MA27434A1 - DERIVES DE 6,7-DIHYDRO-5H-PYRAZOLO [1,2-a] PYRAZOL-1-ONES CONTROLANT LES CYTOKINES INFLAMMATOIRES - Google Patents
DERIVES DE 6,7-DIHYDRO-5H-PYRAZOLO [1,2-a] PYRAZOL-1-ONES CONTROLANT LES CYTOKINES INFLAMMATOIRESInfo
- Publication number
- MA27434A1 MA27434A1 MA28145A MA28145A MA27434A1 MA 27434 A1 MA27434 A1 MA 27434A1 MA 28145 A MA28145 A MA 28145A MA 28145 A MA28145 A MA 28145A MA 27434 A1 MA27434 A1 MA 27434A1
- Authority
- MA
- Morocco
- Prior art keywords
- inflammatory cytokines
- pyrazolo
- pyrazol
- dihydro
- controlling inflammatory
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
- A61K31/4162—1,2-Diazoles condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Immunology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
La présente invention répond aux besoins précités en ce que l'on a découvert, de manière surprenante, que certaines pyrazolones bicycliques et leurs dérivés sont efficaces pour inhiber la libération de cytokines inflammatoires, notamment, l'interleukine-1 (IL-1 ) et le facteur de nécrose tumorale (TNF) de cellules et, de ce fait, pour empêcher, diminuer ou autrement contrôler les enzymes qui sont censées être les composants actifs responsables des états pathologiques décrits dans la présente demande.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US10/246,214 US6730668B2 (en) | 2001-09-20 | 2002-09-18 | 6,7-dihydro-5H-pyrazolo[1,2-a]pyrazol-1-ones which control inflammatory cytokines |
Publications (1)
Publication Number | Publication Date |
---|---|
MA27434A1 true MA27434A1 (fr) | 2005-07-01 |
Family
ID=32028948
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MA28145A MA27434A1 (fr) | 2002-09-18 | 2005-03-15 | DERIVES DE 6,7-DIHYDRO-5H-PYRAZOLO [1,2-a] PYRAZOL-1-ONES CONTROLANT LES CYTOKINES INFLAMMATOIRES |
Country Status (20)
Country | Link |
---|---|
US (3) | US6730668B2 (fr) |
EP (1) | EP1539761B1 (fr) |
JP (1) | JP2006502189A (fr) |
KR (3) | KR20050057444A (fr) |
CN (1) | CN1315834C (fr) |
AT (1) | ATE429434T1 (fr) |
AU (1) | AU2003218280B8 (fr) |
BR (1) | BR0314292A (fr) |
CA (1) | CA2496500A1 (fr) |
DE (1) | DE60327328D1 (fr) |
ES (1) | ES2322046T3 (fr) |
IL (1) | IL166822A0 (fr) |
MA (1) | MA27434A1 (fr) |
MX (1) | MXPA05002984A (fr) |
NO (1) | NO20051686L (fr) |
NZ (1) | NZ538197A (fr) |
PL (1) | PL376086A1 (fr) |
RU (1) | RU2289584C2 (fr) |
WO (1) | WO2004026878A1 (fr) |
ZA (1) | ZA200501590B (fr) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6849627B2 (en) * | 2001-09-20 | 2005-02-01 | The Procter & Gamble Company | 6,7-dihydro-5H-pyrazolo[1,2-a]pyrazol-1-ones which control inflammatory cytokines |
US6566357B1 (en) * | 2001-09-20 | 2003-05-20 | The Procter & Gamble Co. | Spirocyclic-6,7-dihydro-5H-pyrazolo[1,2-a]pyrazol-1-ones which control inflammatory cytokines |
US6730668B2 (en) * | 2001-09-20 | 2004-05-04 | The Procter & Gamble Company | 6,7-dihydro-5H-pyrazolo[1,2-a]pyrazol-1-ones which control inflammatory cytokines |
US7326714B2 (en) * | 2001-09-20 | 2008-02-05 | The Procter & Gamble Company | 6,7-Dihydro-5H-pyrazolo[1,2-a]pyrazol-1-ones which control inflammatory cytokines |
US7473695B2 (en) * | 2001-10-22 | 2009-01-06 | Mitsubishi Tanabe Pharma Corporation | 4-imidazolin-2-one compounds |
US7482356B2 (en) * | 2003-11-10 | 2009-01-27 | The Procter & Gamble Company | Bicyclic pyrazolone cytokine inhibitors |
DE102008060549A1 (de) | 2008-12-04 | 2010-06-10 | MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. | Wirkstoff-Peptid-Konstrukt zur extrazellulären Anreicherung |
RU2011151603A (ru) * | 2009-05-19 | 2013-06-27 | ДАУ АГРОСАЙЕНСИЗ ЭлЭсСи | Соединения и способы борьбы с грибами |
US10512628B2 (en) | 2016-04-24 | 2019-12-24 | Solano S.P. Ltd. | Dinotefuran liquid flea and tick treatment |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1124982A (en) | 1965-02-09 | 1968-08-21 | Lepetit Spa | Diazabicyclo octanes and derivatives thereof |
