MA50128B1 - Anticorps monoclonaux liants le recepteur trbv9 des lymphocytes t et procédés de leur utilisation - Google Patents
Anticorps monoclonaux liants le recepteur trbv9 des lymphocytes t et procédés de leur utilisationInfo
- Publication number
- MA50128B1 MA50128B1 MA50128A MA50128A MA50128B1 MA 50128 B1 MA50128 B1 MA 50128B1 MA 50128 A MA50128 A MA 50128A MA 50128 A MA50128 A MA 50128A MA 50128 B1 MA50128 B1 MA 50128B1
- Authority
- MA
- Morocco
- Prior art keywords
- trbv9
- monoclonal antibodies
- antibody
- receptor
- family
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2809—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against the T-cell receptor (TcR)-CD3 complex
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/10—Cells modified by introduction of foreign genetic material
- C12N5/12—Fused cells, e.g. hybridomas
- C12N5/16—Animal cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Immunology (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biomedical Technology (AREA)
- Biochemistry (AREA)
- Wood Science & Technology (AREA)
- Biotechnology (AREA)
- Zoology (AREA)
- Microbiology (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- General Engineering & Computer Science (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Mycology (AREA)
- Epidemiology (AREA)
- Oncology (AREA)
- Hematology (AREA)
- Plant Pathology (AREA)
- Cell Biology (AREA)
- Physics & Mathematics (AREA)
- Endocrinology (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Abstract
L'invention concerne des anticorps monoclonaux qui se lient spécifiquement à la famille trbv9 ? De récepteurs t de l'humain. L'invention concerne également un acide nucléique codant pour cet anticorps ou son fragment de liaison d'antigènes, un vecteur d'expression, un procédé de production d'anticorps et l'utilisation de l'anticorps pour traiter les maladies ou troubles liés à la famille des récepteurs t de l'humain. L'invention vise à créer des anticorps qui peuvent être utilisés pour éliminer les cellules t portant le récepteur de cellules de la famille t trbv9, notamment pour la thérapie ac, de maladie coeliaque et de maladies malignes du sang dans la pathogénèse desquelles est impliqué récepteur de cellules de la famille t trbv9.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
RU2017145662A RU2694412C9 (ru) | 2017-12-25 | 2017-12-25 | Моноклональные антитела и способы их применения |
PCT/RU2018/050168 WO2019132738A1 (fr) | 2017-12-25 | 2018-12-25 | Anticorps monoclonaux et procédés de leur utilisation |
Publications (2)
Publication Number | Publication Date |
---|---|
MA50128A1 MA50128A1 (fr) | 2021-07-29 |
MA50128B1 true MA50128B1 (fr) | 2022-09-30 |
Family
ID=67002533
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MA50128A MA50128B1 (fr) | 2017-12-25 | 2018-12-25 | Anticorps monoclonaux liants le recepteur trbv9 des lymphocytes t et procédés de leur utilisation |
Country Status (20)
Country | Link |
---|---|
US (2) | US11597767B2 (fr) |
EP (1) | EP3733705A4 (fr) |
JP (1) | JP7339948B2 (fr) |
KR (1) | KR20200103774A (fr) |
CN (1) | CN111801354A (fr) |
AU (1) | AU2018398341A1 (fr) |
BR (1) | BR112020012959A2 (fr) |
CA (1) | CA3086849A1 (fr) |
CL (1) | CL2020001726A1 (fr) |
CR (1) | CR20200324A (fr) |
EA (1) | EA202091569A1 (fr) |
EC (1) | ECSP20039728A (fr) |
JO (1) | JOP20200161A1 (fr) |
MA (1) | MA50128B1 (fr) |
MX (1) | MX2020006736A (fr) |
NI (1) | NI202000051A (fr) |
PH (1) | PH12020551012A1 (fr) |
RU (1) | RU2694412C9 (fr) |
WO (1) | WO2019132738A1 (fr) |
ZA (1) | ZA202003858B (fr) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP3818083A2 (fr) | 2018-07-03 | 2021-05-12 | Elstar Therapeutics, Inc. | Molécules d'anticorps anti-tcr et leurs utilisations |
RU2711871C1 (ru) | 2018-12-25 | 2020-01-23 | Федеральное государственное автономное образовательное учреждение высшего образования "Российский национальный исследовательский медицинский университет имени Н.И. Пирогова" Министерства здравоохранения Российской Федерации (ФГАОУ ВО РНИМУ им. Н.И. Пирогова Минздрава России) | Моноклональные антитела, которые специфически связываются с участком бета цепи семейства TRBV-9 Т-клеточного рецептора человека, и способы их применения |
