ME02535B - Antimalarijski agensi - Google Patents
Antimalarijski agensiInfo
- Publication number
- ME02535B ME02535B MEP-2016-214A MEP2016214A ME02535B ME 02535 B ME02535 B ME 02535B ME P2016214 A MEP2016214 A ME P2016214A ME 02535 B ME02535 B ME 02535B
- Authority
- ME
- Montenegro
- Prior art keywords
- phenyl
- pyrazin
- trifluoromethyl
- amino
- methanone
- Prior art date
Links
- 230000000078 anti-malarial effect Effects 0.000 title 1
- XFTQRUTUGRCSGO-UHFFFAOYSA-N pyrazin-2-amine Chemical compound NC1=CN=CC=N1 XFTQRUTUGRCSGO-UHFFFAOYSA-N 0.000 claims 19
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims 7
- -1 complexes Chemical class 0.000 claims 3
- 125000006552 (C3-C8) cycloalkyl group Chemical group 0.000 claims 2
- 238000006069 Suzuki reaction reaction Methods 0.000 claims 2
- ZADPBFCGQRWHPN-UHFFFAOYSA-N boronic acid Chemical compound OBO ZADPBFCGQRWHPN-UHFFFAOYSA-N 0.000 claims 2
- 150000001875 compounds Chemical class 0.000 claims 2
- 229910052736 halogen Inorganic materials 0.000 claims 2
- 150000002367 halogens Chemical class 0.000 claims 2
- 125000000592 heterocycloalkyl group Chemical group 0.000 claims 2
- 150000004677 hydrates Chemical class 0.000 claims 2
- 238000000034 method Methods 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- 150000003839 salts Chemical class 0.000 claims 2
- IFSRLALWNRZNIR-UHFFFAOYSA-N (3-aminopyrrolidin-1-yl)-[4-[5-amino-6-[4-(trifluoromethyl)phenyl]pyrazin-2-yl]phenyl]methanone Chemical compound C1C(N)CCN1C(=O)C1=CC=C(C=2N=C(C(N)=NC=2)C=2C=CC(=CC=2)C(F)(F)F)C=C1 IFSRLALWNRZNIR-UHFFFAOYSA-N 0.000 claims 1
- ZCGDXSRKXDBFAA-UHFFFAOYSA-N (4-aminocyclohexyl)-[4-[5-amino-6-[4-(trifluoromethyl)phenyl]pyrazin-2-yl]phenyl]methanone Chemical compound C1CC(N)CCC1C(=O)C1=CC=C(C=2N=C(C(N)=NC=2)C=2C=CC(=CC=2)C(F)(F)F)C=C1 ZCGDXSRKXDBFAA-UHFFFAOYSA-N 0.000 claims 1
- UXRREWBCCJNKNA-UHFFFAOYSA-N (4-aminocyclohexyl)-[4-[5-amino-6-[6-(trifluoromethyl)pyridin-3-yl]pyrazin-2-yl]phenyl]methanone Chemical compound C1CC(N)CCC1C(=O)C1=CC=C(C=2N=C(C(N)=NC=2)C=2C=NC(=CC=2)C(F)(F)F)C=C1 UXRREWBCCJNKNA-UHFFFAOYSA-N 0.000 claims 1
- MSGBHWXJZXCMDF-UHFFFAOYSA-N 3-(6-methoxypyridin-3-yl)-5-(4-methylsulfonylphenyl)pyrazin-2-amine Chemical compound C1=NC(OC)=CC=C1C1=NC(C=2C=CC(=CC=2)S(C)(=O)=O)=CN=C1N MSGBHWXJZXCMDF-UHFFFAOYSA-N 0.000 claims 1
- TVMWNJXWFMZIPH-UHFFFAOYSA-N 3-bromo-5-(4-methylsulfonylphenyl)pyrazin-2-amine Chemical group C1=CC(S(=O)(=O)C)=CC=C1C1=CN=C(N)C(Br)=N1 TVMWNJXWFMZIPH-UHFFFAOYSA-N 0.000 claims 1
- KKJXMTLYNLAKNL-UHFFFAOYSA-N 4-[5-amino-6-(4-carbamoylphenyl)pyrazin-2-yl]benzamide Chemical compound C1=CC(C(=O)N)=CC=C1C1=CN=C(N)C(C=2C=CC(=CC=2)C(N)=O)=N1 KKJXMTLYNLAKNL-UHFFFAOYSA-N 0.000 claims 1
