IL136230A0 - An active hedgehog-protein-mutant, a process for its preparation and its use for pharmaceutical purposes - Google Patents

An active hedgehog-protein-mutant, a process for its preparation and its use for pharmaceutical purposes

Info

Publication number
IL136230A0
IL136230A0 IL13623098A IL13623098A IL136230A0 IL 136230 A0 IL136230 A0 IL 136230A0 IL 13623098 A IL13623098 A IL 13623098A IL 13623098 A IL13623098 A IL 13623098A IL 136230 A0 IL136230 A0 IL 136230A0
Authority
IL
Israel
Prior art keywords
mutant
protein
preparation
pharmaceutical purposes
active hedgehog
Prior art date
Application number
IL13623098A
Other languages
English (en)
Original Assignee
Roche Diagnostics Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from EP97120891A external-priority patent/EP0919618A1/fr
Application filed by Roche Diagnostics Gmbh filed Critical Roche Diagnostics Gmbh
Publication of IL136230A0 publication Critical patent/IL136230A0/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/04—Drugs for skeletal disorders for non-specific disorders of the connective tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2799/00—Uses of viruses
    • C12N2799/02—Uses of viruses as vector
    • C12N2799/021—Uses of viruses as vector for the expression of a heterologous nucleic acid
    • C12N2799/026—Uses of viruses as vector for the expression of a heterologous nucleic acid where the vector is derived from a baculovirus

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Rheumatology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
IL13623098A 1997-11-28 1998-11-23 An active hedgehog-protein-mutant, a process for its preparation and its use for pharmaceutical purposes IL136230A0 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP97120891A EP0919618A1 (fr) 1997-11-28 1997-11-28 Mutants de la protéine Hedgehog, méthode de production et application
EP98102095 1998-02-06
PCT/EP1998/007557 WO1999028454A1 (fr) 1997-11-28 1998-11-23 Mutant actif de proteine du herisson, son procede de preparation et son utilisation a des fins pharmaceutiques

Publications (1)

Publication Number Publication Date
IL136230A0 true IL136230A0 (en) 2001-05-20

Family

ID=26145926

Family Applications (2)

Application Number Title Priority Date Filing Date
IL13623098A IL136230A0 (en) 1997-11-28 1998-11-23 An active hedgehog-protein-mutant, a process for its preparation and its use for pharmaceutical purposes
IL136230A IL136230A (en) 1997-11-28 2000-05-18 Active hedgehog-protein-mutant, a process for its preparation and its use for pharmaceutical purposes

Family Applications After (1)

Application Number Title Priority Date Filing Date
IL136230A IL136230A (en) 1997-11-28 2000-05-18 Active hedgehog-protein-mutant, a process for its preparation and its use for pharmaceutical purposes

Country Status (8)

Country Link
US (3) US6994990B1 (fr)
EP (1) EP1034269A1 (fr)
JP (1) JP2001525341A (fr)
AU (1) AU752816B2 (fr)
CA (1) CA2312009A1 (fr)
IL (2) IL136230A0 (fr)
MA (1) MA26570A1 (fr)
WO (1) WO1999028454A1 (fr)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2312009A1 (fr) * 1997-11-28 1999-06-10 Roche Diagnostics Gmbh Mutant actif de proteine du herisson, son procede de preparation et son utilisation a des fins pharmaceutiques
US6897297B1 (en) * 1997-12-03 2005-05-24 Curis, Inc. Hydrophobically-modified protein compositions and methods
EP1557427A3 (fr) * 1998-04-30 2005-10-19 Curis, Inc. Conjugué de protein "hedgehog"

