MA33830B1 - Nouveaux dérivés de 8-hydroxyquinoline-7-carboxamide secondaires - Google Patents
Nouveaux dérivés de 8-hydroxyquinoline-7-carboxamide secondairesInfo
- Publication number
- MA33830B1 MA33830B1 MA34973A MA34973A MA33830B1 MA 33830 B1 MA33830 B1 MA 33830B1 MA 34973 A MA34973 A MA 34973A MA 34973 A MA34973 A MA 34973A MA 33830 B1 MA33830 B1 MA 33830B1
- Authority
- MA
- Morocco
- Prior art keywords
- hydroxyquinoline
- compounds
- novel
- carboxamide
- candida
- Prior art date
Links
- FOXMISVOVQTSGS-UHFFFAOYSA-N 8-hydroxyquinoline-7-carboxamide Chemical compound C1=CC=NC2=C(O)C(C(=O)N)=CC=C21 FOXMISVOVQTSGS-UHFFFAOYSA-N 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 3
- 241000228245 Aspergillus niger Species 0.000 abstract 1
- 241000222120 Candida <Saccharomycetales> Species 0.000 abstract 1
- 241000222122 Candida albicans Species 0.000 abstract 1
- 241000825258 Scopulariopsis brevicaulis Species 0.000 abstract 1
- 241000222126 [Candida] glabrata Species 0.000 abstract 1
- 229940121375 antifungal agent Drugs 0.000 abstract 1
- 239000003429 antifungal agent Substances 0.000 abstract 1
- 229940095731 candida albicans Drugs 0.000 abstract 1
- 208000032343 candida glabrata infection Diseases 0.000 abstract 1
- MYSWGUAQZAJSOK-UHFFFAOYSA-N ciprofloxacin Chemical compound C12=CC(N3CCNCC3)=C(F)C=C2C(=O)C(C(=O)O)=CN1C1CC1 MYSWGUAQZAJSOK-UHFFFAOYSA-N 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
- C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Oncology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Communicable Diseases (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Quinoline Compounds (AREA)
Abstract
Cette invention concerne de nouveaux dérivés de 8-hydroxyquinoline- 7-carboxamide secondaires de formule générale (i) et leurs sels pharmaceutiquement acceptables. Ces composés sont utiles en tant qu'agents antifongiques. Plus spécifiquement, ces composés ont été testés contre tricophyton rubrum, tricophyton mentagrophytes, aspergillus niger et scopulariopsis brevicaulis. Beaucoup de ces composés sont actifs contre l'espèce candida, par exemple, candida albicans et candida glabrata.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP09180895A EP2345641A1 (fr) | 2009-12-29 | 2009-12-29 | Nouveaux dérivés de 8-hydroxyquinoline-7-carboxamide secondaire |
| PCT/EP2010/070793 WO2011080266A1 (fr) | 2009-12-29 | 2010-12-28 | Nouveaux dérivés de 8-hydroxyquinoline-7-carboxamide secondaires |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MA33830B1 true MA33830B1 (fr) | 2012-12-03 |
Family
ID=42025709
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MA34973A MA33830B1 (fr) | 2009-12-29 | 2012-06-15 | Nouveaux dérivés de 8-hydroxyquinoline-7-carboxamide secondaires |
Country Status (38)
| Country | Link |
|---|---|
| US (1) | US8729076B2 (fr) |
| EP (2) | EP2345641A1 (fr) |
| JP (1) | JP5755245B2 (fr) |
| KR (1) | KR20120097407A (fr) |
| CN (1) | CN102712596B (fr) |
| AU (1) | AU2010338269B2 (fr) |
| BR (1) | BR112012015732A2 (fr) |
| CA (1) | CA2783230A1 (fr) |
| CL (1) | CL2012001759A1 (fr) |
| CO (1) | CO6561775A2 (fr) |
