MA26570A1 - Forme active d'une proteine hedgehog, procede pour la produire, et son utilisation therapeutique - Google Patents
Forme active d'une proteine hedgehog, procede pour la produire, et son utilisation therapeutiqueInfo
- Publication number
- MA26570A1 MA26570A1 MA25362A MA25362A MA26570A1 MA 26570 A1 MA26570 A1 MA 26570A1 MA 25362 A MA25362 A MA 25362A MA 25362 A MA25362 A MA 25362A MA 26570 A1 MA26570 A1 MA 26570A1
- Authority
- MA
- Morocco
- Prior art keywords
- producing
- same
- therapeutic use
- active form
- hedgehog protein
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/04—Drugs for skeletal disorders for non-specific disorders of the connective tissue
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2799/00—Uses of viruses
- C12N2799/02—Uses of viruses as vector
- C12N2799/021—Uses of viruses as vector for the expression of a heterologous nucleic acid
- C12N2799/026—Uses of viruses as vector for the expression of a heterologous nucleic acid where the vector is derived from a baculovirus
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Physical Education & Sports Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Toxicology (AREA)
- Zoology (AREA)
- Biomedical Technology (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Genetics & Genomics (AREA)
- Gastroenterology & Hepatology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Rheumatology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP97120891A EP0919618A1 (fr) | 1997-11-28 | 1997-11-28 | Mutants de la protéine Hedgehog, méthode de production et application |
EP98102095 | 1998-02-06 |
Publications (1)
Publication Number | Publication Date |
---|---|
MA26570A1 true MA26570A1 (fr) | 2004-12-20 |
Family
ID=26145926
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MA25362A MA26570A1 (fr) | 1997-11-28 | 1998-11-27 | Forme active d'une proteine hedgehog, procede pour la produire, et son utilisation therapeutique |
Country Status (8)
Country | Link |
---|---|
US (3) | US6994990B1 (fr) |
EP (1) | EP1034269A1 (fr) |
JP (1) | JP2001525341A (fr) |
AU (1) | AU752816B2 (fr) |
CA (1) | CA2312009A1 (fr) |
IL (2) | IL136230A0 (fr) |
MA (1) | MA26570A1 (fr) |
WO (1) | WO1999028454A1 (fr) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IL136230A0 (en) * | 1997-11-28 | 2001-05-20 | Roche Diagnostics Gmbh | An active hedgehog-protein-mutant, a process for its preparation and its use for pharmaceutical purposes |
US6897297B1 (en) * | 1997-12-03 | 2005-05-24 | Curis, Inc. | Hydrophobically-modified protein compositions and methods |
DK0953576T3 (da) * | 1998-04-30 | 2006-03-20 | Curis Inc | Aktivt hedgehog-proteinkonjugat, fremgangsmåde til fremstilling heraf og anvendelse |
Family Cites Families (34)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB2148901A (en) * | 1983-10-04 | 1985-06-05 | Johnson & Johnson | Protein/polysaccharide complexes |
US5374548A (en) * | 1986-05-02 | 1994-12-20 | Genentech, Inc. | Methods and compositions for the attachment of proteins to liposomes using a glycophospholipid anchor |
JPH0725689B2 (ja) * | 1986-10-07 | 1995-03-22 | 中外製薬株式会社 | 顆粒球コロニ−刺激因子を含有する徐放性製剤 |
US5399347A (en) * | 1987-06-24 | 1995-03-21 | Autoimmune, Inc. | Method of treating rheumatoid arthritis with type II collagen |
US5409611A (en) * | 1988-03-24 | 1995-04-25 | Terrapin Technoogies, Inc. | Method to identify analyte-binding ligands |
US5130297A (en) * | 1988-06-23 | 1992-07-14 | Anergen, Inc. | Conjugates useful in ameliorating autoimmunity MHC-II-peptide |
US5078997A (en) * | 1988-07-13 | 1992-01-07 | Cetus Corporation | Pharmaceutical composition for interleukin-2 containing physiologically compatible stabilizers |
US5156623A (en) * | 1990-04-16 | 1992-10-20 | Olympus Optical Co., Ltd. | Sustained release material and method of manufacturing the same |
US5364839A (en) | 1990-06-18 | 1994-11-15 | Genetics Institute, Inc. | Osteoinductive pharmaceutical formulations |
US5416071A (en) * | 1991-03-12 | 1995-05-16 | Takeda Chemical Industries, Ltd. | Water-soluble composition for sustained-release containing epo and hyaluronic acid |
WO1993000050A1 (fr) | 1991-06-21 | 1993-01-07 | Genetics Institute, Inc. | Compositions pharmaceutiques de proteines osteogeniques |
DE4126983A1 (de) * | 1991-08-15 | 1993-02-18 | Boehringer Mannheim Gmbh | Verfahren zur herstellung von humanprotein-enthaltenden, konservierten arzneimitteln fuer infusions- oder injektionszwecke |
