MA31864B1 - Composés nucléosidiques antiviraux - Google Patents

Composés nucléosidiques antiviraux

Info

Publication number
MA31864B1
MA31864B1 MA32870A MA32870A MA31864B1 MA 31864 B1 MA31864 B1 MA 31864B1 MA 32870 A MA32870 A MA 32870A MA 32870 A MA32870 A MA 32870A MA 31864 B1 MA31864 B1 MA 31864B1
Authority
MA
Morocco
Prior art keywords
nucleoside compounds
antiviral nucleoside
hepatitis
compositions
formula
Prior art date
Application number
MA32870A
Other languages
Arabic (ar)
English (en)
Inventor
Brett C Bookser
Scott J Hecker
K Raja Reddy
David Bernard Smith
Zhili Sun
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=40679083&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MA31864(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of MA31864B1 publication Critical patent/MA31864B1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C07H19/10—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Oncology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Communicable Diseases (AREA)
  • Virology (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

L'invention concerne des composés répondant à la formule i ou ii, dans lesquelles r1, r2, b, et v sont tels que définis ici, et qui sont des inhibiteurs de polymérase ns5b du virus de l'hépatite c. Elle concerne également des compositions et des procédés de traitement d'une infection par le hcv et d'inhibition de la réplication de hcv.
MA32870A 2007-11-29 2010-05-27 Composés nucléosidiques antiviraux MA31864B1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US99116307P 2007-11-29 2007-11-29
US8454408P 2008-07-29 2008-07-29
PCT/IB2008/054985 WO2009069095A2 (fr) 2007-11-29 2008-11-27 Composés nucléosidiques antiviraux

Publications (1)

Publication Number Publication Date
MA31864B1 true MA31864B1 (fr) 2010-11-01

Family

ID=40679083

Family Applications (1)

Application Number Title Priority Date Filing Date
MA32870A MA31864B1 (fr) 2007-11-29 2010-05-27 Composés nucléosidiques antiviraux

Country Status (20)

Country Link
US (2) US8063025B2 (fr)
EP (1) EP2227481A4 (fr)
JP (1) JP2011505351A (fr)
KR (1) KR20100103793A (fr)
CN (1) CN102164939A (fr)
AR (1) AR069740A1 (fr)
AU (1) AU2008331158A1 (fr)
BR (1) BRPI0819797A2 (fr)
CA (1) CA2706432A1 (fr)
CL (1) CL2008003511A1 (fr)
CO (1) CO6382185A2 (fr)
CR (1) CR11453A (fr)
EC (1) ECSP10010210A (fr)
IL (1) IL205625A0 (fr)
MA (1) MA31864B1 (fr)
MX (1) MX2010005885A (fr)
RU (1) RU2010126050A (fr)
TW (1) TW200936146A (fr)
WO (1) WO2009069095A2 (fr)
ZA (1) ZA201003438B (fr)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5485164B2 (ja) 2007-11-29 2014-05-07 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング ６，７−ジヒドロ−５Ｈ−イミダゾ［１，２−ａ］イミダゾール−３−カルボン酸アミドの誘導体
BR112012015951A2 (pt) * 2010-01-28 2018-10-16 Hoffmann La Roche 4 azido-nucleosídeos como compostos anti-hcv
ES2701020T3 (es) 2010-09-22 2019-02-20 Alios Biopharma Inc Nucleósidos azido y análogos nucleotídicos
JP6069215B2 (ja) 2010-11-30 2017-02-01 ギリアド ファーマセット エルエルシー 化合物
WO2013070887A1 (fr) * 2011-11-10 2013-05-16 Inhibitex, Inc. Nucléosides de purine substitués, dérivés phosphoramidate et phosphordiamidate destinés à traiter des infections virales
WO2015077368A1 (fr) 2013-11-22 2015-05-28 Ligand Pharmaceuticals Incorporated Dérivés de l'uridine 5'-cyclophosphate utiles pour traiter les infections par le virus de l'hépatite c
CN103848877B (zh) * 2013-12-16 2016-08-24 安徽贝克联合制药有限公司 核苷环磷酸酯化合物及其制备方法和其应用
EP3105238A4 (fr) 2014-02-13 2017-11-08 Ligand Pharmaceuticals, Inc. Composés de promédicaments et leurs utilisations
WO2016003812A1 (fr) 2014-07-02 2016-01-07 Ligand Pharmaceuticals, Inc. Composés de promédicaments et leurs utilisations
EA035664B1 (ru) 2015-08-05 2020-07-23 МЕТРО ИНТЕРНЭШНЛ БАЙОТЕК, ЭлЭлСи Производные никотинамидмононуклеотида и их применение для лечения заболевания или расстройства, связанного с биосинтезом над+
WO2018129039A1 (fr) 2017-01-04 2018-07-12 President And Fellows Of Harvard College Modulation du domaine d'homologie nudix (nhd) au moyen d'analogues de mononucléotide de nicotinamide et leurs dérivés
CN108727450B (zh) * 2017-04-18 2024-02-20 浙江柏拉阿图医药科技有限公司 肝递送抗丙肝前体药物核苷环磷酸酯化合物及应用
CN109956985A (zh) * 2017-12-22 2019-07-02 浙江柏拉阿图医药科技有限公司 肝递送阿糖胞苷前体药物核苷环磷酸酯化合物及应用
CN109956975B (zh) * 2017-12-22 2020-11-06 浙江柏拉阿图医药科技有限公司 肝递送恩替卡韦前体药物核苷环磷酸酯化合物及应用
CN109956986B (zh) * 2017-12-22 2021-04-27 浙江柏拉阿图医药科技有限公司 肝递送吉西他滨前体药物核苷环磷酸酯化合物及应用
CN111788196A (zh) 2018-01-09 2020-10-16 配体药物公司 缩醛化合物及其治疗用途
CN111434671B (zh) * 2019-01-11 2023-07-11 凯思凯迪（上海）医药科技有限公司 肝脏特异性ampk激动剂及其制法和应用
JP7429799B2 (ja) 2020-02-18 2024-02-08 ギリアード サイエンシーズ， インコーポレイテッド 抗ウイルス化合物
TW202322824A (zh) 2020-02-18 2023-06-16 美商基利科學股份有限公司 抗病毒化合物
TWI775313B (zh) 2020-02-18 2022-08-21 美商基利科學股份有限公司 抗病毒化合物
EP4323362A1 (fr) 2021-04-16 2024-02-21 Gilead Sciences, Inc. Procédés de préparation de carbanucléosides à l'aide d'amides
US12116380B2 (en) 2021-08-18 2024-10-15 Gilead Sciences, Inc. Phospholipid compounds and methods of making and using the same

