MC1692A1 - Procede de preparation de derives de phenyltetraenyle derives de phenyltetraenyle et leur application - Google Patents

Procede de preparation de derives de phenyltetraenyle derives de phenyltetraenyle et leur application

Info

Publication number
MC1692A1
MC1692A1 MC851787A MC1787A MC1692A1 MC 1692 A1 MC1692 A1 MC 1692A1 MC 851787 A MC851787 A MC 851787A MC 1787 A MC1787 A MC 1787A MC 1692 A1 MC1692 A1 MC 1692A1
Authority
MC
Monaco
Prior art keywords
formula
compound
dimethyl
phenyl
nonatetraene
Prior art date
Application number
MC851787A
Other languages
English (en)
French (fr)
Inventor
Edward-Roy Aig
John-William Coffey
Allen-John Lovey
Michael Rosenberger
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of MC1692A1 publication Critical patent/MC1692A1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
    • C07C57/30—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing six-membered aromatic rings
    • C07C57/42—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing six-membered aromatic rings having unsaturation outside the rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/66—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
    • C07C69/73—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of unsaturated acids
    • C07C69/734—Ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
    • C07C45/68—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
    • C07C45/72—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction of compounds containing >C = O groups with the same or other compounds containing >C = O groups
    • C07C45/74—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction of compounds containing >C = O groups with the same or other compounds containing >C = O groups combined with dehydration
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C47/00—Compounds having —CHO groups
    • C07C47/52—Compounds having —CHO groups bound to carbon atoms of six—membered aromatic rings
    • C07C47/575—Compounds having —CHO groups bound to carbon atoms of six—membered aromatic rings containing ether groups, groups, groups, or groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/20—Unsaturated compounds containing keto groups bound to acyclic carbon atoms
    • C07C49/255—Unsaturated compounds containing keto groups bound to acyclic carbon atoms containing ether groups, groups, groups, or groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
    • C07C57/46—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing six-membered aromatic rings and other rings, e.g. cyclohexylphenylacetic acid
    • C07C57/48—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing six-membered aromatic rings and other rings, e.g. cyclohexylphenylacetic acid having unsaturation outside the aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40—Unsaturated compounds
    • C07C59/58—Unsaturated compounds containing ether groups, groups, groups, or groups
    • C07C59/64—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C67/00—Preparation of carboxylic acid esters
    • C07C67/30—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group
    • C07C67/333—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group by isomerisation; by change of size of the carbon skeleton
    • C07C67/343—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/54—Quaternary phosphonium compounds
    • C07F9/5456—Arylalkanephosphonium compounds

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Transplantation (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
MC851787A 1984-07-27 1985-07-25 Procede de preparation de derives de phenyltetraenyle derives de phenyltetraenyle et leur application MC1692A1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US63510084A 1984-07-27 1984-07-27

Publications (1)

Publication Number Publication Date
MC1692A1 true MC1692A1 (fr) 1986-07-18

Family

ID=24546455

Family Applications (1)

Application Number Title Priority Date Filing Date
MC851787A MC1692A1 (fr) 1984-07-27 1985-07-25 Procede de preparation de derives de phenyltetraenyle derives de phenyltetraenyle et leur application

Country Status (23)

Country Link
EP (1) EP0169571B1 (en0)
JP (1) JPH06716B2 (en0)
KR (1) KR930000112B1 (en0)
AR (1) AR242023A1 (en0)
AT (1) ATE32882T1 (en0)
AU (2) AU589130B2 (en0)
CA (1) CA1277332C (en0)
CS (1) CS256392B2 (en0)
DE (1) DE3561808D1 (en0)
DK (1) DK173287B1 (en0)
ES (2) ES8703825A1 (en0)
FI (1) FI84345C (en0)
GR (1) GR851841B (en0)
HU (1) HU195480B (en0)
IE (1) IE58735B1 (en0)
IL (1) IL75913A (en0)
MC (1) MC1692A1 (en0)
NO (1) NO161064C (en0)
NZ (1) NZ212868A (en0)
PH (1) PH21556A (en0)
PT (1) PT80876B (en0)
ZA (1) ZA854828B (en0)
ZW (1) ZW12185A1 (en0)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ232865A (en) * 1989-03-21 1992-07-28 Hoffmann La Roche A mixed-micelle solution comprising a micelle former and an immunomodulator
DE4036779A1 (de) * 1990-11-17 1992-05-21 Basf Ag Verwendung von arylpolyencarbonsaeuren und ihren derivaten als lichtschutzmittel in kosmetischen zubereitungen
US7655699B1 (en) 1992-04-22 2010-02-02 Eisai Inc. Compounds having selective activity for retinoid X receptors, and means for modulation of processes mediated by retinoid X receptors
US5369126A (en) * 1993-01-06 1994-11-29 Hoffmann-La Roche Inc. Nonatetraenoic acid derivative for use in treating acne
CA2129773C (en) 1993-09-02 2007-05-01 Michael Klaus Aromatic carboxylic acid derivatives
US7115728B1 (en) 1995-01-30 2006-10-03 Ligand Pharmaceutical Incorporated Human peroxisome proliferator activated receptor γ
WO1999005161A1 (en) 1997-07-25 1999-02-04 Ligand Pharmaceuticals Incorporated HUMAN PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA (PPARη) GENE REGULATORY SEQUENCES AND USES THEREFOR
US7547790B2 (en) * 2004-10-28 2009-06-16 Sankyo Company, Limited Optically active 4,4-di-substituted oxazolidine derivative and method for producing same

