MA49700B1 - Procédé pour la préparation de n-(5-((4-(4-((diméthylamino)méthyl)-3-phényl-1h-pyrazol-1-yl)pyrimidin-2-yl)amino)-4-méthoxy-2-morpholinophényl)acrylamide par réaction de l'amine correspondante avec un 3-halo-propionyl chloride - Google Patents

Procédé pour la préparation de n-(5-((4-(4-((diméthylamino)méthyl)-3-phényl-1h-pyrazol-1-yl)pyrimidin-2-yl)amino)-4-méthoxy-2-morpholinophényl)acrylamide par réaction de l'amine correspondante avec un 3-halo-propionyl chloride

Info

Publication number
MA49700B1
MA49700B1 MA49700A MA49700A MA49700B1 MA 49700 B1 MA49700 B1 MA 49700B1 MA 49700 A MA49700 A MA 49700A MA 49700 A MA49700 A MA 49700A MA 49700 B1 MA49700 B1 MA 49700B1
Authority
MA
Morocco
Prior art keywords
preparation
morpholinophenyl
pyrazol
pyrimidin
acrylamide
Prior art date
Application number
MA49700A
Other languages
English (en)
Other versions
MA49700A (fr
Inventor
Hyun Ju
Sang-Ho Oh
Ja-Heouk Khoo
Jong-Chul Lim
Seong-Ran Lee
Woo-Seob Shin
Dae-Gyu Park
su-min Park
Yoon-Ah Hwang
Original Assignee
Yuhan Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=65040211&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MA49700(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Yuhan Corp filed Critical Yuhan Corp
Publication of MA49700A publication Critical patent/MA49700A/fr
Publication of MA49700B1 publication Critical patent/MA49700B1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/22—Tin compounds
    • C07F7/2284—Compounds with one or more Sn-N linkages
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Catalysts (AREA)

Abstract

La présente invention concerne un procédé amélioré pour la préparation d'un dérivé d'aminopyrimidine ou d'un sel pharmaceutiquement acceptable de celui-ci ayant une activité inhibitrice sélective vis-à-vis des protéines kinases, en particulier contre les protéines kinases pour des récepteurs du facteur de croissance épidermique mutant. La présente invention concerne également de nouveaux intermédiaires utiles pour ledit procédé et des procédés de préparation de ceux-ci.
MA49700A 2017-07-28 2018-07-25 Procédé pour la préparation de n-(5-((4-(4-((diméthylamino)méthyl)-3-phényl-1h-pyrazol-1-yl)pyrimidin-2-yl)amino)-4-méthoxy-2-morpholinophényl)acrylamide par réaction de l'amine correspondante avec un 3-halo-propionyl chloride MA49700B1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR20170096212 2017-07-28
PCT/KR2018/008379 WO2019022485A1 (fr) 2017-07-28 2018-07-25 Procédé amélioré pour la préparation de dérivés d'aminopyrimidine

Publications (2)

Publication Number Publication Date
MA49700A MA49700A (fr) 2021-03-17
MA49700B1 true MA49700B1 (fr) 2023-09-27

Family

ID=65040211

Family Applications (1)

Application Number Title Priority Date Filing Date
MA49700A MA49700B1 (fr) 2017-07-28 2018-07-25 Procédé pour la préparation de n-(5-((4-(4-((diméthylamino)méthyl)-3-phényl-1h-pyrazol-1-yl)pyrimidin-2-yl)amino)-4-méthoxy-2-morpholinophényl)acrylamide par réaction de l'amine correspondante avec un 3-halo-propionyl chloride

Country Status (31)

Country Link
US (4) US10889578B2 (fr)
EP (1) EP3658552B1 (fr)
JP (2) JP7228562B2 (fr)
KR (1) KR20190013553A (fr)
CN (2) CN111315742B (fr)
AU (2) AU2018308038B2 (fr)
BR (1) BR112020001278A2 (fr)
CA (1) CA3070069C (fr)
CO (1) CO2020000374A2 (fr)
DK (1) DK3658552T3 (fr)
EA (1) EA202090383A1 (fr)
ES (1) ES2962961T3 (fr)
FI (1) FI3658552T3 (fr)
HR (1) HRP20231191T1 (fr)
HU (1) HUE063533T2 (fr)
IL (2) IL271973B (fr)
LT (1) LT3658552T (fr)
MA (1) MA49700B1 (fr)
MD (1) MD3658552T2 (fr)
MX (1) MX2022008743A (fr)
NZ (1) NZ761156A (fr)
PH (1) PH12020500059A1 (fr)
PL (1) PL3658552T3 (fr)
PT (1) PT3658552T (fr)
RS (1) RS64654B1 (fr)
SA (1) SA520411112B1 (fr)
SG (1) SG11201913517UA (fr)
SI (1) SI3658552T1 (fr)
UA (1) UA125317C2 (fr)
WO (1) WO2019022485A1 (fr)
ZA (1) ZA202001250B (fr)

