BRPI0915605B8 - Vacina de leishmania usando imunógeno salivar de mosca tipo borrachudo - Google Patents

Vacina de leishmania usando imunógeno salivar de mosca tipo borrachudo

Info

Publication number
BRPI0915605B8
BRPI0915605B8 BRPI0915605A BRPI0915605B8 BR PI0915605 B8 BRPI0915605 B8 BR PI0915605B8 BR PI0915605 A BRPI0915605 A BR PI0915605A BR PI0915605 B8 BRPI0915605 B8 BR PI0915605B8
Authority
BR
Brazil
Prior art keywords
immunogen
fly salivary
leishmania vaccine
rubber
rubber fly
Prior art date
Application number
Other languages
English (en)
Inventor
Laurent Bernard Fischer
Jesus G Valenzuela
Original Assignee
The Government Of The Us Secretary Of The Dept Of Healt & Human Services
Merial Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by The Government Of The Us Secretary Of The Dept Of Healt & Human Services, Merial Inc filed Critical The Government Of The Us Secretary Of The Dept Of Healt & Human Services
Publication of BRPI0915605A2 publication Critical patent/BRPI0915605A2/pt
Publication of BRPI0915605B1 publication Critical patent/BRPI0915605B1/pt
Publication of BRPI0915605B8 publication Critical patent/BRPI0915605B8/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/43504—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates
    • C07K14/43563—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates from insects
    • C07K14/43577—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates from insects from flies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/0003—Invertebrate antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/53—DNA (RNA) vaccination
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/58—Medicinal preparations containing antigens or antibodies raising an immune response against a target which is not the antigen used for immunisation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Insects & Arthropods (AREA)
  • Zoology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Epidemiology (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Immunology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
BRPI0915605-4 2008-05-08 2009-05-06 Vacina de leishmania usando imunógeno salivar de mosca tipo borrachudo BRPI0915605B8 (pt)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US5163508P 2008-05-08 2008-05-08
US61/051,635 2008-05-08
US10134508P 2008-09-30 2008-09-30
US61/101,345 2008-09-30
PCT/US2009/042980 WO2009137577A2 (en) 2008-05-08 2009-05-06 Leishmania vaccine using sand fly salivary immunogen

Publications (3)

Publication Number Publication Date
BRPI0915605A2 BRPI0915605A2 (pt) 2016-02-02
BRPI0915605B1 BRPI0915605B1 (pt) 2021-08-24
BRPI0915605B8 true BRPI0915605B8 (pt) 2021-09-08

Family

ID=41110966

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0915605-4 BRPI0915605B8 (pt) 2008-05-08 2009-05-06 Vacina de leishmania usando imunógeno salivar de mosca tipo borrachudo

Country Status (11)

Country Link
US (2) US8603808B2 (pt)
EP (2) EP2283035B1 (pt)
CN (2) CN103768588A (pt)
AR (1) AR071696A1 (pt)
BR (1) BRPI0915605B8 (pt)
ES (1) ES2760004T3 (pt)
HK (1) HK1150616A1 (pt)
IL (1) IL209107A (pt)
MA (1) MA32376B1 (pt)
MX (2) MX2010012069A (pt)
WO (1) WO2009137577A2 (pt)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX2010012069A (es) * 2008-05-08 2010-12-14 Merial Ltd Vacuna de la leishmaniasis con el uso del inmunogeno salival de la mosca de la arena.
CA2883296A1 (en) 2012-08-30 2014-03-06 Merial, Inc. Hyperbaric device and methods for producing inactivated vaccines and for refolding/solubilizing recombinant proteins
WO2014100073A2 (en) * 2012-12-21 2014-06-26 Merck Sharp & Dohme Corp. Expression vectors for recombinant protein production in mammalian cells
CA2966191A1 (en) 2014-11-03 2016-05-12 Merial, Inc. Methods of using microneedle vaccine formulations to elicit in animals protective immunity against rabies virus
AR111842A1 (es) 2017-06-02 2019-08-21 Amgen Inc Antagonistas de péptido pac1
CN113337542A (zh) * 2021-06-10 2021-09-03 山西大学 高效表达利什曼原虫pepck的人复制缺陷型重组腺病毒载体

