AR045279A1 - Trans-1-(6-cloro-3-fenilindan-1-il)-3,3-dimetilpiperazina - Google Patents

Trans-1-(6-cloro-3-fenilindan-1-il)-3,3-dimetilpiperazina

Info

Publication number
AR045279A1
AR045279A1 ARP040102967A ARP040102967A AR045279A1 AR 045279 A1 AR045279 A1 AR 045279A1 AR P040102967 A ARP040102967 A AR P040102967A AR P040102967 A ARP040102967 A AR P040102967A AR 045279 A1 AR045279 A1 AR 045279A1
Authority
AR
Argentina
Prior art keywords
phenylindan
trans
chloro
dimethylipiperazine
compound
Prior art date
Application number
ARP040102967A
Other languages
English (en)
Original Assignee
Lundbeck & Co As H
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lundbeck & Co As H filed Critical Lundbeck & Co As H
Publication of AR045279A1 publication Critical patent/AR045279A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/06—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by halogen atoms or nitro radicals
    • C07D295/073—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by halogen atoms or nitro radicals with the ring nitrogen atoms and the substituents separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C17/00—Preparation of halogenated hydrocarbons
    • C07C17/093—Preparation of halogenated hydrocarbons by replacement by halogens
    • C07C17/16—Preparation of halogenated hydrocarbons by replacement by halogens of hydroxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C25/00—Compounds containing at least one halogen atom bound to a six-membered aromatic ring
    • C07C25/18—Polycyclic aromatic halogenated hydrocarbons
    • C07C25/22—Polycyclic aromatic halogenated hydrocarbons with condensed rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C29/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring
    • C07C29/132—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by reduction of an oxygen containing functional group
    • C07C29/136—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by reduction of an oxygen containing functional group of >C=O containing groups, e.g. —COOH
    • C07C29/143—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by reduction of an oxygen containing functional group of >C=O containing groups, e.g. —COOH of ketones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C35/00—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a ring other than a six-membered aromatic ring
    • C07C35/22—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a ring other than a six-membered aromatic ring polycyclic, at least one hydroxy group bound to a condensed ring system
    • C07C35/23—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a ring other than a six-membered aromatic ring polycyclic, at least one hydroxy group bound to a condensed ring system with hydroxy on a condensed ring system having two rings
    • C07C35/32—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a ring other than a six-membered aromatic ring polycyclic, at least one hydroxy group bound to a condensed ring system with hydroxy on a condensed ring system having two rings the condensed ring system being a (4.3.0) system, e.g. indenols
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/04—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P41/00—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
    • C12P41/003—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by ester formation, lactone formation or the inverse reactions
    • C12P41/004—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by ester formation, lactone formation or the inverse reactions by esterification of alcohol- or thiol groups in the enantiomers or the inverse reaction
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/02—Preparation of oxygen-containing organic compounds containing a hydroxy group
    • C12P7/22—Preparation of oxygen-containing organic compounds containing a hydroxy group aromatic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Medicinal Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Composiciones farmacéuticas que comprenden al compuesto y sus sales, y uso médico del mismo, incluyendo para tratamiento de la esquizofrenia y de otros trastornos psicóticos. Reivindicación 1: Un compuesto de la fórmula (1) (compuesto (1), trans-1-((1R,3S)-6-cloro-3-fenilindan-1-il)-3,3-dimetilpiperazina) o una sal del mismo.
ARP040102967A 2003-08-18 2004-08-18 Trans-1-(6-cloro-3-fenilindan-1-il)-3,3-dimetilpiperazina AR045279A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DKPA200301180 2003-08-18
DKPA200301305 2003-09-11

Publications (1)

Publication Number Publication Date
AR045279A1 true AR045279A1 (es) 2005-10-19

Family

ID=58707237

Family Applications (2)

Application Number Title Priority Date Filing Date
ARP040102967A AR045279A1 (es) 2003-08-18 2004-08-18 Trans-1-(6-cloro-3-fenilindan-1-il)-3,3-dimetilpiperazina
ARP040102966A AR045278A1 (es) 2003-08-18 2004-08-18 Sales de succinato y malonato de trans-4-((1r, 3s)-6-cloro-3-fenilindan-1-il)-1,2,2-trimetilpiperazina y el uso como medicamento

Family Applications After (1)

Application Number Title Priority Date Filing Date
ARP040102966A AR045278A1 (es) 2003-08-18 2004-08-18 Sales de succinato y malonato de trans-4-((1r, 3s)-6-cloro-3-fenilindan-1-il)-1,2,2-trimetilpiperazina y el uso como medicamento

Country Status (16)

