MA33051B1 - Variants de liaison anti-albumine serique ameliores - Google Patents
Variants de liaison anti-albumine serique amelioresInfo
- Publication number
- MA33051B1 MA33051B1 MA34104A MA34104A MA33051B1 MA 33051 B1 MA33051 B1 MA 33051B1 MA 34104 A MA34104 A MA 34104A MA 34104 A MA34104 A MA 34104A MA 33051 B1 MA33051 B1 MA 33051B1
- Authority
- MA
- Morocco
- Prior art keywords
- serum albumin
- contrasts
- albumin enhancer
- antagonist
- antagonist serum
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/555—Interferons [IFN]
- C07K14/56—IFN-alpha
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/57563—Vasoactive intestinal peptide [VIP]; Related peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2878—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/569—Single domain, e.g. dAb, sdAb, VHH, VNAR or nanobody®
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/31—Fusion polypeptide fusions, other than Fc, for prolonged plasma life, e.g. albumin
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Genetics & Genomics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Immunology (AREA)
- Toxicology (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Endocrinology (AREA)
- Diabetes (AREA)
- Vascular Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Emergency Medicine (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
L'invention porte sur des variants améliorés du domaine variable unique DOM7h-14 de l'immunoglobuline anti-albumine sérique, ainsi que des ligands et des conjugués de médicaments contenant de tels variants, des compositions, des acides nucléiques, des vecteurs et des hôtes.
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US15374609P | 2009-02-19 | 2009-02-19 | |
US16398709P | 2009-03-27 | 2009-03-27 | |
US24713609P | 2009-09-30 | 2009-09-30 | |
PCT/EP2010/052008 WO2010094723A2 (fr) | 2009-02-19 | 2010-02-17 | Variants de liaison anti-albumine sérique améliorés |
Publications (1)
Publication Number | Publication Date |
---|---|
MA33051B1 true MA33051B1 (fr) | 2012-02-01 |
Family
ID=42634270
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MA34104A MA33051B1 (fr) | 2009-02-19 | 2010-02-17 | Variants de liaison anti-albumine serique ameliores |
Country Status (25)
Country | Link |
---|---|
US (3) | US9534043B2 (fr) |
EP (3) | EP3330287B1 (fr) |
JP (2) | JP5759391B2 (fr) |
KR (1) | KR101819754B1 (fr) |
CN (1) | CN102405233B (fr) |
AR (1) | AR075505A1 (fr) |
AU (1) | AU2010215482B2 (fr) |
BR (1) | BRPI1013341B1 (fr) |
CA (2) | CA2767752C (fr) |
CL (1) | CL2011002025A1 (fr) |
CO (1) | CO6410311A2 (fr) |
DO (1) | DOP2011000266A (fr) |
EA (1) | EA028178B1 (fr) |
ES (2) | ES2655071T3 (fr) |
HK (1) | HK1247944A1 (fr) |
IL (1) | IL214480A0 (fr) |
MA (1) | MA33051B1 (fr) |
MX (1) | MX2011008749A (fr) |
NZ (1) | NZ595242A (fr) |
PE (1) | PE20120001A1 (fr) |
SG (1) | SG173489A1 (fr) |
TW (1) | TW201042039A (fr) |
UY (1) | UY32450A (fr) |
WO (1) | WO2010094723A2 (fr) |
ZA (1) | ZA201105657B (fr) |