Family Cites Families (61)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2909462A (en) 1955-12-08 1959-10-20 Bristol Myers Co Acrylic acid polymer laxative compositions
US4722848A (en) 1982-12-08 1988-02-02 Health Research, Incorporated Method for immunizing animals with synthetically modified vaccinia virus
US5338683A (en) 1981-12-24 1994-08-16 Health Research Incorporated Vaccinia virus containing DNA sequences encoding herpesvirus glycoproteins
US5505941A (en) 1981-12-24 1996-04-09 Health Research, Inc. Recombinant avipox virus and method to induce an immune response
US5833975A (en) 1989-03-08 1998-11-10 Virogenetics Corporation Canarypox virus expressing cytokine and/or tumor-associated antigen DNA sequence
US4769330A (en) 1981-12-24 1988-09-06 Health Research, Incorporated Modified vaccinia virus and methods for making and using the same
US5174993A (en) 1981-12-24 1992-12-29 Health Research Inc. Recombinant avipox virus and immunological use thereof
US5110587A (en) 1981-12-24 1992-05-05 Health Research, Incorporated Immunogenic composition comprising synthetically modified vaccinia virus
US4603112A (en) 1981-12-24 1986-07-29 Health Research, Incorporated Modified vaccinia virus
US4745051A (en) 1983-05-27 1988-05-17 The Texas A&M University System Method for producing a recombinant baculovirus expression vector
EP0173552B1 (en) 1984-08-24 1991-10-09 The Upjohn Company Recombinant dna compounds and the expression of polypeptides such as tpa
US5168062A (en) 1985-01-30 1992-12-01 University Of Iowa Research Foundation Transfer vectors and microorganisms containing human cytomegalovirus immediate-early promoter-regulatory DNA sequence
US4963481A (en) 1985-12-18 1990-10-16 Genetics Institute Inc Promoter system
US4968615A (en) 1985-12-18 1990-11-06 Ciba-Geigy Corporation Deoxyribonucleic acid segment from a virus
NZ221790A (en) 1986-09-12 1990-07-26 Genentech Inc Method for the continuous production of a heterologous protein in a eukaryotic host cell
IL84154A0 (en) 1986-10-16 1988-03-31 Microgenesys Inc Polypeptides derived from the envelope gene of human immunodeficiency virus in recombinant baculovirus infected insect cells and vaccines against acquired immune deficiency syndrome containing the same
GB8717430D0 (en) 1987-07-23 1987-08-26 Celltech Ltd Recombinant dna product
DE3743138A1 (de) 1987-12-18 1989-09-14 Mayr Christian Gmbh & Co Kg Schleifringlose, elektromagnetische ueberlastkupplung
CA2003300A1 (en) 1988-11-21 1990-05-21 Franklin Volvovitz Skin test and test kit for aids
US6780407B1 (en) 1989-03-08 2004-08-24 Aventis Pasteur Pox virus comprising DNA sequences encoding CEA and B7 antigen
US5843456A (en) 1991-03-07 1998-12-01 Virogenetics Corporation Alvac poxvirus-rabies compositions and combination compositions and uses
KR100242671B1 (ko) 1991-03-07 2000-03-02 고돈 에릭 유전학적으로 처리한 백신 균주
US6133028A (en) 1993-05-28 2000-10-17 Transgene S.A. Defective adenoviruses and corresponding complementation lines
FR2712603B1 (fr) 1993-11-18 1996-02-09 Centre Nat Rech Scient Virus recombinants, préparation et utilisation en thérapie génique.
US5529780A (en) 1994-03-30 1996-06-25 Virogenetics Corporation Nucleotide and amino acid sequences of canine herpesvirus gB and gC
JPH11504631A (ja) 1995-04-25 1999-04-27 バイカル インコーポレイテッド Ｄｎａ／脂質複合体の単一バイアル製剤
EP0803573A1 (en) 1996-04-25 1997-10-29 Gesellschaft für Biotechnologische Forschung mbH (GBF) Polycistronic expression construct with cytokines for multivalent vaccines
US5846946A (en) 1996-06-14 1998-12-08 Pasteur Merieux Serums Et Vaccins Compositions and methods for administering Borrelia DNA
FR2750865B1 (fr) 1996-06-27 1998-12-04 Rhone Merieux Vaccin vivant recombinant a base d'herpesvirus canin, notamment contre la maladie de carre, la rage ou le virus parainfluenza de type 2
US6090393A (en) 1996-07-03 2000-07-18 Merial Recombinant canine adenoviruses, method for making and uses thereof
US6156567A (en) 1996-07-03 2000-12-05 Merial Truncated transcriptionally active cytomegalovirus promoters
JP2002512501A (ja) 1996-07-03 2002-04-23 メリアル インコーポレイテッド 外来性ｄｎａを含む組換えイヌアデノウィルス（ｃａｖ）
