MA56443A - Inhibiteurs hétérocycliques de monoacylglycérol lipase (magl) - Google Patents

Inhibiteurs hétérocycliques de monoacylglycérol lipase (magl)

Info

Publication number
MA56443A
MA56443A MA056443A MA56443A MA56443A MA 56443 A MA56443 A MA 56443A MA 056443 A MA056443 A MA 056443A MA 56443 A MA56443 A MA 56443A MA 56443 A MA56443 A MA 56443A
Authority
MA
Morocco
Prior art keywords
magl
heterocyclic
inhibitors
monoacylglycerol lipase
monoacylglycerol
Prior art date
Application number
MA056443A
Other languages
English (en)
Inventor
Joerg Benz
Uwe Grether
Benoit Hornsperger
Carsten Kroll
Bernd Kuhn
Fionn O`Hara
Hans Richter
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of MA56443A publication Critical patent/MA56443A/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4866—Organic macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems
    • C07D491/107—Spiro-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2009—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2059—Starch, including chemically or physically modified derivatives; Amylose; Amylopectin; Dextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/485—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4858—Organic compounds

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Epidemiology (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Inorganic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
MA056443A 2019-07-03 2020-06-30 Inhibiteurs hétérocycliques de monoacylglycérol lipase (magl) MA56443A (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP19184218 2019-07-03

Publications (1)

Publication Number Publication Date
MA56443A true MA56443A (fr) 2022-05-11

Family

ID=67180549

Family Applications (1)

Application Number Title Priority Date Filing Date
MA056443A MA56443A (fr) 2019-07-03 2020-06-30 Inhibiteurs hétérocycliques de monoacylglycérol lipase (magl)

Country Status (18)

Country Link
US (1) US20220213093A1 (fr)
EP (1) EP3994137A1 (fr)
JP (1) JP2022540367A (fr)
KR (1) KR20220027991A (fr)
CN (1) CN114072405A (fr)
AR (1) AR119322A1 (fr)
AU (1) AU2020299965A1 (fr)
BR (1) BR112021026820A2 (fr)
CA (1) CA3143280A1 (fr)
CL (1) CL2022000005A1 (fr)
CO (1) CO2022000749A2 (fr)
CR (1) CR20210630A (fr)
IL (1) IL288936A (fr)
MA (1) MA56443A (fr)
MX (1) MX2022000083A (fr)
PE (1) PE20220514A1 (fr)
TW (1) TW202116768A (fr)
WO (1) WO2021001330A1 (fr)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW201938164A (zh) 2018-01-08 2019-10-01 瑞士商赫孚孟拉羅股份公司 新穎雜環化合物
PE20211089A1 (es) 2018-08-13 2021-06-14 Hoffmann La Roche Nuevos compuestos heterociclicos como inhibidores de la monoacilglicerol lipasa
BR112022002375A2 (pt) 2019-09-12 2022-07-19 Hoffmann La Roche Compostos de 4,4a,5,7,8,8a-hexapirido[4,3-b][1,4]oxazin-3-ona como inibidores de magl
MX2023002224A (es) 2020-09-03 2023-03-15 Hoffmann La Roche Compuestos heterociclicos.
AU2022291768A1 (en) 2021-06-16 2023-11-30 Celgene Corporation Azetidinyl compounds comprising a carboxylic acid group for the treatment of neurodegenerative diseases

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW201938164A (zh) * 2018-01-08 2019-10-01 瑞士商赫孚孟拉羅股份公司 新穎雜環化合物

Also Published As

Publication number Publication date
JP2022540367A (ja) 2022-09-15
CL2022000005A1 (es) 2022-10-21
BR112021026820A2 (pt) 2022-02-22
AR119322A1 (es) 2021-12-09
CO2022000749A2 (es) 2022-02-07
WO2021001330A1 (fr) 2021-01-07
TW202116768A (zh) 2021-05-01
EP3994137A1 (fr) 2022-05-11
AU2020299965A1 (en) 2022-02-03
MX2022000083A (es) 2022-02-03
IL288936A (en) 2022-02-01
KR20220027991A (ko) 2022-03-08
CR20210630A (es) 2022-02-11
PE20220514A1 (es) 2022-04-07
US20220213093A1 (en) 2022-07-07
CN114072405A (zh) 2022-02-18
CA3143280A1 (fr) 2021-01-07

Similar Documents

Publication Publication Date Title
DK3768684T3 (da) Oxazin-monoacylglycerol-lipase (MAGL)-hæmmere
IL279173A (en) Heterocyclic compounds as monoacylglycerol lipase inhibitors
IL289594A (en) Heterocyclic monoacylglycerol lipase (magl) inhibitors
MA56443A (fr) Inhibiteurs hétérocycliques de monoacylglycérol lipase (magl)
IL280762A (en) Heterocyclic compounds as monoacylglycerol lipase inhibitors
MA54543A (fr) Inhibiteurs de kif18a
MA54550A (fr) Inhibiteurs de kif18a
MA54327A (fr) Inhibiteurs de kras g12c
MA51616A (fr) Inhibiteurs d'adn-pk
MA52635A (fr) Inhibiteurs de magl
MA52413A (fr) Inhibiteurs de cd73
DK3704120T3 (da) Heterocykliske forbindelser som prmt5-inhibitorer
MA52812A (fr) Inhibiteurs de sarm1
MA55909A (fr) Inhibiteurs de cdk
MA53721A (fr) Modulateurs de la monoacylglycérol lipase
MA55478A (fr) Inhibiteurs bicycliques de hpk1
DK3746446T3 (da) PRC2-inhibitorer
MA54901A (fr) Inhibiteur de 15-pgdh
MA55477A (fr) Inhibiteurs de hpk1
MA52809A (fr) Inhibiteurs de sarm1
MA53722A (fr) Modulateurs de la monoacylglycérol lipase
MA51611A (fr) Inhibiteurs de pi4kiiibêta
MA52813A (fr) Inhibiteurs de sarm1
MA52072A (fr) Inhibiteurs d'oxazine monoacylglycerol lipase (magl)
AR128365A1 (es) Inhibidores de parp7