MD20150049A2 - Modulatori selectivi noi de receptor androgenic - Google Patents

Modulatori selectivi noi de receptor androgenic Download PDF

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Publication number
MD20150049A2
MD20150049A2 MDA20150049A MD20150049A MD20150049A2 MD 20150049 A2 MD20150049 A2 MD 20150049A2 MD A20150049 A MDA20150049 A MD A20150049A MD 20150049 A MD20150049 A MD 20150049A MD 20150049 A2 MD20150049 A2 MD 20150049A2
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MD
Moldova
Prior art keywords
linear
branched chain
chain alkyl
hydrogen
androgen receptor
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MDA20150049A
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English (en)
Russian (ru)
Inventor
Джеймс Томас Андерсон
Еуджен Львович Пятницкий ЧЕКЛЕР
Эдмунд Л. ЭЛСУОРТ
Брюс Кипп Эриксон
Адам Мэтью Гилберт
Энтони П. Рикеттс
Дэвид П. Томпсон
Райоманд Джал Унвалла
Патрик Роберт Верхоэст
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Pfizer Inc.
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Application filed by Pfizer Inc. filed Critical Pfizer Inc.
Publication of MD20150049A2 publication Critical patent/MD20150049A2/ro

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    • C07C255/58—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and singly-bound nitrogen atoms, not being further bound to other hetero atoms, bound to the carbon skeleton
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    • C07C255/59—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and singly-bound nitrogen atoms, not being further bound to other hetero atoms, bound to the carbon skeleton the carbon skeleton being further substituted by singly-bound oxygen atoms
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    • C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
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    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
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    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/20—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms
    • C07D211/22—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms by oxygen atoms
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    • C07D285/02—Thiadiazoles; Hydrogenated thiadiazoles
    • C07D285/04—Thiadiazoles; Hydrogenated thiadiazoles not condensed with other rings
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Abstract

Prezenta invenţie se referă la compusul cu formula 1, 2 sau 3:unde A este N sau -CR0--, unde R0 este hidrogen, alchil C1-C6 cu catena liniară sau ramificată etc., Z este -CRe-- sau -N--, unde Re este hidrogen, alchil C1-C6 cu catena liniară sau ramificată etc.; R1 este hidrogen, alchil C1-C6 cu catena liniară sau ramificată, etc.; R2 sunt independent hidrogen sau alchil C1-C6 cu catena liniară sau ramificată; R3 şi R4 sunt independent hidrogen, alchil C1-C6 cu catena liniară sau ramificată etc.; R5 şi R6 sunt independent hidrogen sau alchil C1-C6 cu catena liniară sau ramificată etc.; R8 este hidrogen, achil C1-C6 cu catena liniară sau ramificată etc.; R9 şi R10 sunt independent hidrogen sau alchil C1-C6 cu catena liniară sau ramificată etc.; Q este --CO--, --(CH2)q--, --(CHRs)q-- sau -(CRsRt)q--, unde Rs şi Rt sunt independent alchil, aril, alchilaril, heteroaril sau alchilheteroaril C1-C6 cu catenă liniară sau ramificată; unde q este 0, 1, 2 sau 3; şi unde n este 0, 1, 2, 3, 4 sau 5; sau la o sare farmaceutic acceptabilă a acestora, la compoziţiile ce conţin asemenea compuşi; şi la utilizarea acestor compuşi în tratamentul diferitelor boli, în particular, al celor afectate sau mediate de receptorul androgen.
MDA20150049A 2012-12-03 2013-11-25 Modulatori selectivi noi de receptor androgenic MD20150049A2 (ro)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201261732617P 2012-12-03 2012-12-03
PCT/IB2013/060381 WO2014087298A1 (en) 2012-12-03 2013-11-25 Novel selective androgen receptor modulators

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US (1) US9328104B2 (ro)
EP (1) EP2925725B1 (ro)
JP (1) JP6039100B2 (ro)
KR (1) KR101745225B1 (ro)
CN (1) CN104854093B (ro)
AP (1) AP2015008444A0 (ro)
AR (1) AR093697A1 (ro)
AU (1) AU2013353723B2 (ro)
BR (1) BR112015011897B1 (ro)
CA (1) CA2891234C (ro)
CL (1) CL2015001495A1 (ro)
CO (1) CO7400864A2 (ro)
CR (1) CR20150290A (ro)
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EA (1) EA026562B1 (ro)
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IL (1) IL239076B (ro)
MA (1) MA38114A1 (ro)
MD (1) MD20150049A2 (ro)
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NZ (1) NZ707752A (ro)
PE (1) PE20151158A1 (ro)
PH (1) PH12015501215A1 (ro)
SG (1) SG11201503580WA (ro)
TN (1) TN2015000237A1 (ro)
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UA (1) UA110766C2 (ro)
UY (1) UY35158A (ro)
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CN106459025B (zh) 2014-05-15 2019-05-28 辉瑞公司 6-[(4r)-4-甲基-1，1-二氧化-1，2，6-噻二嗪烷-2-基]异喹啉-1-腈的结晶形式
ES2864079T3 (es) 2014-05-30 2021-10-13 Pfizer Derivados de carbonitrilo como moduladores selectivos del receptor de andrógenos
TWI726969B (zh) 2016-01-11 2021-05-11 比利時商健生藥品公司 用作雄性激素受體拮抗劑之經取代之硫尿囊素衍生物
CN107573270B (zh) * 2017-09-29 2019-11-29 河南师范大学 一种α-甲酰基吡咯烷类化合物的合成方法
CN110372628B (zh) * 2019-07-09 2021-04-02 武汉大学 内磺酰胺类化合物及其制备方法
EP4028013A4 (en) 2019-09-12 2023-10-18 Disarm Therapeutics, Inc. MRSA1 INHIBITORS
WO2023275715A1 (en) * 2021-06-30 2023-01-05 Pfizer Inc. Metabolites of selective androgen receptor modulators

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US20140155390A1 (en) 2014-06-05
EP2925725A1 (en) 2015-10-07
MX368898B (es) 2019-10-21
WO2014087298A1 (en) 2014-06-12
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DOP2015000132A (es) 2015-12-31
AR093697A1 (es) 2015-06-17
AU2013353723A1 (en) 2015-05-21
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SG11201503580WA (en) 2015-06-29
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