DE60327328D1 - 6,7-DIHYDRO-5H-PYRAZOLOi1,2-A PYRAZOL-1-ONE ZUR KONTROLLE VON ENTZÜNDUNGSFÖRDERNDEN CYTOKINEN - Google Patents
6,7-DIHYDRO-5H-PYRAZOLOi1,2-A PYRAZOL-1-ONE ZUR KONTROLLE VON ENTZÜNDUNGSFÖRDERNDEN CYTOKINENInfo
- Publication number
- DE60327328D1 DE60327328D1 DE60327328T DE60327328T DE60327328D1 DE 60327328 D1 DE60327328 D1 DE 60327328D1 DE 60327328 T DE60327328 T DE 60327328T DE 60327328 T DE60327328 T DE 60327328T DE 60327328 D1 DE60327328 D1 DE 60327328D1
- Authority
- DE
- Germany
- Prior art keywords
- pyrazol
- dihydro
- interleukin
- inflammatory cytokines
- pyrazoloi1
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
- A61K31/4162—1,2-Diazoles condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Immunology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US10/246,214 US6730668B2 (en) | 2001-09-20 | 2002-09-18 | 6,7-dihydro-5H-pyrazolo[1,2-a]pyrazol-1-ones which control inflammatory cytokines |
PCT/US2003/008477 WO2004026878A1 (en) | 2002-09-18 | 2003-03-18 | 6,7-DIHYDRO-5H-PYRAZOLO[1,2-a]PYRAZOL-1-ONES WHICH CONTROL INFLAMMATORY CYTOKINES |
Publications (1)
Publication Number | Publication Date |
---|---|
DE60327328D1 true DE60327328D1 (de) | 2009-06-04 |
Family
ID=32028948
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE60327328T Expired - Fee Related DE60327328D1 (de) | 2002-09-18 | 2003-03-18 | 6,7-DIHYDRO-5H-PYRAZOLOi1,2-A PYRAZOL-1-ONE ZUR KONTROLLE VON ENTZÜNDUNGSFÖRDERNDEN CYTOKINEN |
Country Status (20)
Country | Link |
---|---|
US (3) | US6730668B2 (de) |
EP (1) | EP1539761B1 (de) |
JP (1) | JP2006502189A (de) |
KR (3) | KR20050057444A (de) |
CN (1) | CN1315834C (de) |
AT (1) | ATE429434T1 (de) |
AU (1) | AU2003218280B8 (de) |
BR (1) | BR0314292A (de) |
CA (1) | CA2496500A1 (de) |
DE (1) | DE60327328D1 (de) |
ES (1) | ES2322046T3 (de) |
IL (1) | IL166822A0 (de) |
MA (1) | MA27434A1 (de) |
MX (1) | MXPA05002984A (de) |
NO (1) | NO20051686L (de) |
NZ (1) | NZ538197A (de) |
PL (1) | PL376086A1 (de) |
RU (1) | RU2289584C2 (de) |
WO (1) | WO2004026878A1 (de) |
ZA (1) | ZA200501590B (de) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6849627B2 (en) * | 2001-09-20 | 2005-02-01 | The Procter & Gamble Company | 6,7-dihydro-5H-pyrazolo[1,2-a]pyrazol-1-ones which control inflammatory cytokines |
US6566357B1 (en) * | 2001-09-20 | 2003-05-20 | The Procter & Gamble Co. | Spirocyclic-6,7-dihydro-5H-pyrazolo[1,2-a]pyrazol-1-ones which control inflammatory cytokines |
US6730668B2 (en) * | 2001-09-20 | 2004-05-04 | The Procter & Gamble Company | 6,7-dihydro-5H-pyrazolo[1,2-a]pyrazol-1-ones which control inflammatory cytokines |
US7326714B2 (en) * | 2001-09-20 | 2008-02-05 | The Procter & Gamble Company | 6,7-Dihydro-5H-pyrazolo[1,2-a]pyrazol-1-ones which control inflammatory cytokines |
US7473695B2 (en) * | 2001-10-22 | 2009-01-06 | Mitsubishi Tanabe Pharma Corporation | 4-imidazolin-2-one compounds |
US7482356B2 (en) * | 2003-11-10 | 2009-01-27 | The Procter & Gamble Company | Bicyclic pyrazolone cytokine inhibitors |
DE102008060549A1 (de) | 2008-12-04 | 2010-06-10 | MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. | Wirkstoff-Peptid-Konstrukt zur extrazellulären Anreicherung |
NZ596123A (en) * | 2009-05-19 | 2014-08-29 | Dow Agrosciences Llc | Compounds and methods for controlling fungi |
