ME02954B - Poboljšana tnf veziva - Google Patents

Poboljšana tnf veziva

Info

Publication number
ME02954B
ME02954B MEP-2017-291A MEP2017291A ME02954B ME 02954 B ME02954 B ME 02954B ME P2017291 A MEP2017291 A ME P2017291A ME 02954 B ME02954 B ME 02954B
Authority
ME
Montenegro
Prior art keywords
tnf binders
improved tnf
improved
binders
tnf
Prior art date
Application number
MEP-2017-291A
Other languages
German (de)
English (en)
French (fr)
Unknown language (me)
Inventor
Marie-Ange Buyse
Joachim Boucneau
Peter Casteels
Heeke Gino Van
Original Assignee
Ablynx Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ablynx Nv filed Critical Ablynx Nv
Publication of ME02954B publication Critical patent/ME02954B/me

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/241Tumor Necrosis Factors
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/02Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/10Immunoglobulins specific features characterized by their source of isolation or production
    • C07K2317/14Specific host cells or culture conditions, e.g. components, pH or temperature
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/20Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/22Immunoglobulins specific features characterized by taxonomic origin from camelids, e.g. camel, llama or dromedary
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/20Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/30Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565Complementarity determining region [CDR]
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/567Framework region [FR]
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/569Single domain, e.g. dAb, sdAb, VHH, VNAR or nanobody®
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/70Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/90Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/90Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/94Stability, e.g. half-life, pH, temperature or enzyme-resistance

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • Dermatology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicinal Preparation (AREA)
  • Treatment Of Liquids With Adsorbents In General (AREA)
  • Organic Insulating Materials (AREA)
  • Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
MEP-2017-291A 2015-11-12 2016-11-14 Poboljšana tnf veziva ME02954B (me)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562254375P 2015-11-12 2015-11-12
EP16798122.4A EP3191511B1 (en) 2015-11-12 2016-11-14 Improved tnf binders
PCT/EP2016/077595 WO2017081320A1 (en) 2015-11-12 2016-11-14 Improved tnf binders

Publications (1)

Publication Number Publication Date
ME02954B true ME02954B (me) 2018-07-20

Family

ID=57348648

Family Applications (1)

Application Number Title Priority Date Filing Date
MEP-2017-291A ME02954B (me) 2015-11-12 2016-11-14 Poboljšana tnf veziva

Country Status (37)

Country Link
US (2) US10544211B2 (show.php)
EP (2) EP3266798A3 (show.php)
JP (2) JP6962915B2 (show.php)
KR (2) KR20240029115A (show.php)
CN (1) CN108473563B (show.php)
AU (2) AU2016352943B2 (show.php)
BR (1) BR112018009714A8 (show.php)
CA (2) CA3005085C (show.php)
CL (1) CL2018001291A1 (show.php)
CO (1) CO2018005915A2 (show.php)
CR (1) CR20180311A (show.php)
CY (1) CY1120303T1 (show.php)
DK (1) DK3191511T3 (show.php)
DO (1) DOP2018000122A (show.php)
EC (1) ECSP18042569A (show.php)
ES (1) ES2662418T3 (show.php)
GT (1) GT201800095A (show.php)
HK (1) HK1248716A1 (show.php)
HR (1) HRP20171949T1 (show.php)
HU (1) HUE035805T2 (show.php)
IL (2) IL310373A (show.php)
LT (1) LT3191511T (show.php)
MA (1) MA41653A (show.php)
MD (1) MD3191511T2 (show.php)
ME (1) ME02954B (show.php)
MX (1) MX385207B (show.php)
NO (1) NO2768984T3 (show.php)
PE (1) PE20181317A1 (show.php)
PH (1) PH12018501025A1 (show.php)
PL (1) PL3191511T3 (show.php)
PT (1) PT3191511T (show.php)
RS (1) RS56676B1 (show.php)
SG (1) SG11201803975SA (show.php)
SI (1) SI3191511T1 (show.php)
SM (1) SMT201700590T1 (show.php)
TN (1) TN2018000159A1 (show.php)
WO (1) WO2017081320A1 (show.php)

