-01-25
FR2834511B1 (fr) 2004-02-13
BR0306707A (pt) 2005-02-09
TWI336703B (en) 2011-02-01
UA77229C2 (uk) 2006-11-15
EA200400770A1 (ru) 2004-12-30
JP2005514422A (ja) 2005-05-19
IS2470B (is) 2008-12-15
CA2471628C (en) 2011-03-22

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