MA32376B1 - VACCIN CONTRE LA LEISHMANIOSE UTILISANT UN IMMUNOGèNE SALIVAIRE DE PHLÉBOTOME - Google Patents

VACCIN CONTRE LA LEISHMANIOSE UTILISANT UN IMMUNOGèNE SALIVAIRE DE PHLÉBOTOME

Info

Publication number
MA32376B1
MA32376B1 MA33392A MA33392A MA32376B1 MA 32376 B1 MA32376 B1 MA 32376B1 MA 33392 A MA33392 A MA 33392A MA 33392 A MA33392 A MA 33392A MA 32376 B1 MA32376 B1 MA 32376B1
Authority
MA
Morocco
Prior art keywords
leishmaniasis
immunosuppressant
fever
vaccine
longipalpis
Prior art date
Application number
MA33392A
Other languages
Arabic (ar)
English (en)
Inventor
Laurent Bernard Fischer
Jesus G Valenzuela
Original Assignee
Merial Ltd
Gov Of The Usa As Represented By The Secretary Of The Dept Of Health & Humain Services
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merial Ltd, Gov Of The Usa As Represented By The Secretary Of The Dept Of Health & Humain Services filed Critical Merial Ltd
Publication of MA32376B1 publication Critical patent/MA32376B1/fr

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/43504Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates
    • C07K14/43563Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates from insects
    • C07K14/43577Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates from insects from flies
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/0003Invertebrate antigens
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00Antiparasitic agents
    • A61P33/02Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/51Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/53DNA (RNA) vaccination
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/58Medicinal preparations containing antigens or antibodies raising an immune response against a target which is not the antigen used for immunisation
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02ATECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Insects & Arthropods (AREA)
  • Zoology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Epidemiology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Toxicology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Immunology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

La présente invention concerne des vecteurs qui contiennent et expriment in vivo ou in vitro des antigènes salivaires du phlébotome lu. Longipalpis capables de susciter une réponse immunitaire contre la leishmaniose chez l'animal ou l'être humain, des compositions vaccinales comprenant lesdits vecteurs et/ou des polypeptides salivaires de lu. Longipalpis, des procédés de vaccination contre la leishmaniose et des nécessaires à utiliser avec lesdits procédés et compositions.
MA33392A 2008-05-08 2010-12-03 VACCIN CONTRE LA LEISHMANIOSE UTILISANT UN IMMUNOGèNE SALIVAIRE DE PHLÉBOTOME MA32376B1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US5163508P 2008-05-08 2008-05-08
US10134508P 2008-09-30 2008-09-30
PCT/US2009/042980 WO2009137577A2 (fr) 2008-05-08 2009-05-06 Vaccin contre la leishmaniose utilisant un immunogène salivaire de phlébotome

Publications (1)

Publication Number Publication Date
MA32376B1 true MA32376B1 (fr) 2011-06-01

Family

ID=41110966

Family Applications (1)

Application Number Title Priority Date Filing Date
MA33392A MA32376B1 (fr) 2008-05-08 2010-12-03 VACCIN CONTRE LA LEISHMANIOSE UTILISANT UN IMMUNOGèNE SALIVAIRE DE PHLÉBOTOME

Country Status (11)

Country Link
US (2) US8603808B2 (fr)
EP (2) EP2283035B1 (fr)
CN (2) CN103768588A (fr)
AR (1) AR071696A1 (fr)
BR (1) BRPI0915605B8 (fr)
ES (1) ES2760004T3 (fr)
HK (1) HK1150616A1 (fr)
IL (1) IL209107A (fr)
MA (1) MA32376B1 (fr)
MX (2) MX348137B (fr)
WO (1) WO2009137577A2 (fr)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103768588A (zh) * 2008-05-08 2014-05-07 梅里亚有限公司 使用白蛉唾液免疫原的利什曼原虫疫苗
AU2013308623B2 (en) 2012-08-30 2017-03-02 Merial, Inc. Hyperbaric device and methods for producing inactivated vaccines and for refolding/solubilizing recombinant proteins
WO2014100073A2 (fr) * 2012-12-21 2014-06-26 Merck Sharp & Dohme Corp. Vecteurs d'expression utilisables en vue de la production de protéines recombinées dans des cellules de mammifère
EP3215188A1 (fr) 2014-11-03 2017-09-13 Merial, Inc. Procédés d'utilisation de formulations de vaccin par micro-aiguilles pour éliciter une immunité de protection contre le virus de la rage chez les animaux
UY37753A (es) 2017-06-02 2018-11-30 Amgen Inc Antagonistas de péptido pac1
CN113337542A (zh) * 2021-06-10 2021-09-03 山西大学 高效表达利什曼原虫pepck的人复制缺陷型重组腺病毒载体

