MD1418F2 - Analogi ai acilfulvenei si compozitie farmaceutica pe baza lor - Google Patents

Analogi ai acilfulvenei si compozitie farmaceutica pe baza lor

Info

Publication number
MD1418F2
MD1418F2 MD96-0212A MD960212A MD1418F2 MD 1418 F2 MD1418 F2 MD 1418F2 MD 960212 A MD960212 A MD 960212A MD 1418 F2 MD1418 F2 MD 1418F2
Authority
MD
Moldova
Prior art keywords
acylfulven
analogues
pharmaceutical composition
base
alkyl
Prior art date
Application number
MD96-0212A
Other languages
English (en)
Other versions
MD960212A (ro
MD1418G2 (ro
Inventor
Michael J Kelner
Trevor C Mcmorris
Raymond Taetle
Original Assignee
Univ California
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ California filed Critical Univ California
Publication of MD960212A publication Critical patent/MD960212A/ro
Publication of MD1418F2 publication Critical patent/MD1418F2/ro
Publication of MD1418G2 publication Critical patent/MD1418G2/ro

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06—Esters of carbamic acids
    • C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
    • C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C271/12—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/12—Ketones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/27—Esters, e.g. nitroglycerine, selenocyanates of carbamic or thiocarbamic acids, meprobamate, carbachol, neostigmine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/45—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by condensation
    • C07C45/455—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by condensation with carboxylic acids or their derivatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/45—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by condensation
    • C07C45/46—Friedel-Crafts reactions
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/65—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by splitting-off hydrogen atoms or functional groups; by hydrogenolysis of functional groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
    • C07C45/673—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by change of size of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/587—Unsaturated compounds containing a keto groups being part of a ring
    • C07C49/657—Unsaturated compounds containing a keto groups being part of a ring containing six-membered aromatic rings
    • C07C49/665—Unsaturated compounds containing a keto groups being part of a ring containing six-membered aromatic rings a keto group being part of a condensed ring system
    • C07C49/67—Unsaturated compounds containing a keto groups being part of a ring containing six-membered aromatic rings a keto group being part of a condensed ring system having two rings, e.g. tetralones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/587—Unsaturated compounds containing a keto groups being part of a ring
    • C07C49/657—Unsaturated compounds containing a keto groups being part of a ring containing six-membered aromatic rings
    • C07C49/683—Unsaturated compounds containing a keto groups being part of a ring containing six-membered aromatic rings having unsaturation outside the aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/587—Unsaturated compounds containing a keto groups being part of a ring
    • C07C49/703—Unsaturated compounds containing a keto groups being part of a ring containing hydroxy groups
    • C07C49/723—Unsaturated compounds containing a keto groups being part of a ring containing hydroxy groups polycyclic
    • C07C49/727—Unsaturated compounds containing a keto groups being part of a ring containing hydroxy groups polycyclic a keto group being part of a condensed ring system
    • C07C49/737—Unsaturated compounds containing a keto groups being part of a ring containing hydroxy groups polycyclic a keto group being part of a condensed ring system having three rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/587—Unsaturated compounds containing a keto groups being part of a ring
    • C07C49/703—Unsaturated compounds containing a keto groups being part of a ring containing hydroxy groups
    • C07C49/747—Unsaturated compounds containing a keto groups being part of a ring containing hydroxy groups containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/587—Unsaturated compounds containing a keto groups being part of a ring
    • C07C49/753—Unsaturated compounds containing a keto groups being part of a ring containing ether groups, groups, groups, or groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/587—Unsaturated compounds containing a keto groups being part of a ring
    • C07C49/753—Unsaturated compounds containing a keto groups being part of a ring containing ether groups, groups, groups, or groups
    • C07C49/755—Unsaturated compounds containing a keto groups being part of a ring containing ether groups, groups, groups, or groups a keto group being part of a condensed ring system with two or three rings, at least one ring being a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/007—Esters of unsaturated alcohols having the esterified hydroxy group bound to an acyclic carbon atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2603/00—Systems containing at least three condensed rings
    • C07C2603/93—Spiro compounds
    • C07C2603/94—Spiro compounds containing "free" spiro atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Emergency Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicinal Preparation (AREA)
  • Saccharide Compounds (AREA)
  • Medicines Containing Plant Substances (AREA)
MD96-0212A 1993-02-09 1994-02-02 Analogi ai acilfulvenei şi compoziţie farmaceutică pe baza lor MD1418G2 (ro)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/015,179 US5439936A (en) 1989-10-03 1993-02-09 Method of treating certain tumors using illudin analogs
PCT/US1994/001232 WO1994018151A1 (en) 1993-02-09 1994-02-02 Acylfulvene analogues as antitumor agents

Publications (3)

