HRP20040617B1 - Derivati 5-(piridin-3-il)-1-azabiciklo[3.2.1]oktana, njihova priprava i primjena u nekim terapijskim sredstvima - Google Patents

Derivati 5-(piridin-3-il)-1-azabiciklo[3.2.1]oktana, njihova priprava i primjena u nekim terapijskim sredstvima

Info

Publication number
HRP20040617B1
HRP20040617B1 HRP20040617AA HRP20040617A HRP20040617B1 HR P20040617 B1 HRP20040617 B1 HR P20040617B1 HR P20040617A A HRP20040617A A HR P20040617AA HR P20040617 A HRP20040617 A HR P20040617A HR P20040617 B1 HRP20040617 B1 HR P20040617B1
Authority
HR
Croatia
Prior art keywords
sub
groups
azabicyclo
pyridin
therapeutics
Prior art date
Application number
HRP20040617AA
Other languages
English (en)
Inventor
Frédéric Galli
Odile Leclerc
Alistair Lochead
Alain Nedelec
Original Assignee
Sanofi-Aventis
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi-Aventis filed Critical Sanofi-Aventis
Publication of HRP20040617A2 publication Critical patent/HRP20040617A2/hr
Publication of HRP20040617B1 publication Critical patent/HRP20040617B1/hr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/08—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Psychiatry (AREA)
  • Psychology (AREA)
  • Pain & Pain Management (AREA)
  • Addiction (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

<IMAGE NAME="20040617_01" TYPE="jpg" CENTER=TRUE/><BR/>Izum se odnosi na spojeve koji imaju opću formulu (I), gdje se R odnosi na halogeni atom, fenilnu skupinu koja je supstituirana jednom ili više skupina odabranih između halogenog atoma i (C<SUB>1</SUB>-C<SUB>6</SUB>)alkila, (C<SUB>1</SUB>-C<SUB>6</SUB>)alkoksi, nitro, amino, trifluormetil, cijano, hidroksi, acetil ili metilendioksi skupine, piridinilne skupine, tienilne skupine, indolilne skupine, ili pirimidilne skupine koja je po želji supstituirana jednom ili više (C<SUB>1</SUB>-C<SUB>6</SUB>)alkoksi skupina. Nadalje, između dvije veze ugljik-ugljik označene s <U>----</U>, jedna je jednostruka, a druga može biti jednostruka ili dvostruka. Izumljeni spojevi su ligandi nikotinskih receptora.
HRP20040617AA 2002-01-07 2004-07-07 Derivati 5-(piridin-3-il)-1-azabiciklo[3.2.1]oktana, njihova priprava i primjena u nekim terapijskim sredstvima HRP20040617B1 (hr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR0200109A FR2834511B1 (fr) 2002-01-07 2002-01-07 Derives de 5-(pyridin-3-yl)-1-azabicyclo[3.2.1]octane, leur preparation et leur application en therapeutique
PCT/FR2003/000004 WO2003057697A1 (fr) 2002-01-07 2003-01-03 Derives de 5-(pyridin-3-yl)-1-azabicyclo [3.2.1] octane, leur preparation et leur application en therapeutique

Publications (2)

Publication Number Publication Date
HRP20040617A2 HRP20040617A2 (en) 2004-10-31
HRP20040617B1 true HRP20040617B1 (hr) 2012-10-31

Family

ID=8871176

Family Applications (1)

Application Number Title Priority Date Filing Date
HRP20040617AA HRP20040617B1 (hr) 2002-01-07 2004-07-07 Derivati 5-(piridin-3-il)-1-azabiciklo[3.2.1]oktana, njihova priprava i primjena u nekim terapijskim sredstvima

Country Status (36)

Country Link
US (2) US7223750B2 (hr)
EP (1) EP1465893B1 (hr)
JP (1) JP4402957B2 (hr)
KR (1) KR100977332B1 (hr)
CN (2) CN1911928A (hr)
AR (2) AR038098A1 (hr)
AT (1) ATE355290T1 (hr)
AU (1) AU2003216777B2 (hr)
BR (1) BR0306707A (hr)
CA (1) CA2471628C (hr)
CO (1) CO5590914A2 (hr)
CY (1) CY1106580T1 (hr)
DE (1) DE60312123T2 (hr)
DK (1) DK1465893T3 (hr)
EA (1) EA007793B1 (hr)
EC (1) ECSP045176A (hr)
ES (1) ES2281631T3 (hr)
FR (1) FR2834511B1 (hr)
HK (1) HK1066547A1 (hr)
HR (1) HRP20040617B1 (hr)
IL (2) IL162524A0 (hr)
IS (1) IS2470B (hr)
MA (1) MA27165A1 (hr)
ME (2) MEP24408A (hr)
MX (1) MXPA04006630A (hr)
NO (1) NO329309B1 (hr)
NZ (1) NZ533793A (hr)
PL (1) PL216665B1 (hr)
PT (1) PT1465893E (hr)
RS (1) RS50921B (hr)
SI (1) SI1465893T1 (hr)
TN (1) TNSN04120A1 (hr)
TW (1) TWI336703B (hr)
UA (1) UA77229C2 (hr)
WO (1) WO2003057697A1 (hr)
ZA (1) ZA200405002B (hr)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9902007D0 (en) * 1999-01-30 1999-03-17 Thomas Carpentry Services Limi Improvements relating to door frames
FR2834511B1 (fr) * 2002-01-07 2004-02-13 Sanofi Synthelabo Derives de 5-(pyridin-3-yl)-1-azabicyclo[3.2.1]octane, leur preparation et leur application en therapeutique
FR2889701B1 (fr) * 2005-08-12 2007-10-05 Sanofi Aventis Sa Derives de 5-pyridinyl-1-azabicyclo[3.2.1]octane, leur preparation en therapeutique.
FR2889847B1 (fr) 2005-08-18 2007-10-05 Sanofi Aventis Sa Derives de 5-pyridazinyl-1-azabicyclo[3.2.1]octave, leur preparation en therapeutique.
FR2912404B1 (fr) * 2007-02-09 2009-04-10 Sanofi Aventis Sa Derives d'azabicycloalkane,leur preparation et leur application en therapeutique.
KR101928505B1 (ko) * 2011-01-28 2018-12-12 에스케이바이오팜 주식회사 피리돈 유도체 및 이를 포함하는 약학적 조성물
KR101925971B1 (ko) 2011-01-28 2018-12-06 에스케이바이오팜 주식회사 피리돈 유도체 및 이를 포함하는 약학적 조성물
CA3205816A1 (en) 2017-11-03 2019-05-09 Alcon Inc. Azabicyclo and diazepine derivatives for treating ocular disorders

