MD2670B2 - Procedeu de aplicare a unui invelis antibiotic pe corpurile cu microcavitati interconexe, corp cu invelis antibiotic si utilizarea acestuia - Google Patents
Procedeu de aplicare a unui invelis antibiotic pe corpurile cu microcavitati interconexe, corp cu invelis antibiotic si utilizarea acestuia Download PDFInfo
- Publication number
- MD2670B2 MD2670B2 MDA20020154A MD20020154A MD2670B2 MD 2670 B2 MD2670 B2 MD 2670B2 MD A20020154 A MDA20020154 A MD A20020154A MD 20020154 A MD20020154 A MD 20020154A MD 2670 B2 MD2670 B2 MD 2670B2
- Authority
- MD
- Moldova
- Prior art keywords
- bodies
- microcavities
- antibiotic coating
- coating
- antibiotic
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
- A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
Landscapes
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Dermatology (AREA)
- Physical Education & Sports Medicine (AREA)
- Communicable Diseases (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Oncology (AREA)
- Epidemiology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Rheumatology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Materials For Medical Uses (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Prostheses (AREA)
- Manufacturing Of Micro-Capsules (AREA)
- Medicines Containing Plant Substances (AREA)
- Saccharide Compounds (AREA)
- Cosmetics (AREA)
- Application Of Or Painting With Fluid Materials (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Inventia se refera la medicina si la medicina veterinara, in particular la un procedeu de aplicare a unui invelis antibiotic pe corpurile cu microcavitati interconexe, la un corp cu invelis antibiotic si la utilizarea acestuia. Procedeul de aplicare a unui invelis antibiotic pe corpurile cu microcavitati interconexe include introducerea in microcavitati prin impregnare, pulverizare sau picurare a solutiei apoase 1, care contine cel putin un component antibiotic usor solubil in apa din grupa aminoglicozidelor, tetraciclinelor, lincosamidelor, 4-chinolonelor si clorhexidine, si a solutiei apoase 2, care contine cel putin un component amfifilic usor solubil in apa din grupa alchilsulfatilor, alchilsulfonatilor, alchilaril sulfatilor, dialchilarilsulfatilor, alchilarilsulfonatilor, dialchilarilsulfonatilor, cicloalchilsulfatilor, cicloalchilsulfonatilor, alchilcicloalchilsulfatilor, totodata in intervalul de timp dintre introducerea solutiilor 1 si 2 apa, de regula, se elimina cu formarea in microcavitati din componentele solutiilor 1 si 2 a unui reziduu putin solubil in apa. Corpurile propuse sunt executate in asa fel incat pe suprafata microcavitatilor se formeaza un invelis din cel putin o sare sau un complex, acesta continand cel putin un component cationic, format din unul sau mai multi reprezentanti ai antibioticelor aminoglicozide, tetracicline, lincosamide, 4-chinolone si clorhexidine, si cel putin un component anionic, format din unul sau mai multi reprezentanti ai grupei alchilsulfatilor, alchilsulfonatilor, alchilarilsulfatilor, dialchilsulfatilor, alchilarilsulfonatilor, dialchilarilsulfonatilor, cicloalchilsulfatilor, cicloalchilsulfonatilor, alchilcicloalchilsulfatilor. Corpurile cu invelis antibiotic aplicat pot fi utilizate in calitate de implanturi. ŕ
