MC1143A1 - Derives de thiouree - Google Patents

Derives de thiouree

Info

Publication number
MC1143A1
MC1143A1 MC771238A MC1238A MC1143A1 MC 1143 A1 MC1143 A1 MC 1143A1 MC 771238 A MC771238 A MC 771238A MC 1238 A MC1238 A MC 1238A MC 1143 A1 MC1143 A1 MC 1143A1
Authority
MC
Monaco
Prior art keywords
general formula
compound
same meaning
compounds
ch2ch2
Prior art date
Application number
MC771238A
Other languages
English (en)
French (fr)
Inventor
M Cohen
J Tilley
R Kierstead
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of MC1143A1 publication Critical patent/MC1143A1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
    • C07D295/125—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/13—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
    • C07C279/18—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to carbon atoms of six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C335/00—Thioureas, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C335/04—Derivatives of thiourea
    • C07C335/16—Derivatives of thiourea having nitrogen atoms of thiourea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C335/00—Thioureas, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C335/30—Isothioureas
    • C07C335/32—Isothioureas having sulfur atoms of isothiourea groups bound to acyclic carbon atoms

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Cardiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Compositions Of Oxide Ceramics (AREA)
  • Ceramic Products (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
MC771238A 1976-04-15 1977-04-13 Derives de thiouree MC1143A1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US67710676A 1976-04-15 1976-04-15

Publications (1)

Publication Number Publication Date
MC1143A1 true MC1143A1 (fr) 1978-01-30

Family

ID=24717351

Family Applications (1)

Application Number Title Priority Date Filing Date
MC771238A MC1143A1 (fr) 1976-04-15 1977-04-13 Derives de thiouree

Country Status (26)

Country Link
US (2) US4066695A (enExample)
JP (1) JPS52128332A (enExample)
AR (1) AR218247A1 (enExample)
AT (1) AT353282B (enExample)
AU (1) AU509570B2 (enExample)
BE (1) BE853578A (enExample)
DE (1) DE2716838A1 (enExample)
DK (1) DK165677A (enExample)
ES (1) ES457805A1 (enExample)
FI (1) FI771199A7 (enExample)
FR (1) FR2350340A1 (enExample)
GB (1) GB1579181A (enExample)
GR (1) GR63193B (enExample)
HU (1) HU176110B (enExample)
IE (1) IE44425B1 (enExample)
IL (1) IL51850A (enExample)
IT (1) IT1075834B (enExample)
LU (1) LU77137A1 (enExample)
MC (1) MC1143A1 (enExample)
NL (1) NL7704153A (enExample)
NO (1) NO771309L (enExample)
NZ (1) NZ183848A (enExample)
PH (1) PH13392A (enExample)
PT (1) PT66440B (enExample)
SE (1) SE7704322L (enExample)
ZA (1) ZA772083B (enExample)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1980000151A1 (en) * 1978-07-03 1980-02-07 American Home Prod N-(3-alkylaminopropyl)-n'-phenylureas
US4224242A (en) * 1978-07-03 1980-09-23 American Home Products Corporation N-[3-(lower)alkylaminopropyl]-N'-(disubstituted)phenylureas
US4290971A (en) * 1979-01-19 1981-09-22 Dso "Pharmachim" Method of preparing 2-(phenylamino)-imidazolines-(2)
US4348413A (en) * 1979-05-21 1982-09-07 American Home Products Corporation Anti-arrhythmic N-[3-alkylaminopropyl]-N'-phenylureas
EP0025010B1 (de) * 1979-07-03 1983-07-20 Ciba-Geigy Ag Thioharnstoffderivate und Isothioharnstoffderivate, Verfahren zu ihrer Herstellung, diese Verbindungen enthaltende Mittel und ihre Verwendung zur Bekämpfung von Schädlingen
US4328247A (en) * 1979-09-19 1982-05-04 Ciba-Geigy Corporation Phenoxyphenylisothioureas, production thereof and use thereof in pest control, and phenoxyphenylthioureas as intermediates for the production of the phenoxyphenylisothioureas and use thereof in pest control
US4474707A (en) * 1980-10-09 1984-10-02 American Home Products Corporation N-3-Propenylaminopropyl-N'-phenylureas
US4399286A (en) * 1981-07-16 1983-08-16 Mead Johnson & Company Antiarrhythmic phenethylpiperidine compounds
US5593993A (en) * 1991-08-02 1997-01-14 Medivir Ab Method for inhibition of HIV related viruses
IL102548A (en) * 1991-08-02 1998-08-16 Medivir Ab Thiourea derivatives for use in the preparation of medicaments for the inhibition of hiv and the treatment of aids and some such novel compounds

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2849306A (en) * 1954-03-19 1958-08-26 Du Pont Herbicidal method and composition employing aryl pseudoureas
US3717633A (en) * 1965-10-01 1973-02-20 Boehringer Sohn Ingelheim 2-anilino-1,3-diazacyclopentene-(2) derivative
DE1618158A1 (de) * 1967-05-16 1970-10-29 Boehringer Sohn Ingelheim Verfahren zur Herstellung neuer Guanidinderivate
US3950537A (en) * 1973-06-29 1976-04-13 Rohm And Haas Company Gastrointestinally active thioureas

