MA23717A1 - Nouveaux derives de (3-(4-phenyl piperazine-1-yl) - propylamino) - pyridine de pyrimidine, et de benzene, servant d'antagonistes des adrenorecepteurs a1, leur utilisation comme agents therapeutiques, et procede pour leur preparation - Google Patents
Nouveaux derives de (3-(4-phenyl piperazine-1-yl) - propylamino) - pyridine de pyrimidine, et de benzene, servant d'antagonistes des adrenorecepteurs a1, leur utilisation comme agents therapeutiques, et procede pour leur preparationInfo
- Publication number
- MA23717A1 MA23717A1 MA24062A MA24062A MA23717A1 MA 23717 A1 MA23717 A1 MA 23717A1 MA 24062 A MA24062 A MA 24062A MA 24062 A MA24062 A MA 24062A MA 23717 A1 MA23717 A1 MA 23717A1
- Authority
- MA
- Morocco
- Prior art keywords
- antiagonists
- adrenorepeptors
- propylamino
- benzene
- preparation
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/74—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/81—Amides; Imides
- C07D213/82—Amides; Imides in position 3
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/84—Nitriles
- C07D213/85—Nitriles in position 3
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/89—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members with hetero atoms directly attached to the ring nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/32—One oxygen, sulfur or nitrogen atom
- C07D239/42—One nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
- C07D295/125—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
- C07D295/13—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Urology & Nephrology (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyridine Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/336,368 US5688795A (en) | 1994-11-08 | 1994-11-08 | 3-(4-phenylpiperazin-1-yl)propyl-amino, thio and oxy!-pyridine, pyrimidine and benzene derivatives as α1 -adrenoceptor antagonists |
Publications (1)
Publication Number | Publication Date |
---|---|
MA23717A1 true MA23717A1 (fr) | 1996-07-01 |
Family
ID=23315765
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MA24062A MA23717A1 (fr) | 1994-11-08 | 1995-11-08 | Nouveaux derives de (3-(4-phenyl piperazine-1-yl) - propylamino) - pyridine de pyrimidine, et de benzene, servant d'antagonistes des adrenorecepteurs a1, leur utilisation comme agents therapeutiques, et procede pour leur preparation |
Country Status (22)
Country | Link |
---|---|
US (1) | US5688795A (fr) |
EP (1) | EP0711757A1 (fr) |
JP (1) | JPH08208614A (fr) |
KR (1) | KR960017658A (fr) |
CN (1) | CN1136039A (fr) |
AR (1) | AR002244A1 (fr) |
AU (1) | AU3459995A (fr) |
BR (1) | BR9505107A (fr) |
CA (1) | CA2162089A1 (fr) |
CO (1) | CO4520230A1 (fr) |
CZ (1) | CZ291095A3 (fr) |
FI (1) | FI955376A (fr) |
HU (1) | HUT73843A (fr) |
IL (1) | IL115844A0 (fr) |
MA (1) | MA23717A1 (fr) |
NO (1) | NO954453L (fr) |
NZ (1) | NZ280396A (fr) |
PE (1) | PE10997A1 (fr) |
PL (1) | PL311261A1 (fr) |
SG (1) | SG70950A1 (fr) |
TR (1) | TR199501387A2 (fr) |
ZA (1) | ZA959268B (fr) |
Families Citing this family (28)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE4425143A1 (de) | 1994-07-15 | 1996-01-18 | Basf Ag | Substituierte Pyrimidinverbindungen und deren Verwendung |