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE2001142464 DE10142464A1 (de) | 2001-08-31 | 2001-08-31 | Verfahren zur antibiotischen Beschichtung von nichtmetallischen Körpern mit interkonnektierenden Mikrohohlräumen sowie nichtmetallischer Körper und seine Verwendung |
| DE10204308 | 2002-02-01 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| MD20020154A MD20020154A (ro) | 2003-04-30 |
| MD2670B2 true MD2670B2 (ro) | 2005-01-31 |
| MD2670C2 MD2670C2 (ro) | 2005-08-31 |
Family
ID=26010027
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MDA20020154A MD2670C2 (ro) | 2001-08-31 | 2002-06-03 | Procedeu de aplicare a unui înveliş antibiotic pe corpurile cu microcavităţi interconexe, corp cu înveliş antibiotic şi utilizarea acestuia |
Country Status (29)
| Country | Link |
|---|---|
| US (1) | US7358232B2 (ro) |
| EP (1) | EP1287819B1 (ro) |
| JP (2) | JP4041367B2 (ro) |
| CN (1) | CN1197630C (ro) |
| AT (1) | ATE390120T1 (ro) |
| AU (1) | AU2002300639B2 (ro) |
| BG (1) | BG65793B1 (ro) |
| BR (1) | BR0203416A (ro) |
| CA (1) | CA2396151C (ro) |
| CZ (1) | CZ301805B6 (ro) |
| DE (1) | DE50211948D1 (ro) |
| DK (1) | DK1287819T3 (ro) |
| EE (1) | EE200200492A (ro) |
| ES (1) | ES2301595T3 (ro) |
| GE (1) | GEP20043332B (ro) |
| HR (1) | HRP20020679A2 (ro) |
| HU (1) | HUP0202915A3 (ro) |
| IL (1) | IL150998A (ro) |
| IS (1) | IS6389A (ro) |
| MD (1) | MD2670C2 (ro) |
| MX (1) | MXPA02008327A (ro) |
| NO (1) | NO20024103L (ro) |
| NZ (1) | NZ521042A (ro) |
| PL (1) | PL206971B1 (ro) |
| PT (1) | PT1287819E (ro) |
| RU (1) | RU2236871C2 (ro) |
| SA (1) | SA02230289B1 (ro) |
| SK (1) | SK287128B6 (ro) |
| YU (1) | YU52002A (ro) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2330685C2 (ru) * | 2005-07-12 | 2008-08-10 | Александр Юрьевич Базаров | Способ фиксации антибиотиков в пористых имплантатах |
| US20070134287A1 (en) * | 2005-12-09 | 2007-06-14 | Biomet Manufacturing Corp | Method for coating biocompatible substrates with antibiotics |
| DE102005061290B4 (de) * | 2005-12-20 | 2021-03-18 | Heraeus Medical Gmbh | Verfahren zur Herstellung von Antibiotikum-/Antibiotika-Partikeln und deren Verwendung |
| JP5161452B2 (ja) | 2006-10-03 | 2013-03-13 | 日本コヴィディエン株式会社 | 医療用具の製造方法、医療用具の表面に抗生物質を付与する方法および医療用具 |
| CN101636186A (zh) * | 2006-11-10 | 2010-01-27 | 山特维克知识产权股份有限公司 | 外科植入物复合材料和试剂盒以及制造方法 |
| DE102010020940B4 (de) * | 2010-05-19 | 2014-09-25 | Heraeus Medical Gmbh | Antibiotische Beschichtung |
| WO2014174437A1 (en) * | 2013-04-22 | 2014-10-30 | Sandvik Intellectual Property Ab | Method for drug loading hydroxyapatite coated implant surfaces |
| EP3010557B1 (en) | 2013-06-21 | 2019-08-21 | Stryker European Holdings I, LLC | Co-precipitation of tobramycin into hydroxyapatite coatings |
| WO2015003756A1 (en) | 2013-07-11 | 2015-01-15 | Stryker Leibinger Gmbh & Co. Kg | Fixation assembly with a flexible elongated member for securing parts of a sternum |
| WO2015028100A1 (en) | 2013-09-02 | 2015-03-05 | Stryker Trauma Gmbh | Method of manufacturing an implant for use in a surgical procedure |