Publication Number Publication Date
MD960212A MD960212A (ro) 1999-01-31
MD1418F2 true MD1418F2 (ro) 2000-02-29
MD1418G2 MD1418G2 (ro) 2000-10-31

Family

ID=21769946

Family Applications (1)

Application Number Title Priority Date Filing Date
MD96-0212A MD1418G2 (ro) 1993-02-09 1994-02-02 Analogi ai acilfulvenei şi compoziţie farmaceutică pe baza lor

Country Status (22)

Country Link
US (3) US5439936A (ro)
EP (1) EP0683762B1 (ro)
JP (1) JP3908270B2 (ro)
KR (1) KR100311327B1 (ro)
CN (1) CN1046934C (ro)
AT (1) ATE174894T1 (ro)
AU (1) AU676889B2 (ro)
BR (1) BR9405689A (ro)
CA (1) CA2155329C (ro)
CZ (1) CZ288596B6 (ro)
DE (1) DE69415507T2 (ro)
DK (1) DK0683762T3 (ro)
ES (1) ES2125441T3 (ro)
GR (1) GR3029736T3 (ro)
HU (1) HU220059B (ro)
MD (1) MD1418G2 (ro)
NO (1) NO318648B1 (ro)
NZ (1) NZ262282A (ro)
PL (1) PL175024B1 (ro)
RU (1) RU2145849C1 (ro)
TJ (1) TJ266B (ro)
WO (1) WO1994018151A1 (ro)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5932553A (en) * 1996-07-18 1999-08-03 The Regents Of The University Of California Illudin analogs useful as antitumor agents
US5723632A (en) 1996-08-08 1998-03-03 Mgi Pharma, Inc. Total synthesis of antitumor acylfulvenes
US7141603B2 (en) * 1999-02-19 2006-11-28 The Regents Of The University California Antitumor agents
US6025328A (en) * 1998-02-20 2000-02-15 The Regents Of The University Of California Antitumor agents
US7015247B2 (en) * 2000-10-12 2006-03-21 Alvin Guttag Ibuprofen-aspirin, hydroxymethylacylfulvene analogs and L-sugar illudin analogs
US6436916B1 (en) 2000-10-12 2002-08-20 Alvin Guttag Ibuprofen-aspirin and hydroxymethylacylfulvene analogs
CA2571421A1 (en) 2004-06-24 2006-01-05 Nicholas Valiante Compounds for immunopotentiation
JP4989648B2 (ja) * 2005-08-03 2012-08-01 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア 抗癌剤として有用なイルジン類似体
CN102333528B (zh) * 2009-01-26 2013-12-18 台北医学大学 蕨素化合物用于治疗糖尿病及肥胖之用途
US11135182B2 (en) 2014-04-10 2021-10-05 Af Chemicals, Llc Affinity medicant conjugates
US10285955B2 (en) 2014-04-10 2019-05-14 Af Chemicals, Llc Affinity medicant conjugate
CN106458922A (zh) 2014-04-10 2017-02-22 Af化学药品有限责任公司 亲和药物共轭物
CN106083953A (zh) * 2016-06-15 2016-11-09 成都医学院 一种从蕨菜中提取原蕨苷以及制备高纯度原蕨苷的方法
WO2018170230A1 (en) * 2017-03-15 2018-09-20 Memorial Sloan Kettering Cancer Center Diagnosis & treatment of ercc3-mutant cancer
JP7489966B2 (ja) * 2018-09-04 2024-05-24 ランタン ファルマ インコーポレイテッド イルジン類似体、それらの使用、およびそれらを合成する方法
EP3667323B1 (en) 2018-12-11 2024-11-13 AF Chemical LLC Methods, compositions and devices for treating cancer with illudofulvenes
EP4035684A1 (en) 2019-11-25 2022-08-03 AF Chemical LLC Affinity illudofulvene conjugates
US11591295B2 (en) 2019-11-25 2023-02-28 Af Chemicals Llc Affinity illudofulvene conjugates
CN112972443A (zh) * 2021-03-29 2021-06-18 杭州添帆生物科技有限公司 一种抗癌药物及其应用
KR20230170695A (ko) * 2021-04-12 2023-12-19 랜턴 파마 인코포레이티드 폐암 및 비-소세포 폐암의 치료 방법
EP4541425A3 (en) * 2022-06-07 2025-05-21 Lantern Pharma Inc. Treating cancers with combinations of acylfulvenes with ibrutinib or bortezomib
EP4554683A2 (en) * 2022-07-15 2025-05-21 Lantern Pharma Inc. Method for treating breast cancers and parp resistant breast cancers

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL95875A (en) * 1989-10-03 1994-10-21 Univ California Pharmaceutical compositions containing analogues of illudin m and s for inhibiting tumor cell growth
GB9017024D0 (en) * 1990-08-03 1990-09-19 Erba Carlo Spa New linker for bioactive agents
FI85318C (fi) * 1990-08-14 1992-03-25 Tecnomen Oy Kompensering av felet i en klockas gaong.
JPH06223404A (ja) * 1993-01-25 1994-08-12 Mitsubishi Kasei Corp 光学的情報記録用媒体

