SI3658552T1 - Postopek za pripravo N-(5-((4-(4-((dimetilamino)metil)-3-fenil-1H-pirazol-1-il)pirimidin-2-il )amino)-4-metoksi-2-morfolinofenil)akrilamida z reagiranjem ustreznega amina s 3-halo-propionil kloridom - Google Patents

Postopek za pripravo N-(5-((4-(4-((dimetilamino)metil)-3-fenil-1H-pirazol-1-il)pirimidin-2-il )amino)-4-metoksi-2-morfolinofenil)akrilamida z reagiranjem ustreznega amina s 3-halo-propionil kloridom

Info

Publication number
SI3658552T1
SI3658552T1 SI201830998T SI201830998T SI3658552T1 SI 3658552 T1 SI3658552 T1 SI 3658552T1 SI 201830998 T SI201830998 T SI 201830998T SI 201830998 T SI201830998 T SI 201830998T SI 3658552 T1 SI3658552 T1 SI 3658552T1
Authority
SI
Slovenia
Prior art keywords
morpholinophenyl
pyrazol
pyrimidin
acrylamide
dimethylamino
Prior art date
Application number
SI201830998T
Other languages
English (en)
Inventor
Sang-Ho Oh
Ja-Heouk Khoo
Jong-Chul Lim
Seong-Ran Lee
Hyun Ju
Woo-Seob Shin
Dae-Gyu Park
su-min Park
Yoon-Ah Hwang
Original Assignee
Yuhan Corporation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=65040211&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=SI3658552(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Yuhan Corporation filed Critical Yuhan Corporation
Publication of SI3658552T1 publication Critical patent/SI3658552T1/sl

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/22Tin compounds
    • C07F7/2284Compounds with one or more Sn-N linkages
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/53751,4-Oxazines, e.g. morpholine
    • A61K31/53771,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D403/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Catalysts (AREA)
SI201830998T 2017-07-28 2018-07-25 Postopek za pripravo N-(5-((4-(4-((dimetilamino)metil)-3-fenil-1H-pirazol-1-il)pirimidin-2-il )amino)-4-metoksi-2-morfolinofenil)akrilamida z reagiranjem ustreznega amina s 3-halo-propionil kloridom SI3658552T1 (sl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
KR20170096212 2017-07-28
EP18837360.9A EP3658552B1 (en) 2017-07-28 2018-07-25 Process for preparing n-(5-((4-(4-((dimethylamino)methyl)-3-phenyl-1h-pyrazol-1-yl)pyrimidin-2-yl)amino)-4-methoxy-2-morpholinophenyl)acrylamide by reacting the corresponding amine with a 3-halo-propionyl chloride
PCT/KR2018/008379 WO2019022485A1 (en) 2017-07-28 2018-07-25 IMPROVED PROCESS FOR THE PREPARATION OF AMINOPYRIMIDINE DERIVATIVES

Publications (1)

Publication Number Publication Date
SI3658552T1 true SI3658552T1 (sl) 2023-11-30

Family

ID=65040211

Family Applications (1)

Application Number Title Priority Date Filing Date
SI201830998T SI3658552T1 (sl) 2017-07-28 2018-07-25 Postopek za pripravo N-(5-((4-(4-((dimetilamino)metil)-3-fenil-1H-pirazol-1-il)pirimidin-2-il )amino)-4-metoksi-2-morfolinofenil)akrilamida z reagiranjem ustreznega amina s 3-halo-propionil kloridom

Country Status (30)

