MD4879B1 - Utilizare a derivatului bisamidic al acidului malonic pentru tratarea bolilor alergice şi altor boli umane şi animaliere - Google Patents
Utilizare a derivatului bisamidic al acidului malonic pentru tratarea bolilor alergice şi altor boli umane şi animaliereInfo
- Publication number
- MD4879B1 MD4879B1 MDA20200086A MD20200086A MD4879B1 MD 4879 B1 MD4879 B1 MD 4879B1 MD A20200086 A MDA20200086 A MD A20200086A MD 20200086 A MD20200086 A MD 20200086A MD 4879 B1 MD4879 B1 MD 4879B1
- Authority
- MD
- Moldova
- Prior art keywords
- diseases
- humans
- animals
- treating allergic
- malonic acid
- Prior art date
Links
- 201000010099 disease Diseases 0.000 title abstract 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title abstract 3
- 208000026935 allergic disease Diseases 0.000 title abstract 2
- 241001465754 Metazoa Species 0.000 title 1
- OFOBLEOULBTSOW-UHFFFAOYSA-N Propanedioic acid Natural products OC(=O)CC(O)=O OFOBLEOULBTSOW-UHFFFAOYSA-N 0.000 title 1
- FTQWRYSLUYAIRQ-UHFFFAOYSA-N n-[(octadecanoylamino)methyl]octadecanamide Chemical class CCCCCCCCCCCCCCCCCC(=O)NCNC(=O)CCCCCCCCCCCCCCCCC FTQWRYSLUYAIRQ-UHFFFAOYSA-N 0.000 title 1
- 102000000543 Histamine Receptors Human genes 0.000 abstract 3
- 108010002059 Histamine Receptors Proteins 0.000 abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 2
- 230000000694 effects Effects 0.000 abstract 2
- 238000002560 therapeutic procedure Methods 0.000 abstract 2
- 208000003251 Pruritus Diseases 0.000 abstract 1
- 206010039085 Rhinitis allergic Diseases 0.000 abstract 1
- 201000010105 allergic rhinitis Diseases 0.000 abstract 1
- 239000005557 antagonist Substances 0.000 abstract 1
- 150000004677 hydrates Chemical class 0.000 abstract 1
- WRIRWRKPLXCTFD-UHFFFAOYSA-N malonamide Chemical compound NC(=O)CC(N)=O WRIRWRKPLXCTFD-UHFFFAOYSA-N 0.000 abstract 1
- AICOOMRHRUFYCM-ZRRPKQBOSA-N oxazine, 1 Chemical compound C([C@@H]1[C@H](C(C[C@]2(C)[C@@H]([C@H](C)N(C)C)[C@H](O)C[C@]21C)=O)CC1=CC2)C[C@H]1[C@@]1(C)[C@H]2N=C(C(C)C)OC1 AICOOMRHRUFYCM-ZRRPKQBOSA-N 0.000 abstract 1
- 230000002085 persistent effect Effects 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000012453 solvate Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4178—1,3-Diazoles not condensed 1,3-diazoles and containing further heterocyclic rings, e.g. pilocarpine, nitrofurantoin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/04—Antipruritics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Organic Chemistry (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pulmonology (AREA)
- Immunology (AREA)
- Dermatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Invenţia se referă la terapia bolilor, asociate cu activitatea receptorilor histaminici, în particular pentru tratamentul bolilor alergice, de preferinţă terapia rinitei alergice perene şi persistente, pruritului, precum şi unei serii de alte boli, asociate cu activitatea receptorilor histaminici de tipul trei şi/sau patru prin utilizarea compusului N,N'-bis(2-(1H-imidazol-5-il) etil)malonamidă:(I).Acest compus, precum şi sărurile, hidraţii, solvaţii acestuia farmaceutic acceptabili sunt antagonişti ai receptorilor histaminici de tipul trei şi/sau patru. Această invenţie, de asemenea, se referă la compoziţii farmaceutice, care conţin o cantitate terapeutic eficientă a compusului 1.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| RU2018119193A RU2685277C1 (ru) | 2018-05-24 | 2018-05-24 | Применение бисамидного производного малоновой кислоты для лечения аллергических и других заболеваний человека и животных |
| PCT/RU2019/050066 WO2019226082A1 (ru) | 2018-05-24 | 2019-05-22 | Применение бисамидного производного малоновой кислоты для лечения аллергических и других заболеваний человека и животных |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| MD20200086A2 MD20200086A2 (ro) | 2021-04-30 |