FR2775601B1 (fr) 1998-03-03 2001-09-21 Merial Sas Vaccins vivants recombines et adjuves
FR2776928B1 (fr) 1998-04-03 2000-06-23 Merial Sas Vaccins adn adjuves
TWI224107B (en) 1998-10-22 2004-11-21 Pfizer Prod Inc Novel proteins from actinobacillus pleuropneumoniae
US6017537A (en) 1998-12-18 2000-01-25 Connaught Laboratories, Inc. Formyl methionyl peptide vaccine adjuvant
US6645740B1 (en) 1999-06-10 2003-11-11 Merial Limited Nucleic acids encodings equine GM-CSF
FR2796397B1 (fr) 1999-07-16 2006-09-01 Merial Sas Genes de calicivirus felin et vaccins notamment vaccins recombines
RU2245149C2 (ru) 1999-09-25 2005-01-27 Юниверсити Оф Айова Рисерч Фаундейшн Иммуностимулирующие нуклеиновые кислоты
US6852705B2 (en) 2000-01-21 2005-02-08 Merial DNA vaccines for farm animals, in particular bovines and porcines
EP1203819A3 (en) 2000-10-06 2002-08-07 Transgene S.A. Anti-inflammatory vectors
AU2002347464A1 (en) * 2001-06-19 2003-01-02 The Gouvernment Of The United States Of America, As Represented By The Secretary Department Of Healt Anti-arthropod vector vaccines methods of selecting and uses thereof
FR2829498B1 (fr) 2001-09-11 2003-11-28 Merial Sas Igf-1 comme adjuvant de vaccin felin, notamment contre les retrovirus felins
WO2003062374A2 (en) 2001-11-09 2003-07-31 Entremed, Inc. Synthetic genes for malarial proteins and methods of use
AU2003245416A1 (en) 2002-06-07 2004-04-30 University Of Florida Endodontic files made using bulk metallic glasses
US7485306B2 (en) * 2002-10-29 2009-02-03 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Lutzomyia longipalpis polypeptides and methods of use
DE502004005784D1 (de) * 2003-10-24 2008-02-07 Mologen Ag Mittel zur behandlung von infektionen mit leishmanien
CA2570156C (en) 2004-06-04 2014-09-30 Merial Limited Needle-free administration of felv vaccines
US7512883B2 (en) * 2004-06-30 2009-03-31 Microsoft Corporation Portable solution for automatic camera management
CA2540736A1 (en) * 2005-04-08 2006-10-08 Institut Pasteur Polypeptides of leishmania major and polynucleotides encoding same and vaccinal, therapeutical and diagnostic applications thereof
WO2008064181A2 (en) 2006-11-21 2008-05-29 Merial Limited Prime boost canine leishmania vaccine
WO2009017689A2 (en) * 2007-08-02 2009-02-05 Government Of The U. S. A., As Represented By The Secretary, Dept. Of Health And Human Services Methods for detection and prevention of tick infestation and pathogen transmission
MX2010012069A (es) * 2008-05-08 2010-12-14 Merial Ltd Vacuna de la leishmaniasis con el uso del inmunogeno salival de la mosca de la arena.
US8410258B2 (en) * 2008-05-21 2013-04-02 Infections Disease Research Institute Recombinant polyprotein vaccines for the treatment and diagnosis of leishmaniasis
BRPI0912768A2 (pt) * 2008-05-21 2016-05-17 Infectious Disease Res Inst vacinas de poliproteínas recombinante para o tratamento e diagnóstico de leishmaniose
WO2010078469A2 (en) * 2008-12-31 2010-07-08 The Usa As Represented By The Secretary, Department Of Health And Human Services Sand fly salivary proteins as novel factor xa inhibitors and methods of use
WO2010078466A2 (en) * 2008-12-31 2010-07-08 The United States Of America, As Represented By The Secretary, Dept. Of Health And Human Services Sand fly salivary proteins with anti-complement activity and methods of their use
WO2012138377A2 (en) * 2010-10-01 2012-10-11 Trustees Of The University Of Pennsylvania The use of listeria vaccine vectors to reverse vaccine unresponsiveness in parasitically infected individuals
MX350099B (es) * 2010-11-18 2017-08-25 Us Gov Health & Human Services Modelo de estimulación canino para leishmania mediante picaduras de moscas de arena.
BR112014001086A2 (pt) * 2011-07-21 2017-02-21 Consejo Superior De Investig Cientificas/Csic molécula quimérica útil na imunoterapia contra a leishmaniose, a qual compreende um fragmento da proteína pfr1 de leishmania infantum com epítopos específicos imunodominantes
WO2013142371A1 (en) * 2012-03-20 2013-09-26 Merial Limited Recombinant equine herpesvirus-1 vaccine containing mutated glycoprotein c and uses thereof