Families Citing this family (14)

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US11644471B2 (en) 2010-09-30 2023-05-09 Ablynx N.V. Techniques for predicting, detecting and reducing aspecific protein interference in assays involving immunoglobulin single variable domains
CA2837998C (en) 2011-06-23 2022-03-01 Ablynx Nv Techniques for predicting, detecting and reducing aspecific protein interference in assays involving immunoglobulin single variable domains
KR20230145503A (ko) 2014-05-16 2023-10-17 아블린쓰 엔.브이. 개선된 면역글로불린 가변 도메인
KR20250099289A (ko) 2014-05-16 2025-07-01 아블린쓰 엔.브이. 개선된 면역글로불린 가변 도메인
NO2768984T3 (show.php) * 2015-11-12 2018-06-09
GB201522394D0 (en) 2015-12-18 2016-02-03 Ucb Biopharma Sprl Antibodies
CN114981300B (zh) 2019-12-06 2025-10-31 艾伯霖克斯公司 包含靶向TNFα和IL-23的免疫球蛋白单个可变结构域的多肽
JP7719775B2 (ja) 2019-12-06 2025-08-06 アブリンクス エン.ヴェー. TNFαおよびOX40Lを標的とする免疫グロブリン単一可変ドメインを含むポリペプチド
CN112300289B (zh) * 2019-12-30 2022-06-10 中国药科大学 RGD4C融合抗TNFα纳米抗体蛋白、制备方法及其应用
EP4263602A1 (en) 2020-12-18 2023-10-25 Ablynx N.V. Polypeptides comprising immunoglobulin single variable domains targeting il-6 and tnf-alpha
CN118339179A (zh) * 2021-11-29 2024-07-12 江苏恒瑞医药股份有限公司 经修饰的蛋白或多肽
WO2024097571A1 (en) * 2022-11-04 2024-05-10 St. Jude Children's Research Hospital, Inc. Nlrp12 and nlrc5 modulators and methods for using the same to modulate diseases
WO2024133935A1 (en) 2022-12-23 2024-06-27 Ablynx Nv Protein-based conjugation carriers
TW202448926A (zh) 2023-02-17 2024-12-16 比利時商艾伯霖克斯公司 結合新生兒fc受體之多肽

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EP0739981A1 (en) 1995-04-25 1996-10-30 Vrije Universiteit Brussel Variable fragments of immunoglobulins - use for therapeutic or veterinary purposes
EP1027439B1 (en) 1997-10-27 2010-03-17 Bac Ip B.V. Multivalent antigen-binding proteins
EP1469883A2 (en) 1998-02-19 2004-10-27 Xcyte Therapies, Inc. Compositions and methods for regulating lymphocyte activation
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WO2006040153A2 (en) 2004-10-13 2006-04-20 Ablynx N.V. Single domain camelide anti -amyloid beta antibodies and polypeptides comprising the same for the treatment and diagnosis of degenarative neural diseases such as alzheimer's disease
JP2008521870A (ja) 2004-12-02 2008-06-26 ドマンティス リミテッド 抗il−1r1単一ドメイン抗体および治療使用
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SG174862A1 (en) 2009-04-10 2011-11-28 Ablynx Nv Improved amino acid sequences directed against il-6r and polypeptides comprising the same for the treatment of il-6r related diseases and disorder
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CN102574914A (zh) 2009-07-16 2012-07-11 葛兰素集团有限公司 改进的抗血清清蛋白结合性单可变区
US9120855B2 (en) 2010-02-10 2015-09-01 Novartis Ag Biologic compounds directed against death receptor 5
JP6181040B2 (ja) 2011-03-28 2017-08-16 アブリンクス エン.ヴェー. 二特異性抗cxcr7免疫グロブリン単一可変ドメイン
US9573992B2 (en) 2011-06-23 2017-02-21 Ablynx N.V. Serum albumin binding proteins
CA2837998C (en) * 2011-06-23 2022-03-01 Ablynx Nv Techniques for predicting, detecting and reducing aspecific protein interference in assays involving immunoglobulin single variable domains
ES2813432T3 (es) * 2011-08-17 2021-03-23 Glaxo Group Ltd Proteínas y péptidos modificados
WO2014111550A1 (en) 2013-01-17 2014-07-24 Glaxosmithkline Intellectual Property Development Limited Modified anti-serum albumin binding proteins
KR20230145503A (ko) * 2014-05-16 2023-10-17 아블린쓰 엔.브이. 개선된 면역글로불린 가변 도메인
NO2768984T3 (show.php) 2015-11-12 2018-06-09
CA3014443A1 (en) * 2016-02-12 2017-08-17 Ablynx Nv Method for the production of immunoglobulin single variable domains