HUP0100048A3 (en) * | 1997-05-12 | 2002-12-28 | Ortho Mcneil Pharm Inc | Arylsubstituted piperazine-derivatives, useful in the treatement of benign prostatic hyperlasia use of them for producing pharmaceutical compositions and pharmaceutical compositions containing them |
DE19728996A1 (de) | 1997-07-07 | 1999-01-14 | Basf Ag | Triazolverbindungen und deren Verwendung |
US20020193383A1 (en) * | 1997-08-01 | 2002-12-19 | Recordati S.A., Chemical And Pharmaceutical Comoany | 1-(N-phenylalkylaminoalkyl)piperazine derivatives substituted at position 2 of the phenyl ring |
IT1293807B1 (it) * | 1997-08-01 | 1999-03-10 | Recordati Chem Pharm | Derivati 1- (n-fenilaminoalchil) piperazinici sostituiti alla posizione 2 dell'anello fenilico |
IT1293804B1 (it) | 1997-08-01 | 1999-03-10 | Recordati Chem Pharm | Diarilalchilpiperazine attive sulle basse vie urinarie |
US6399614B1 (en) | 1997-08-01 | 2002-06-04 | Recordati S.A. Chemical And Pharmaceutical Company | 1-(N-phenylaminoalkyl)piperazine derivatives substituted at position 2 of the phenyl ring |
US6271234B1 (en) | 1997-08-01 | 2001-08-07 | Recordati S.A., Chemical And Pharmaceutical Company | 1,4-disubstituted piperazines |
US6218396B1 (en) | 1998-02-20 | 2001-04-17 | Orth-Mcneil Pharmaceutical, Inc. | Substituted pyridino arylpiperazines useful in the treatment of benign prostatic hyperplasia |
US7045519B2 (en) * | 1998-06-19 | 2006-05-16 | Chiron Corporation | Inhibitors of glycogen synthase kinase 3 |
WO1999065897A1 (fr) | 1998-06-19 | 1999-12-23 | Chiron Corporation | Inhibiteurs de glycogene synthase kinase 3 |
US6465467B1 (en) | 1999-05-21 | 2002-10-15 | Biovitrum Ab | Certain aryl-aliphatic and heteroaryl-aliphatic piperazinyl pyrazines and their use in the treatment of serotonin-related diseases |
US6355801B1 (en) * | 1999-11-08 | 2002-03-12 | Schering Corporation | Process for preparing N-(4-hydroxyphenyl)-N′-(4′-aminophenyl)-piperazine |
ES2328671T3 (es) | 2000-11-20 | 2009-11-17 | Biovitrum Ab (Publ) | Compuestos de piperazilpirazinas como antagonistas del receptor de serotonina 5-ht2. |
EP1339682A1 (fr) | 2000-11-30 | 2003-09-03 | Ranbaxy Laboratories, Ltd. | Derives de piperazine 1,4-disubstitues utiles comme bloqueurs uroselectifs des recepteurs alpha 1?-adrenergiques |
CN100484933C (zh) | 2002-06-19 | 2009-05-06 | 比奥维特罗姆股份公开公司 | 新的吡嗪化合物及其在制备用于治疗与5-羟色胺相关的疾病的药物中的用途 |
UA89035C2 (ru) | 2003-12-03 | 2009-12-25 | Лео Фарма А/С | Эфиры гидроксамовых кислот и их фармацевтическое применение |
MY140489A (en) * | 2003-12-26 | 2009-12-31 | Eisai R&D Man Co Ltd | 1,2-di (cyclic) substituted benzene compounds |
US20070219213A1 (en) * | 2004-05-20 | 2007-09-20 | Soares Romeiro Luiz A | Use of Adrenergic N-Phenylpiperazine Antagonists, Pahrmaceutical Compositions Containning Them, and Methods of Preparing Them |
EP2077262A4 (fr) * | 2006-10-23 | 2011-12-28 | Takeda Pharmaceutical | Dérivé de l'iminopyridine et son utilisation |
US8329691B2 (en) | 2007-10-15 | 2012-12-11 | Takeda Pharmaceutical Company Limited | Amide compounds and use of the same |
ES2478823T3 (es) * | 2008-04-23 | 2014-07-23 | Takeda Pharmaceutical Company Limited | Derivados de iminopiridina y uso de los mismos |