| MD4879B1 true MD4879B1 (ro) | 2023-12-31 |
Family
ID=66168282
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MDA20200086A MD4879B1 (ro) | 2018-05-24 | 2019-05-22 | Utilizare a derivatului bisamidic al acidului malonic pentru tratarea bolilor alergice şi altor boli umane şi animaliere |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US11571411B2 (ro) |
| KR (1) | KR20210015895A (ro) |
| CN (1) | CN112334464B (ro) |
| EA (1) | EA202092763A1 (ro) |
| GE (1) | GEP20237493B (ro) |
| MD (1) | MD4879B1 (ro) |
| RU (1) | RU2685277C1 (ro) |
| WO (1) | WO2019226082A1 (ro) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2023224518A1 (ru) * | 2022-05-18 | 2023-11-23 | Общество С Ограниченной Ответственностью "Валента-Интеллект" | Жидкая фармацевтическая композиция n,n'-бис[2-(1н-имидазол-4-ил)этил]малонамида для лечения и/или профилактики ринита |
| WO2023224519A1 (ru) * | 2022-05-19 | 2023-11-23 | Общество С Ограниченной Ответственностью "Валента-Интеллект" | Новая кристаллическая форма n,n'-бис-[2-(1н-имидазол-4-ил)этил]пропандиамида и ее фармацевтическое применение |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE314071T1 (de) * | 1996-08-16 | 2006-01-15 | Schering Corp | Behandlung von allergischen reaktionen im oberen respirationstrakt mit einer kombination von histamin-rezeptor-antagonisten |
| RU2287524C1 (ru) * | 2005-03-31 | 2006-11-20 | ООО "Фарминтерпрайсез" | Аспартильные производные гистамина, способ их получения, фармацевтическая композиция и их применение в качестве модуляторов активности ферментов антиоксидантной защиты |
| RU2665688C2 (ru) * | 2013-04-12 | 2018-09-04 | Общество С Ограниченной Ответственностью "Фарминтерпрайсез" | Производные бисамидов дикарбоновых кислот, их применение, фармацевтическая композиция на их основе, способы их получения |
| KR20200010164A (ko) * | 2017-05-26 | 2020-01-30 | 오브셰스트보 에스 오그라니첸노이 오트베트스트벤노스티주 “파름엔터프라지즈” | 신규한 글루타미닐 고리화효소 억제제 및 다양한 질환의 치료에서의 이의 용도 |
-
2018
- 2018-05-24 RU RU2018119193A patent/RU2685277C1/ru active
-
2019
- 2019-05-22 GE GEAP201915523A patent/GEP20237493B/en unknown
- 2019-05-22 KR KR1020207037178A patent/KR20210015895A/ko unknown
- 2019-05-22 US US17/058,105 patent/US11571411B2/en active Active
- 2019-05-22 WO PCT/RU2019/050066 patent/WO2019226082A1/ru active Application Filing
- 2019-05-22 EA EA202092763A patent/EA202092763A1/ru unknown
- 2019-05-22 CN CN201980042868.9A patent/CN112334464B/zh active Active
- 2019-05-22 MD MDA20200086A patent/MD4879B1/ro unknown
Also Published As
| Publication number | Publication date |
|---|---|
| KR20210015895A (ko) | 2021-02-10 |
| CN112334464B (zh) | 2023-11-24 |
| EA202092763A1 (ru) | 2021-03-17 |
| GEP20237493B (en) | 2023-04-10 |
| WO2019226082A1 (ru) | 2019-11-28 |
| RU2685277C1 (ru) | 2019-04-17 |
| US20210361624A1 (en) | 2021-11-25 |
| CN112334464A (zh) | 2021-02-05 |
| US11571411B2 (en) | 2023-02-07 |
| MD20200086A2 (ro) | 2021-04-30 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| HB9A | Name or address of applicant corrected (patent for invention) | ||
| GB9A | Change of applicant (patent for invention) |
Owner name: LTD VALENTA-INTELLEKT, RU UL. RYABINOVAYA, D. 26 BUILDING 10, CAB. 6-26, MOSCOW, 121471, FEDERATIA RUSAIP NEBOLSIN VLADIMIR EVGHENIEVICH, RU STR. GOLITSYNSKAYA, 457, ISTRINSKIY R-N, D. BORZYE, MOSKOVSKAYA OBL., 143581, FEDERATIA RUSA Free format text: PREVIOUS APPLICANT: OBSCHESTVO S OGRANICHENNOI OTVETSTVENNOSTIYU PHARMENTERPRISES ALLERGY, RU 121205, MOSCOW, MOZHAISKY MUNICIPAL DISTRICT, TERRITORY OF THESKOLKOVO INNOVATION CENTER, BOLSHOY BOULEVARD, HOUSE 42, BUILDING 1, FLOOR 2, ROOM 64, FEDERATIA RUSA |