MD2670C2 - Procedeu de aplicare a unui înveliş antibiotic pe corpurile cu microcavităţi interconexe, corp cu înveliş antibiotic şi utilizarea acestuia - Google Patents
Procedeu de aplicare a unui înveliş antibiotic pe corpurile cu microcavităţi interconexe, corp cu înveliş antibiotic şi utilizarea acestuiaInfo
- Publication number
- MD2670C2 MD2670C2 MDA20020154A MD20020154A MD2670C2 MD 2670 C2 MD2670 C2 MD 2670C2 MD A20020154 A MDA20020154 A MD A20020154A MD 20020154 A MD20020154 A MD 20020154A MD 2670 C2 MD2670 C2 MD 2670C2
- Authority
- MD
- Moldova
- Prior art keywords
- sulphonates
- alkyl
- sulphates
- cycloalkyl
- bodies
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
- A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
Landscapes
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Dermatology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Communicable Diseases (AREA)
- Epidemiology (AREA)
- Physical Education & Sports Medicine (AREA)
- Oncology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Rheumatology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Materials For Medical Uses (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Prostheses (AREA)
- Application Of Or Painting With Fluid Materials (AREA)
- Saccharide Compounds (AREA)
- Medicines Containing Plant Substances (AREA)
- Manufacturing Of Micro-Capsules (AREA)
- Cosmetics (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Invenţia se referă la medicina umană şi veterinară, în particular la un procedeu de aplicare a unui înveliş antibiotic pe corpurile cu microcavităţi interconexe, la un corp cu înveliş antibiotic şi la utilizarea acestuia.Procedeul de aplicare a unui înveliş antibiotic pe corpurile cu microcavităţi interconexe include introducerea în microcavităţi prin impregnare, pulverizare sau picurare a soluţiei apoase 1, care conţine cel puţin un component antibiotic uşor solubil în apă din grupa aminoglicozidelor, tetraciclinelor, lincosamidelor, 4-chinolonelor şi clorhexidine, şi a soluţiei apoase 2, care conţine cel puţin un component amfifilic uşor solubil în apă din grupa alchilsulfaţilor, alchilsulfonaţilor, alchilaril sulfaţilor, dialchilarilsulfaţilor, alchilarilsulfonaţilor, dialchilarilsulfonaţilor, cicloalchilsulfaţilor, cicloalchilsulfonaţilor, alchilcicloalchilsulfaţilor, totodată în intervalul de timp dintre introducerea soluţiilor 1 şi 2 apa, de regulă, se elimină cu formarea în microcavităţi din componentele soluţiilor 1 şi 2 a unui reziduu puţin solubil în apă.Corpurile propuse sunt executate în aşa fel încât pe suprafaţa microcavităţilor se formează un înveliş din cel puţin o sare sau un complex, acesta conţinând cel puţin un component cationic, format din unul sau mai mulţi reprezentanţi ai antibioticelor aminoglicozide, tetracicline, lincosamide, 4-chinolone şi clorhexidine, şi cel puţin un component anionic, format din unul sau mai mulţi reprezentanţi ai grupei alchilsulfaţilor, alchilsulfonaţilor, alchilarilsulfaţilor, dialchilsulfaţilor, alchilarilsulfonaţilor, dialchilarilsulfonaţilor, cicloalchilsulfaţilor, cicloalchilsulfonaţilor, alchilcicloalchilsulfaţilor.Corpurile cu înveliş antibiotic aplicat pot fi utilizate în calitate de implanturi.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE2001142464 DE10142464A1 (de) | 2001-08-31 | 2001-08-31 | Verfahren zur antibiotischen Beschichtung von nichtmetallischen Körpern mit interkonnektierenden Mikrohohlräumen sowie nichtmetallischer Körper und seine Verwendung |