Families Citing this family (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SG174497A1 (en) * | 2009-03-27 | 2011-10-28 | Glaxo Group Ltd | Drug fusions and conjugates |
WO2011008814A2 (fr) | 2009-07-14 | 2011-01-20 | Immune Tolerance Institute, Inc., A California Not-For-Profit Corporation | Mesure multiplexée d'adn endogène et exogène |
US20120276098A1 (en) * | 2009-09-30 | 2012-11-01 | Bruce Hamilton | Drug fusions and conjugates with extended half life |
UA107200C2 (uk) * | 2009-10-27 | 2014-12-10 | Ґлаксо Ґруп Лімітед | ОДИНИЧНИЙ ВАРІАБЕЛЬНИЙ ДОМЕН ІМУНОГЛОБУЛІНУ ПРОТИ РЕЦЕПТОРА ТИПУ 1 TNFα |
CN103003303A (zh) * | 2010-05-20 | 2013-03-27 | 葛兰素集团有限公司 | 改进的抗-血清白蛋白结合变体 |
WO2012020143A1 (fr) * | 2010-08-13 | 2012-02-16 | Glaxo Group Limited | Variants de liaison anti-sérum-albumine améliorés |
CA2818621A1 (fr) * | 2010-11-24 | 2012-05-31 | Glaxo Group Limited | Proteines multispecifique se liant a un antigene et ciblant hgf |
WO2012072731A2 (fr) | 2010-12-01 | 2012-06-07 | Glaxo Group Limited | Domaines variables améliorés à liaison unique d'anti-albumine sérique |
US20130310281A1 (en) | 2011-02-02 | 2013-11-21 | Glaxo Group Limited | Novel antigen binding proteins |
WO2017201340A2 (fr) | 2016-05-18 | 2017-11-23 | Modernatx, Inc. | Polynucléotides codant la relaxine |
KR20200015505A (ko) | 2017-06-05 | 2020-02-12 | 누맙 세러퓨틱스 아게 | 신규 항 hsa 항체 |
WO2018224439A1 (fr) * | 2017-06-05 | 2018-12-13 | Numab Innovation Ag | Nouveaux anticorps anti-hsa |
Family Cites Families (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IL127127A0 (en) | 1998-11-18 | 1999-09-22 | Peptor Ltd | Small functional units of antibody heavy chain variable regions |
US20100081792A1 (en) * | 2001-06-28 | 2010-04-01 | Smithkline Beecham Corporation | Ligand |
US9321832B2 (en) | 2002-06-28 | 2016-04-26 | Domantis Limited | Ligand |
ES2263984T3 (es) | 2002-06-28 | 2006-12-16 | Domantis Limited | Ligandos doble-especificos con una vida media serica aumentada. |
US20060002935A1 (en) | 2002-06-28 | 2006-01-05 | Domantis Limited | Tumor Necrosis Factor Receptor 1 antagonists and methods of use therefor |
EP2172553A1 (fr) | 2004-03-24 | 2010-04-07 | Domantis Limited | Sequence de tete universelle gas1 |
MXPA06014031A (es) | 2004-06-01 | 2007-10-08 | Domantis Ltd | Anticuerpos de fusion biespecificos con vida media de serica mejorada. |
EP2769990A3 (fr) | 2004-12-02 | 2015-02-25 | Domantis Limited | Anticorps bispecifiques de domaine visant l'albumine serique et GPL-1 ou PYY |
CA2632424A1 (fr) * | 2005-12-06 | 2007-06-14 | Domantis Limited | Ligands bispecifiques ayant une specificite de liaison a des cibles de surface cellulaire et procedes d'utilisation de ceux-ci |
AU2007209201A1 (en) | 2006-01-24 | 2007-08-02 | Domantis Limited | Fusion proteins that contain natural junctions |
GB0621513D0 (en) | 2006-10-30 | 2006-12-06 | Domantis Ltd | Novel polypeptides and uses thereof |
CA2688433A1 (fr) | 2007-06-06 | 2008-12-11 | Domantis Limited | Procede de selection de polypeptides resistant aux proteases |
GB0724331D0 (en) | 2007-12-13 | 2008-01-23 | Domantis Ltd | Compositions for pulmonary delivery |