US10512628B2 (en) | 2016-04-24 | 2019-12-24 | Solano S.P. Ltd. | Dinotefuran liquid flea and tick treatment |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1124982A (en) * | 1965-02-09 | 1968-08-21 | Lepetit Spa | Diazabicyclo octanes and derivatives thereof |
CH529154A (fr) | 1969-10-27 | 1972-10-15 | Lepetit Spa | Procédé de préparation de pyrazolo (1,2-b) phtalazine-1,5 (10H)-diones |
US6472416B1 (en) * | 1999-08-27 | 2002-10-29 | Abbott Laboratories | Sulfonylphenylpyrazole compounds useful as COX-2 inhibitors |
DE10004157A1 (de) * | 2000-02-01 | 2001-08-02 | Merckle Gmbh Chem Pharm Fabrik | 4-Pyridyl-und 2,4-Pyrimidinyl-substituierte Pyrrolderivate und ihre Anwendung in der Pharmazie |
US6566357B1 (en) * | 2001-09-20 | 2003-05-20 | The Procter & Gamble Co. | Spirocyclic-6,7-dihydro-5H-pyrazolo[1,2-a]pyrazol-1-ones which control inflammatory cytokines |
US6730668B2 (en) * | 2001-09-20 | 2004-05-04 | The Procter & Gamble Company | 6,7-dihydro-5H-pyrazolo[1,2-a]pyrazol-1-ones which control inflammatory cytokines |
-
2002
- 2002-09-18 US US10/246,214 patent/US6730668B2/en not_active Expired - Fee Related
-
2003
- 2003-03-18 AU AU2003218280A patent/AU2003218280B8/en not_active Ceased
- 2003-03-18 WO PCT/US2003/008477 patent/WO2004026878A1/en active Application Filing
- 2003-03-18 RU RU2005111220/04A patent/RU2289584C2/ru active
- 2003-03-18 EP EP03714274A patent/EP1539761B1/de not_active Expired - Lifetime
- 2003-03-18 KR KR1020057004666A patent/KR20050057444A/ko not_active Application Discontinuation
- 2003-03-18 CN CNB03821850XA patent/CN1315834C/zh not_active Expired - Fee Related
- 2003-03-18 KR KR1020077010029A patent/KR100842191B1/ko not_active IP Right Cessation
- 2003-03-18 CA CA002496500A patent/CA2496500A1/en not_active Abandoned
- 2003-03-18 MX MXPA05002984A patent/MXPA05002984A/es active IP Right Grant
- 2003-03-18 KR KR1020077016926A patent/KR20070087684A/ko active IP Right Grant
- 2003-03-18 AT AT03714274T patent/ATE429434T1/de not_active IP Right Cessation
- 2003-03-18 BR BR0314292-2A patent/BR0314292A/pt not_active IP Right Cessation
- 2003-03-18 ES ES03714274T patent/ES2322046T3/es not_active Expired - Lifetime
- 2003-03-18 NZ NZ538197A patent/NZ538197A/en unknown
- 2003-03-18 DE DE60327328T patent/DE60327328D1/de not_active Expired - Fee Related
- 2003-03-18 PL PL03376086A patent/PL376086A1/xx not_active Application Discontinuation
- 2003-03-18 JP JP2004538151A patent/JP2006502189A/ja active Pending
- 2003-09-12 US US10/661,730 patent/US6960593B2/en not_active Expired - Fee Related
-
2005
- 2005-02-10 IL IL16682205A patent/IL166822A0/xx unknown
- 2005-02-23 ZA ZA200501590A patent/ZA200501590B/xx unknown
- 2005-03-15 MA MA28145A patent/MA27434A1/fr unknown
- 2005-04-05 NO NO20051686A patent/NO20051686L/no not_active Application Discontinuation
- 2005-06-23 US US11/159,662 patent/US7368455B2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
MA27434A1 (fr) | 2005-07-01 |
ES2322046T3 (es) | 2009-06-16 |
KR20070051374A (ko) | 2007-05-17 |
KR20050057444A (ko) | 2005-06-16 |
RU2005111220A (ru) | 2006-02-27 |
US20030134867A1 (en) | 2003-07-17 |
AU2003218280B2 (en) | 2008-05-15 |
PL376086A1 (en) | 2005-12-12 |
EP1539761B1 (de) | 2009-04-22 |
KR20070087684A (ko) | 2007-08-28 |
