MA42301B1 - Sel cristallin de fumarate de (s)-[3,4-difluoro-2-(2-fluoro-4-iodophénylamino)phényl][3-hydroxy-3-(pipéridin-2-yl)azétidin-1-yl]-méthanone - Google Patents

Sel cristallin de fumarate de (s)-[3,4-difluoro-2-(2-fluoro-4-iodophénylamino)phényl][3-hydroxy-3-(pipéridin-2-yl)azétidin-1-yl]-méthanone

Info

Publication number
MA42301B1
MA42301B1 MA42301A MA42301A MA42301B1 MA 42301 B1 MA42301 B1 MA 42301B1 MA 42301 A MA42301 A MA 42301A MA 42301 A MA42301 A MA 42301A MA 42301 B1 MA42301 B1 MA 42301B1
Authority
MA
Morocco
Prior art keywords
iodophenylamino
azetidin
piperidin
fluoro
hydroxy
Prior art date
Application number
MA42301A
Other languages
English (en)
Other versions
MA42301A (fr
Inventor
Adrian St. Clair BROWN
Original Assignee
Exelixis, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=56411938&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MA42301(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Exelixis, Inc. filed Critical Exelixis, Inc.
Publication of MA42301A publication Critical patent/MA42301A/fr
Publication of MA42301B1 publication Critical patent/MA42301B1/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/397—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having four-membered rings, e.g. azetidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

La présente invention concerne le sel cristallin de fumarate de (S)-[3,4-difluoro-2-(2-fluoro-4-iodophénylamino)phényl][3-hydroxy-3-(pipéridin-2-yl)azétidin-1-yl]-méthanone. L'invention concerne également des compositions pharmaceutiques comprenant le sel cristallin de fumarate de (S)-[3,4-difluoro-2-(2-fluoro-4-iodophénylamino)phényl][3-hydroxy-3-(pipéridin-2-yl)azétidin-1-yl]-méthanone. L'invention concerne également des procédés de traitement de cancers comprenant l'administration à un patient qui en a besoin du sel cristallin de fumarate de (S)-[3,4-difluoro-2-(2-fluoro-4-iodophénylamino)phényl][3-hydroxy-3-(pipéridin-2-yl)azétidin-1-yl]-méthanone.
MA42301A 2015-06-30 2016-06-30 Sel cristallin de fumarate de (s)-[3,4-difluoro-2-(2-fluoro-4-iodophénylamino)phényl][3-hydroxy-3-(pipéridin-2-yl)azétidin-1-yl]-méthanone MA42301B1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562187009P 2015-06-30 2015-06-30
EP16738971.7A EP3317264B1 (fr) 2015-06-30 2016-06-30 Sel cristallin de fumarate de (s)-[3,4-difluoro-2-(2-fluoro-4-iodophénylamino)phényl][3-hydroxy-3-(pipéridin-2-yl)azétidin-1-yl]-méthanone
PCT/US2016/040444 WO2017004393A1 (fr) 2015-06-30 2016-06-30 Sel cristallin de fumarate de (s)-[3,4-difluoro-2-(2-fluoro-4-iodophénylamino)phényl][3-hydroxy-3-(pipéridin-2-yl)azétidin-1-yl]-méthanone

Publications (2)

Publication Number Publication Date
MA42301A MA42301A (fr) 2018-05-09
MA42301B1 true MA42301B1 (fr) 2025-12-31

Family

ID=56411938

Family Applications (1)

Application Number Title Priority Date Filing Date
MA42301A MA42301B1 (fr) 2015-06-30 2016-06-30 Sel cristallin de fumarate de (s)-[3,4-difluoro-2-(2-fluoro-4-iodophénylamino)phényl][3-hydroxy-3-(pipéridin-2-yl)azétidin-1-yl]-méthanone

Country Status (35)

