MC2289A1 - Composes heterocycliques - Google Patents

Composes heterocycliques

Info

Publication number
MC2289A1
MC2289A1 MC91@@D MC2289D MC2289A1 MC 2289 A1 MC2289 A1 MC 2289A1 MC 2289 D MC2289 D MC 2289D MC 2289 A1 MC2289 A1 MC 2289A1
Authority
MC
Monaco
Prior art keywords
heterocyclic compounds
pharmaceutically acceptable
acceptable esters
ara
useful
Prior art date
Application number
MC91@@D
Other languages
English (en)
French (fr)
Inventor
Thomas Krenitsky
Devron Averett
Jeffrey Wilson
Allan Moorman
George KOSZALKA
Stanley Chamberlain
David Porter
Gerald Wolberg
Original Assignee
Wellcome Found
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wellcome Found filed Critical Wellcome Found
Publication of MC2289A1 publication Critical patent/MC2289A1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Stereophonic System (AREA)
  • Use Of Switch Circuits For Exchanges And Methods Of Control Of Multiplex Exchanges (AREA)
  • Earth Drilling (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
MC91@@D 1990-07-19 1991-07-18 Composes heterocycliques MC2289A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB909015914A GB9015914D0 (en) 1990-07-19 1990-07-19 Heterocyclic compounds
PCT/GB1991/001196 WO1992001456A1 (en) 1990-07-19 1991-07-18 Heterocyclic compounds

Publications (1)

Publication Number Publication Date
MC2289A1 true MC2289A1 (fr) 1993-07-14

Family

ID=10679359

Family Applications (1)

Application Number Title Priority Date Filing Date
MC91@@D MC2289A1 (fr) 1990-07-19 1991-07-18 Composes heterocycliques

Country Status (23)

Country Link
US (3) US5492897A (de)
EP (1) EP0539479B1 (de)
JP (1) JP2873086B2 (de)
KR (1) KR100187326B1 (de)
AT (1) ATE151637T1 (de)
CA (1) CA2087543C (de)
CY (1) CY2165B1 (de)
DE (1) DE69125715T2 (de)
DK (1) DK0539479T3 (de)
ES (1) ES2103311T3 (de)
GB (1) GB9015914D0 (de)
GR (1) GR3023776T3 (de)
HU (2) HUT62911A (de)
IE (1) IE912513A1 (de)
IL (1) IL98881A (de)
MC (1) MC2289A1 (de)
MY (1) MY111871A (de)
NZ (1) NZ239025A (de)
PT (1) PT98371B (de)
RU (1) RU2114860C1 (de)
TW (1) TW208655B (de)
WO (1) WO1992001456A1 (de)
ZA (1) ZA915656B (de)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9015914D0 (en) * 1990-07-19 1990-09-05 Wellcome Found Heterocyclic compounds
WO1998042352A1 (en) * 1997-03-24 1998-10-01 Glaxo Group Ltd. Method for treating b-cell tumors with ara-g nucleoside derivatives
US6489331B1 (en) * 1998-07-02 2002-12-03 Kyowa Hakko Kogyo Co., Ltd. Remedies for diabetes
US6753322B2 (en) * 2000-06-06 2004-06-22 Pfizer Inc 2-aminocarbonyl-9H-purine derivatives
AP2004003069A0 (en) 2001-11-27 2004-06-30 Anadys Pharmaceuticals Inc 3-beta-d-ribofuranosynthiazolo [4-5-d] pyridimine nucleosides and uses thereof.
US7321033B2 (en) * 2001-11-27 2008-01-22 Anadys Pharmaceuticals, Inc. 3-B-D-ribofuranosylthiazolo [4,5-d] pyrimidine nucleosides and uses thereof
US20040127435A1 (en) * 2002-08-02 2004-07-01 Regents Of The University Of California Uses for inhibitors of inosine monophosphate dehydrogenase
AU2004271972B2 (en) * 2003-09-05 2010-06-03 Anadys Pharmaceuticals, Inc. TLR7 ligands for the treatment of hepatitis C
GB0321613D0 (en) * 2003-09-15 2003-10-15 Drug Discovery Lab As Compounds
EP1804838A2 (de) * 2004-09-15 2007-07-11 Drug Discovery Laboratory AS Arzneikonjugate einer langkettigen fettsäure oder ester-reste als proteinbindende prodrugs
CA2596543A1 (en) * 2004-11-12 2006-05-18 Northwestern University Methods of treating hematological malignancies with nucleoside analog drugs
PT1824482E (pt) * 2004-12-17 2014-05-13 Anadys Pharmaceuticals Inc Compostos 3h-oxazolo e 3h-tiazolo[4,5-d]pirimidin-2-ona 3,5- -di-substituídos e 3,5,7-tri-substituídos e seus pró- -fármacos
US20060189543A1 (en) * 2005-02-23 2006-08-24 Rosenbloom Richard A Compositions and methods for the treatment of leukemia
CA2630463C (en) 2005-11-21 2015-01-06 Anadys Pharmaceuticals, Inc. Novel process for the preparation of 5-amino-3h-thiazolo[4,5-d]pyrimidin-2-one
JP5345527B2 (ja) * 2006-06-22 2013-11-20 アナディス ファーマシューティカルズ インク プロドラッグである５−アミノ−３−（３’−デオキシ−β−Ｄ−リボフラノシル）−チアゾロ［４，５−ｄ］ピリミジン−２，７−ジオン
DE602007012881D1 (en) 2006-07-18 2011-04-14 Anadys Pharmaceuticals Inc Carbonat- und carbamat-prodrugs von thiazolo ä4,5-dü-pyrimidinen
CN101768197A (zh) * 2008-12-29 2010-07-07 北京德众万全药物技术开发有限公司 一种奈拉滨的制备方法
WO2012092484A2 (en) * 2010-12-29 2012-07-05 Inhibitex, Inc. Substituted purine nucleosides, phosphoroamidate and phosphorodiamidate derivatives for treatment of viral infections
WO2018230479A1 (ja) * 2017-06-13 2018-12-20 大原薬品工業株式会社 ヌクレオシド系抗がん剤又は抗ウィルス剤の５'位シリルエーテル誘導体
US20240317754A1 (en) * 2020-12-30 2024-09-26 Southern University Of Science And Technology Methods and modified nucleosides for treating coronavirus infections