- ILTQXXBYLJQOLK-UHFFFAOYSA-N 4-[5-amino-6-(4-methylsulfonylphenyl)pyrazin-2-yl]benzamide Chemical compound C1=CC(S(=O)(=O)C)=CC=C1C1=NC(C=2C=CC(=CC=2)C(N)=O)=CN=C1N ILTQXXBYLJQOLK-UHFFFAOYSA-N 0.000 claims 1
- XNPURVXRWUXOPE-UHFFFAOYSA-N 4-[5-amino-6-[3-fluoro-4-(trifluoromethyl)phenyl]pyrazin-2-yl]benzamide Chemical compound C1=CC(C(=O)N)=CC=C1C1=CN=C(N)C(C=2C=C(F)C(=CC=2)C(F)(F)F)=N1 XNPURVXRWUXOPE-UHFFFAOYSA-N 0.000 claims 1
- KFGMWGIKMVHIJZ-UHFFFAOYSA-N 4-[5-amino-6-[4-(methylcarbamoyl)phenyl]pyrazin-2-yl]benzamide Chemical compound C1=CC(C(=O)NC)=CC=C1C1=NC(C=2C=CC(=CC=2)C(N)=O)=CN=C1N KFGMWGIKMVHIJZ-UHFFFAOYSA-N 0.000 claims 1
- UBIZVPPIFUXEEB-UHFFFAOYSA-N 4-[5-amino-6-[4-(trifluoromethyl)phenyl]pyrazin-2-yl]benzamide Chemical compound C1=CC(C(=O)N)=CC=C1C1=CN=C(N)C(C=2C=CC(=CC=2)C(F)(F)F)=N1 UBIZVPPIFUXEEB-UHFFFAOYSA-N 0.000 claims 1
- HARBDNRHGGVYDE-UHFFFAOYSA-N 4-[5-amino-6-[6-(trifluoromethyl)pyridin-3-yl]pyrazin-2-yl]-n-methylbenzenesulfonamide Chemical compound C1=CC(S(=O)(=O)NC)=CC=C1C1=CN=C(N)C(C=2C=NC(=CC=2)C(F)(F)F)=N1 HARBDNRHGGVYDE-UHFFFAOYSA-N 0.000 claims 1
- FRVNCQOSGYBWDN-UHFFFAOYSA-N 4-[5-amino-6-[6-(trifluoromethyl)pyridin-3-yl]pyrazin-2-yl]benzamide Chemical compound C1=CC(C(=O)N)=CC=C1C1=CN=C(N)C(C=2C=NC(=CC=2)C(F)(F)F)=N1 FRVNCQOSGYBWDN-UHFFFAOYSA-N 0.000 claims 1
- WNLGPWQMIXOKQG-UHFFFAOYSA-N 5-(4-cyclopropylsulfonylphenyl)-3-[6-(trifluoromethyl)pyridin-3-yl]pyrazin-2-amine Chemical compound NC1=NC=C(C=2C=CC(=CC=2)S(=O)(=O)C2CC2)N=C1C1=CC=C(C(F)(F)F)N=C1 WNLGPWQMIXOKQG-UHFFFAOYSA-N 0.000 claims 1
- MOVWXDGLBZSEPD-UHFFFAOYSA-N 5-(4-ethylsulfonylphenyl)-3-[6-(trifluoromethyl)pyridin-3-yl]pyrazin-2-amine Chemical compound C1=CC(S(=O)(=O)CC)=CC=C1C1=CN=C(N)C(C=2C=NC(=CC=2)C(F)(F)F)=N1 MOVWXDGLBZSEPD-UHFFFAOYSA-N 0.000 claims 1
- RGYXFRIHYUQXFL-UHFFFAOYSA-N 5-(4-methylsulfonylphenyl)-3-[4-(trifluoromethyl)phenyl]pyrazin-2-amine;5-(4-methylsulfonylphenyl)-3-[6-(trifluoromethyl)pyridin-3-yl]pyrazin-2-amine Chemical compound C1=CC(S(=O)(=O)C)=CC=C1C1=CN=C(N)C(C=2C=CC(=CC=2)C(F)(F)F)=N1.C1=CC(S(=O)(=O)C)=CC=C1C1=CN=C(N)C(C=2C=NC(=CC=2)C(F)(F)F)=N1 RGYXFRIHYUQXFL-UHFFFAOYSA-N 0.000 claims 1
- UAEQPLLFQAIGHI-UHFFFAOYSA-N 5-(4-propan-2-ylsulfonylphenyl)-3-[6-(trifluoromethyl)pyridin-3-yl]pyrazin-2-amine Chemical compound C1=CC(S(=O)(=O)C(C)C)=CC=C1C1=CN=C(N)C(C=2C=NC(=CC=2)C(F)(F)F)=N1 UAEQPLLFQAIGHI-UHFFFAOYSA-N 0.000 claims 1
- IKVDKCGDERAICR-UHFFFAOYSA-N 5-[4-(cyclopropylmethylsulfonyl)phenyl]-3-[6-(trifluoromethyl)pyridin-3-yl]pyrazin-2-amine Chemical compound NC1=NC=C(C=2C=CC(=CC=2)S(=O)(=O)CC2CC2)N=C1C1=CC=C(C(F)(F)F)N=C1 IKVDKCGDERAICR-UHFFFAOYSA-N 0.000 claims 1