Country Link
US (3) US10590102B2 (fr)
EP (1) EP3317264B1 (fr)
JP (3) JP7338950B2 (fr)
KR (1) KR102695324B1 (fr)
CN (2) CN118290395A (fr)
AR (1) AR105483A1 (fr)
AU (2) AU2016288209B2 (fr)
CA (1) CA2990222C (fr)
CL (1) CL2017003475A1 (fr)
CO (1) CO2018000086A2 (fr)
CR (1) CR20180056A (fr)
DK (1) DK3317264T3 (fr)
ES (1) ES3058194T3 (fr)
FI (1) FI3317264T3 (fr)
HK (1) HK1252433A1 (fr)
HR (1) HRP20251507T1 (fr)
IL (2) IL256423B (fr)
LT (1) LT3317264T (fr)
MA (1) MA42301B1 (fr)
MD (1) MD3317264T2 (fr)
MX (1) MX390250B (fr)
MY (1) MY192545A (fr)
PE (1) PE20180692A1 (fr)
PH (1) PH12017502414A1 (fr)
PL (1) PL3317264T3 (fr)
PT (1) PT3317264T (fr)
RS (1) RS67509B1 (fr)
RU (2) RU2021132394A (fr)
SG (1) SG10202105196YA (fr)
SI (1) SI3317264T1 (fr)
SM (1) SMT202500458T1 (fr)
TW (2) TWI710556B (fr)
UA (1) UA124728C2 (fr)
WO (1) WO2017004393A1 (fr)
ZA (1) ZA201708760B (fr)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP6300042B2 (ja) 2012-10-12 2018-03-28 エグゼリクシス， インコーポレイテッド 癌の処置に使用するための化合物の製造方法
EP3881833B1 (fr) * 2015-06-30 2023-11-01 Genentech, Inc. Comprimés à libération immédiate contenant un médicament et procédés pour former les comprimés
AR105483A1 (es) 2015-06-30 2017-10-11 Exelixis Inc Sal de fumarato cristalina de (s)-[3,4-difluoro-2-(2-fluoro-4-yodofenilamino)fenil][3-hidroxi-3-(piperidin-2-il)azetidin-1-il]-metanona
MX393780B (es) 2017-01-17 2025-03-24 Heparegenix Gmbh Inhibidores de proteina cinasa para promover la regeneracion hepatica o reducir o prevenir la muerte de hepatocitos
GB201717809D0 (en) * 2017-10-30 2017-12-13 Azad Pharmaceutical Ingredients Ag Process for the production of cobimetinib
WO2020187674A1 (fr) 2019-03-15 2020-09-24 Sandoz Ag Hémisuccinate de (s)-[3,4-difluoro-2-(2-fluoro-4-iodophénylamino)phényl][3-hydroxy-3-(pipéridin-2-yl) azétidin-1-yl]méthanone cristallin
AU2023384196A1 (en) * 2022-11-25 2025-06-12 Msn Laboratories Private Limited, R&D Center Crystalline forms of n-(4-(6,7-dimethoxyquinolin-4-yloxy)phenyl)-n'-(4-fluorophenyl) cyclopropane-1,1-dicarboxamide fumarate and process for its preparation