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999045016A2 (fr) * 1998-03-06 1999-09-10 Metabasis Therapeutics, Inc. Nouveaux promedicaments pour composes contenant du phosphore
GB0114286D0 (en) * 2001-06-12 2001-08-01 Hoffmann La Roche Nucleoside Derivatives
WO2004041837A1 (fr) 2002-10-31 2004-05-21 Metabasis Therapeutics, Inc. Nouveaux promedicaments de cytarabine monophosphate
TWI332507B (en) * 2002-11-19 2010-11-01 Hoffmann La Roche Antiviral nucleoside derivatives
WO2005009418A2 (fr) 2003-07-25 2005-02-03 Idenix (Cayman) Limited Analogues des nucleosides puriques pour traiter flaviviridae et notamment l'hepatite c
WO2006033709A2 (fr) 2004-07-29 2006-03-30 Metabasis Therapeutics, Inc. Nouveaux derives de nucleosides
CA2618335C (fr) * 2005-08-15 2015-03-31 F.Hoffmann-La Roche Ag Phosphoramidates antiviraux
JP4954573B2 (ja) * 2006-02-28 2012-06-20 オリンパス株式会社 内視鏡システム

Also Published As

Publication number Publication date
EP2227481A4 (fr) 2011-03-09
JP2011505351A (ja) 2011-02-24
AR069740A1 (es) 2010-02-17
WO2009069095A3 (fr) 2009-12-23
ECSP10010210A (es) 2010-08-31
BRPI0819797A2 (pt) 2019-09-24
KR20100103793A (ko) 2010-09-28
CL2008003511A1 (es) 2010-02-19
CA2706432A1 (fr) 2009-06-04
WO2009069095A2 (fr) 2009-06-04
US20090209481A1 (en) 2009-08-20
ZA201003438B (en) 2011-04-28
CN102164939A (zh) 2011-08-24
US20120039845A1 (en) 2012-02-16
CR11453A (es) 2010-10-27
RU2010126050A (ru) 2012-01-10
AU2008331158A1 (en) 2009-06-04
TW200936146A (en) 2009-09-01
EP2227481A2 (fr) 2010-09-15
MX2010005885A (es) 2010-11-24
IL205625A0 (en) 2010-11-30
CO6382185A2 (es) 2012-02-15
US8063025B2 (en) 2011-11-22

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