US8481569B2 (en) | 2008-04-23 | 2013-07-09 | Takeda Pharmaceutical Company Limited | Iminopyridine derivatives and use thereof |
US20110039892A1 (en) * | 2008-04-23 | 2011-02-17 | Takeda Pharmaceutical Company Limited | Iminopyridine derivative and use thereof |
CN101585781B (zh) * | 2009-07-08 | 2012-08-08 | 北京颖新泰康国际贸易有限公司 | 一种邻氨基-n,n-二甲基苯甲酰胺的制备方法 |
CN103387531A (zh) * | 2012-05-10 | 2013-11-13 | 广州医学院 | 酰胺类芳基哌嗪衍生物及其制备方法和在抗良性前列腺增生中的应用 |
CN114163383A (zh) * | 2021-12-24 | 2022-03-11 | 江苏丰山集团股份有限公司 | 一种烟嘧磺隆中间体烟酰胺和磺酰胺的绿色生产工艺 |
CN115611802B (zh) * | 2022-12-02 | 2023-03-14 | 北京迪泰医药科技有限公司 | 一种3-乙酰基-2-氯吡啶的合成方法 |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3635976A (en) * | 1967-12-20 | 1972-01-18 | Pennwalt Corp | 1 - heterocyclic alkyl-1 2 3 4-tetrahydroquinazolinones and analgesic intermediates thereof |
BE787126A (fr) * | 1971-08-04 | 1973-02-05 | Byk Gulden Lomberg Chem Fab | Pyrimidines substituees, procedes de preparation de ces composes et medicaments contenant lesdits composes |
DE2143730A1 (de) * | 1971-09-01 | 1973-03-08 | Byk Gulden Lomberg Chem Fab | Substituierte pyridine, verfahren zu deren herstellung und sie enthaltende arzneimittel |
JPS49133380A (fr) * | 1973-04-25 | 1974-12-21 | ||
US4616017A (en) * | 1984-06-04 | 1986-10-07 | Merck & Co., Inc. | Aminohydroxypropoxy substituted aryl compounds |
GB2163150B (en) * | 1984-07-19 | 1988-05-25 | Sandoz Ltd | 3-aminopropoxyaryl derivatives |
FR2656609B1 (fr) * | 1989-12-28 | 1992-03-27 | Synthelabo | Derives de 2-aminopyrimidine-4-carboxamide, leur preparation et leur application en therapeutique. |
FR2678272B1 (fr) * | 1991-06-27 | 1994-01-14 | Synthelabo | Derives de 2-aminopyrimidine-4-carboxamide, leur preparation et leur application en therapeutique. |
-
1994
- 1994-11-08 US US08/336,368 patent/US5688795A/en not_active Expired - Fee Related
-
1995
- 1995-10-27 EP EP95116942A patent/EP0711757A1/fr not_active Withdrawn
- 1995-11-01 AU AU34599/95A patent/AU3459995A/en not_active Abandoned
- 1995-11-01 IL IL11584495A patent/IL115844A0/xx unknown
- 1995-11-01 SG SG1995001704A patent/SG70950A1/en unknown
- 1995-11-02 ZA ZA9509268A patent/ZA959268B/xx unknown
- 1995-11-03 CA CA002162089A patent/CA2162089A1/fr not_active Abandoned
- 1995-11-03 NZ NZ280396A patent/NZ280396A/en unknown
- 1995-11-06 AR ARP950100065A patent/AR002244A1/es unknown
- 1995-11-06 HU HU9503178A patent/HUT73843A/hu unknown
- 1995-11-06 CN CN95118772A patent/CN1136039A/zh active Pending
- 1995-11-06 PE PE1995283893A patent/PE10997A1/es not_active Application Discontinuation
- 1995-11-07 CZ CZ952910A patent/CZ291095A3/cs unknown
- 1995-11-07 JP JP7287753A patent/JPH08208614A/ja active Pending
- 1995-11-07 NO NO954453A patent/NO954453L/no unknown
- 1995-11-07 CO CO95052482A patent/CO4520230A1/es unknown
- 1995-11-07 PL PL95311261A patent/PL311261A1/xx unknown
- 1995-11-07 BR BR9505107A patent/BR9505107A/pt not_active Application Discontinuation
- 1995-11-08 KR KR1019950040349A patent/KR960017658A/ko not_active Application Discontinuation
- 1995-11-08 TR TR95/01387A patent/TR199501387A2/xx unknown
- 1995-11-08 MA MA24062A patent/MA23717A1/fr unknown
- 1995-11-08 FI FI955376A patent/FI955376A/fi unknown
Also Published As
Publication number | Publication date |
---|---|