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2152486A1 (de) * 1970-11-20 1972-06-29 Akad Wissenschaften Ddr Verfahren zur Herstellung von 5'-Desoxy-5'-fluor-6-methyl-mercaptopurinribosid
US3872084A (en) * 1972-10-10 1975-03-18 Syntex Inc Purine nucleoside 3,5-cyclicphosphate compounds
US4081534A (en) * 1973-09-11 1978-03-28 Burroughs Wellcome Co. Amino purine nucleosides as autoimmune suppressant agents
GB1573777A (en) * 1977-11-03 1980-08-28 Wellcome Found 9-d-arabinonucleosides and an enzymatic process for their preparation
JPS61233696A (ja) * 1985-04-08 1986-10-17 Kanegafuchi Chem Ind Co Ltd ７−ヒドロキシグアニン誘導体及びその製造方法並びにそれを有効成分とする抗腫瘍剤
GB8712745D0 (en) * 1987-05-30 1987-07-01 Wellcome Found Antiviral compounds
CA1317291C (en) * 1987-12-14 1993-05-04 Naeem Botros Hanna Antitumor 6-sulfenamide, 6-sulfinamide and 6-sulfonamide purines, purine nucleosides, purine nucleotides and related compounds
US5352669A (en) * 1990-03-13 1994-10-04 The Of The United States Of America As Represented By The Department Of Health And Human Services O6 -benzylated guanine, guanosine and 2'-deoxyguanosine compounds possessing O6 -alkylguanine-DNA alkyltransferase depleting activity
GB9015914D0 (en) * 1990-07-19 1990-09-05 Wellcome Found Heterocyclic compounds