Also Published As

Publication number Publication date
CA2155329A1 (en) 1994-08-18
HU220059B (hu) 2001-10-28
CN1119854A (zh) 1996-04-03
JP3908270B2 (ja) 2007-04-25
CA2155329C (en) 2006-08-15
CZ198695A3 (en) 1996-01-17
NO318648B1 (no) 2005-04-25
NO953099D0 (no) 1995-08-07
MD960212A (ro) 1999-01-31
US5439936A (en) 1995-08-08
MD1418G2 (ro) 2000-10-31
US5523490A (en) 1996-06-04
EP0683762B1 (en) 1998-12-23
NZ262282A (en) 1997-06-24
ES2125441T3 (es) 1999-03-01
PL310159A1 (en) 1995-11-27
TJ266B (en) 2000-08-07
WO1994018151A1 (en) 1994-08-18
EP0683762A1 (en) 1995-11-29
NO953099L (no) 1995-10-09
DK0683762T3 (da) 1999-08-23
BR9405689A (pt) 1995-11-21
CZ288596B6 (cs) 2001-07-11
PL175024B1 (pl) 1998-10-30
HU9502358D0 (en) 1995-10-30
US5563176A (en) 1996-10-08
CN1046934C (zh) 1999-12-01
KR100311327B1 (ko) 2001-12-28
AU6170094A (en) 1994-08-29
ATE174894T1 (de) 1999-01-15
DE69415507T2 (de) 1999-08-12
RU2145849C1 (ru) 2000-02-27
HUT72450A (en) 1996-04-29
DE69415507D1 (de) 1999-02-04
JPH08506812A (ja) 1996-07-23
GR3029736T3 (en) 1999-06-30
AU676889B2 (en) 1997-03-27

Similar Documents

Publication Publication Date Title
MD1418G2 (ro) Analogi ai acilfulvenei şi compoziţie farmaceutică pe baza lor
BG104597A (en) Inhibition of raf kinase using substituted heterocyclic ureas
EP0982301A3 (en) Delta 6,7-taxols antineoplastic use and pharmaceutical compositions containing them
IL107950A0 (en) 7-Halo- and 7 beta, 8 beta-methano-taxols, antineoplastic use and pharmaceutical compositions containing them
EP0528858A4 (en) Inhibitors of dipeptidyl-aminopeptidase type iv
MY108261A (en) Water soluble camptothecin derivatives
MY130544A (en) Antineoplastic use and pharmaceutical compositions containing them
YU21100A (sh) Izohinolini kao urokinazni inhibitori
MX9700026A (es) Analogos de 7-eter-taxol, su uso antineoplastico y composiciones farmaceuticas que los contienen.
GR3021182T3 (en) New peptide compound and a process for the preparation thereof
IL137964A0 (en) Antitumor agents
CA2155018A1 (en) C7 taxane derivatives and pharmaceutical compositions containing them
GR3023427T3 (en) Heteroarylmethylbenzols aromatase inhibitors
AU639804B2 (en) Novel platinum (ii) complex and drug for treating malignant tumor
HUT63618A (en) Process for producing 2,5-diamino-4,6-dichloropyrimidine derivatives protected on the 5-positioned nitrogen atom, as well as pharmaceutical compositions comprising same
EP0369398A3 (en) Polyphosphazene derivatives containing carbonyl groups suitable for photoreticulation processes
CA2070497A1 (en) Novel platinum (ii) complex and antitumor agent
EP1261344A1 (en) Use of a compound for preparing a drug
GB1466623A (en) Nutrient compsoitions including heterocyclic compounds and methods involving the use of such compounds
DE69023288D1 (de) Carbonylgruppen und unterschiedlich alkylierte, tertiäre Aminogruppen aufweisende Polyphosphazenderivate.
PL334624A1 (en) Novel compounds of 8h-thiene-/2,3-b/pyrolysin-8-one, method of obtaining them and pharmaceutic compositions containing such compounds
EP1752446A3 (en) Compounds for modulating cell proliferation
JO1648B1 (en) Nitrogen compounds
GB1500054A (en) 5-fluorouracil derivatives and preparation thereof
TH51195A (th) ไนโทร-ซัลโฟเบนซามีด

Legal Events

Date Code Title Description
PD99 Pending application
KA4A Patent for invention lapsed due to non-payment of fees (with right of restoration)
NF4A Restoration of lapsed patent for invention
KA4A Patent for invention lapsed due to non-payment of fees (with right of restoration)
MM4A Patent for invention definitely lapsed due to non-payment of fees