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3334125A (en) * 1964-02-26 1967-08-01 Velsicol Chemical Corp Esters of 3-6-dichloro-2-methoxy-benzyl alcohol
CH585166A5 (en0) * 1973-03-30 1977-02-28 Hoffmann La Roche
CH605562A5 (en0) * 1974-09-26 1978-09-29 Hoffmann La Roche
DE2933985A1 (de) * 1979-08-22 1981-04-09 Bayer Ag, 5090 Leverkusen Neue 4-fluor-3-phenoxy-benzyl-ether und verfahren zu deren herstellung sowie neue zwischenprodukte hierfuer und verfahren zu deren herstellung

Also Published As

Publication number Publication date
NO161064B (no) 1989-03-20
IE851881L (en) 1986-01-27
AU619901B2 (en) 1992-02-06
PT80876A (en) 1986-07-17
CS550285A2 (en) 1987-08-13
HU195480B (en) 1988-05-30
AR242023A1 (es) 1993-02-26
AU589130B2 (en) 1989-10-05
NZ212868A (en) 1989-05-29
IE58735B1 (en) 1993-11-03
FI852899A0 (fi) 1985-07-25
IL75913A (en) 1989-06-30
AU4260889A (en) 1990-01-25
NO161064C (no) 1989-06-28
ZW12185A1 (en) 1986-02-26
ES8705355A1 (es) 1987-05-01
FI852899L (fi) 1986-01-28
PH21556A (en) 1987-12-11
NO852980L (no) 1986-01-28
ATE32882T1 (de) 1988-03-15
GR851841B (en0) 1985-12-02
KR860001044A (ko) 1986-02-22
FI84345B (fi) 1991-08-15
EP0169571B1 (de) 1988-03-09
DE3561808D1 (en) 1988-04-14
EP0169571A1 (de) 1986-01-29
CA1277332C (en) 1990-12-04
JPS6143135A (ja) 1986-03-01
DK340485A (da) 1986-01-28
KR930000112B1 (ko) 1993-01-09
IL75913A0 (en) 1985-12-31
FI84345C (fi) 1991-11-25
ES545565A0 (es) 1987-03-01
JPH06716B2 (ja) 1994-01-05
ES552061A0 (es) 1987-05-01
ES8703825A1 (es) 1987-03-01
DK340485D0 (da) 1985-07-25
CS256392B2 (en) 1988-04-15
AU4557585A (en) 1986-01-30
PT80876B (pt) 1987-11-30
DK173287B1 (da) 2000-06-13
ZA854828B (en) 1986-03-26
HUT38306A (en) 1986-05-28

Similar Documents

Publication Publication Date Title
MC1596A1 (fr) Composes utiles pour le traitement des etats allergiques
MC1230A1 (fr) Derives de stilbene
LU80509A1 (fr) Nouveaux 1,9-dihydroxyoctahydrophenanthrenes et medicamentmedicament les contenant
MC1817A1 (fr) Derives de tetrahydronaphtalene
CA1134371A (fr) Derives de pyrrolidine-2 methanol utilisables comme medicaments
LU80220A1 (fr) Procede de preparation de cycloalcanones et cycloalcanols substitues en position 3 par un groupe 2-hydroxyphenyle substitue en position 4 et d'une composition pharmaceutique les contenant
MC1692A1 (fr) Procede de preparation de derives de phenyltetraenyle derives de phenyltetraenyle et leur application
MC1641A1 (fr) Oxazolidines
EP0428423A2 (fr) Nouveaux aryloxy alcoyl benzènes, leurs procédés de préparation et les compositions pharmaceutiques en renfermant
FR2833259A1 (fr) Procede de preparation de 2-arylbenzofuranes, composes intermediaires, 2-arylbenzofuranes et compositions les comprenant
FR2584400A1 (fr) Esters et amides de l'acide eicosatriynoique et leur application en pharmacie et en cosmetique
US4648996A (en) Phenyl substituted-2,4,6,8-nonatetraenoic acid
EP0591046A1 (fr) Dérivés chromeniques à chaîne triénique, utilisables dans le traitement de l'ostéoporose et des affections inflammatoires
MC1175A1 (fr) Derives polyeniques
FR2509725A1 (fr) (hydroxyalkyl)phenylsulfures, leurs procedes de preparation et compositions pharmaceutiques les contenant
FR2463136A1 (fr) Nouveaux acides alcoxybenzofuranne-2-carboxyliques, leurs sels et esters, utiles notamment comme agents hypolipemiants, et leur procede de preparation
MC1981A1 (fr) Derives d'acides catechol carboxyliques
US4894480A (en) Phenyl substituted-2,4,6,8-nonatetraenoic acid
US4883613A (en) Phenyl substituted-2,4,6,8-nonatetraenoic acid
US4780251A (en) Phenyl substituted-2,4,6,8-nonatetraenoic acid
US4883614A (en) Phenyl substituted-2,4,6,8-nonatetraenoic acid
EP0337885A1 (fr) Nouveaux dérivés triéniques de structure chroménique, leurs procédés de préparation et les compositions pharmaceutiques qui les contiennent
EP0172041A1 (fr) Acides dihydro-5,6-4H-cyclopenta [b] thiophènecarboxyliques-6, procédés de préparation et médicaments les contenant
FR2595359A1 (fr) Nouveaux derives du benzo(4, 5)cyclohepta(1,2-b)thiophene, leur preparation et leur utilisation comme medicaments
FR2464251A1 (fr) Nouvelles 4-(4-cinnamoyl-1-piperidino)butyrophenones, utiles notamment comme agents antipsychotiques, et leur procede de preparation

Legal Events

Date Code Title Description
YP Annual fee paid