MEP2408A - Trans-1-(6-hloro-3 fenilindan-1-1l)-3,3-dimetilpiperazin - Google Patents
Trans-1-(6-hloro-3 fenilindan-1-1l)-3,3-dimetilpiperazinInfo
- Publication number
- MEP2408A MEP2408A MEP-24/08A MEP2408A MEP2408A ME P2408 A MEP2408 A ME P2408A ME P2408 A MEP2408 A ME P2408A ME P2408 A MEP2408 A ME P2408A
- Authority
- ME
- Montenegro
- Prior art keywords
- phenylindan
- dimethylpiperazine
- chloro
- trans
- salts
- Prior art date
Links
- FBCSWIXKXHSYBN-AZUAARDMSA-N 1-[(1r,3s)-6-chloro-3-phenyl-2,3-dihydro-1h-inden-1-yl]-3,3-dimethylpiperazine Chemical compound C1CNC(C)(C)CN1[C@H]1C2=CC(Cl)=CC=C2[C@H](C=2C=CC=CC=2)C1 FBCSWIXKXHSYBN-AZUAARDMSA-N 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- 208000020114 Schizophrenia and other psychotic disease Diseases 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/06—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by halogen atoms or nitro radicals
- C07D295/073—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by halogen atoms or nitro radicals with the ring nitrogen atoms and the substituents separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C17/00—Preparation of halogenated hydrocarbons
- C07C17/093—Preparation of halogenated hydrocarbons by replacement by halogens
- C07C17/16—Preparation of halogenated hydrocarbons by replacement by halogens of hydroxyl groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C25/00—Compounds containing at least one halogen atom bound to a six-membered aromatic ring
- C07C25/18—Polycyclic aromatic halogenated hydrocarbons
- C07C25/22—Polycyclic aromatic halogenated hydrocarbons with condensed rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C29/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring
- C07C29/132—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by reduction of an oxygen containing functional group
- C07C29/136—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by reduction of an oxygen containing functional group of >C=O containing groups, e.g. —COOH
- C07C29/143—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by reduction of an oxygen containing functional group of >C=O containing groups, e.g. —COOH of ketones
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C35/00—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a ring other than a six-membered aromatic ring
- C07C35/22—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a ring other than a six-membered aromatic ring polycyclic, at least one hydroxy group bound to a condensed ring system
- C07C35/23—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a ring other than a six-membered aromatic ring polycyclic, at least one hydroxy group bound to a condensed ring system with hydroxy on a condensed ring system having two rings
- C07C35/32—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a ring other than a six-membered aromatic ring polycyclic, at least one hydroxy group bound to a condensed ring system with hydroxy on a condensed ring system having two rings the condensed ring system being a (4.3.0) system, e.g. indenols
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
- C07D241/04—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P41/00—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
- C12P41/003—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by ester formation, lactone formation or the inverse reactions
- C12P41/004—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by ester formation, lactone formation or the inverse reactions by esterification of alcohol- or thiol groups in the enantiomers or the inverse reaction
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/02—Preparation of oxygen-containing organic compounds containing a hydroxy group
- C12P7/22—Preparation of oxygen-containing organic compounds containing a hydroxy group aromatic
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/07—Optical isomers
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Wood Science & Technology (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biotechnology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Medicinal Chemistry (AREA)
- Analytical Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DKPA200301180 | 2003-08-18 | ||
| DKPA200301305 | 2003-09-11 | ||