| EP3042622B1 (en) | 2015-01-09 | 2018-05-09 | Stryker European Holdings I, LLC | Implant for bone fixation |
| EP3320868B1 (en) | 2016-11-11 | 2019-05-01 | Stryker European Holdings I, LLC | Implant for bone fixation |
| US11198831B2 (en) | 2019-01-31 | 2021-12-14 | Kvi Llc | Lubricant for a device |
Family Cites Families (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US183265A (en) * | 1876-10-17 | Improvement in swinging outriggers for row-boats | ||
| US3091572A (en) | 1962-07-16 | 1963-05-28 | Schering Corp | Gentamycin and method of production |
| ES315101A1 (es) | 1965-07-08 | 1966-01-01 | Folch Vazquez Conrado | Procedimiento de preparaciën de nuevos derivados de tetraciclina |
| CA950831A (en) | 1972-04-25 | 1974-07-09 | Leonard D. Kurtz | Biocidal salts |
| FR2272680B1 (ro) | 1974-05-29 | 1978-07-21 | Hosbon Sa Lab | |
| DE2843963A1 (de) | 1978-10-09 | 1980-04-24 | Merck Patent Gmbh | Im koerper resorbierbare geformte masse auf basis von kollagen und ihre verwendung in der medizin |
| DE2807132C2 (de) * | 1978-02-20 | 1983-11-03 | Battelle-Institut E.V., 6000 Frankfurt | Implantierbares Pharmaka-Depot |
| DE3206725A1 (de) | 1981-05-13 | 1982-12-02 | Merck Patent Gmbh, 6100 Darmstadt | Schwer loesliche salze von aminoglykosidantibiotika |
| DE3206726A1 (de) | 1982-02-25 | 1983-09-01 | Merck Patent Gmbh, 6100 Darmstadt | Pharmakadepot |
| DE3248328A1 (de) | 1982-12-28 | 1984-06-28 | Bayer Ag, 5090 Leverkusen | Schwerloesliche salze von aminoglykosiden sowie diese enthaltende formulierungen mit verzoegerter wirkstoff-freigabe |
| US4879135A (en) * | 1984-07-23 | 1989-11-07 | University Of Medicine And Dentistry Of New Jersey | Drug bonded prosthesis and process for producing same |
| US4740382A (en) * | 1984-07-23 | 1988-04-26 | University Of Medicine & Dentistry Of New Jersey | Antibiotic bonded prosthesis and process for producing same |
| FR2613619B1 (fr) * | 1987-04-07 | 1993-10-15 | Recherche Informatique Pharmacie | Medicaments, produits dietetiques ou produits d'hygiene sous forme de compositions pulverulentes obtenues par adsorption de principes actifs sur un sucre a dissolution rapide |
| US5034421A (en) * | 1988-12-13 | 1991-07-23 | Fuisz Pharmaceutical Ltd. | Moderated spun fibrous system and method of manufacture |
| US5019096A (en) * | 1988-02-11 | 1991-05-28 | Trustees Of Columbia University In The City Of New York | Infection-resistant compositions, medical devices and surfaces and methods for preparing and using same |
| US5169778A (en) * | 1989-02-28 | 1992-12-08 | Sawao Murao | Amycolatopsis trehalostatica strain |
| AU638245B2 (en) * | 1989-03-31 | 1993-06-24 | Regents Of The University Of California, The | Preparation of liposome and lipid complex compositions |
| GB9009473D0 (en) * | 1990-04-27 | 1990-06-20 | Beecham Group Plc | Pharmaceutical formulation |
| CA2079509C (en) * | 1991-10-01 | 2002-05-14 | Shigeyuki Takada | Prolonged release microparticle preparation and production of the same |
| AU4198793A (en) * | 1992-07-24 | 1994-01-27 | Takeda Chemical Industries Ltd. | Microparticle preparation and production thereof |