- 241000694408 Isomeris Species 0.000 claims 1
- YLJVIDYBSMUBRL-UHFFFAOYSA-N [4-(5-amino-6-bromopyrazin-2-yl)phenyl]-(3-hydroxypyrrolidin-1-yl)methanone Chemical compound N1=C(Br)C(N)=NC=C1C1=CC=C(C(=O)N2CC(O)CC2)C=C1 YLJVIDYBSMUBRL-UHFFFAOYSA-N 0.000 claims 1
- QKMGZWDGSBJZNW-UHFFFAOYSA-N [4-[5-amino-6-[4-(trifluoromethyl)phenyl]pyrazin-2-yl]phenyl]-(1,4-diazepan-1-yl)methanone Chemical compound NC1=NC=C(C=2C=CC(=CC=2)C(=O)N2CCNCCC2)N=C1C1=CC=C(C(F)(F)F)C=C1 QKMGZWDGSBJZNW-UHFFFAOYSA-N 0.000 claims 1
- QRCMCFJPTPLCCR-UHFFFAOYSA-N [4-[5-amino-6-[4-(trifluoromethyl)phenyl]pyrazin-2-yl]phenyl]-(3-hydroxypyrrolidin-1-yl)methanone Chemical compound NC1=NC=C(C=2C=CC(=CC=2)C(=O)N2CC(O)CC2)N=C1C1=CC=C(C(F)(F)F)C=C1 QRCMCFJPTPLCCR-UHFFFAOYSA-N 0.000 claims 1
- FKDIWALLMXDOBS-UHFFFAOYSA-N [4-[5-amino-6-[4-(trifluoromethyl)phenyl]pyrazin-2-yl]phenyl]-(4-hydroxypiperidin-1-yl)methanone Chemical compound NC1=NC=C(C=2C=CC(=CC=2)C(=O)N2CCC(O)CC2)N=C1C1=CC=C(C(F)(F)F)C=C1 FKDIWALLMXDOBS-UHFFFAOYSA-N 0.000 claims 1
- JKGSEXNAJXBRDM-UHFFFAOYSA-N [4-[5-amino-6-[4-(trifluoromethyl)phenyl]pyrazin-2-yl]phenyl]-(4-methyl-1,4-diazepan-1-yl)methanone Chemical compound C1CN(C)CCCN1C(=O)C1=CC=C(C=2N=C(C(N)=NC=2)C=2C=CC(=CC=2)C(F)(F)F)C=C1 JKGSEXNAJXBRDM-UHFFFAOYSA-N 0.000 claims 1
- RMTRGLNLRIPBEP-UHFFFAOYSA-N [4-[5-amino-6-[4-(trifluoromethyl)phenyl]pyrazin-2-yl]phenyl]-(4-methylpiperazin-1-yl)methanone Chemical compound C1CN(C)CCN1C(=O)C1=CC=C(C=2N=C(C(N)=NC=2)C=2C=CC(=CC=2)C(F)(F)F)C=C1 RMTRGLNLRIPBEP-UHFFFAOYSA-N 0.000 claims 1
- MPJVEQUTYMMVFV-UHFFFAOYSA-N [4-[5-amino-6-[4-(trifluoromethyl)phenyl]pyrazin-2-yl]phenyl]-(4-tert-butylpiperazin-1-yl)methanone Chemical compound C1CN(C(C)(C)C)CCN1C(=O)C1=CC=C(C=2N=C(C(N)=NC=2)C=2C=CC(=CC=2)C(F)(F)F)C=C1 MPJVEQUTYMMVFV-UHFFFAOYSA-N 0.000 claims 1
- JTVQYNCQTWIEOM-UHFFFAOYSA-N [4-[5-amino-6-[4-(trifluoromethyl)phenyl]pyrazin-2-yl]phenyl]-morpholin-4-ylmethanone Chemical compound NC1=NC=C(C=2C=CC(=CC=2)C(=O)N2CCOCC2)N=C1C1=CC=C(C(F)(F)F)C=C1 JTVQYNCQTWIEOM-UHFFFAOYSA-N 0.000 claims 1
- GGOFGCMPKAWHEZ-UHFFFAOYSA-N [4-[5-amino-6-[4-(trifluoromethyl)phenyl]pyrazin-2-yl]phenyl]-piperazin-1-ylmethanone Chemical compound NC1=NC=C(C=2C=CC(=CC=2)C(=O)N2CCNCC2)N=C1C1=CC=C(C(F)(F)F)C=C1 GGOFGCMPKAWHEZ-UHFFFAOYSA-N 0.000 claims 1
- HMDDHIGAWLFZAP-UHFFFAOYSA-N [4-[5-amino-6-[6-(trifluoromethyl)pyridin-3-yl]pyrazin-2-yl]phenyl]-(1,4-diazepan-1-yl)methanone Chemical compound NC1=NC=C(C=2C=CC(=CC=2)C(=O)N2CCNCCC2)N=C1C1=CC=C(C(F)(F)F)N=C1 HMDDHIGAWLFZAP-UHFFFAOYSA-N 0.000 claims 1