| CY (1) | CY1115060T1 (fr) |
| DK (1) | DK2519504T3 (fr) |
| DO (1) | DOP2012000185A (fr) |
| EA (1) | EA020487B1 (fr) |
| EC (1) | ECSP12012008A (fr) |
| ES (1) | ES2460626T3 (fr) |
| GE (1) | GEP20156269B (fr) |
| GT (1) | GT201200214A (fr) |
| HK (1) | HK1178525A1 (fr) |
| HR (1) | HRP20140348T1 (fr) |
| IL (1) | IL220307A (fr) |
| MA (1) | MA33830B1 (fr) |
| ME (1) | ME01748B (fr) |
| MX (1) | MX2012007746A (fr) |
| MY (1) | MY162548A (fr) |
| NI (1) | NI201200115A (fr) |
| NZ (1) | NZ600782A (fr) |
| PE (1) | PE20121804A1 (fr) |
| PL (1) | PL2519504T3 (fr) |
| PT (1) | PT2519504E (fr) |
| RS (1) | RS53303B (fr) |
| SG (1) | SG181588A1 (fr) |
| SI (1) | SI2519504T1 (fr) |
| SM (1) | SMT201400059B (fr) |
| TN (1) | TN2012000319A1 (fr) |
| UA (1) | UA109422C2 (fr) |
| WO (1) | WO2011080266A1 (fr) |
| ZA (1) | ZA201204349B (fr) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2345642A1 (fr) * | 2009-12-29 | 2011-07-20 | Polichem S.A. | Dérivés de 8-hydroxyquinoline-7-carboxamide secondaire pour une utilisation en tant qu'agents antifongiques |
| EP2345643A1 (fr) * | 2009-12-29 | 2011-07-20 | Polichem S.A. | Nouveaux dérivés de 8-hydroxyquinoline-7-carboxamide et leurs utilisations |
| CN104805147B (zh) * | 2014-01-26 | 2018-01-05 | 上海医药工业研究院 | 一种二噁英类化合物的制备方法、纯化方法及应用 |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US326328A (en) | 1885-09-15 | Broiler | ||
| US326330A (en) | 1885-09-15 | Harness-support | ||
| DE540842C (de) | 1930-08-06 | 1931-12-28 | Chinosol Fabrik Akt Ges | Verfahren zur Darstellung der 8-Acetyloxychinolin-7-carbonsaeure |
| FR2160718A1 (en) * | 1971-11-23 | 1973-07-06 | Roussel Uclaf | 7-benzyl aminomethyl-8-hydroxy quinolines - bacteriostats and fungistats |
| DE3426995A1 (de) | 1984-07-21 | 1986-01-30 | Dr.Ing.H.C. F. Porsche Ag, 7000 Stuttgart | Halterung einer scheibe, vorzugsweise einer windschutzscheibe |
| BR9604823A (pt) | 1995-04-08 | 1999-01-05 | Basf Ag | Processo para controlar funggs nocivos e pragas fúngicas mistura sinérgica adequada para controlar pragas fúngicas e uso de compostos |
| US6310211B1 (en) | 1996-09-10 | 2001-10-30 | Pharmacia & Upjohn Company | 8-hydroxy-7-substituted quinolines as anti-viral agents |
| US6919351B2 (en) | 2000-10-12 | 2005-07-19 | Merck & Co., Inc. | Aza-and polyaza-naphthalenyl-carboxamides useful as HIV integrase inhibitors |
| AU1152702A (en) | 2000-10-12 | 2002-04-22 | Merck & Co Inc | Aza- and polyaza-naphthalenyl carboxamides useful as hiv integrase inhibitors |
| ATE411292T1 (de) | 2001-03-01 | 2008-10-15 | Shionogi & Co | Stickstoffhaltige heteroarylverbindungen mit hiv- integrase inhibierender wirkung |
| US7358249B2 (en) | 2002-08-13 | 2008-04-15 | Shionogi & Co., Ltd. | Heterocyclic compounds having inhibitory activity against HIV integrase |
| WO2005033079A1 (fr) * | 2003-09-30 | 2005-04-14 | Eisai Co., Ltd. | Agent antifongique a compose heterocyclique |
| FR2889192A1 (fr) * | 2005-07-27 | 2007-02-02 | Cytomics Systems Sa | Composes antifongiques, compositions contenant ces composes et leurs utilisations |
| EP2079699A1 (fr) * | 2006-07-25 | 2009-07-22 | Envivo Pharmaceuticals, Inc. | Dérivés de quinoline |