Also Published As

Publication number Publication date
ECSP18042569A (es) 2018-07-31
DOP2018000122A (es) 2018-09-30
US20170267752A1 (en) 2017-09-21
PH12018501025A1 (en) 2019-01-28
KR20180083382A (ko) 2018-07-20
CN108473563B (zh) 2022-06-14
MX2018005992A (es) 2019-01-31
PL3191511T3 (pl) 2018-03-30
CN108473563A (zh) 2018-08-31
US9745372B2 (en) 2017-08-29
CY1120303T1 (el) 2019-07-10
TN2018000159A1 (en) 2019-10-04
HK1248716A1 (en) 2018-10-19
IL259269B1 (en) 2024-03-01
AU2016352943A1 (en) 2018-06-07
SI3191511T1 (en) 2018-01-31
RS56676B1 (sr) 2018-03-30
GT201800095A (es) 2019-08-15
MD3191511T2 (ro) 2018-03-31
US10544211B2 (en) 2020-01-28
PE20181317A1 (es) 2018-08-14
EP3266798A3 (en) 2018-03-28
EP3191511B1 (en) 2017-09-20
WO2017081320A1 (en) 2017-05-18
JP2019506839A (ja) 2019-03-14
JP2022020666A (ja) 2022-02-01
CR20180311A (es) 2018-10-18
SMT201700590T1 (it) 2018-01-11
MX385207B (es) 2025-03-04
RU2018120524A (ru) 2019-12-13
EP3191511A1 (en) 2017-07-19
AU2023200113A1 (en) 2023-02-16
RU2018120524A3 (show.php) 2020-09-24
AU2016352943B2 (en) 2022-10-20
CL2018001291A1 (es) 2018-09-14
KR102641194B1 (ko) 2024-02-26
US20170190769A1 (en) 2017-07-06
IL259269B2 (en) 2024-07-01
CO2018005915A2 (es) 2018-06-20
JP7357038B2 (ja) 2023-10-05
SG11201803975SA (en) 2018-06-28
LT3191511T (lt) 2018-01-10
HUE035805T2 (en) 2018-05-28
JP6962915B2 (ja) 2021-11-10
CA3234178A1 (en) 2017-05-18
IL259269A (en) 2018-07-31
CA3005085A1 (en) 2017-05-18
BR112018009714A8 (pt) 2019-02-26
PT3191511T (pt) 2017-11-30
NO2768984T3 (show.php) 2018-06-09
IL310373A (en) 2024-03-01
HRP20171949T1 (hr) 2018-01-26
MA41653A (fr) 2018-01-09
BR112018009714A2 (en) 2018-11-21
DK3191511T3 (en) 2018-01-08
CA3005085C (en) 2024-09-10
KR20240029115A (ko) 2024-03-05
ES2662418T3 (es) 2018-04-06
EP3266798A2 (en) 2018-01-10

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