MD20140124A2 - Compuşi inhibitori ai activităţii catehol O-metiltransferazei - Google Patents

Compuşi inhibitori ai activităţii catehol O-metiltransferazei

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Publication number
MD20140124A2
MD20140124A2 MDA20140124A MD20140124A MD20140124A2 MD 20140124 A2 MD20140124 A2 MD 20140124A2 MD A20140124 A MDA20140124 A MD A20140124A MD 20140124 A MD20140124 A MD 20140124A MD 20140124 A2 MD20140124 A2 MD 20140124A2
Authority
MD
Moldova
Prior art keywords
catechol
inhibiting compounds
methyltransferase activity
activity inhibiting
comt
Prior art date
Application number
MDA20140124A
Other languages
English (en)
Russian (ru)
Other versions
MD4556B1 (ro
MD4556C1 (ro
Inventor
Marko Ahlmark
Belle David Din
Mika Kauppala
Anne Luiro
Taina Pajunen
Jarmo Pystynen
Eija Tiainen
Matti Vaismaa
Josef Messinger
Original Assignee
Orion Corporation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Orion Corporation filed Critical Orion Corporation
Publication of MD20140124A2 publication Critical patent/MD20140124A2/ro
Publication of MD4556B1 publication Critical patent/MD4556B1/ro
Publication of MD4556C1 publication Critical patent/MD4556C1/ro

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    • A61K31/275—Nitriles; Isonitriles
    • A61K31/277—Nitriles; Isonitriles having a ring, e.g. verapamil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
    • A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A61K31/341—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide not condensed with another ring, e.g. ranitidine, furosemide, bufetolol, muscarine
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    • A61K31/343—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide condensed with a carbocyclic ring, e.g. coumaran, bufuralol, befunolol, clobenfurol, amiodarone
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
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    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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    • C07C255/59—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and singly-bound nitrogen atoms, not being further bound to other hetero atoms, bound to the carbon skeleton the carbon skeleton being further substituted by singly-bound oxygen atoms
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Abstract

Invenţia se referă la 4,5-dihidroxiizoftalonitrili 2-substituiţi cu activitate farmacologică sau la săruri şi esteri farmaceutic acceptabili ai acestora, precum şi la compoziţii farmaceutice care îi conţin şi la utilizarea lor ca inhibitori ai enzimei catehol O-metiltransferazei (COMT).Sunt descrişi compuşi cu formula I,în care R1 are semnificaţiile definite în revendicări, şi care exercită activitate de inhibare a enzimei COMT.
MDA20140124A 2012-05-24 2013-05-23 Compuşi inhibitori ai activităţii catehol O-metiltransferazei MD4556C1 (ro)

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KR102100612B1 (ko) 2020-04-16
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