MD937C2 - Sistem terapeutic transdermal pentru aplicarea cutanală a fizostigminei pe piele şi procedeu de obţinere a lui - Google Patents
Sistem terapeutic transdermal pentru aplicarea cutanală a fizostigminei pe piele şi procedeu de obţinere a luiInfo
- Publication number
- MD937C2 MD937C2 MD94-0311A MD940311A MD937C2 MD 937 C2 MD937 C2 MD 937C2 MD 940311 A MD940311 A MD 940311A MD 937 C2 MD937 C2 MD 937C2
- Authority
- MD
- Moldova
- Prior art keywords
- physostigmin
- skin
- administering
- therapeutic system
- transdermal therapeutic
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
- A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
- A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
- A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
- A61K9/7053—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained by reactions only involving carbon to carbon unsaturated bonds, e.g. polyvinyl, polyisobutylene, polystyrene
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
- A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
- A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
- A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
- A61K9/7053—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained by reactions only involving carbon to carbon unsaturated bonds, e.g. polyvinyl, polyisobutylene, polystyrene
- A61K9/7061—Polyacrylates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
Abstract
Invenţia se referă la sistemul terapeutic transdermic (STT) pentru aplicarea fizostigminei în calitate de component activ, precum şi la procedeul de obţinere a acestuia.Sistem terapeutic transdermic pentru aplicarea cutanată a fizostigminei, care constă dintr-o bază a stratului intermediar adeziv impermeabilă pentru substanţa activă, ce conţine 40...90% de material polimeric şi 0,1...20% bază de fizostigmină sau sărurile ei farmaceutic acceptabile, precum şi dintr-un strat de protecţie ce acoperă stratul intermediar, totodată stratul intermediar conţine material polimeric pe bază de acrilat şi/sau metacrilat şi 0,1...40% de plastifiant cu grupe hidroxil având HLB între 1,1...12,0.Rezultatul tehnic al invenţiei constă în sporirea durabilităţii şi timpului de fixare a STT pe piele şi păstrarea stabilităţii fizostigminei timp îndelungat.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE4238223A DE4238223C1 (de) | 1992-11-12 | 1992-11-12 | Transdermales therapeutisches System zur Verabreichung von Physostigmin an die Haut und Verfahren zu dessen Herstellung |
Publications (3)
Publication Number | Publication Date |
---|---|
MD940311A MD940311A (ro) | 1998-03-31 |
MD937B2 MD937B2 (ro) | 1998-03-31 |
MD937C2 true MD937C2 (ro) | 1999-01-31 |
Family
ID=6472735
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MD94-0311A MD937C2 (ro) | 1992-11-12 | 1994-07-26 | Sistem terapeutic transdermal pentru aplicarea cutanală a fizostigminei pe piele şi procedeu de obţinere a lui |
Country Status (32)
Country | Link |
---|---|
US (1) | US5698216A (ro) |
EP (1) | EP0667774B1 (ro) |
JP (1) | JP3407073B2 (ro) |
KR (1) | KR100254573B1 (ro) |
CN (1) | CN1088457A (ro) |
AT (1) | ATE156356T1 (ro) |
AU (1) | AU684256B2 (ro) |
CA (1) | CA2147274C (ro) |
CZ (1) | CZ284008B6 (ro) |
DE (2) | DE4238223C1 (ro) |
DK (1) | DK0667774T3 (ro) |
EE (1) | EE03135B1 (ro) |
EG (1) | EG20527A (ro) |
ES (1) | ES2105334T3 (ro) |
FI (1) | FI952269A0 (ro) |
GR (1) | GR3024720T3 (ro) |
HR (1) | HRP931391B1 (ro) |
HU (1) | HUT72963A (ro) |
IL (1) | IL107547A (ro) |
LT (1) | LT3107B (ro) |
LV (1) | LV10749B (ro) |
MD (1) | MD937C2 (ro) |
MY (1) | MY111373A (ro) |
NO (1) | NO306760B1 (ro) |
NZ (1) | NZ257136A (ro) |
PL (1) | PL172999B1 (ro) |
RU (1) | RU2108812C1 (ro) |
SI (1) | SI9300589A (ro) |
SK (1) | SK280185B6 (ro) |
WO (1) | WO1994010999A1 (ro) |
YU (1) | YU71293A (ro) |
ZA (1) | ZA938413B (ro) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE4446600A1 (de) * | 1994-12-24 | 1996-06-27 | Lohmann Therapie Syst Lts | Transdermale Resorption von Wirkstoffen aus unterkühlten Schmelzen |
DE19828273B4 (de) * | 1998-06-25 | 2005-02-24 | Lts Lohmann Therapie-Systeme Ag | Transdermales therapeutisches System, enthaltend Hormone und Kristallisationsinhibitoren |
DE19923551A1 (de) * | 1999-05-21 | 2000-11-30 | Lohmann Therapie Syst Lts | Pharmazeutisches Präparat mit dem Wirkstoff Diamorphin und seine Verwendung in einem Verfahren zur Behandlung der Opiatsucht |
AT500143A1 (de) * | 2004-04-22 | 2005-11-15 | Sanochemia Pharmazeutika Ag | Cholinesterase-inhibitoren in liposomen sowie deren herstellung und verwendung |
Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3921363A (en) * | 1974-05-17 | 1975-11-25 | Preston Metal & Roofing Prod | Cross member with end connector |
DE3528979A1 (de) * | 1984-08-14 | 1986-02-27 | State Of Israel Represented By The Prime Minister's Office Israel Institute For Biological Research, Ness-Ziona | Arzneimittelfreigabesystem |
DE3606892A1 (de) * | 1985-03-05 | 1986-09-18 | Ciba-Geigy Ag, Basel | Pharmazeutische formulierungen und verfahren zur behandlung von gedaechtnisstoerungen |
DE3843238C1 (ro) * | 1988-12-22 | 1990-02-22 | Lohmann Therapie Syst Lts | |
DE3843239C1 (ro) * | 1988-12-22 | 1990-02-22 | Lohmann Therapie Syst Lts | |
WO1991015176A1 (en) * | 1990-04-06 | 1991-10-17 | Pharmetrix Corporation | Device and method for enhanced administration of physostigmine |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5350581A (en) * | 1989-12-14 | 1994-09-27 | Pharmetrix Corporation | Method for manufacturing transdermal devices |
NZ237241A (en) * | 1990-03-02 | 1993-11-25 | Pharmetrix Corp | Method for increasing the storage stability of physostigmine |
JP4355469B2 (ja) * | 2002-03-08 | 2009-11-04 | 日本碍子株式会社 | アルミナ担持担体、触媒体及びアルミナ担持担体の製造方法 |
-
1992
- 1992-11-12 DE DE4238223A patent/DE4238223C1/de not_active Expired - Lifetime
-
1993
- 1993-10-27 CA CA002147274A patent/CA2147274C/en not_active Expired - Fee Related
- 1993-10-27 PL PL93308531A patent/PL172999B1/pl unknown
- 1993-10-27 EP EP93923558A patent/EP0667774B1/de not_active Expired - Lifetime
- 1993-10-27 DE DE59307089T patent/DE59307089D1/de not_active Expired - Lifetime
- 1993-10-27 US US08/433,459 patent/US5698216A/en not_active Expired - Lifetime
- 1993-10-27 DK DK93923558.6T patent/DK0667774T3/da active
- 1993-10-27 SK SK593-95A patent/SK280185B6/sk unknown
- 1993-10-27 KR KR1019950701873A patent/KR100254573B1/ko not_active IP Right Cessation
- 1993-10-27 ES ES93923558T patent/ES2105334T3/es not_active Expired - Lifetime
- 1993-10-27 HU HU9501390A patent/HUT72963A/hu unknown
- 1993-10-27 WO PCT/EP1993/002970 patent/WO1994010999A1/de active IP Right Grant
- 1993-10-27 AU AU53385/94A patent/AU684256B2/en not_active Ceased
- 1993-10-27 CZ CZ951244A patent/CZ284008B6/cs not_active IP Right Cessation
- 1993-10-27 AT AT93923558T patent/ATE156356T1/de active
- 1993-10-27 JP JP51164994A patent/JP3407073B2/ja not_active Expired - Fee Related
- 1993-10-27 RU RU95113504A patent/RU2108812C1/ru active
- 1993-10-27 NZ NZ257136A patent/NZ257136A/en unknown
- 1993-11-05 LV LVP-93-1204A patent/LV10749B/lv unknown
- 1993-11-09 IL IL10754793A patent/IL107547A/en not_active IP Right Cessation
- 1993-11-10 YU YU71293A patent/YU71293A/sh unknown
- 1993-11-11 ZA ZA938413A patent/ZA938413B/xx unknown
- 1993-11-11 CN CN93112909A patent/CN1088457A/zh active Pending
- 1993-11-11 EG EG71993A patent/EG20527A/xx active
- 1993-11-11 MY MYPI93002363A patent/MY111373A/en unknown
- 1993-11-11 HR HRP4238223.8A patent/HRP931391B1/xx not_active IP Right Cessation
- 1993-11-11 SI SI9300589A patent/SI9300589A/sl unknown
- 1993-11-12 LT LTIP1469A patent/LT3107B/lt not_active IP Right Cessation
-
1994
- 1994-07-26 MD MD94-0311A patent/MD937C2/ro active IP Right Grant
- 1994-11-18 EE EE9400145A patent/EE03135B1/xx unknown
-
1995
- 1995-05-10 FI FI952269A patent/FI952269A0/fi unknown
- 1995-05-11 NO NO951864A patent/NO306760B1/no not_active IP Right Cessation
-
1997
- 1997-09-16 GR GR970402363T patent/GR3024720T3/el unknown
Patent Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3921363A (en) * | 1974-05-17 | 1975-11-25 | Preston Metal & Roofing Prod | Cross member with end connector |
DE3528979A1 (de) * | 1984-08-14 | 1986-02-27 | State Of Israel Represented By The Prime Minister's Office Israel Institute For Biological Research, Ness-Ziona | Arzneimittelfreigabesystem |
DE3606892A1 (de) * | 1985-03-05 | 1986-09-18 | Ciba-Geigy Ag, Basel | Pharmazeutische formulierungen und verfahren zur behandlung von gedaechtnisstoerungen |
DE3843238C1 (ro) * | 1988-12-22 | 1990-02-22 | Lohmann Therapie Syst Lts | |
DE3843239C1 (ro) * | 1988-12-22 | 1990-02-22 | Lohmann Therapie Syst Lts | |
WO1991015176A1 (en) * | 1990-04-06 | 1991-10-17 | Pharmetrix Corporation | Device and method for enhanced administration of physostigmine |
Also Published As
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG4A | Patent for invention issued | ||
IF99 | Valid patent on 19990615 |
Free format text: EXPIRES: 20140726 |