MD2313C2 - Process for vitamin B12 obtaining - Google Patents
Process for vitamin B12 obtaining Download PDFInfo
- Publication number
- MD2313C2 MD2313C2 MDA20010162A MD20010162A MD2313C2 MD 2313 C2 MD2313 C2 MD 2313C2 MD A20010162 A MDA20010162 A MD A20010162A MD 20010162 A MD20010162 A MD 20010162A MD 2313 C2 MD2313 C2 MD 2313C2
- Authority
- MD
- Moldova
- Prior art keywords
- vitamin
- cultivation
- obtaining
- medium
- days
- Prior art date
Links
- 229930003779 Vitamin B12 Natural products 0.000 title abstract 4
- FDJOLVPMNUYSCM-WZHZPDAFSA-L cobalt(3+);[(2r,3s,4r,5s)-5-(5,6-dimethylbenzimidazol-1-yl)-4-hydroxy-2-(hydroxymethyl)oxolan-3-yl] [(2r)-1-[3-[(1r,2r,3r,4z,7s,9z,12s,13s,14z,17s,18s,19r)-2,13,18-tris(2-amino-2-oxoethyl)-7,12,17-tris(3-amino-3-oxopropyl)-3,5,8,8,13,15,18,19-octamethyl-2 Chemical compound [Co+3].N#[C-].N([C@@H]([C@]1(C)[N-]\C([C@H]([C@@]1(CC(N)=O)C)CCC(N)=O)=C(\C)/C1=N/C([C@H]([C@@]1(CC(N)=O)C)CCC(N)=O)=C\C1=N\C([C@H](C1(C)C)CCC(N)=O)=C/1C)[C@@H]2CC(N)=O)=C\1[C@]2(C)CCC(=O)NC[C@@H](C)OP([O-])(=O)O[C@H]1[C@@H](O)[C@@H](N2C3=CC(C)=C(C)C=C3N=C2)O[C@@H]1CO FDJOLVPMNUYSCM-WZHZPDAFSA-L 0.000 title abstract 4
- 239000011715 vitamin B12 Substances 0.000 title abstract 4
- 235000019163 vitamin B12 Nutrition 0.000 title abstract 4
- 238000000034 method Methods 0.000 title abstract 3
- LJUQGASMPRMWIW-UHFFFAOYSA-N 5,6-dimethylbenzimidazole Chemical compound C1=C(C)C(C)=CC2=C1NC=N2 LJUQGASMPRMWIW-UHFFFAOYSA-N 0.000 abstract 1
- 241000894006 Bacteria Species 0.000 abstract 1
- 239000002028 Biomass Substances 0.000 abstract 1
- 229910021580 Cobalt(II) chloride Inorganic materials 0.000 abstract 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 abstract 1
- 240000008042 Zea mays Species 0.000 abstract 1
- 235000005824 Zea mays ssp. parviglumis Nutrition 0.000 abstract 1
- 235000002017 Zea mays subsp mays Nutrition 0.000 abstract 1
- BFNBIHQBYMNNAN-UHFFFAOYSA-N ammonium sulfate Chemical compound N.N.OS(O)(=O)=O BFNBIHQBYMNNAN-UHFFFAOYSA-N 0.000 abstract 1
- 229910052921 ammonium sulfate Inorganic materials 0.000 abstract 1
- 235000011130 ammonium sulphate Nutrition 0.000 abstract 1
- 230000001580 bacterial effect Effects 0.000 abstract 1
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 abstract 1
- 150000004649 carbonic acid derivatives Chemical class 0.000 abstract 1
- 235000005822 corn Nutrition 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 239000008103 glucose Substances 0.000 abstract 1
- 208000015181 infectious disease Diseases 0.000 abstract 1
- 229910052500 inorganic mineral Inorganic materials 0.000 abstract 1
- 239000011707 mineral Substances 0.000 abstract 1
- 235000015097 nutrients Nutrition 0.000 abstract 1
- 230000006641 stabilisation Effects 0.000 abstract 1
- 238000011105 stabilization Methods 0.000 abstract 1
Landscapes
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The invention refers to biotechnology, in particular to processes for obtaining of vitamin B12 that may be used in zootechny and medicine.The process for vitamin B12 obtaining includes cultivation of propionic bacteria in facultative aerobic conditions during 7 days on a nutrient medium with pH 6,8…7,0, containing corn extract, glucose, (NH4)2SO4, CoCl2•6H2O, a natural mineral with increased content of carbonates and 5,6-dimethyl benzimidazole, the latter being introduced on the 5-th day of cultivation. After 7 days of cultivation the obtained biomass is separated from the medium and it is extracted the vitamin B12 there from.The result of the invention consists in providing for the stabilization of medium pH and in avoiding the bacterial culture infection.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| MDA20010162A MD2313C2 (en) | 2001-05-25 | 2001-05-25 | Process for vitamin B12 obtaining |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| MDA20010162A MD2313C2 (en) | 2001-05-25 | 2001-05-25 | Process for vitamin B12 obtaining |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| MD20010162A MD20010162A (en) | 2003-02-28 |
| MD2313B2 MD2313B2 (en) | 2003-11-30 |
| MD2313C2 true MD2313C2 (en) | 2004-05-31 |
Family
ID=19739852
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MDA20010162A MD2313C2 (en) | 2001-05-25 | 2001-05-25 | Process for vitamin B12 obtaining |
Country Status (1)
| Country | Link |
|---|---|
| MD (1) | MD2313C2 (en) |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US1983023A (en) * | 1932-01-14 | 1934-12-04 | Auditorium Conditioning Corp | Method and apparatus for ventilation |
| MD460G2 (en) * | 1995-07-12 | 1997-03-31 | Государственный Университет Молд0 | Method for cianocobalamine synthesis |
| MD749G2 (en) * | 1996-07-11 | 1998-02-28 | Государственный Университет Молд0 | Process for cyanocobalamine synthesis by propionic acid bacteria |
| US6492141B1 (en) * | 1998-12-18 | 2002-12-10 | Dsm N.V. | Process for the production of vitamin b12 |
-
2001
- 2001-05-25 MD MDA20010162A patent/MD2313C2/en not_active IP Right Cessation
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US1983023A (en) * | 1932-01-14 | 1934-12-04 | Auditorium Conditioning Corp | Method and apparatus for ventilation |
| MD460G2 (en) * | 1995-07-12 | 1997-03-31 | Государственный Университет Молд0 | Method for cianocobalamine synthesis |
| MD749G2 (en) * | 1996-07-11 | 1998-02-28 | Государственный Университет Молд0 | Process for cyanocobalamine synthesis by propionic acid bacteria |
| US6492141B1 (en) * | 1998-12-18 | 2002-12-10 | Dsm N.V. | Process for the production of vitamin b12 |
Non-Patent Citations (2)
| Title |
|---|
| Быховский В.Я. Микробиологический синтез витамина В12. Москва, 1984, с. 42 * |
| Быховский В.Я., Зайцева Н.И. Микробиологический синтез тетрапиррольных соединений. Биологическая химия, 1989, т. 32, с. 139-140 * |
Also Published As
| Publication number | Publication date |
|---|---|
| MD20010162A (en) | 2003-02-28 |
| MD2313B2 (en) | 2003-11-30 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| KA4A | Patent for invention lapsed due to non-payment of fees (with right of restoration) | ||
| MM4A | Patent for invention definitely lapsed due to non-payment of fees |