| DE10204308 | 2002-02-01 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| MD20020154A MD20020154A (ro) | 2003-04-30 |
| MD2670B2 MD2670B2 (ro) | 2005-01-31 |
| MD2670C2 true MD2670C2 (ro) | 2005-08-31 |
Family
ID=26010027
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MDA20020154A MD2670C2 (ro) | 2001-08-31 | 2002-06-03 | Procedeu de aplicare a unui înveliş antibiotic pe corpurile cu microcavităţi interconexe, corp cu înveliş antibiotic şi utilizarea acestuia |
Country Status (29)
| Country | Link |
|---|---|
| US (1) | US7358232B2 (ro) |
| EP (1) | EP1287819B1 (ro) |
| JP (2) | JP4041367B2 (ro) |
| CN (1) | CN1197630C (ro) |
| AT (1) | ATE390120T1 (ro) |
| AU (1) | AU2002300639B2 (ro) |
| BG (1) | BG65793B1 (ro) |
| BR (1) | BR0203416A (ro) |
| CA (1) | CA2396151C (ro) |
| CZ (1) | CZ301805B6 (ro) |
| DE (1) | DE50211948D1 (ro) |
| DK (1) | DK1287819T3 (ro) |
| EE (1) | EE200200492A (ro) |
| ES (1) | ES2301595T3 (ro) |
| GE (1) | GEP20043332B (ro) |
| HR (1) | HRP20020679A2 (ro) |
| HU (1) | HUP0202915A3 (ro) |
| IL (1) | IL150998A (ro) |
| IS (1) | IS6389A (ro) |
| MD (1) | MD2670C2 (ro) |
| MX (1) | MXPA02008327A (ro) |
| NO (1) | NO20024103L (ro) |
| NZ (1) | NZ521042A (ro) |
| PL (1) | PL206971B1 (ro) |
| PT (1) | PT1287819E (ro) |
| RU (1) | RU2236871C2 (ro) |
| SA (1) | SA02230289B1 (ro) |
| SK (1) | SK287128B6 (ro) |
| YU (1) | YU52002A (ro) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20070134287A1 (en) * | 2005-12-09 | 2007-06-14 | Biomet Manufacturing Corp | Method for coating biocompatible substrates with antibiotics |
| DE102005061290B4 (de) * | 2005-12-20 | 2021-03-18 | Heraeus Medical Gmbh | Verfahren zur Herstellung von Antibiotikum-/Antibiotika-Partikeln und deren Verwendung |
| JP5161452B2 (ja) | 2006-10-03 | 2013-03-13 | 日本コヴィディエン株式会社 | 医療用具の製造方法、医療用具の表面に抗生物質を付与する方法および医療用具 |
| EP2081611A1 (en) * | 2006-11-10 | 2009-07-29 | Sandvik Intellectual Property Ab | Surgical implant composite materials and kits and methods of manufacture |
| DE102010020940B4 (de) * | 2010-05-19 | 2014-09-25 | Heraeus Medical Gmbh | Antibiotische Beschichtung |
| WO2014174437A1 (en) * | 2013-04-22 | 2014-10-30 | Sandvik Intellectual Property Ab | Method for drug loading hydroxyapatite coated implant surfaces |
| EP3010557B1 (en) | 2013-06-21 | 2019-08-21 | Stryker European Holdings I, LLC | Co-precipitation of tobramycin into hydroxyapatite coatings |
| EP2823780B1 (en) | 2013-07-11 | 2021-05-19 | Stryker European Holdings I, LLC | Fixation assembly with multiple sections for securing parts of a sternum |
| EP3041521B1 (en) | 2013-09-02 | 2017-08-30 | Stryker European Holdings I, LLC | Method of manufacturing an implant for use in a surgical procedure |
| EP3042622B1 (en) | 2015-01-09 | 2018-05-09 | Stryker European Holdings I, LLC | Implant for bone fixation |
| EP3320868B1 (en) | 2016-11-11 | 2019-05-01 | Stryker European Holdings I, LLC | Implant for bone fixation |