- SXLQIWVYFPJURZ-UHFFFAOYSA-N [4-[5-amino-6-[6-(trifluoromethyl)pyridin-3-yl]pyrazin-2-yl]phenyl]-(3-hydroxypyrrolidin-1-yl)methanone Chemical compound NC1=NC=C(C=2C=CC(=CC=2)C(=O)N2CC(O)CC2)N=C1C1=CC=C(C(F)(F)F)N=C1 SXLQIWVYFPJURZ-UHFFFAOYSA-N 0.000 claims 1
- BFOZDYPVOAYCER-UHFFFAOYSA-N [4-[5-amino-6-[6-(trifluoromethyl)pyridin-3-yl]pyrazin-2-yl]phenyl]-(4-hydroxypiperidin-1-yl)methanone Chemical compound NC1=NC=C(C=2C=CC(=CC=2)C(=O)N2CCC(O)CC2)N=C1C1=CC=C(C(F)(F)F)N=C1 BFOZDYPVOAYCER-UHFFFAOYSA-N 0.000 claims 1
- VGLYCNNNCNWXSU-UHFFFAOYSA-N [4-[5-amino-6-[6-(trifluoromethyl)pyridin-3-yl]pyrazin-2-yl]phenyl]-(4-methyl-1,4-diazepan-1-yl)methanone Chemical compound C1CN(C)CCCN1C(=O)C1=CC=C(C=2N=C(C(N)=NC=2)C=2C=NC(=CC=2)C(F)(F)F)C=C1 VGLYCNNNCNWXSU-UHFFFAOYSA-N 0.000 claims 1
- GJQCXICOYCNNKH-UHFFFAOYSA-N [4-[5-amino-6-[6-(trifluoromethyl)pyridin-3-yl]pyrazin-2-yl]phenyl]-(4-methylpiperazin-1-yl)methanone Chemical compound C1CN(C)CCN1C(=O)C1=CC=C(C=2N=C(C(N)=NC=2)C=2C=NC(=CC=2)C(F)(F)F)C=C1 GJQCXICOYCNNKH-UHFFFAOYSA-N 0.000 claims 1
- QYLBQFPRQVBPDZ-UHFFFAOYSA-N [4-[5-amino-6-[6-(trifluoromethyl)pyridin-3-yl]pyrazin-2-yl]phenyl]-(4-tert-butylpiperazin-1-yl)methanone Chemical compound C1CN(C(C)(C)C)CCN1C(=O)C1=CC=C(C=2N=C(C(N)=NC=2)C=2C=NC(=CC=2)C(F)(F)F)C=C1 QYLBQFPRQVBPDZ-UHFFFAOYSA-N 0.000 claims 1
- OIZOYBBNHJPCGH-UHFFFAOYSA-N [4-[5-amino-6-[6-(trifluoromethyl)pyridin-3-yl]pyrazin-2-yl]phenyl]-morpholin-4-ylmethanone Chemical compound NC1=NC=C(C=2C=CC(=CC=2)C(=O)N2CCOCC2)N=C1C1=CC=C(C(F)(F)F)N=C1 OIZOYBBNHJPCGH-UHFFFAOYSA-N 0.000 claims 1
- KTOXEDIFORKAKJ-UHFFFAOYSA-N [4-[5-amino-6-[6-(trifluoromethyl)pyridin-3-yl]pyrazin-2-yl]phenyl]-piperazin-1-ylmethanone Chemical compound NC1=NC=C(C=2C=CC(=CC=2)C(=O)N2CCNCC2)N=C1C1=CC=C(C(F)(F)F)N=C1 KTOXEDIFORKAKJ-UHFFFAOYSA-N 0.000 claims 1
- 239000003430 antimalarial agent Substances 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 1
- 201000004792 malaria Diseases 0.000 claims 1
- CKJNUZNMWOVDFN-UHFFFAOYSA-N methanone Chemical compound O=[CH-] CKJNUZNMWOVDFN-UHFFFAOYSA-N 0.000 claims 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 230000002265 prevention Effects 0.000 claims 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 1
- 239000012453 solvate Substances 0.000 claims 1
- 125000001424 substituent group Chemical group 0.000 claims 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
- C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D241/20—Nitrogen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4965—Non-condensed pyrazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4965—Non-condensed pyrazines
- A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
- A61P33/06—Antimalarials
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261600324P | 2012-02-17 | 2012-02-17 | |