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX2007004781A (es) 2004-10-20 2007-05-11 Applied Research Systems Derivados de 3-arilamino piridina.
NZ563692A (en) 2005-05-23 2011-04-29 Novartis Ag Crystalline and other forms of 4-amino-5-fluoro-3-[6-(4-methylpiperazin-1-yl)-1H-benzimidazol-2-yl]-1H-quinolin-2-one lactic acid salts
DE602006021205D1 (de) 2005-10-07 2011-05-19 Exelixis Inc Azetidine als mek-inhibitoren bei der behandlung proliferativer erkrankungen
JP2010500994A (ja) 2006-08-16 2010-01-14 エグゼリクシス， インコーポレイテッド Ｐｉ３ｋおよびｍｅｋモジュレーターを使用する方法
JP5311673B2 (ja) * 2006-12-14 2013-10-09 エグゼリクシス， インコーポレイテッド Ｍｅｋ阻害剤の使用方法
WO2008124085A2 (fr) 2007-04-03 2008-10-16 Exelixis, Inc. Méthodes d'utilisation de combinaisons d'inhibiteurs de mek et de jak-2
JP6300042B2 (ja) 2012-10-12 2018-03-28 エグゼリクシス， インコーポレイテッド 癌の処置に使用するための化合物の製造方法
EP2964028A4 (fr) 2013-03-05 2017-06-07 University of Tennessee Research Foundation Composés pour le traitement du cancer
BR112015022576A2 (pt) 2013-03-14 2017-10-24 Genentech Inc produto farmacêutico e seu uso, kit e método para tratar uma disfunção hiperproliferativa
AR105483A1 (es) 2015-06-30 2017-10-11 Exelixis Inc Sal de fumarato cristalina de (s)-[3,4-difluoro-2-(2-fluoro-4-yodofenilamino)fenil][3-hidroxi-3-(piperidin-2-il)azetidin-1-il]-metanona

Also Published As

Publication number Publication date
NZ777527A (en) 2024-10-25
CO2018000086A2 (es) 2018-04-10
US20200255398A1 (en) 2020-08-13
EP3317264A1 (fr) 2018-05-09
JP2023025000A (ja) 2023-02-21
WO2017004393A1 (fr) 2017-01-05
PE20180692A1 (es) 2018-04-23
NZ739160A (en) 2024-10-25
CA2990222C (fr) 2023-09-26
RU2018103172A3 (fr) 2019-10-31
LT3317264T (lt) 2025-12-29
US20220056010A1 (en) 2022-02-24
US20180346442A1 (en) 2018-12-06
CN107810183A (zh) 2018-03-16
TW202108568A (zh) 2021-03-01
AU2021200202A1 (en) 2021-03-18
HRP20251507T1 (hr) 2026-01-02
SI3317264T1 (sl) 2026-01-30
KR20180021775A (ko) 2018-03-05
US11254649B2 (en) 2022-02-22
CL2017003475A1 (es) 2018-07-13
TWI710556B (zh) 2020-11-21
CN118290395A (zh) 2024-07-05
MD3317264T2 (ro) 2026-01-31
MA42301A (fr) 2018-05-09
PL3317264T3 (pl) 2026-02-16
JP2018519318A (ja) 2018-07-19
MY192545A (en) 2022-08-26
RU2762181C2 (ru) 2021-12-16
SMT202500458T1 (it) 2026-01-12
PH12017502414A1 (en) 2018-06-25
JP7338950B2 (ja) 2023-09-05
AU2016288209B2 (en) 2020-10-22
RU2021132394A (ru) 2021-11-18
MX390250B (es) 2025-03-20
CR20180056A (es) 2018-05-25
TW201718535A (zh) 2017-06-01
ZA201708760B (en) 2022-06-29
AR105483A1 (es) 2017-10-11
JP2021035967A (ja) 2021-03-04
DK3317264T3 (da) 2025-12-01
IL295052A (en) 2022-09-01
AU2021200202B2 (en) 2022-09-08
TWI775187B (zh) 2022-08-21
HK1252433A1 (zh) 2019-05-24
AU2016288209A1 (en) 2018-02-08
MX2017017037A (es) 2018-04-30
PT3317264T (pt) 2025-12-12
CA2990222A1 (fr) 2017-01-05
ES3058194T3 (en) 2026-03-09
IL256423A (en) 2018-02-28
FI3317264T3 (fi) 2025-12-05
IL256423B (en) 2022-09-01
RS67509B1 (sr) 2025-12-31
SG10202105196YA (en) 2021-06-29
EP3317264B1 (fr) 2025-09-10
BR112017028516A2 (pt) 2018-08-28
US10590102B2 (en) 2020-03-17
UA124728C2 (uk) 2021-11-10
RU2018103172A (ru) 2019-07-31
KR102695324B1 (ko) 2024-08-13

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