| US11198831B2 (en) | 2019-01-31 | 2021-12-14 | Kvi Llc | Lubricant for a device |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2807132A1 (de) * | 1978-02-20 | 1979-08-23 | Battelle Institut E V | Implantierbares pharmaka-depot |
| EP0191789A1 (en) * | 1984-07-23 | 1986-08-27 | Univ New Jersey Med | ANTIBIOTIC BONDED PROSTHESES AND THEIR PRODUCTION. |
| EP0623349A1 (de) * | 1993-05-05 | 1994-11-09 | MERCK PATENT GmbH | Lösungsmittel für ein schwerlösliches Gentamicin-Salz |
Family Cites Families (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US183265A (en) * | 1876-10-17 | Improvement in swinging outriggers for row-boats | ||
| US3091572A (en) | 1962-07-16 | 1963-05-28 | Schering Corp | Gentamycin and method of production |
| ES315101A1 (es) | 1965-07-08 | 1966-01-01 | Folch Vazquez Conrado | Procedimiento de preparaciën de nuevos derivados de tetraciclina |
| CA950831A (en) | 1972-04-25 | 1974-07-09 | Leonard D. Kurtz | Biocidal salts |
| FR2272680B1 (ro) | 1974-05-29 | 1978-07-21 | Hosbon Sa Lab | |
| DE2843963A1 (de) | 1978-10-09 | 1980-04-24 | Merck Patent Gmbh | Im koerper resorbierbare geformte masse auf basis von kollagen und ihre verwendung in der medizin |
| DE3206725A1 (de) | 1981-05-13 | 1982-12-02 | Merck Patent Gmbh, 6100 Darmstadt | Schwer loesliche salze von aminoglykosidantibiotika |
| DE3206726A1 (de) | 1982-02-25 | 1983-09-01 | Merck Patent Gmbh, 6100 Darmstadt | Pharmakadepot |
| DE3248328A1 (de) | 1982-12-28 | 1984-06-28 | Bayer Ag, 5090 Leverkusen | Schwerloesliche salze von aminoglykosiden sowie diese enthaltende formulierungen mit verzoegerter wirkstoff-freigabe |
| US4879135A (en) * | 1984-07-23 | 1989-11-07 | University Of Medicine And Dentistry Of New Jersey | Drug bonded prosthesis and process for producing same |
| FR2613619B1 (fr) * | 1987-04-07 | 1993-10-15 | Recherche Informatique Pharmacie | Medicaments, produits dietetiques ou produits d'hygiene sous forme de compositions pulverulentes obtenues par adsorption de principes actifs sur un sucre a dissolution rapide |
| US5034421A (en) * | 1988-12-13 | 1991-07-23 | Fuisz Pharmaceutical Ltd. | Moderated spun fibrous system and method of manufacture |
| US5019096A (en) * | 1988-02-11 | 1991-05-28 | Trustees Of Columbia University In The City Of New York | Infection-resistant compositions, medical devices and surfaces and methods for preparing and using same |
| ATE105562T1 (de) * | 1989-02-28 | 1994-05-15 | Suntory Ltd | Trehalostatin und seine herstellung. |
| AU638245B2 (en) * | 1989-03-31 | 1993-06-24 | Regents Of The University Of California, The | Preparation of liposome and lipid complex compositions |
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| CA2079509C (en) * | 1991-10-01 | 2002-05-14 | Shigeyuki Takada | Prolonged release microparticle preparation and production of the same |
| AU4198793A (en) * | 1992-07-24 | 1994-01-27 | Takeda Chemical Industries Ltd. | Microparticle preparation and production thereof |
| WO1994008599A1 (en) | 1992-10-14 | 1994-04-28 | The Regents Of The University Of Colorado | Ion-pairing of drugs for improved efficacy and delivery |
| ES2121627T3 (es) * | 1994-06-10 | 1998-12-01 | Dumex Ltd As | Sales medicamentosas. |