| EP13712926.8A EP2814820B1 (en) | 2012-02-17 | 2013-02-15 | Anti-malarial agents |
| PCT/IB2013/051235 WO2013121387A1 (en) | 2012-02-17 | 2013-02-15 | Anti -malarial agents |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ME02535B true ME02535B (me) | 2017-02-20 |
Family
ID=48014134
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MEP-2016-214A ME02535B (me) | 2012-02-17 | 2013-02-15 | Antimalarijski agensi |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US9266842B2 (enExample) |
| EP (1) | EP2814820B1 (enExample) |
| JP (1) | JP6226889B2 (enExample) |
| CN (1) | CN104136426B (enExample) |
| BR (1) | BR112014020212B1 (enExample) |
| CA (1) | CA2864483A1 (enExample) |
| CY (1) | CY1118074T1 (enExample) |
| DK (1) | DK2814820T3 (enExample) |
| ES (1) | ES2589283T3 (enExample) |
| HR (1) | HRP20161237T1 (enExample) |
| HU (1) | HUE029876T2 (enExample) |
| IN (1) | IN2014MN01622A (enExample) |
| LT (1) | LT2814820T (enExample) |
| ME (1) | ME02535B (enExample) |
| PL (1) | PL2814820T3 (enExample) |
| PT (1) | PT2814820T (enExample) |
| SI (1) | SI2814820T1 (enExample) |
| SM (1) | SMT201600441B (enExample) |
| WO (1) | WO2013121387A1 (enExample) |
| ZA (1) | ZA201406786B (enExample) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BR112014020212B1 (pt) * | 2012-02-17 | 2021-11-23 | University Of Cape Town | Aminopirazina, formulação farmacêutica, método para prevenir ou tratar malária em um paciente, processo para a preparação de um derivado de aminopirazina, e, intermediário |
| EP3118198A1 (en) | 2015-07-13 | 2017-01-18 | MMV Medicines for Malaria Venture | Anti-malarial agents |
| WO2017067881A1 (en) | 2015-10-19 | 2017-04-27 | Glaxosmithkline Intellectual Property Development Limited | Pyrazine compounds for use in the treatment of parasitic protozoal infections |
| CA3088471A1 (en) * | 2018-01-24 | 2019-08-01 | Glaxosmithkline Intellectual Property Development Limited | Novel compounds |
| CN112142715A (zh) * | 2020-10-10 | 2020-12-29 | 鲁南制药集团股份有限公司 | 一种2-氨基-5-杂环基取代的吡嗪衍生物及其用途 |
| CN118355005A (zh) * | 2021-11-23 | 2024-07-16 | 葛兰素史密斯克莱知识产权发展有限公司 | 用于治疗寄生原虫感染的吡嗪化合物 |
| CA3264304A1 (en) | 2022-08-09 | 2024-02-15 | Merck Patent Gmbh | FURO-PYRIMIDINE DERIVATIVES |
| WO2024033280A1 (en) | 2022-08-09 | 2024-02-15 | Merck Patent Gmbh | Furopyridin and furopyrimidin, inhibitors of pi4k, for use in the treatment of parasite infection and malaria |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR101206843B1 (ko) * | 2003-12-03 | 2012-11-30 | 와이엠 바이오사이언시즈 오스트레일리아 피티와이 엘티디 | 튜불린 저해제 |
| WO2007147874A1 (en) * | 2006-06-22 | 2007-12-27 | Biovitrum Ab (Publ) | Pyridine and pyrazine derivatives as mnk kinase inhibitors |