Also Published As

Publication number Publication date
ATA262977A (de) 1979-04-15
FR2350340A1 (fr) 1977-12-02
IT1075834B (it) 1985-04-22
DE2716838A1 (de) 1977-10-27
HU176110B (en) 1980-12-28
IE44425L (en) 1977-10-15
NZ183848A (en) 1978-09-20
JPS52128332A (en) 1977-10-27
NL7704153A (nl) 1977-10-18
NO771309L (no) 1977-10-18
PT66440B (en) 1979-03-09
LU77137A1 (enExample) 1978-06-01
AU2425377A (en) 1978-10-19
SE7704322L (sv) 1977-10-16
DK165677A (da) 1977-10-16
ES457805A1 (es) 1978-11-01
GB1579181A (en) 1980-11-12
PT66440A (en) 1977-05-01
US4066695A (en) 1978-01-03
AU509570B2 (en) 1980-05-15
IE44425B1 (en) 1981-11-18
US4096276A (en) 1978-06-20
GR63193B (en) 1979-10-04
AT353282B (de) 1979-11-12
BE853578A (fr) 1977-10-14
PH13392A (en) 1980-03-28
FI771199A7 (enExample) 1977-10-16
IL51850A (en) 1980-03-31
AR218247A1 (es) 1980-05-30
ZA772083B (en) 1978-03-29
IL51850A0 (en) 1977-06-30

Similar Documents

Publication Publication Date Title
LU79761A1 (fr) Procede de preparation de nouveaux composes de phtalazine et de composition pharmaceutique les contenant
MC1143A1 (fr) Derives de thiouree
EP0069664B1 (fr) Amidobenzamides, leurs sels, procédé pour leur préparation et compositions pharmaceutiques les renfermant
EP0076199B1 (fr) Nouvelles triazoloquinazolones et leurs sels, procédé et intermédiaires de préparation, leur application comme médicaments et les compositions les renfermant
EP1242389B1 (fr) Nouveaux derives amino substitues ramifies du 3-amino-1-phenyl-1h[1,2,4]triazole, procedes pour leur preparation et compositions pharmaceutiques les contenant
EP0383690A1 (fr) Nouveaux dérivés de l'acide 2-amino pentanedioique, leur procédé et les intermédiaires de préparation, leur application comme médicaments et les compositons les renfermant
LU86421A1 (fr) Derives de piperazine 1,4-disubstitues,composition pharmaceutique les contenant;leur procede d'obtention
FR2477150A1 (fr) Nouveaux derives heterocycliques, procedes pour leur preparation et compositions pharmaceutiques les comportant
EP0000452B1 (fr) Dérivés d'oxadiazole-1,2,4, leur préparation et leur application en thérapeutique.
CA1100968A (fr) Procedes de preparation de nouvelles piperazines disubstituees
EP0101379B1 (fr) Benzamides, leurs sels, procédé pour leur préparation et compositions pharmaceutiques les renfermant
EP0105881B1 (fr) Nouvelles cyanoguanidines, leur procede d'obtention et les compositions pharmaceutiques en renfermant
EP0275762B1 (fr) Dérivés de l'indole carboxamide ainsi que leurs sels, procédé et intermédiaires de préparation, application à titre de médicaments de ces dérivés et compositions les renfermant
EP0094303B1 (fr) Amides, leurs sels, procédé pour leur préparation et compositions pharmaceutiques les renfermant
CA1207768A (fr) Carboxamidoguanidines, leur procede d'obtention et les compositions pharmaceutiques en renfermant
EP0060182B1 (fr) Thioalkylamide de l'acide nicotinique 1-oxyde, ses sels, procédé pour leur préparation et compositions pharmaceutiques
EP0433163A2 (fr) Nouveau procédé de préparation d'imidazobenzodiazépines et de leurs sels
BE882071A (fr) Composes du guanidinothiazole utiles comme inhibiteurs des secretions d'acide gastrique, leurs procedes de preparation et les compositions medicales contenant de tels composes
EP0280627B1 (fr) Nouveaux dérivés N-substitués de l'alpha-mercaptométhyl benzène propanamide, leur procédé de préparation, leur application à titre de médicaments et les compositions les renfermant
CH620678A5 (en) Process for the preparation of a derivative of piperidine
FI71554B (fi) Foerfarande foer framstaellning av terapeutiskt anvaendbara 5- s-trans-amino-3,4,5,6-tetrahydro-1h-cyklohept/c d/indol- 6-lderivat och av deras syraadditionssalter
FR2689126A1 (fr) 2-(imino substitué)-thiazolidines, procédé pour les préparer et utilisation pour la préparation des compositions pharmaceutiques.
FR2683817A1 (fr) Nouveaux derives d'alpha-amino n-pyridyl benzene propanamide, leurs procedes de preparation, compositions pharmaceutiques les contenant.
MC1537A1 (fr) Derives d'imidazole et procede pour les preparer
FR2509305A1 (fr) Benzamides, procede pour leur preparation et compositions pharmaceutiques les renfermant

Legal Events

Date Code Title Description
YP Annual fee paid