| EP0719845B1 (en) * | 1994-12-27 | 1999-09-22 | Seiko Epson Corporation | Water-base ink composition and process for producing the same |
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| DE10114245A1 (de) | 2001-03-22 | 2002-10-02 | Heraeus Kulzer Gmbh & Co Kg | Herstellung und Verwendung einer Antibiotikum-/Antibiotika-Zubereitung |
-
2002
- 2002-05-17 IS IS6389A patent/IS6389A/is unknown
- 2002-06-03 MD MDA20020154A patent/MD2670C2/ro not_active IP Right Cessation
- 2002-06-19 US US10/174,682 patent/US7358232B2/en not_active Expired - Fee Related
- 2002-06-27 BG BG106880A patent/BG65793B1/bg unknown
- 2002-07-02 CZ CZ20022321A patent/CZ301805B6/cs not_active IP Right Cessation
- 2002-07-05 YU YU52002A patent/YU52002A/sh unknown
- 2002-07-08 SK SK995-2002A patent/SK287128B6/sk not_active IP Right Cessation
- 2002-07-29 CA CA002396151A patent/CA2396151C/en not_active Expired - Fee Related
- 2002-07-31 IL IL150998A patent/IL150998A/en not_active IP Right Cessation
- 2002-08-12 GE GE4870A patent/GEP20043332B/en unknown
- 2002-08-14 AT AT02018323T patent/ATE390120T1/de active
- 2002-08-14 DK DK02018323T patent/DK1287819T3/da active
- 2002-08-14 ES ES02018323T patent/ES2301595T3/es not_active Expired - Lifetime
- 2002-08-14 DE DE50211948T patent/DE50211948D1/de not_active Expired - Lifetime
- 2002-08-14 EP EP02018323A patent/EP1287819B1/de not_active Expired - Lifetime
- 2002-08-14 PT PT02018323T patent/PT1287819E/pt unknown
- 2002-08-16 AU AU2002300639A patent/AU2002300639B2/en not_active Ceased
- 2002-08-20 HR HR20020679A patent/HRP20020679A2/hr not_active Application Discontinuation
- 2002-08-27 MX MXPA02008327A patent/MXPA02008327A/es active IP Right Grant
- 2002-08-27 NZ NZ521042A patent/NZ521042A/xx not_active IP Right Cessation
- 2002-08-28 BR BR0203416-6A patent/BR0203416A/pt not_active IP Right Cessation
- 2002-08-28 JP JP2002249579A patent/JP4041367B2/ja not_active Expired - Fee Related
- 2002-08-28 NO NO20024103A patent/NO20024103L/no not_active Application Discontinuation
- 2002-08-29 PL PL355777A patent/PL206971B1/pl not_active IP Right Cessation
- 2002-08-30 EE EEP200200492A patent/EE200200492A/xx unknown
- 2002-08-30 HU HU0202915A patent/HUP0202915A3/hu unknown
- 2002-08-30 CN CNB021415048A patent/CN1197630C/zh not_active Expired - Fee Related
- 2002-08-30 RU RU2002123421/15A patent/RU2236871C2/ru not_active IP Right Cessation
- 2002-09-03 SA SA2230289A patent/SA02230289B1/ar unknown
-
2004
- 2004-06-14 JP JP2004176070A patent/JP4808938B2/ja not_active Expired - Fee Related
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2807132A1 (de) * | 1978-02-20 | 1979-08-23 | Battelle Institut E V | Implantierbares pharmaka-depot |
| EP0191789A1 (en) * | 1984-07-23 | 1986-08-27 | Univ New Jersey Med | ANTIBIOTIC BONDED PROSTHESES AND THEIR PRODUCTION. |
| EP0623349A1 (de) * | 1993-05-05 | 1994-11-09 | MERCK PATENT GmbH | Lösungsmittel für ein schwerlösliches Gentamicin-Salz |
Also Published As
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| KA4A | Patent for invention lapsed due to non-payment of fees (with right of restoration) | ||
| MM4A | Patent for invention definitely lapsed due to non-payment of fees |