RU2712251C1 (ru) * | 2018-12-25 | 2020-01-27 | Федеральное государственное автономное образовательное учреждение высшего образования "Российский национальный исследовательский медицинский университет имени Н.И. Пирогова" Министерства здравоохранения Российской Федерации (ФГАОУ ВО РНИМУ им. Н.И. Пирогова Минздрава России) | Гуманизированные антитела против участка бета цепи 9-го семейства TRBV9 TKP человека, и способы их применения |
WO2024039268A1 (fr) * | 2022-08-18 | 2024-02-22 | Акционерное общество "БИОКАД" | Procédé de traitement de maladie induite par des lymphocytes t |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5223426A (en) | 1988-12-15 | 1993-06-29 | T Cell Sciences, Inc. | Monoclonal antibodies reactive with defined regions of the t-cell antigen receptor |
US5766947A (en) | 1988-12-14 | 1998-06-16 | Astra Ab | Monoclonal antibodies reactive with an epitope of a Vβ3.1 variable region of a T cell receptor |
RU2014144463A (ru) * | 2009-06-25 | 2015-06-20 | Фред Хатчинсон Кансэр Рисёч Сентер | Способ измерения адаптивного иммунитета |
EP3202784A1 (fr) * | 2016-02-08 | 2017-08-09 | Polybiocept AB | Séquences de récepteurs de lymphocytes t pour une immunothérapie active |
JP6952225B2 (ja) * | 2016-03-18 | 2021-10-20 | 北海道公立大学法人 札幌医科大学 | T細胞レセプターとその利用 |
EP3472208B9 (fr) | 2016-06-17 | 2023-10-04 | Medigene Immunotherapies GmbH | Récepteurs de lymphocytes t et leurs utilisations |
-
2017
- 2017-12-25 RU RU2017145662A patent/RU2694412C9/ru active
-
2018
- 2018-12-25 EA EA202091569A patent/EA202091569A1/ru unknown
- 2018-12-25 CR CR20200324A patent/CR20200324A/es unknown
- 2018-12-25 BR BR112020012959-3A patent/BR112020012959A2/pt unknown
- 2018-12-25 WO PCT/RU2018/050168 patent/WO2019132738A1/fr active Application Filing
- 2018-12-25 US US16/957,328 patent/US11597767B2/en active Active
- 2018-12-25 KR KR1020207021655A patent/KR20200103774A/ko active Search and Examination
- 2018-12-25 MX MX2020006736A patent/MX2020006736A/es unknown
- 2018-12-25 JP JP2020535637A patent/JP7339948B2/ja active Active
- 2018-12-25 AU AU2018398341A patent/AU2018398341A1/en active Pending
- 2018-12-25 MA MA50128A patent/MA50128B1/fr unknown
- 2018-12-25 JO JOP/2020/0161A patent/JOP20200161A1/ar unknown
- 2018-12-25 EP EP18895626.2A patent/EP3733705A4/fr active Pending
- 2018-12-25 CN CN201880090210.0A patent/CN111801354A/zh active Pending
- 2018-12-25 CA CA3086849A patent/CA3086849A1/fr active Pending
-
2020
- 2020-06-24 CL CL2020001726A patent/CL2020001726A1/es unknown
- 2020-06-25 PH PH12020551012A patent/PH12020551012A1/en unknown
- 2020-06-25 NI NI202000051A patent/NI202000051A/es unknown
- 2020-06-25 ZA ZA2020/03858A patent/ZA202003858B/en unknown
- 2020-07-13 EC ECSENADI202039728A patent/ECSP20039728A/es unknown
-
2023
- 2023-01-30 US US18/103,194 patent/US20230357396A1/en active Pending
Also Published As
Publication number | Publication date |
---|---|
CA3086849A1 (fr) | 2019-07-04 |
RU2694412C9 (ru) | 2019-09-18 |
RU2694412C2 (ru) | 2019-07-12 |
EP3733705A1 (fr) | 2020-11-04 |
RU2017145662A3 (fr) | 2019-06-25 |
ZA202003858B (en) | 2021-07-28 |
BR112020012959A2 (pt) | 2020-12-01 |
AU2018398341A1 (en) | 2020-07-30 |
WO2019132738A1 (fr) | 2019-07-04 |
US11597767B2 (en) | 2023-03-07 |
US20200332003A1 (en) | 2020-10-22 |
JOP20200161A1 (ar) | 2022-10-30 |
CL2020001726A1 (es) | 2021-03-05 |
JP2021509274A (ja) | 2021-03-25 |
KR20200103774A (ko) | 2020-09-02 |
PH12020551012A1 (en) | 2021-09-01 |
US20230357396A1 (en) | 2023-11-09 |
ECSP20039728A (es) | 2020-08-31 |
JP7339948B2 (ja) | 2023-09-06 |
NI202000051A (es) | 2021-12-16 |
CR20200324A (es) | 2020-10-08 |
EA202091569A1 (ru) | 2021-02-11 |
MA50128A1 (fr) | 2021-07-29 |
MX2020006736A (es) | 2020-08-24 |
CN111801354A (zh) | 2020-10-20 |
RU2017145662A (ru) | 2019-06-25 |
EP3733705A4 (fr) | 2021-09-01 |
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