Country Link
US (4) US10889578B2 (sl)
EP (1) EP3658552B1 (sl)
JP (2) JP7228562B2 (sl)
KR (1) KR102688084B1 (sl)
CN (2) CN116987112A (sl)
AU (2) AU2018308038B2 (sl)
BR (1) BR112020001278A2 (sl)
CA (1) CA3070069C (sl)
CO (1) CO2020000374A2 (sl)
DK (1) DK3658552T3 (sl)
EA (1) EA202090383A1 (sl)
ES (1) ES2962961T3 (sl)
FI (1) FI3658552T3 (sl)
HR (1) HRP20231191T1 (sl)
HU (1) HUE063533T2 (sl)
IL (2) IL271973B (sl)
LT (1) LT3658552T (sl)
MA (1) MA49700B1 (sl)
MD (1) MD3658552T2 (sl)
MX (1) MX2022008743A (sl)
PH (1) PH12020500059A1 (sl)
PL (1) PL3658552T3 (sl)
PT (1) PT3658552T (sl)
RS (1) RS64654B1 (sl)
SA (1) SA520411112B1 (sl)
SG (1) SG11201913517UA (sl)
SI (1) SI3658552T1 (sl)
UA (1) UA125317C2 (sl)
WO (1) WO2019022485A1 (sl)
ZA (1) ZA202001250B (sl)

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WO2020230091A1 (en) 2019-05-14 2020-11-19 Janssen Biotech, Inc. Combination therapies with bispecific anti-egfr/c-met antibodies and third generation egfr tyrosine kinase inhibitors
US11850248B2 (en) * 2019-05-14 2023-12-26 Yuhan Corporation Therapies with 3rd generation EGFR tyrosine kinase inhibitors
US11780824B2 (en) * 2020-12-16 2023-10-10 Scinopharm Taiwan, Ltd. Process for preparing osimertinib or a salt thereof
CN116199701A (zh) * 2023-02-27 2023-06-02 安徽中医药大学 一种基于分子内自由基环加成制备吡唑并恶嗪草酮类化合物及其制备方法

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BR112012008677A2 (pt) 2009-10-12 2018-03-20 Myrexis Inc compostos amino-pirimidina como inibidores de tbkl e/ou ikk epsilon
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Also Published As

Publication number Publication date
US10889578B2 (en) 2021-01-12
RS64654B1 (sr) 2023-10-31
IL292429A (en) 2022-06-01
CA3070069C (en) 2024-02-20
CN111315742B (zh) 2023-09-01
CA3070069A1 (en) 2019-01-31
EP3658552A1 (en) 2020-06-03
US20200165236A1 (en) 2020-05-28
BR112020001278A2 (pt) 2020-07-21
EA202090383A1 (ru) 2020-06-15
KR102688084B1 (ko) 2024-07-24
IL292429B1 (en) 2023-05-01
PT3658552T (pt) 2023-11-03
EP3658552A4 (en) 2021-06-23
KR20190013553A (ko) 2019-02-11
HUE063533T2 (hu) 2024-01-28
PH12020500059A1 (en) 2020-09-28
CO2020000374A2 (es) 2020-05-05
UA125317C2 (uk) 2022-02-16
US20230312545A1 (en) 2023-10-05
JP7539451B2 (ja) 2024-08-23
ZA202001250B (en) 2023-04-26
IL271973B (en) 2022-08-01
AU2018308038A1 (en) 2020-01-30
MX2022008743A (es) 2023-02-02
US11708362B2 (en) 2023-07-25
FI3658552T3 (fi) 2023-11-16
WO2019022485A1 (en) 2019-01-31
IL271973A (en) 2020-02-27
MA49700B1 (fr) 2023-09-27
MA49700A (fr) 2021-03-17
PL3658552T3 (pl) 2024-02-19
NZ761156A (en) 2024-01-26
DK3658552T3 (da) 2023-11-20
LT3658552T (lt) 2023-11-27
JP2020528440A (ja) 2020-09-24
AU2022202936B2 (en) 2023-04-27
CN116987112A (zh) 2023-11-03
AU2018308038B2 (en) 2022-02-03
US20210269427A1 (en) 2021-09-02
US20220281861A1 (en) 2022-09-08
IL292429B2 (en) 2023-09-01
SG11201913517UA (en) 2020-02-27
HRP20231191T1 (hr) 2024-02-02
AU2022202936A1 (en) 2022-05-26
SA520411112B1 (ar) 2022-02-21
CN111315742A (zh) 2020-06-19
JP7228562B2 (ja) 2023-02-24
ES2962961T3 (es) 2024-03-22
MD3658552T2 (ro) 2024-02-29
EP3658552B1 (en) 2023-09-13
JP2023027091A (ja) 2023-03-01
US11286253B2 (en) 2022-03-29

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