Also Published As

Publication number Publication date
ATE151637T1 (de) 1997-05-15
AU8196091A (en) 1992-02-18
US5747472A (en) 1998-05-05
KR100187326B1 (ko) 1999-05-01
ZA915656B (en) 1993-03-31
IL98881A0 (en) 1992-07-15
GB9015914D0 (en) 1990-09-05
US5821236A (en) 1998-10-13
RU2114860C1 (ru) 1998-07-10
IL98881A (en) 1996-01-19
CY2165B1 (en) 2002-08-23
DE69125715T2 (de) 1997-08-07
JPH05508649A (ja) 1993-12-02
US5492897A (en) 1996-02-20
MY111871A (en) 2001-02-28
EP0539479A1 (de) 1993-05-05
ES2103311T3 (es) 1997-09-16
EP0539479B1 (de) 1997-04-16
CA2087543A1 (en) 1992-01-20
AU641533B2 (en) 1993-09-23
PT98371A (pt) 1992-06-30
GR3023776T3 (en) 1997-09-30
NZ239025A (en) 1993-08-26
HU9300115D0 (en) 1993-04-28
CA2087543C (en) 1998-08-25
WO1992001456A1 (en) 1992-02-06
HUT62911A (en) 1993-06-28
TW208655B (de) 1993-07-01
IE912513A1 (en) 1992-01-29
DK0539479T3 (da) 1997-08-25
DE69125715D1 (de) 1997-05-22
PT98371B (pt) 1999-01-29
JP2873086B2 (ja) 1999-03-24

Similar Documents

Publication Publication Date Title
MC2289A1 (fr) Composes heterocycliques
MY108616A (en) Pyridine and pyridine n-oxide derivatives of diaryl methyl piperidines of piperazines, and compositions and methods of use thereof
CA2272705A1 (en) Fused bicyclic pyrimidine derivatives
NO914667L (no) Fremgangsmaate for fremstilling av terapeutisk aktive arylderivater
FI963424A0 (fi) Menetelmä terapeuttisesti aktiivisten tiofeenisulfonamidien valmistamiseksi
FI862011A0 (fi) Terapeutiska nukleosider.
SE8804629D0 (sv) New therapeutically active compounds
NO914036D0 (no) Fremgangsmaate for fremstilling av terapeutisk aktive kinazolin-derivater
NO173998C (no) Analogifremgangsmaate for fremstilling av terapeutisk aktive benzimidazolderivater
RU93004860A (ru) Гетероциклические соединения, способ их получения, использование и фармацевтическая композиция
GR920100570A (el) Παραγωγα 3(2η)-πυριδαζινονης και μεθοδος για την παρασκευη τους.
AU563762B2 (en) S-adenosyl-l-methionine salts preparation
NO810480L (no) Anologifremgangsmaate for fremstilling av terapeutisk aktive 1,3,4-oksadiazolylfenol-derivater
ES8200678A1 (es) Un procedimiento para la produccion de 10-(4-piperidinil)-10, 11-dihidro-dibenzo b,f 1,4 oxarepinas; tiazepinas y diaze-pinas.
NO881884D0 (no) Fremgangsmaate for fremstilling av terapeutisk aktive pyrrolidin-derivater.
NO913644D0 (no) Fremgangsmaate for fremstilling av terapeutisk aktive aminosyrederivater.
TR199900013T2 (xx) Yeni bile�ikler.
TW374085B (en) Novel piperidine derivatives, their preparation, pharmaceutical formulation and medical use
NO174963C (no) Analogifremgangsmåte for fremstilling av terapeutisk aktive 8-fluorantracyklinglucosider
UA41326C2 (uk) Фармацевтична композиція для профілактики або лікування вірусних захворювань, засіб для профілактики або лікування вірусних захворювань
ITMI910133A1 (it) Derivati salini del gliceril fosforil mioinositolo ad attivita' terapeutica, procedimento per la loro preparazione e composizioni farmaceutiche che li contengono
AP9200405A0 (en) Pharmaceutical formulations comprised of micronised halofantrine.
NO900812L (no) Fremgangsmaate for fremstilling av terapeutisk aktive laktamderivater.
NO168106C (no) Analogifremgangsmaate for fremstilling av terapeutisk aktive estere av hexahydro-8-hydroxy-2,6-methano-2h-kinolizin-3(4h)-on