CN1315834C (zh) | 2007-05-16 |
CA2496500A1 (en) | 2004-04-01 |
JP2006502189A (ja) | 2006-01-19 |
MXPA05002984A (es) | 2005-06-22 |
CN1681819A (zh) | 2005-10-12 |
IL166822A0 (en) | 2006-01-15 |
NZ538197A (en) | 2007-01-26 |
NO20051686L (no) | 2005-04-05 |
AU2003218280A1 (en) | 2004-04-08 |
ZA200501590B (en) | 2006-02-22 |
US7368455B2 (en) | 2008-05-06 |
US6730668B2 (en) | 2004-05-04 |
AU2003218280B8 (en) | 2008-06-26 |
US6960593B2 (en) | 2005-11-01 |
US20040058944A1 (en) | 2004-03-25 |
EP1539761A1 (de) | 2005-06-15 |
RU2289584C2 (ru) | 2006-12-20 |
ATE429434T1 (de) | 2009-05-15 |
KR100842191B1 (ko) | 2008-06-30 |
BR0314292A (pt) | 2005-12-13 |
WO2004026878A1 (en) | 2004-04-01 |
US20050282844A1 (en) | 2005-12-22 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
ZA200501590B (en) | 6,7-Dihydro-5H-pyrazoloÄ1,2-aÜpyrazol-1-ones whichcontrol inflammatory cytokines. | |
NO20054959D0 (no) | Fremgangsmater for behandling av interleukin-6 relaterte sykdommer | |
ES2193256T3 (es) | Aril pirroles 2-sustituidos, composiciones que contienen tales compuestos y procedimientos de uso. | |
MXPA05010958A (es) | Derivados indazol como inhibidores jnk. | |
EA200601571A1 (ru) | 3-[4-гетероциклил-1,2,3-триазол-1-ил]-n-арилбензамиды в качестве ингибиторов продуцирования цитокинов, предназначенные для лечения хронических воспалительных заболеваний | |
ATE365733T1 (de) | Zusammensetzungen brauchbar als protein-kinase- inhibitoren | |
FI963101A0 (fi) | Anti-TNF-vasta-aineiden käyttö lääkkeenä sellaisten sairauksien hoitoon, joissa seerumin interleukiini-6-taso on kohonnut | |
WO2005014533A3 (en) | Aryl and heteroaryl compounds, compositions, and methods of use | |
MXPA03008955A (es) | Agente terapeutico para enfermedades de tipo artritides cronicas o enfermedades relacionadas con la ninez. | |
WO2008064321A3 (en) | Methods of treating chronic inflammatory diseases using a gm-csf antagonist | |
WO2001087328A3 (en) | Interleukin-1 inhibitors in the treatment of diseases | |
DK1525200T3 (da) | 2-(3-aminoaryl)amino-4-aryl-thiazoler til sygdomsbehandling | |
DE602004024374D1 (de) | Zusammensetzungen zur verwendung als protein-kinase-inhibitoren | |
WO2004089286A3 (en) | Novel compounds and compositions as protein kinase inhibitors | |
DE60332433D1 (de) | Azolylaminoazine als proteinkinasehemmer | |
DE60332604D1 (de) | Azolylaminoazine als proteinkinasehemmer | |
ATE466085T1 (de) | Protease-resistente modifizierte interferon alpha polypeptide | |
DE60327745D1 (de) | Verwendung von adapalen zur behandlung dermatologischer erkrankungen | |
ATE540948T1 (de) | Pyrrolopyridine als proteinkinasehemmer | |
RU95113454A (ru) | Катехольные диэфиры как селективные ингибиторы фдэiv, фармацевтическая композиция, способы лечения | |
IL163090A (en) | Nicotinamide derivates, pharmaceutical compositions comprising them and their use for manufacture of medicaments useful as p38 inhibitors | |
SE9800836D0 (sv) | New Compounds | |
EA200801711A1 (ru) | Пролекарства возбуждающих аминокислот | |
CY1108932T1 (el) | Ενωσεις 4-(ετεροκυκλυλ)-βενζολοσουλφοξιμινης για την θεραπευτικη αγωγη φλεγμονωδων ασθενειων | |
ATE476438T1 (de) | Makrolide mit entzündungshemmender wirkung |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition | ||
8339 | Ceased/non-payment of the annual fee |