Family Cites Families (61)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2909462A (en) 1955-12-08 1959-10-20 Bristol Myers Co Acrylic acid polymer laxative compositions
US5505941A (en) 1981-12-24 1996-04-09 Health Research, Inc. Recombinant avipox virus and method to induce an immune response
US5174993A (en) 1981-12-24 1992-12-29 Health Research Inc. Recombinant avipox virus and immunological use thereof
US5338683A (en) 1981-12-24 1994-08-16 Health Research Incorporated Vaccinia virus containing DNA sequences encoding herpesvirus glycoproteins
US4769330A (en) 1981-12-24 1988-09-06 Health Research, Incorporated Modified vaccinia virus and methods for making and using the same
US4603112A (en) 1981-12-24 1986-07-29 Health Research, Incorporated Modified vaccinia virus
US4722848A (en) 1982-12-08 1988-02-02 Health Research, Incorporated Method for immunizing animals with synthetically modified vaccinia virus
US5833975A (en) 1989-03-08 1998-11-10 Virogenetics Corporation Canarypox virus expressing cytokine and/or tumor-associated antigen DNA sequence
US5110587A (en) 1981-12-24 1992-05-05 Health Research, Incorporated Immunogenic composition comprising synthetically modified vaccinia virus
US4745051A (en) 1983-05-27 1988-05-17 The Texas A&M University System Method for producing a recombinant baculovirus expression vector
EP0173552B1 (fr) 1984-08-24 1991-10-09 The Upjohn Company Composés recombinants d'ADN et l'expression de polypeptides comme le tPA
US5168062A (en) 1985-01-30 1992-12-01 University Of Iowa Research Foundation Transfer vectors and microorganisms containing human cytomegalovirus immediate-early promoter-regulatory DNA sequence
US4963481A (en) 1985-12-18 1990-10-16 Genetics Institute Inc Promoter system
US4968615A (en) 1985-12-18 1990-11-06 Ciba-Geigy Corporation Deoxyribonucleic acid segment from a virus
NZ221790A (en) 1986-09-12 1990-07-26 Genentech Inc Method for the continuous production of a heterologous protein in a eukaryotic host cell
IL84154A0 (en) 1986-10-16 1988-03-31 Microgenesys Inc Polypeptides derived from the envelope gene of human immunodeficiency virus in recombinant baculovirus infected insect cells and vaccines against acquired immune deficiency syndrome containing the same
GB8717430D0 (en) 1987-07-23 1987-08-26 Celltech Ltd Recombinant dna product
DE3743138A1 (de) 1987-12-18 1989-09-14 Mayr Christian Gmbh & Co Kg Schleifringlose, elektromagnetische ueberlastkupplung
CA2003300A1 (fr) 1988-11-21 1990-05-21 Franklin Volvovitz Cutireaction et trousse pour le depistage du sida
US6780407B1 (en) 1989-03-08 2004-08-24 Aventis Pasteur Pox virus comprising DNA sequences encoding CEA and B7 antigen
JP3602530B2 (ja) 1991-03-07 2004-12-15 ヴァイロジェネティクス コーポレイション 遺伝子操作したワクチン菌株
US5843456A (en) 1991-03-07 1998-12-01 Virogenetics Corporation Alvac poxvirus-rabies compositions and combination compositions and uses
US6133028A (en) 1993-05-28 2000-10-17 Transgene S.A. Defective adenoviruses and corresponding complementation lines
FR2712603B1 (fr) 1993-11-18 1996-02-09 Centre Nat Rech Scient Virus recombinants, préparation et utilisation en thérapie génique.
US5529780A (en) 1994-03-30 1996-06-25 Virogenetics Corporation Nucleotide and amino acid sequences of canine herpesvirus gB and gC
EP0826063A1 (fr) 1995-04-25 1998-03-04 Vical Incorporated Formulations en ampoule unidose de complexes adn/lipides
EP0803573A1 (fr) 1996-04-25 1997-10-29 Gesellschaft für Biotechnologische Forschung mbH (GBF) Construction pour l'expression polycistronique contenant des cytokines pour des vaccins multivalents
US5846946A (en) 1996-06-14 1998-12-08 Pasteur Merieux Serums Et Vaccins Compositions and methods for administering Borrelia DNA
FR2750865B1 (fr) 1996-06-27 1998-12-04 Rhone Merieux Vaccin vivant recombinant a base d'herpesvirus canin, notamment contre la maladie de carre, la rage ou le virus parainfluenza de type 2
US6156567A (en) 1996-07-03 2000-12-05 Merial Truncated transcriptionally active cytomegalovirus promoters
US6090393A (en) 1996-07-03 2000-07-18 Merial Recombinant canine adenoviruses, method for making and uses thereof