| AU5171293A (en) | 1992-10-14 | 1994-05-09 | Regents Of The University Of Colorado, The | Ion-pairing of drugs for improved efficacy and delivery |
| DE4314871A1 (de) * | 1993-05-05 | 1994-11-10 | Merck Patent Gmbh | Lösungsmittel für ein schwerlösliches Gentamicin-Salz |
| AU702042B2 (en) * | 1994-06-10 | 1999-02-11 | Dumex-Alpharma A/S | Drug salts |
| DE69512365T2 (de) * | 1994-12-27 | 2000-02-24 | Seiko Epson Corp., Tokio/Tokyo | Wässerige Tintenzusammensetzung und Verfahren zur Herstellung derselben |
| WO1997038698A1 (en) | 1996-04-18 | 1997-10-23 | University Technology Corporation | Methods for treating middle and inner ear disorders |
| DE10114245A1 (de) | 2001-03-22 | 2002-10-02 | Heraeus Kulzer Gmbh & Co Kg | Herstellung und Verwendung einer Antibiotikum-/Antibiotika-Zubereitung |
-
2002
- 2002-05-17 IS IS6389A patent/IS6389A/is unknown
- 2002-06-03 MD MDA20020154A patent/MD2670C2/ro not_active IP Right Cessation
- 2002-06-19 US US10/174,682 patent/US7358232B2/en not_active Expired - Fee Related
- 2002-06-27 BG BG106880A patent/BG65793B1/bg unknown
- 2002-07-02 CZ CZ20022321A patent/CZ301805B6/cs not_active IP Right Cessation
- 2002-07-05 YU YU52002A patent/YU52002A/sh unknown
- 2002-07-08 SK SK995-2002A patent/SK287128B6/sk not_active IP Right Cessation
- 2002-07-29 CA CA002396151A patent/CA2396151C/en not_active Expired - Fee Related
- 2002-07-31 IL IL150998A patent/IL150998A/en not_active IP Right Cessation
- 2002-08-12 GE GE4870A patent/GEP20043332B/en unknown
- 2002-08-14 DE DE50211948T patent/DE50211948D1/de not_active Expired - Lifetime
- 2002-08-14 EP EP02018323A patent/EP1287819B1/de not_active Expired - Lifetime
- 2002-08-14 PT PT02018323T patent/PT1287819E/pt unknown
- 2002-08-14 ES ES02018323T patent/ES2301595T3/es not_active Expired - Lifetime
- 2002-08-14 DK DK02018323T patent/DK1287819T3/da active
- 2002-08-14 AT AT02018323T patent/ATE390120T1/de active
- 2002-08-16 AU AU2002300639A patent/AU2002300639B2/en not_active Ceased
- 2002-08-20 HR HR20020679A patent/HRP20020679A2/hr not_active Application Discontinuation
- 2002-08-27 NZ NZ521042A patent/NZ521042A/xx not_active IP Right Cessation
- 2002-08-27 MX MXPA02008327A patent/MXPA02008327A/es active IP Right Grant
- 2002-08-28 NO NO20024103A patent/NO20024103L/no not_active Application Discontinuation
- 2002-08-28 JP JP2002249579A patent/JP4041367B2/ja not_active Expired - Fee Related
- 2002-08-28 BR BR0203416-6A patent/BR0203416A/pt not_active IP Right Cessation
- 2002-08-29 PL PL355777A patent/PL206971B1/pl not_active IP Right Cessation
- 2002-08-30 HU HU0202915A patent/HUP0202915A3/hu unknown
- 2002-08-30 CN CNB021415048A patent/CN1197630C/zh not_active Expired - Fee Related
- 2002-08-30 RU RU2002123421/15A patent/RU2236871C2/ru not_active IP Right Cessation
- 2002-08-30 EE EEP200200492A patent/EE200200492A/xx unknown
- 2002-09-03 SA SA2230289A patent/SA02230289B1/ar unknown
-
2004
- 2004-06-14 JP JP2004176070A patent/JP4808938B2/ja not_active Expired - Fee Related
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| KA4A | Patent for invention lapsed due to non-payment of fees (with right of restoration) | ||
| MM4A | Patent for invention definitely lapsed due to non-payment of fees |