Family Cites Families (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2148901A (en) * 1983-10-04 1985-06-05 Johnson & Johnson Protein/polysaccharide complexes
US5374548A (en) * 1986-05-02 1994-12-20 Genentech, Inc. Methods and compositions for the attachment of proteins to liposomes using a glycophospholipid anchor
JPH0725689B2 (ja) * 1986-10-07 1995-03-22 中外製薬株式会社 顆粒球コロニ−刺激因子を含有する徐放性製剤
US5399347A (en) * 1987-06-24 1995-03-21 Autoimmune, Inc. Method of treating rheumatoid arthritis with type II collagen
US5409611A (en) * 1988-03-24 1995-04-25 Terrapin Technoogies, Inc. Method to identify analyte-binding ligands
US5130297A (en) * 1988-06-23 1992-07-14 Anergen, Inc. Conjugates useful in ameliorating autoimmunity MHC-II-peptide
US5078997A (en) * 1988-07-13 1992-01-07 Cetus Corporation Pharmaceutical composition for interleukin-2 containing physiologically compatible stabilizers
US5156623A (en) * 1990-04-16 1992-10-20 Olympus Optical Co., Ltd. Sustained release material and method of manufacturing the same
US5364839A (en) 1990-06-18 1994-11-15 Genetics Institute, Inc. Osteoinductive pharmaceutical formulations
US5416071A (en) * 1991-03-12 1995-05-16 Takeda Chemical Industries, Ltd. Water-soluble composition for sustained-release containing epo and hyaluronic acid
JP3351525B2 (ja) 1991-06-21 2002-11-25 ジェネティックス・インスティテュート・インコーポレイテッド 骨形成性蛋白医薬処方物
DE4126983A1 (de) * 1991-08-15 1993-02-18 Boehringer Mannheim Gmbh Verfahren zur herstellung von humanprotein-enthaltenden, konservierten arzneimitteln fuer infusions- oder injektionszwecke
US5789543A (en) * 1993-12-30 1998-08-04 President And Fellows Of Harvard College Vertebrate embryonic pattern-inducing proteins and uses related thereto
US6610656B1 (en) * 1993-12-30 2003-08-26 President And Fellows Of Harvard College Method of promoting chondrocyte differentiation with hedgehog related polypeptides
US5824315A (en) * 1993-10-25 1998-10-20 Anergen, Inc. Binding affinity of antigenic peptides for MHC molecules
CA2176942C (fr) 1993-12-07 2011-11-01 Anthony J. Celeste Bmp-12, bmp-13 et compositions de celles-ci pour l'induction de tendons
US6261786B1 (en) * 1993-12-30 2001-07-17 Imperial Cancer Res. Technology Screening assays for hedgehog agonists and antagonists
US6165747A (en) * 1993-12-30 2000-12-26 President & Fellows Of Harvard College Nucleic acids encoding hedgehog proteins
US6884775B1 (en) * 1993-12-30 2005-04-26 President And Fellows Of Harvard College Methods and compositions for regulating skeletogenic formation
US7060450B1 (en) * 1993-12-30 2006-06-13 President And Fellows Of Harvard College Screening assays for agonists and antagonists of the hedgehog signaling pathway
US6384192B1 (en) * 1993-12-30 2002-05-07 President & Fellows Of Harvard College Vertebrate embryonic pattern-inducing proteins
US20030186357A1 (en) * 1993-12-30 2003-10-02 Philip W. Ingham Vertebrate embryonic pattern-inducing proteins, and uses related thereto
US6281332B1 (en) * 1994-12-02 2001-08-28 The Johns Hopkins University School Of Medicine Hedgehog-derived polypeptides
US5700774A (en) * 1996-03-26 1997-12-23 Genetics Institute, Inc. Compositions comprising bone morphogenic proteins and truncated parathyroid hormone related peptide, and methods of inducing cartilage by administration of same
GB9614871D0 (en) 1996-07-15 1996-09-04 Smithkline Beecham Plc Compounds
JP2002503088A (ja) 1996-10-07 2002-01-29 ザ ジョーンズ ホプキンス ユニバーシティー スクール オブ メディシン 新規ヘッジホッグ由来ポリペプチド
CA2312009A1 (fr) * 1997-11-28 1999-06-10 Roche Diagnostics Gmbh Mutant actif de proteine du herisson, son procede de preparation et son utilisation a des fins pharmaceutiques
ES2243018T3 (es) * 1997-12-03 2005-11-16 Biogen Idec Ma, Inc. Composiciones y metodos de proteinas erizo modificadas hidrofobamente.
US6897297B1 (en) * 1997-12-03 2005-05-24 Curis, Inc. Hydrophobically-modified protein compositions and methods
EP1557427A3 (fr) * 1998-04-30 2005-10-19 Curis, Inc. Conjugué de protein "hedgehog"
DE69928472T2 (de) * 1998-08-07 2006-08-10 Curis, Inc., Cambridge Stabilisierte pharmazeutische Zusammensetzungen von Hedgehog-Proteinen und deren Verwendung
ATE404583T1 (de) * 1998-11-02 2008-08-15 Curis Inc Funktionelle antagonisten von hedgehog-aktivität
WO2000073337A1 (fr) * 1999-06-01 2000-12-07 Biogen, Inc. Conjugues polymeres de proteines hedgehog et leurs utilisations
US7052514B2 (en) * 2000-04-28 2006-05-30 Curis, Inc. Methods and reagents for tissue engineering of cartilage in vitro

Also Published As

Publication number Publication date
IL136230A (en) 2007-08-19
US6994990B1 (en) 2006-02-07
EP1034269A1 (fr) 2000-09-13
US20040138130A1 (en) 2004-07-15
WO1999028454A1 (fr) 1999-06-10
US20060073566A1 (en) 2006-04-06
AU1757099A (en) 1999-06-16
JP2001525341A (ja) 2001-12-11
MA26570A1 (fr) 2004-12-20
AU752816B2 (en) 2002-10-03
CA2312009A1 (fr) 1999-06-10

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Legal Events

Date Code Title Description
FF Patent granted
KB20 Patent renewed for 20 years