WO1998000166A1 (fr) 1996-07-03 1998-01-08 Merial, Inc. ADENOVIRUS CANIN DE RECOMBINAISON (ACR) CONTENANT DE l'ADN EXOGENE
FR2775601B1 (fr) 1998-03-03 2001-09-21 Merial Sas Vaccins vivants recombines et adjuves
FR2776928B1 (fr) 1998-04-03 2000-06-23 Merial Sas Vaccins adn adjuves
TWI224107B (en) 1998-10-22 2004-11-21 Pfizer Prod Inc Novel proteins from actinobacillus pleuropneumoniae
US6017537A (en) 1998-12-18 2000-01-25 Connaught Laboratories, Inc. Formyl methionyl peptide vaccine adjuvant
US6645740B1 (en) 1999-06-10 2003-11-11 Merial Limited Nucleic acids encodings equine GM-CSF
FR2796397B1 (fr) 1999-07-16 2006-09-01 Merial Sas Genes de calicivirus felin et vaccins notamment vaccins recombines
AP1775A (en) 1999-09-25 2007-08-28 Univ Iowa Res Found Immunostimulatory nucleic acids.
US6852705B2 (en) 2000-01-21 2005-02-08 Merial DNA vaccines for farm animals, in particular bovines and porcines
EP1203819A3 (fr) 2000-10-06 2002-08-07 Transgene S.A. Vecteurs anti-inflammatoires
IL159463A0 (en) * 2001-06-19 2004-06-01 Us Gov Health & Human Serv Anti-arthropod vector vaccines methods of selecting and use thereof
FR2829498B1 (fr) 2001-09-11 2003-11-28 Merial Sas Igf-1 comme adjuvant de vaccin felin, notamment contre les retrovirus felins
WO2003062374A2 (fr) 2001-11-09 2003-07-31 Entremed, Inc. Genes de synthese de proteines de la malaria et leurs procedes d'utilisation
WO2004024027A2 (fr) 2002-06-07 2004-03-25 University Of Florida Limes endodontiques fabriquees au moyen de verres metalliques en vrac
WO2004039958A2 (fr) * 2002-10-29 2004-05-13 The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Polypeptides de lutzomyia longipalpis et methodes d'utilisation desdits polypeptides
ES2298829T3 (es) * 2003-10-24 2008-05-16 Mologen Ag Agente para el tratamiento de infecciones por leishmania.
US7582302B2 (en) 2004-06-04 2009-09-01 Merial Limited Needle-free administration of FeLV vaccines
US7512883B2 (en) * 2004-06-30 2009-03-31 Microsoft Corporation Portable solution for automatic camera management
CA2540736A1 (fr) * 2005-04-08 2006-10-08 Institut Pasteur Polypeptides de leishmania major et polynucleotides les encodant, applications vaccinales, therapeutiques et diagnostiques de ceux-ci
EP2086580A2 (fr) * 2006-11-21 2009-08-12 Merial Limited Vaccin contre la leishmania canine
WO2009017689A2 (fr) * 2007-08-02 2009-02-05 Government Of The U. S. A., As Represented By The Secretary, Dept. Of Health And Human Services Procédés de détection et de prévention d'une infestation de tiques et d'une transmission de pathogènes
CN103768588A (zh) * 2008-05-08 2014-05-07 梅里亚有限公司 使用白蛉唾液免疫原的利什曼原虫疫苗
EP2300051B1 (fr) * 2008-05-21 2014-11-12 Infectious Disease Research Institute Vaccins polyprotéiques recombinants destinés au traitement et au diagnostic de la leishmaniose
US8410258B2 (en) * 2008-05-21 2013-04-02 Infections Disease Research Institute Recombinant polyprotein vaccines for the treatment and diagnosis of leishmaniasis
WO2010078469A2 (fr) * 2008-12-31 2010-07-08 The Usa As Represented By The Secretary, Department Of Health And Human Services Protéines salivaires de phlébotome en tant que nouveaux inhibiteurs du facteur xa et procédés d'utilisation
WO2010078466A2 (fr) * 2008-12-31 2010-07-08 The United States Of America, As Represented By The Secretary, Dept. Of Health And Human Services Protéines salivaires de phlébotome avec une activité anticomplément et leurs procédés d'utilisation
US9226958B2 (en) * 2010-10-01 2016-01-05 University Of Georgia Research Foundation, Inc. Use of Listeria vaccine vectors to reverse vaccine unresponsiveness in parasitically infected individuals
US8414882B2 (en) * 2010-11-18 2013-04-09 Merial Limited Leishmania challenge model
BR112014001086A2 (pt) * 2011-07-21 2017-02-21 Consejo Superior De Investig Cientificas/Csic molécula quimérica útil na imunoterapia contra a leishmaniose, a qual compreende um fragmento da proteína pfr1 de leishmania infantum com epítopos específicos imunodominantes
US8916371B2 (en) * 2012-03-20 2014-12-23 Merial Limited Recombinant equine herpesvirus-1 vaccine containing mutated glycoprotein C and uses thereof