CH529153A (fr) | 1969-10-27 | 1972-10-15 | Lepetit Spa | Procédé de préparation de pyrazolo (1,2-b) phtalazine-1,5 (10H)-diones |
US6472416B1 (en) * | 1999-08-27 | 2002-10-29 | Abbott Laboratories | Sulfonylphenylpyrazole compounds useful as COX-2 inhibitors |
DE10004157A1 (de) * | 2000-02-01 | 2001-08-02 | Merckle Gmbh Chem Pharm Fabrik | 4-Pyridyl-und 2,4-Pyrimidinyl-substituierte Pyrrolderivate und ihre Anwendung in der Pharmazie |
US6566357B1 (en) * | 2001-09-20 | 2003-05-20 | The Procter & Gamble Co. | Spirocyclic-6,7-dihydro-5H-pyrazolo[1,2-a]pyrazol-1-ones which control inflammatory cytokines |
US6730668B2 (en) * | 2001-09-20 | 2004-05-04 | The Procter & Gamble Company | 6,7-dihydro-5H-pyrazolo[1,2-a]pyrazol-1-ones which control inflammatory cytokines |
-
2002
- 2002-09-18 US US10/246,214 patent/US6730668B2/en not_active Expired - Fee Related
-
2003
- 2003-03-18 JP JP2004538151A patent/JP2006502189A/ja active Pending
- 2003-03-18 CA CA002496500A patent/CA2496500A1/fr not_active Abandoned
- 2003-03-18 EP EP03714274A patent/EP1539761B1/fr not_active Expired - Lifetime
- 2003-03-18 WO PCT/US2003/008477 patent/WO2004026878A1/fr active Application Filing
- 2003-03-18 KR KR1020057004666A patent/KR20050057444A/ko not_active Application Discontinuation
- 2003-03-18 KR KR1020077010029A patent/KR100842191B1/ko not_active IP Right Cessation
- 2003-03-18 CN CNB03821850XA patent/CN1315834C/zh not_active Expired - Fee Related
- 2003-03-18 ES ES03714274T patent/ES2322046T3/es not_active Expired - Lifetime
- 2003-03-18 NZ NZ538197A patent/NZ538197A/en unknown
- 2003-03-18 DE DE60327328T patent/DE60327328D1/de not_active Expired - Fee Related
- 2003-03-18 BR BR0314292-2A patent/BR0314292A/pt not_active IP Right Cessation
- 2003-03-18 AT AT03714274T patent/ATE429434T1/de not_active IP Right Cessation
- 2003-03-18 MX MXPA05002984A patent/MXPA05002984A/es active IP Right Grant
- 2003-03-18 RU RU2005111220/04A patent/RU2289584C2/ru active
- 2003-03-18 AU AU2003218280A patent/AU2003218280B8/en not_active Ceased
- 2003-03-18 KR KR1020077016926A patent/KR20070087684A/ko active IP Right Grant
- 2003-03-18 PL PL03376086A patent/PL376086A1/xx not_active Application Discontinuation
- 2003-09-12 US US10/661,730 patent/US6960593B2/en not_active Expired - Fee Related
-
2005
- 2005-02-10 IL IL16682205A patent/IL166822A0/xx unknown
- 2005-02-23 ZA ZA200501590A patent/ZA200501590B/xx unknown
- 2005-03-15 MA MA28145A patent/MA27434A1/fr unknown
- 2005-04-05 NO NO20051686A patent/NO20051686L/no not_active Application Discontinuation
- 2005-06-23 US US11/159,662 patent/US7368455B2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
AU2003218280A1 (en) | 2004-04-08 |
KR100842191B1 (ko) | 2008-06-30 |
PL376086A1 (en) | 2005-12-12 |
KR20070087684A (ko) | 2007-08-28 |
CN1681819A (zh) | 2005-10-12 |
RU2005111220A (ru) | 2006-02-27 |
KR20070051374A (ko) | 2007-05-17 |
US20040058944A1 (en) | 2004-03-25 |
US7368455B2 (en) | 2008-05-06 |
BR0314292A (pt) | 2005-12-13 |
JP2006502189A (ja) | 2006-01-19 |
DE60327328D1 (de) | 2009-06-04 |
ZA200501590B (en) | 2006-02-22 |
NZ538197A (en) | 2007-01-26 |
ES2322046T3 (es) | 2009-06-16 |
US6960593B2 (en) | 2005-11-01 |
AU2003218280B2 (en) | 2008-05-15 |
EP1539761B1 (fr) | 2009-04-22 |
RU2289584C2 (ru) | 2006-12-20 |
CN1315834C (zh) | 2007-05-16 |
IL166822A0 (en) | 2006-01-15 |
MXPA05002984A (es) | 2005-06-22 |
ATE429434T1 (de) | 2009-05-15 |
WO2004026878A1 (fr) | 2004-04-01 |
CA2496500A1 (fr) | 2004-04-01 |
EP1539761A1 (fr) | 2005-06-15 |
KR20050057444A (ko) | 2005-06-16 |
US6730668B2 (en) | 2004-05-04 |
US20030134867A1 (en) | 2003-07-17 |
AU2003218280B8 (en) | 2008-06-26 |
US20050282844A1 (en) | 2005-12-22 |
NO20051686L (no) | 2005-04-05 |
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