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HRP20231191T1 (hr) * 2017-07-28 2024-02-02 Yuhan Corporation Postupak za proizvodnju n-(5-((4-(4-((dimetilamino)metil)-3-fenil-1h-pirazol-1-il)pirimidin-2-il)amino)-4-metoksi-2-morfolinofenil)akrilamida putem reakcije odgovarajućeg amina s 3-halo-propionilkloridom
WO2020230091A1 (fr) 2019-05-14 2020-11-19 Janssen Biotech, Inc. Polythérapies avec des anticorps anti-egfr/c-met bispécifiques et des inhibiteurs de tyrosine kinase egfr de troisième génération
US11850248B2 (en) * 2019-05-14 2023-12-26 Yuhan Corporation Therapies with 3rd generation EGFR tyrosine kinase inhibitors
US11780824B2 (en) * 2020-12-16 2023-10-10 Scinopharm Taiwan, Ltd. Process for preparing osimertinib or a salt thereof

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CA2777762A1 (fr) 2009-10-12 2011-04-21 Myrexis, Inc. Composes d'amino-pyrimidine en tant qu'inhibiteurs de tbkl et ou d'ikk epsilon
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HRP20231191T1 (hr) * 2017-07-28 2024-02-02 Yuhan Corporation Postupak za proizvodnju n-(5-((4-(4-((dimetilamino)metil)-3-fenil-1h-pirazol-1-il)pirimidin-2-il)amino)-4-metoksi-2-morfolinofenil)akrilamida putem reakcije odgovarajućeg amina s 3-halo-propionilkloridom
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Also Published As

Publication number Publication date
CN111315742A (zh) 2020-06-19
PT3658552T (pt) 2023-11-03
CN111315742B (zh) 2023-09-01
RS64654B1 (sr) 2023-10-31
EP3658552A1 (fr) 2020-06-03
AU2018308038B2 (en) 2022-02-03
PL3658552T3 (pl) 2024-02-19
US20220281861A1 (en) 2022-09-08
IL271973B (en) 2022-08-01
AU2018308038A1 (en) 2020-01-30
SG11201913517UA (en) 2020-02-27
JP2023027091A (ja) 2023-03-01
MA49700A (fr) 2021-03-17
WO2019022485A1 (fr) 2019-01-31
JP7228562B2 (ja) 2023-02-24
ZA202001250B (en) 2023-04-26
AU2022202936A1 (en) 2022-05-26
DK3658552T3 (da) 2023-11-20
EA202090383A1 (ru) 2020-06-15
CO2020000374A2 (es) 2020-05-05
EP3658552A4 (fr) 2021-06-23
IL292429B1 (en) 2023-05-01
SA520411112B1 (ar) 2022-02-21
HRP20231191T1 (hr) 2024-02-02
IL271973A (en) 2020-02-27
MD3658552T2 (ro) 2024-02-29
FI3658552T3 (fi) 2023-11-16
NZ761156A (en) 2024-01-26
US20200165236A1 (en) 2020-05-28
MX2022008743A (es) 2023-02-02
CN116987112A (zh) 2023-11-03
SI3658552T1 (sl) 2023-11-30
JP2020528440A (ja) 2020-09-24
PH12020500059A1 (en) 2020-09-28
BR112020001278A2 (pt) 2020-07-21
US20230312545A1 (en) 2023-10-05
US20210269427A1 (en) 2021-09-02
CA3070069C (fr) 2024-02-20
IL292429B2 (en) 2023-09-01
US10889578B2 (en) 2021-01-12
UA125317C2 (uk) 2022-02-16
CA3070069A1 (fr) 2019-01-31
US11286253B2 (en) 2022-03-29
ES2962961T3 (es) 2024-03-22
EP3658552B1 (fr) 2023-09-13
HUE063533T2 (hu) 2024-01-28
IL292429A (en) 2022-06-01
KR20190013553A (ko) 2019-02-11
US11708362B2 (en) 2023-07-25
LT3658552T (lt) 2023-11-27
AU2022202936B2 (en) 2023-04-27

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