Also Published As

Publication number Publication date
US9228002B2 (en) 2016-01-05
EP2283035B1 (fr) 2015-07-29
MX2010012069A (es) 2010-12-14
US8603808B2 (en) 2013-12-10
EP2899203A2 (fr) 2015-07-29
IL209107A (en) 2017-08-31
ES2760004T3 (es) 2020-05-12
BRPI0915605B1 (pt) 2021-08-24
HK1150616A1 (zh) 2012-01-06
BRPI0915605B8 (pt) 2021-09-08
BRPI0915605A2 (pt) 2016-02-02
WO2009137577A3 (fr) 2010-03-25
EP2283035A2 (fr) 2011-02-16
CN103768588A (zh) 2014-05-07
US20090324649A1 (en) 2009-12-31
WO2009137577A2 (fr) 2009-11-12
EP2899203A3 (fr) 2015-08-05
MX348137B (es) 2017-05-29
IL209107A0 (en) 2011-01-31
AR071696A1 (es) 2010-07-07
US20140294875A1 (en) 2014-10-02
EP2899203B1 (fr) 2019-07-10
CN102066411A (zh) 2011-05-18

Similar Documents

Publication Publication Date Title
EA201070329A1 (ru) Векторы и конструкции для доставки гриппозного антигена
MA32376B1 (fr) VACCIN CONTRE LA LEISHMANIOSE UTILISANT UN IMMUNOGèNE SALIVAIRE DE PHLÉBOTOME
WO2005099752A3 (fr) Vecteurs et constructions d'administration d'antigenes
EP2517557A3 (fr) Modèles animaux et molécules thérapeutiques
MY154956A (en) Chimeric adenoviral vectors
EA200702532A1 (ru) Антитела против мср-1, композиции, способы и применения
UA101301C2 (ru) ВЫДЕЛЕННОЕ АНТИТЕЛО ПРОТИВ IL-23pl 9 И ЕГО ПРИМЕНЕНИЕ
MA31231B1 (fr) Anticorps anti-robo4 et utilisations de ceux-ci
CY1120430T1 (el) Ανασυνδυασμενες cdv συνθεσεις και χρησεις αυτων
MX2009006594A (es) Formulaciones de ph regulado y estables que contienen polipeptidos.
EA200701362A1 (ru) Агонисты glp-1, композиции, способы и применения
HN2012001223A (es) Antagonistas de pcsk 9
TR201000668T1 (tr) Neoplasti̇k veya enfeksi̇yoz bozukluklara yöneli̇k i̇mmunoprofi̇laksi̇ veya i̇mmünoterapi̇ i̇çi̇n poli̇pepti̇d-nüklei̇k asi̇t konjugati
WO2009133378A3 (fr) Produits et procédés permettant de stimuler une réponse immunitaire
SV2006002513A (es) Anticuerpos anti-il-6, composiciones, metodos y usos ref. docket cen5094svnp
MA33208B1 (fr) Anticorps anti-fgfr3 et procédés d'utilisation de ceux-ci
WO2006090389A3 (fr) Nouveaux marqueurs diagnostiques, en particulier pour l'imagerie in vivo, et dosage et procedes d'utilisation associes
WO2008103819A3 (fr) Pseudo-particules virales (vlp) chimériques de la maladie de newcastle
MA31014B1 (fr) Vaccin contre la leishmania canine.
CL2011002994A1 (es) Construccion de proteina que comprende polipeptido casb7439; composicion inmunogenica que comprende dicha construccion; uso de la composicion porque sirve para inducir respuesta inmunitaria al casb7439 en un animal.
MA32770B1 (fr) Anticorps anti-peptides igf-1/e humain modifie
EA201100674A1 (ru) Вакцина против вируса африканской чумы лошадей
WO2006117538A3 (fr) Dosages et leur utilisation
EP1858548A4 (fr) Compositions de peptides de hsp60 et d'antigènes viraux utiles à des fins de vaccination et de diagnostic
IN2014CN00547A (fr)