KR20110092328A (ko) | 2008-11-26 | 2011-08-17 | 글락소 그룹 리미티드 | Il-13에 결합하는 리간드 |
US20110301335A1 (en) * | 2009-02-19 | 2011-12-08 | Stephen Duffield | Anti-tnfr1 polypeptides, antibody variable domains & antagonists |
PE20120170A1 (es) | 2009-02-19 | 2012-03-21 | Glaxo Group Ltd | Variantes de union a anti-albumina de suero mejoradas |
US20120107330A1 (en) * | 2009-07-16 | 2012-05-03 | Adriaan Allart Stoop | Antagonists, uses & methods for partially inhibiting tnfr1 |
US20120276098A1 (en) * | 2009-09-30 | 2012-11-01 | Bruce Hamilton | Drug fusions and conjugates with extended half life |
CA2796932A1 (fr) * | 2010-04-21 | 2011-10-27 | Glaxo Group Limited | Domaines de liaison |
-
2010
- 2010-02-17 CN CN201080017241.7A patent/CN102405233B/zh active Active
- 2010-02-17 CA CA2767752A patent/CA2767752C/fr active Active
- 2010-02-17 US US13/202,353 patent/US9534043B2/en active Active
- 2010-02-17 ES ES10706187.1T patent/ES2655071T3/es active Active
- 2010-02-17 CA CA3079184A patent/CA3079184A1/fr not_active Abandoned
- 2010-02-17 EP EP17194953.0A patent/EP3330287B1/fr active Active
- 2010-02-17 MA MA34104A patent/MA33051B1/fr unknown
- 2010-02-17 MX MX2011008749A patent/MX2011008749A/es not_active Application Discontinuation
- 2010-02-17 NZ NZ595242A patent/NZ595242A/xx not_active IP Right Cessation
- 2010-02-17 ES ES17194953T patent/ES2774192T3/es active Active
- 2010-02-17 KR KR1020117021611A patent/KR101819754B1/ko active IP Right Grant
- 2010-02-17 EA EA201171068A patent/EA028178B1/ru not_active IP Right Cessation
- 2010-02-17 JP JP2011550554A patent/JP5759391B2/ja active Active
- 2010-02-17 AR ARP100100460A patent/AR075505A1/es not_active Application Discontinuation
- 2010-02-17 WO PCT/EP2010/052008 patent/WO2010094723A2/fr active Application Filing
- 2010-02-17 EP EP10706187.1A patent/EP2398826B1/fr active Active
- 2010-02-17 AU AU2010215482A patent/AU2010215482B2/en not_active Ceased
- 2010-02-17 UY UY0001032450A patent/UY32450A/es not_active Application Discontinuation
- 2010-02-17 EP EP19216528.0A patent/EP3656788A3/fr not_active Withdrawn
- 2010-02-17 PE PE2011001432A patent/PE20120001A1/es not_active Application Discontinuation
- 2010-02-17 BR BRPI1013341-0A patent/BRPI1013341B1/pt active IP Right Grant
- 2010-02-17 SG SG2011055357A patent/SG173489A1/en unknown
- 2010-02-22 TW TW099105020A patent/TW201042039A/zh unknown
-
2011
- 2011-08-01 ZA ZA2011/05657A patent/ZA201105657B/en unknown
- 2011-08-04 IL IL214480A patent/IL214480A0/en unknown
- 2011-08-18 CL CL2011002025A patent/CL2011002025A1/es unknown
- 2011-08-19 DO DO2011000266A patent/DOP2011000266A/es unknown
- 2011-08-30 CO CO11111121A patent/CO6410311A2/es not_active Application Discontinuation
-
2015
- 2015-06-05 JP JP2015114985A patent/JP6100315B2/ja active Active
-
2017
- 2017-02-02 US US15/363,223 patent/US10696738B2/en active Active
-
2018
- 2018-06-07 HK HK18107445.6A patent/HK1247944A1/zh unknown
-
2020
- 2020-05-20 US US16/879,238 patent/US20200283512A1/en not_active Abandoned
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