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5817679A (en) * 1993-04-01 1998-10-06 University Of Virginia 7-Azabicyclo 2.2.1!-heptane and -heptene derivatives as cholinergic receptor ligands
WO2000034279A1 (fr) * 1998-12-04 2000-06-15 Sanofi-Synthelabo Derives de 1,4-diazabicyclo[3.2.2]nonane, leur preparation et leur application en therapeutique
WO2000034284A1 (fr) * 1998-12-04 2000-06-15 Sanofi-Synthelabo Derives de 2,5-diazabicyclo[2.2.1]heptane, leur preparation et leur application en therapeutique

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995003306A1 (en) 1993-07-22 1995-02-02 E.I. Du Pont De Nemours And Company Arthropodicidal azacyclic heterocycles
FR2834511B1 (fr) * 2002-01-07 2004-02-13 Sanofi Synthelabo Derives de 5-(pyridin-3-yl)-1-azabicyclo[3.2.1]octane, leur preparation et leur application en therapeutique

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5817679A (en) * 1993-04-01 1998-10-06 University Of Virginia 7-Azabicyclo 2.2.1!-heptane and -heptene derivatives as cholinergic receptor ligands
WO2000034279A1 (fr) * 1998-12-04 2000-06-15 Sanofi-Synthelabo Derives de 1,4-diazabicyclo[3.2.2]nonane, leur preparation et leur application en therapeutique
WO2000034284A1 (fr) * 1998-12-04 2000-06-15 Sanofi-Synthelabo Derives de 2,5-diazabicyclo[2.2.1]heptane, leur preparation et leur application en therapeutique

Also Published As

Publication number Publication date
NZ533793A (en) 2007-01-26
CN1911928A (zh) 2007-02-14
CN1276921C (zh) 2006-09-27
FR2834511A1 (fr) 2003-07-11
CA2471628C (en) 2011-03-22
MEP24408A (hr) 2010-10-10
HRP20040617A2 (en) 2004-10-31
ME00213B (me) 2011-02-10
ZA200405002B (en) 2006-05-31
TW200305413A (en) 2003-11-01
DE60312123T2 (de) 2007-09-13
AR038098A1 (es) 2004-12-29
RS59904A (en) 2006-10-27
PL216665B1 (pl) 2014-04-30
US20050020568A1 (en) 2005-01-27
KR100977332B1 (ko) 2010-08-20
MXPA04006630A (es) 2004-11-10
SI1465893T1 (sl) 2007-08-31
PT1465893E (pt) 2007-05-31
AU2003216777B2 (en) 2008-10-02
JP2005514422A (ja) 2005-05-19
CA2471628A1 (en) 2003-07-17
RS50921B (sr) 2010-08-31
DE60312123D1 (de) 2007-04-12
TWI336703B (en) 2011-02-01
PL370065A1 (en) 2005-05-16
CO5590914A2 (es) 2005-12-30
EP1465893A1 (fr) 2004-10-13
IS2470B (is) 2008-12-15
AR086573A2 (es) 2014-01-08
MA27165A1 (fr) 2005-01-03
WO2003057697A1 (fr) 2003-07-17
NO20042846L (no) 2004-09-21
AU2003216777A1 (en) 2003-07-24
UA77229C2 (uk) 2006-11-15
IL162524A (en) 2010-05-17
BR0306707A (pt) 2005-02-09
US20070185137A1 (en) 2007-08-09
ECSP045176A (es) 2004-08-27
DK1465893T3 (da) 2007-06-04
NO329309B1 (no) 2010-09-27
ATE355290T1 (de) 2006-03-15
IL162524A0 (en) 2005-11-20
TNSN04120A1 (fr) 2006-06-01
US7585974B2 (en) 2009-09-08
IS7322A (is) 2004-06-16
ES2281631T3 (es) 2007-10-01
KR20040077705A (ko) 2004-09-06
CN1612876A (zh) 2005-05-04
EA007793B1 (ru) 2007-02-27
CY1106580T1 (el) 2012-01-25
JP4402957B2 (ja) 2010-01-20
US7223750B2 (en) 2007-05-29
EP1465893B1 (fr) 2007-02-28
EA200400770A1 (ru) 2004-12-30
HK1066547A1 (en) 2005-03-24
FR2834511B1 (fr) 2004-02-13

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A1OB Publication of a patent application
PNAN Change of the applicant name, address/residence

Owner name: SANOFI-AVENTIS, FR

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B1PR Patent granted
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Payment date: 20161214

Year of fee payment: 15

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Effective date: 20180103