Country Link
KR (2) KR101227789B1 (es)
CN (1) CN101935305B (es)
AR (2) AR045279A1 (es)
AT (1) ATE552247T1 (es)
DK (1) DK1658277T3 (es)
EA (2) EA014641B1 (es)
ES (1) ES2383369T3 (es)
HK (2) HK1096089A1 (es)
IS (1) IS8264A (es)
ME (1) MEP2408A (es)
MY (2) MY154535A (es)
PT (1) PT1658277E (es)
RS (3) RS20060121A (es)
SG (2) SG148183A1 (es)
SI (1) SI1658277T1 (es)
TW (2) TWI403505B (es)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI453198B (zh) * 2005-02-16 2014-09-21 Lundbeck & Co As H 製造反式-1-((1r,3s)-6-氯基-3-苯基茚滿-1-基) -3 , 3 -二甲基六氫吡與其鹽類之方法及製造4-((1r , 3s）-6 -氯基-3-苯基茚滿-1-基 )-1,2,2-三甲基六氫吡與其鹽類之方法
JP5668177B2 (ja) 2011-06-20 2015-02-12 ハー・ルンドベック・アクチエゼルスカベット 統合失調症の治療のための重水素化１−ピペラジノ−３−フェニルインダン

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ196284A (en) * 1980-02-29 1983-12-16 Kefalas As 1-piperazino-3-phenylindane derivatives:pharmaceutical compositions
DK55192D0 (da) * 1992-04-28 1992-04-28 Lundbeck & Co As H 1-piperazino-1,2-dihydroindenderivater

Also Published As

Publication number Publication date
CN101935305B (zh) 2013-04-10
TWI403505B (zh) 2013-08-01
SG148183A1 (en) 2008-12-31
EA200600443A1 (ru) 2006-08-25
AR045278A1 (es) 2005-10-19
CN101935305A (zh) 2011-01-05
HK1096089A1 (en) 2007-05-25
RS20060121A (en) 2008-09-29
MEP2408A (xx) 2010-02-10
DK1658277T3 (da) 2012-06-18
ATE552247T1 (de) 2012-04-15
HK1152699A1 (en) 2012-03-09
EA200600441A1 (ru) 2006-08-25
TWI388550B (zh) 2013-03-11
RS20060083A (en) 2008-08-07
KR20060066094A (ko) 2006-06-15
ES2383369T3 (es) 2012-06-20
SI1658277T1 (sl) 2012-10-30
RS53369B (en) 2014-10-31
KR101227789B1 (ko) 2013-01-30
TW200519098A (en) 2005-06-16
MY149089A (en) 2013-07-15
TW201111351A (en) 2011-04-01
MY154535A (en) 2015-06-30
KR20060066104A (ko) 2006-06-15
IS8264A (is) 2006-01-26
PT1658277E (pt) 2012-05-25
SG145723A1 (en) 2008-09-29
EA014641B1 (ru) 2010-12-30

Similar Documents

Publication Publication Date Title
BRPI0413555A (pt) composto ou sal do mesmo, composição farmacêutica, uso de um composto ou sal, e, método para o tratamento de uma doença, para a fabricação de um composto e para a preparação de composto
CR7583A (es) Nueva sal formiato de o-desmetil venlafaxina
ECSP034774A (es) Pirazolopirimmidinas como agentes terapeuticos
ECSP034773A (es) Pirazolopirimmidinas como agentes terapeuticos
HRP20090281T1 (en) 1,2,3,4-tetrasubstituted indole for the treatment of respiratory diseases
CY1111867T1 (el) Ενωση ενεργοποιησης ppar και φαρμακευτικη συνθεση που περιεχει αυτη
RS52625B (en) FLUORO SUBSTITUTED OMEGA-CARBOXYARYL DIPHENYL UREA FOR TREATMENT AND PREVENTION OF DISEASES AND DISEASES
NO331013B1 (no) Nye forbindelser som er anti-inflammasjons, immunomodulerende og anti-proliferative midler, anvendelse av forbindelsene samt farmasoytisk preparat
UY28348A1 (es) Compuestos novedosos
BR0312729A (pt) Novos derivados de indol-3-enxofre
SE0201544D0 (sv) Novel compounds and thier use
SE0301446D0 (sv) New Compounds
CY1111857T1 (el) Κρυσταλλικη βαση trans-1-((1r,3s)-6-xλωpo-3-φαινυλινδαν-1-υλο)-3,3-διμεθυλοπιπεραζινης
NO20074593L (no) Tartrat- og malatsalter av trans-1-(6-klor-3-fenylindan-1-yl)-3,3-dimetylpiperazin
ES2421948T3 (es) Compuestos y composiciones para suministrar agentes activos
CY1110130T1 (el) Παραγωγα μορφολινης για χρηση ως αγωνιστες ντοπαμινης στην θεραπευτικη αγωγη σεξουαλικης δυσλειτουργιας i.α.
SE0302546D0 (sv) New compounds
BRPI0417858A (pt) composto, composição farmacêutica, e, uso de uma composição farmacêutica
EA200701856A1 (ru) Тетрагидропиридоазепин-8-оны и родственные соединения для лечения шизофрении
BRPI0406824A (pt) Indolonaoxazoldinonas antiibacterianas, intermediários para seu preparo e composições farmacêuticas que as contêm
ECSP045397A (es) 6-ALQUILIDEN-PENEMS BICÍCLICOS COMO INHIBIDORES DE LAS b-LACTAMASAS
UY27324A1 (es) Nuevas sales de napsilato i
AR045279A1 (es) Trans-1-(6-cloro-3-fenilindan-1-il)-3,3-dimetilpiperazina
SE0403118D0 (sv) New compounds 2
SE0403117D0 (sv) New compounds 1

Legal Events

Date Code Title Description
FA Abandonment or withdrawal