MA43667B1 - Nouveaux dérivés de pyrrolidine - Google Patents
Nouveaux dérivés de pyrrolidineInfo
- Publication number
- MA43667B1 MA43667B1 MA43667A MA43667A MA43667B1 MA 43667 B1 MA43667 B1 MA 43667B1 MA 43667 A MA43667 A MA 43667A MA 43667 A MA43667 A MA 43667A MA 43667 B1 MA43667 B1 MA 43667B1
- Authority
- MA
- Morocco
- Prior art keywords
- pyrrolidine derivatives
- new pyrrolidine
- new
- compound
- formula
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/4025—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil not condensed and containing further heterocyclic rings, e.g. cromakalim
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
- A61K31/4155—1,2-Diazoles non condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4192—1,2,3-Triazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4196—1,2,4-Triazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Diabetes (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Ophthalmology & Optometry (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyrrole Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
L'invention concerne un composé de formule (i) dans laquelle r1 et r2 sont définis comme dans la description et dans les revendications. Le composé de formule (i) peut être utilisé comme médicament contre le diabète, l'athérosclérose et d'autres affections liées à la cathepsine.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP16157679 | 2016-02-26 | ||
| EP17705662.9A EP3419970B1 (fr) | 2016-02-26 | 2017-02-22 | Nouveaux dérivés de pyrrolidine |
| PCT/EP2017/053967 WO2017144483A1 (fr) | 2016-02-26 | 2017-02-22 | Nouveaux dérivés de pyrrolidine |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MA43667B1 true MA43667B1 (fr) | 2020-03-31 |
Family
ID=55443159
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MA43667A MA43667B1 (fr) | 2016-02-26 | 2017-02-22 | Nouveaux dérivés de pyrrolidine |
Country Status (31)
| Country | Link |
|---|---|
| US (1) | US10689339B2 (fr) |
| EP (1) | EP3419970B1 (fr) |
| JP (1) | JP6952044B2 (fr) |
| KR (1) | KR20180111862A (fr) |
| CN (1) | CN108699044B (fr) |
| AR (1) | AR107717A1 (fr) |
| AU (1) | AU2017224343B2 (fr) |
| CA (1) | CA3011652C (fr) |
| CL (1) | CL2018002347A1 (fr) |
| CO (1) | CO2018007756A2 (fr) |
| CR (1) | CR20180404A (fr) |
| DK (1) | DK3419970T3 (fr) |
| ES (1) | ES2775781T3 (fr) |
| HR (1) | HRP20200307T1 (fr) |
| HU (1) | HUE047842T2 (fr) |
| IL (1) | IL260130B (fr) |
| LT (1) | LT3419970T (fr) |
| MA (1) | MA43667B1 (fr) |
| MX (1) | MX2018009638A (fr) |
| MY (1) | MY196560A (fr) |
| PH (1) | PH12018501585B1 (fr) |
| PL (1) | PL3419970T3 (fr) |
| PT (1) | PT3419970T (fr) |
| RS (1) | RS59938B1 (fr) |
| RU (1) | RU2736498C1 (fr) |
| SG (1) | SG11201807074VA (fr) |
| SI (1) | SI3419970T1 (fr) |
| TW (1) | TWI740903B (fr) |
| UA (1) | UA122084C2 (fr) |
| WO (1) | WO2017144483A1 (fr) |
| ZA (1) | ZA201804120B (fr) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3575284B1 (fr) | 2017-01-24 | 2021-08-25 | Astellas Pharma Inc. | Composé de prolineamide substitué par un phényldifluorométhyle |
| TW202023542A (zh) | 2018-09-18 | 2020-07-01 | 瑞士商赫孚孟拉羅股份公司 | 組織蛋白酶(cathepsin)S抑制劑之對抗抗藥抗體形成之用途 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PT2421826E (pt) * | 2009-04-20 | 2014-01-03 | Hoffmann La Roche | Derivados de prolina como inibidores de catepsina |
| MX339996B (es) * | 2011-11-11 | 2016-06-21 | Hoffmann La Roche | Proceso para la preparacion de derivados de 1-acil-4-fenilsulfonil prolinamida y nuevos intermediarios. |
| US8729061B2 (en) * | 2011-11-25 | 2014-05-20 | Hoffmann-La Roche Inc. | Pyrrolidine derivatives |
| CN104114068B (zh) * | 2011-12-09 | 2017-07-11 | W.C.布拉德利公司 | 具有可调整的加热特征的烹饪炉排 |
| EP2814822B1 (fr) * | 2012-02-17 | 2016-04-20 | F.Hoffmann-La Roche Ag | Nouveaux dérivés de pyrrolidine |
| PE20150995A1 (es) * | 2012-08-21 | 2015-06-29 | Hoffmann La Roche | Nuevos derivados de piridina |
-
2017
- 2017-02-22 SG SG11201807074VA patent/SG11201807074VA/en unknown
- 2017-02-22 JP JP2018541661A patent/JP6952044B2/ja active Active
- 2017-02-22 RU RU2018133640A patent/RU2736498C1/ru active
- 2017-02-22 MX MX2018009638A patent/MX2018009638A/es unknown
- 2017-02-22 PL PL17705662T patent/PL3419970T3/pl unknown
- 2017-02-22 UA UAA201809397A patent/UA122084C2/uk unknown
- 2017-02-22 MY MYPI2018001465A patent/MY196560A/en unknown
- 2017-02-22 ES ES17705662T patent/ES2775781T3/es active Active
- 2017-02-22 EP EP17705662.9A patent/EP3419970B1/fr active Active
- 2017-02-22 KR KR1020187024347A patent/KR20180111862A/ko active Search and Examination
- 2017-02-22 MA MA43667A patent/MA43667B1/fr unknown
- 2017-02-22 LT LTEP17705662.9T patent/LT3419970T/lt unknown
- 2017-02-22 CR CR20180404A patent/CR20180404A/es unknown
- 2017-02-22 HU HUE17705662A patent/HUE047842T2/hu unknown
- 2017-02-22 DK DK17705662.9T patent/DK3419970T3/da active
- 2017-02-22 SI SI201730195T patent/SI3419970T1/sl unknown
- 2017-02-22 AU AU2017224343A patent/AU2017224343B2/en active Active
- 2017-02-22 CN CN201780013397.XA patent/CN108699044B/zh active Active
- 2017-02-22 RS RS20200183A patent/RS59938B1/sr unknown
- 2017-02-22 CA CA3011652A patent/CA3011652C/fr active Active
- 2017-02-22 WO PCT/EP2017/053967 patent/WO2017144483A1/fr active Application Filing
- 2017-02-22 PT PT177056629T patent/PT3419970T/pt unknown
- 2017-02-24 TW TW106106388A patent/TWI740903B/zh active
- 2017-02-24 AR ARP170100467A patent/AR107717A1/es unknown
-
2018
- 2018-06-19 IL IL260130A patent/IL260130B/en active IP Right Grant
- 2018-06-20 ZA ZA2018/04120A patent/ZA201804120B/en unknown
- 2018-07-25 PH PH12018501585A patent/PH12018501585B1/en unknown
- 2018-07-26 CO CONC2018/0007756A patent/CO2018007756A2/es unknown
- 2018-08-16 CL CL2018002347A patent/CL2018002347A1/es unknown
- 2018-08-24 US US16/111,721 patent/US10689339B2/en active Active
-
2020
- 2020-02-24 HR HRP20200307TT patent/HRP20200307T1/hr unknown
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