| EP1900727A1 (en) * | 2006-08-30 | 2008-03-19 | Cellzome Ag | Aminopyridine derivatives as kinase inhibitors |
| GB0625659D0 (en) * | 2006-12-21 | 2007-01-31 | Cancer Rec Tech Ltd | Therapeutic compounds and their use |
| HRP20151143T1 (hr) | 2010-01-18 | 2015-12-04 | Mmv Medicines For Malaria Venture | Novi antimalarijski agensi |
| US9062008B2 (en) * | 2010-05-12 | 2015-06-23 | Vertex Pharmaceuticals Incorporated | Compounds useful as inhibitors of ATR kinase |
| MX2013009953A (es) * | 2011-03-04 | 2013-09-26 | Lexicon Pharmaceuticals Inc | Inhibidores de cinasa de mst1 y metodos de su uso. |
| BR112014020212B1 (pt) * | 2012-02-17 | 2021-11-23 | University Of Cape Town | Aminopirazina, formulação farmacêutica, método para prevenir ou tratar malária em um paciente, processo para a preparação de um derivado de aminopirazina, e, intermediário |
-
2013
- 2013-02-15 BR BR112014020212-5A patent/BR112014020212B1/pt not_active IP Right Cessation
- 2013-02-15 US US14/379,332 patent/US9266842B2/en not_active Expired - Fee Related
- 2013-02-15 PT PT137129268T patent/PT2814820T/pt unknown
- 2013-02-15 IN IN1622MUN2014 patent/IN2014MN01622A/en unknown
- 2013-02-15 PL PL13712926T patent/PL2814820T3/pl unknown
- 2013-02-15 HU HUE13712926A patent/HUE029876T2/en unknown
- 2013-02-15 SI SI201330290A patent/SI2814820T1/sl unknown
- 2013-02-15 HR HRP20161237TT patent/HRP20161237T1/hr unknown
- 2013-02-15 DK DK13712926.8T patent/DK2814820T3/en active
- 2013-02-15 CN CN201380009373.9A patent/CN104136426B/zh not_active Expired - Fee Related
- 2013-02-15 JP JP2014557157A patent/JP6226889B2/ja not_active Expired - Fee Related
- 2013-02-15 EP EP13712926.8A patent/EP2814820B1/en active Active
- 2013-02-15 ME MEP-2016-214A patent/ME02535B/me unknown
- 2013-02-15 WO PCT/IB2013/051235 patent/WO2013121387A1/en not_active Ceased
- 2013-02-15 ES ES13712926.8T patent/ES2589283T3/es active Active
- 2013-02-15 CA CA2864483A patent/CA2864483A1/en not_active Abandoned
- 2013-02-15 LT LTEP13712926.8T patent/LT2814820T/lt unknown
-
2014
- 2014-09-16 ZA ZA2014/06786A patent/ZA201406786B/en unknown
-
2016
- 2016-10-10 CY CY20161100998T patent/CY1118074T1/el unknown
- 2016-12-02 SM SM201600441T patent/SMT201600441B/it unknown
Also Published As
| Publication number | Publication date |
|---|---|
| ES2589283T3 (es) | 2016-11-11 |
| CA2864483A1 (en) | 2013-08-22 |
| EP2814820A1 (en) | 2014-12-24 |
| CN104136426A (zh) | 2014-11-05 |
| JP2015507004A (ja) | 2015-03-05 |
| CN104136426B (zh) | 2017-10-03 |
| LT2814820T (lt) | 2016-10-25 |
| IN2014MN01622A (enExample) | 2015-05-15 |
| PT2814820T (pt) | 2016-10-25 |