| PCT/DK2004/000546 WO2005016901A1 (en) | 2003-08-18 | 2004-08-18 | Trans-1(6-chloro-3-phenylindan-1-yl)-3,3-dimethylpiperazine |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MEP2408A true MEP2408A (xx) | 2010-02-10 |
Family
ID=58707237
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MEP-24/08A MEP2408A (xx) | 2003-08-18 | 2004-08-18 | Trans-1-(6-hloro-3 fenilindan-1-1l)-3,3-dimetilpiperazin |
Country Status (15)
| Country | Link |
|---|---|
| KR (2) | KR101227789B1 (de) |
| CN (1) | CN101935305B (de) |
| AR (2) | AR045279A1 (de) |
| AT (1) | ATE552247T1 (de) |
| DK (1) | DK1658277T3 (de) |
| EA (2) | EA200600443A1 (de) |
| ES (1) | ES2383369T3 (de) |
| IS (1) | IS8264A (de) |
| ME (1) | MEP2408A (de) |
| MY (2) | MY154535A (de) |
| PT (1) | PT1658277E (de) |
| RS (3) | RS53369B (de) |
| SG (2) | SG148183A1 (de) |
| SI (1) | SI1658277T1 (de) |
| TW (2) | TWI388550B (de) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI453198B (zh) * | 2005-02-16 | 2014-09-21 | Lundbeck & Co As H | 製造反式-1-((1r,3s)-6-氯基-3-苯基茚滿-1-基) -3 , 3 -二甲基六氫吡與其鹽類之方法及製造4-((1r , 3s）-6 -氯基-3-苯基茚滿-1-基 )-1,2,2-三甲基六氫吡與其鹽類之方法 |
| LT2720989T (lt) | 2011-06-20 | 2016-11-25 | H. Lundbeck A/S | Deuterinti 1-piperazin-3-fenilindanai, skirti šizofrenijos gydymui |
| JP7555350B2 (ja) | 2019-04-11 | 2024-09-24 | メイ ファーマ，インク． | ボルシクリブ多形、並びにそれを作製する方法及び使用する方法 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IE50867B1 (en) * | 1980-02-29 | 1986-08-06 | Kefalas As | Indane derivatives |
| DK55192D0 (da) * | 1992-04-28 | 1992-04-28 | Lundbeck & Co As H | 1-piperazino-1,2-dihydroindenderivater |
-
2004
- 2004-08-18 RS RS20060121A patent/RS53369B/sr unknown
- 2004-08-18 MY MYPI20082882A patent/MY154535A/en unknown
- 2004-08-18 PT PT04762772T patent/PT1658277E/pt unknown
- 2004-08-18 ME MEP-24/08A patent/MEP2408A/xx unknown
- 2004-08-18 SI SI200431885T patent/SI1658277T1/sl unknown
- 2004-08-18 SG SG200808521-9A patent/SG148183A1/en unknown
- 2004-08-18 TW TW093124784A patent/TWI388550B/zh not_active IP Right Cessation
- 2004-08-18 TW TW099140932A patent/TWI403505B/zh not_active IP Right Cessation
- 2004-08-18 AT AT04762772T patent/ATE552247T1/de active
- 2004-08-18 EA EA200600443A patent/EA200600443A1/ru unknown
- 2004-08-18 AR ARP040102967A patent/AR045279A1/es not_active Application Discontinuation
- 2004-08-18 SG SG200805893-5A patent/SG145723A1/en unknown
- 2004-08-18 AR ARP040102966A patent/AR045278A1/es not_active Application Discontinuation
- 2004-08-18 RS YUP-2006/0121A patent/RS20060121A/sr unknown
- 2004-08-18 KR KR1020067003177A patent/KR101227789B1/ko not_active Expired - Fee Related
- 2004-08-18 ES ES04762772T patent/ES2383369T3/es not_active Expired - Lifetime
- 2004-08-18 DK DK04762772.4T patent/DK1658277T3/da active
- 2004-08-18 EA EA200600441A patent/EA014641B1/ru not_active IP Right Cessation
- 2004-08-18 CN CN2010101632528A patent/CN101935305B/zh not_active Expired - Fee Related
- 2004-08-18 MY MYPI20043353A patent/MY149089A/en unknown
- 2004-08-18 KR KR1020067003357A patent/KR20060066104A/ko not_active Withdrawn
- 2004-08-18 RS YUP-2006/0083A patent/RS20060083A/sr unknown
-
2006
- 2006-01-26 IS IS8264A patent/IS8264A/is unknown
Also Published As
| Publication number | Publication date |
|---|---|
| TWI403505B (zh) | 2013-08-01 |
| PT1658277E (pt) | 2012-05-25 |
| EA200600443A1 (ru) | 2006-08-25 |
| HK1152699A1 (en) | 2012-03-09 |
| DK1658277T3 (da) | 2012-06-18 |
| SG148183A1 (en) | 2008-12-31 |
| CN101935305B (zh) | 2013-04-10 |
| RS20060083A (sr) | 2008-08-07 |
| RS20060121A (sr) | 2008-09-29 |
| AR045279A1 (es) | 2005-10-19 |
| KR101227789B1 (ko) | 2013-01-30 |
| AR045278A1 (es) | 2005-10-19 |
| ES2383369T3 (es) | 2012-06-20 |
| KR20060066104A (ko) | 2006-06-15 |
| TW200519098A (en) | 2005-06-16 |
| KR20060066094A (ko) | 2006-06-15 |
| TWI388550B (zh) | 2013-03-11 |
| RS53369B (sr) | 2014-10-31 |
| HK1096089A1 (en) | 2007-05-25 |
| MY149089A (en) | 2013-07-15 |
| MY154535A (en) | 2015-06-30 |
| TW201111351A (en) | 2011-04-01 |
| EA014641B1 (ru) | 2010-12-30 |
| SI1658277T1 (sl) | 2012-10-30 |
| EA200600441A1 (ru) | 2006-08-25 |
| ATE552247T1 (de) | 2012-04-15 |
| IS8264A (is) | 2006-01-26 |
| SG145723A1 (en) | 2008-09-29 |
| CN101935305A (zh) | 2011-01-05 |
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