US6610656B1 (en) * | 1993-12-30 | 2003-08-26 | President And Fellows Of Harvard College | Method of promoting chondrocyte differentiation with hedgehog related polypeptides |
US5789543A (en) * | 1993-12-30 | 1998-08-04 | President And Fellows Of Harvard College | Vertebrate embryonic pattern-inducing proteins and uses related thereto |
US5824315A (en) * | 1993-10-25 | 1998-10-20 | Anergen, Inc. | Binding affinity of antigenic peptides for MHC molecules |
PT733109E (pt) | 1993-12-07 | 2006-07-31 | Genetics Inst Llc | Proteinas morfogeneticas dos 0ss0s pmo-12 e pmo-13 e as suas composicoes para inducao de tendao |
US6884775B1 (en) * | 1993-12-30 | 2005-04-26 | President And Fellows Of Harvard College | Methods and compositions for regulating skeletogenic formation |
US6261786B1 (en) * | 1993-12-30 | 2001-07-17 | Imperial Cancer Res. Technology | Screening assays for hedgehog agonists and antagonists |
US6165747A (en) * | 1993-12-30 | 2000-12-26 | President & Fellows Of Harvard College | Nucleic acids encoding hedgehog proteins |
US7060450B1 (en) * | 1993-12-30 | 2006-06-13 | President And Fellows Of Harvard College | Screening assays for agonists and antagonists of the hedgehog signaling pathway |
US20030186357A1 (en) * | 1993-12-30 | 2003-10-02 | Philip W. Ingham | Vertebrate embryonic pattern-inducing proteins, and uses related thereto |
US6384192B1 (en) * | 1993-12-30 | 2002-05-07 | President & Fellows Of Harvard College | Vertebrate embryonic pattern-inducing proteins |
US6281332B1 (en) * | 1994-12-02 | 2001-08-28 | The Johns Hopkins University School Of Medicine | Hedgehog-derived polypeptides |
US5700774A (en) | 1996-03-26 | 1997-12-23 | Genetics Institute, Inc. | Compositions comprising bone morphogenic proteins and truncated parathyroid hormone related peptide, and methods of inducing cartilage by administration of same |
GB9614871D0 (en) | 1996-07-15 | 1996-09-04 | Smithkline Beecham Plc | Compounds |
JP2002503088A (ja) | 1996-10-07 | 2002-01-29 | ザ ジョーンズ ホプキンス ユニバーシティー スクール オブ メディシン | 新規ヘッジホッグ由来ポリペプチド |
IL136230A0 (en) * | 1997-11-28 | 2001-05-20 | Roche Diagnostics Gmbh | An active hedgehog-protein-mutant, a process for its preparation and its use for pharmaceutical purposes |
US6897297B1 (en) * | 1997-12-03 | 2005-05-24 | Curis, Inc. | Hydrophobically-modified protein compositions and methods |
EA003739B1 (ru) * | 1997-12-03 | 2003-08-28 | Байоджен, Инк. | Гидрофобно-модифицированные белки, способы их получения и их применение |
DK0953576T3 (da) * | 1998-04-30 | 2006-03-20 | Curis Inc | Aktivt hedgehog-proteinkonjugat, fremgangsmåde til fremstilling heraf og anvendelse |
DK0978285T3 (da) * | 1998-08-07 | 2006-03-27 | Curis Inc | Stabilt farmaceutisk præparat af hedgehogproteiner og anvendelse deraf |
CA2348773C (fr) * | 1998-11-02 | 2010-04-13 | Biogen, Inc. | Antagonistes fonctionnels de l'activite hedgehog |
EP1183271A1 (fr) * | 1999-06-01 | 2002-03-06 | Biogen, Inc. | Conjugues polymeres de proteines hedgehog et leurs utilisations |
AU2001255767A1 (en) * | 2000-04-28 | 2001-11-12 | Curis, Inc. | Methods and reagents for tissue engineering of cartilage in vitro |
-
1998
- 1998-11-23 IL IL13623098A patent/IL136230A0/xx active IP Right Grant
- 1998-11-23 CA CA002312009A patent/CA2312009A1/fr not_active Abandoned
- 1998-11-23 EP EP98962388A patent/EP1034269A1/fr not_active Ceased
- 1998-11-23 AU AU17570/99A patent/AU752816B2/en not_active Ceased
- 1998-11-23 JP JP2000523331A patent/JP2001525341A/ja active Pending
- 1998-11-23 WO PCT/EP1998/007557 patent/WO1999028454A1/fr active IP Right Grant
- 1998-11-24 US US09/198,975 patent/US6994990B1/en not_active Expired - Fee Related
- 1998-11-27 MA MA25362A patent/MA26570A1/fr unknown
-
2000
- 2000-05-18 IL IL136230A patent/IL136230A/en not_active IP Right Cessation
-
2004
- 2004-01-14 US US10/757,669 patent/US20040138130A1/en not_active Abandoned
-
2005
- 2005-11-15 US US11/273,989 patent/US20060073566A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
WO1999028454A1 (fr) | 1999-06-10 |
AU1757099A (en) | 1999-06-16 |
US20060073566A1 (en) | 2006-04-06 |
US20040138130A1 (en) | 2004-07-15 |
EP1034269A1 (fr) | 2000-09-13 |
IL136230A0 (en) | 2001-05-20 |
US6994990B1 (en) | 2006-02-07 |
AU752816B2 (en) | 2002-10-03 |
JP2001525341A (ja) | 2001-12-11 |
CA2312009A1 (fr) | 1999-06-10 |
IL136230A (en) | 2007-08-19 |
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