| PL2814820T3 (pl) | 2017-01-31 |
| HRP20161237T1 (hr) | 2016-11-04 |
| HUE029876T2 (en) | 2017-04-28 |
| SI2814820T1 (sl) | 2016-10-28 |
| BR112014020212B1 (pt) | 2021-11-23 |
| HK1202859A1 (en) | 2015-10-09 |
| DK2814820T3 (en) | 2016-10-03 |
| JP6226889B2 (ja) | 2017-11-08 |
| US20150031682A1 (en) | 2015-01-29 |
| SMT201600441B (it) | 2017-01-10 |
| CY1118074T1 (el) | 2017-06-28 |
| WO2013121387A1 (en) | 2013-08-22 |
| ZA201406786B (en) | 2015-06-24 |
| BR112014020212A8 (pt) | 2018-01-23 |
| EP2814820B1 (en) | 2016-07-20 |
| US9266842B2 (en) | 2016-02-23 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ME02535B (me) | Antimalarijski agensi | |
| AU2014233414B2 (en) | N-acyl-N'-(pyridin-2-yl) ureas and analogs exhibiting anti-cancer and anti-proliferative activities | |
| JP2020033357A5 (enExample) | ||
| KR102022866B1 (ko) | 섬유 아세포 성장 인자 수용체 키나아제 억제제인 인다졸계 화합물 및 이의 제조와 응용 | |
| RU2017122364A (ru) | N-((гет)арилметил)-гетероарил-карбоксамидные соединения в качестве ингибиторов плазменного калликреина | |
| US10968203B2 (en) | Pyrimidinyl-pyridyloxy-naphthyl compounds and methods of treating IRE1-related diseases and disorders | |
| HRP20200648T1 (hr) | Derivati sulfamoilpirolamida i njihova uporaba kao lijekova za liječenje hepatitisa b | |
| JP2016517417A5 (enExample) | ||
| SI3024819T1 (en) | Glyoxamide-substituted pyrrolamide derivatives and their use as medicines for the treatment of hepatitis B | |
| JP2019527718A5 (enExample) | ||
| HRP20171453T1 (hr) | Derivati imidazotiadiazola i imidazopirazina kao inhibitori proteazom aktiviranog receptora 4 (par4) za liječenje agregacije trombocita | |
| HRP20191826T4 (hr) | Derivati n-piridinil acetamida kao inhibitori wnt signalnog puta | |
| HRP20241768T1 (hr) | Heterociklički spoj | |
| JP2015507004A5 (enExample) | ||
| JP2016506369A5 (enExample) | ||
| PE20110835A1 (es) | Piridiloxi-indoles inhibidores del vegf-r2 y uso de los mismos para el tratamiento de enfermedades | |
| RU2016108753A (ru) | Ингибиторы ферментов | |
| PE20190336A1 (es) | Nuevos derivados de amonio, un proceso para su preparacion y composiciones farmaceuticas que los contienen | |
| IL256191A (en) | New amino acid histories, the process for their preparation and the pharmaceutical preparations that contain them | |
| ME02664B (me) | Derivati premeštanja piridina u toku transfekcije inhibitora (ret) kinaze | |
| NZ705589A (en) | Pyrrolo[3,2-d]pyrimidine derivatives for the treatment of viral infections and other diseases | |
| JP2015531366A5 (enExample) | ||
| JP2017502033A5 (enExample) | ||
| HRP20230313T1 (hr) | Modulatori receptora cxcr7 piperidina | |
| JP2016517878A5 (enExample) |