Also Published As

Publication number Publication date
BRPI0915605B1 (pt) 2021-08-24
US20090324649A1 (en) 2009-12-31
CN103768588A (zh) 2014-05-07
MA32376B1 (fr) 2011-06-01
EP2899203A2 (en) 2015-07-29
WO2009137577A3 (en) 2010-03-25
HK1150616A1 (zh) 2012-01-06
ES2760004T3 (es) 2020-05-12
IL209107A0 (en) 2011-01-31
EP2283035A2 (en) 2011-02-16
MX348137B (es) 2017-05-29
EP2283035B1 (en) 2015-07-29
US9228002B2 (en) 2016-01-05
EP2899203B1 (en) 2019-07-10
BRPI0915605A2 (pt) 2016-02-02
WO2009137577A2 (en) 2009-11-12
EP2899203A3 (en) 2015-08-05
MX2010012069A (es) 2010-12-14
US8603808B2 (en) 2013-12-10
IL209107A (en) 2017-08-31
CN102066411A (zh) 2011-05-18
AR071696A1 (es) 2010-07-07
US20140294875A1 (en) 2014-10-02

Similar Documents

Publication Publication Date Title
BRPI0911604A2 (pt) vacinas de polipeptídeo de flagelina
NO20084470L (no) Tradlos fjernstyring for sementhode
BRPI0917623A2 (pt) dispositivo de interface respiratória
BRPI1005289A2 (pt) cabeça de cimentar
DK2114993T3 (da) Vaccine
BRPI0918097A2 (pt) dispositivo respiratório de interface
BRPI0917205A2 (pt) vacina polivalente
BRPI0923006A2 (pt) vacinas meningococicas incluindo receptor de hemoglobina
BRPI0920630A2 (pt) vacina combinada com pertússis acelular
BRPI0920240A2 (pt) formulação de adjuvante de combinação
FI20095051A (fi) Optinen sääanturi
BRPI0906734A2 (pt) Dispositivo de virola
BRPI0915605B8 (pt) Vacina de leishmania usando imunógeno salivar de mosca tipo borrachudo
BRPI0921578A2 (pt) vacinas unitemporais
FI20095837A (fi) Lähellä maata oleva valo-opaste
DE112009001149A5 (de) Fernoptisches Beobachtungsgerät
DK2175881T3 (da) Intradermal influenzavaccine
DE112009000421A5 (de) Klauenpolmotor
BRPI0918719A2 (pt) vacina contra nematódeos
ES1067504Y (es) Recolector de excrementos caninos
BRPI0908197A2 (pt) antígenos recombinantes
ITMI20080051U1 (it) "vaso"
TH100474B (th) ของเล่น(รถหัดเดิน)
TH111728B (th) องค์ประกอบยาง
TH136411B (th) เส้นใยขัดฟัน

Legal Events

Date Code Title Description
B15I Others concerning applications: loss of priority

Free format text: PERDA DAS PRIORIDADES US 61/051,635 DE 08/05/2008 E US 61/101,345 DE 30/09/2008 REIVINDICADAS NO PCT/US2009/042980, CONFORME AS DISPOSICOES PREVISTAS NA LEI 9.279 DE 14/05/1996 (LPI) ART. 16 7O, ITEM 28 DO ATO NORMATIVO 128/97 E NO ART. 29 DA RESOLUCAO INPI-PR 77/2013. ESTA PERDA SE DEU PELO FATO DE O DEPOSITANTE CONSTANTE DA PETICAO DE REQUERIMENTO DO PEDIDO PCT SER DISTINTO DAQUELE QUE DEPOSITOU A PRIORIDADE REIVINDICADA E NAO APRESENTOU DOCUMENTO COMPROBATORIO DE CESSAO, CONFORME AS DISPOSICOES PREVISTAS NA LEI 9.279 DE 14/05/1996 (LPI) ART. 16 6O, ITEM 27 DO ATO NORMATIVO 128/97 E NO ART. 28 DA RESOLUCAO INPI-PR 77/2013.

B12F Other appeals [chapter 12.6 patent gazette]
B25C Requirement related to requested transfer of rights

Owner name: THE GOVERNMENT OF THE UNITED STATES OF AMERICA AS

B25A Requested transfer of rights approved

Owner name: THE GOVERNMENT OF THE UNITED STATES OF AMERICA AS

B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]
B06U Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette]
B350 Update of information on the portal [chapter 15.35 patent gazette]
B09A Decision: intention to grant [chapter 9.1 patent gazette]
B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]

Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 06/05/2009, OBSERVADAS AS CONDICOES LEGAIS. PATENTE CONCEDIDA CONFORME ADI 5.529/DF, QUE DETERMINA A ALTERACAO DO PRAZO DE CONCESSAO.

B16C Correction of notification of the grant [chapter 16.3 patent gazette]

Free format text: REF. RPI 2642 DE 24/08/2021 QUANTO AO TITULAR.

B25A Requested transfer of rights approved

Owner name: THE GOVERNMENT OF THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE DEPT. OF HEALTH AND HUMAN SERVICES (US) ; BOEHRINGER INGELHEIM ANIMAL HEALTH USA INC. (US)