| EP2345643A1 (fr) * | 2009-12-29 | 2011-07-20 | Polichem S.A. | Nouveaux dérivés de 8-hydroxyquinoline-7-carboxamide et leurs utilisations |
| EP2345642A1 (fr) * | 2009-12-29 | 2011-07-20 | Polichem S.A. | Dérivés de 8-hydroxyquinoline-7-carboxamide secondaire pour une utilisation en tant qu'agents antifongiques |
-
2009
- 2009-12-29 EP EP09180895A patent/EP2345641A1/fr not_active Withdrawn
-
2010
- 2010-12-28 DK DK10798129.2T patent/DK2519504T3/da active
- 2010-12-28 BR BR112012015732A patent/BR112012015732A2/pt not_active IP Right Cessation
- 2010-12-28 JP JP2012546434A patent/JP5755245B2/ja not_active Expired - Fee Related
- 2010-12-28 AU AU2010338269A patent/AU2010338269B2/en not_active Ceased
- 2010-12-28 PT PT107981292T patent/PT2519504E/pt unknown
- 2010-12-28 PE PE2012000846A patent/PE20121804A1/es not_active Application Discontinuation
- 2010-12-28 GE GEAP201012811A patent/GEP20156269B/en unknown
- 2010-12-28 PL PL10798129T patent/PL2519504T3/pl unknown
- 2010-12-28 EA EA201270672A patent/EA020487B1/ru not_active IP Right Cessation
- 2010-12-28 WO PCT/EP2010/070793 patent/WO2011080266A1/fr active Application Filing
- 2010-12-28 ME MEP-2014-36A patent/ME01748B/me unknown
- 2010-12-28 RS RS20140238A patent/RS53303B/en unknown
- 2010-12-28 UA UAA201207792A patent/UA109422C2/uk unknown
- 2010-12-28 EP EP10798129.2A patent/EP2519504B1/fr active Active
- 2010-12-28 US US13/519,686 patent/US8729076B2/en not_active Expired - Fee Related
- 2010-12-28 MY MYPI2012002954A patent/MY162548A/en unknown
- 2010-12-28 ES ES10798129.2T patent/ES2460626T3/es active Active
- 2010-12-28 SG SG2012042305A patent/SG181588A1/en unknown
- 2010-12-28 CA CA2783230A patent/CA2783230A1/fr not_active Abandoned
- 2010-12-28 CN CN201080059735.1A patent/CN102712596B/zh not_active Expired - Fee Related
- 2010-12-28 MX MX2012007746A patent/MX2012007746A/es active IP Right Grant
- 2010-12-28 NZ NZ600782A patent/NZ600782A/xx not_active IP Right Cessation
- 2010-12-28 KR KR1020127019423A patent/KR20120097407A/ko not_active Application Discontinuation
- 2010-12-28 SI SI201030586T patent/SI2519504T1/sl unknown
-
2012
- 2012-06-11 IL IL220307A patent/IL220307A/en not_active IP Right Cessation
- 2012-06-13 ZA ZA2012/04349A patent/ZA201204349B/en unknown
- 2012-06-15 MA MA34973A patent/MA33830B1/fr unknown
- 2012-06-22 TN TNP2012000319A patent/TN2012000319A1/en unknown
- 2012-06-25 GT GT201200214A patent/GT201200214A/es unknown
- 2012-06-26 CO CO12106820A patent/CO6561775A2/es unknown
- 2012-06-26 CL CL2012001759A patent/CL2012001759A1/es unknown
- 2012-06-27 DO DO2012000185A patent/DOP2012000185A/es unknown
- 2012-06-28 EC ECSP12012008 patent/ECSP12012008A/es unknown
- 2012-06-28 NI NI201200115A patent/NI201200115A/es unknown
-
2013
- 2013-05-06 HK HK13105404.4A patent/HK1178525A1/xx not_active IP Right Cessation
-
2014
- 2014-04-11 HR HRP20140348AT patent/HRP20140348T1/hr unknown
- 2014-05-13 CY CY20141100340T patent/CY1115060T1/el unknown
- 2014-05-21 SM SM201400059T patent/SMT201400059B/xx unknown
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