US5688795A (en) | 1997-11-18 |
HU9503178D0 (en) | 1996-01-29 |
ZA959268B (en) | 1997-01-31 |
FI955376A0 (fi) | 1995-11-08 |
CZ291095A3 (en) | 1996-09-11 |
TR199501387A2 (tr) | 1996-07-21 |
CA2162089A1 (fr) | 1996-05-09 |
HUT73843A (en) | 1996-09-30 |
NZ280396A (en) | 1997-05-26 |
IL115844A0 (en) | 1996-01-31 |
KR960017658A (ko) | 1996-06-17 |
SG70950A1 (en) | 2000-03-21 |
JPH08208614A (ja) | 1996-08-13 |
BR9505107A (pt) | 1997-09-09 |
NO954453L (no) | 1996-05-09 |
AU3459995A (en) | 1996-05-16 |
PE10997A1 (es) | 1997-04-26 |
FI955376A (fi) | 1996-05-09 |
CN1136039A (zh) | 1996-11-20 |
NO954453D0 (no) | 1995-11-07 |
EP0711757A1 (fr) | 1996-05-15 |
CO4520230A1 (es) | 1997-10-15 |
PL311261A1 (en) | 1996-05-13 |
AR002244A1 (es) | 1998-03-11 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
MA23717A1 (fr) | Nouveaux derives de (3-(4-phenyl piperazine-1-yl) - propylamino) - pyridine de pyrimidine, et de benzene, servant d'antagonistes des adrenorecepteurs a1, leur utilisation comme agents therapeutiques, et procede pour leur preparation | |
MA25493A1 (fr) | Derives de 3(5)-amino-pyrazole, procede pour leur preparation et leur utilisation en tant qu'agents antitumoraux. | |
MA23831A1 (fr) | Derives de quinazoline, procede pour leur preparation et composition les contenant | |
MA24484A1 (fr) | Atropisomeres de 3-aryl-4(3h)-quinazolinones, procede pour leur preparation et compositions les contenant . | |
MA24469A1 (fr) | Derives d'acide arylsulfonyhydroxamique, procede pour leur preparation et compositions les contenant | |
MA26479A1 (fr) | Derives de nicotinamide, procede pour leur preparation et compositions pharmaceutiques les contenant | |
MA26430A1 (fr) | 4 (3h)-quinazolinones 2,3-disubstituees nouvelles, procede pour leur preparation et compositions pharmaceutiques les contenant | |
MA26432A1 (fr) | Derives de 2-(2-oxo-ethylidene)-imidazolidine-4-one, procede pour leur preparation et compositions pharmaceutiques les contenant. | |
FR2740136B1 (fr) | Derives d'indolin-2-one, procede pour leur preparation et les compositions pharmaceutiques les contenant | |
MA23899A1 (fr) | Procede pour la preparation de derives de pyrimidinedione et -trione, triazinedione et quinazolinedione, procede de preparation de compositions pharmaceutiques les contenant et leur utilisation | |
MA26439A1 (fr) | Derives d'indazole nouveaux, procede pour leur preparation et compositions pharmaceutiques les contenant | |
HUP9701096A3 (en) | Use of benzenesulfonamides for the preparation of pharmaceutical compositions treating disorders of the central nervous system, novel derivatives, process for their preparation and pharmaceutical compositions containing them | |
FR2665898B1 (fr) | Derives d'amido-3 pyrazole, procede pour leur preparation et compositions pharmaceutiques les contenant. | |
DZ2045A1 (fr) | Amides thérapeutiques, procédé pour leur préparation et compositions les contenant. | |
EE200100252A (et) | Pürimidiinderivaadid, nende valmistamismeetod ja kasutamine, farmatseutiline kompositsioon ja sellevalmistamismeetod, kombinatsioon ning saadus | |
MY107799A (en) | Neuroprotective indolone and related derivatives | |
MA26559A1 (fr) | Derives de d-proline, procede pour leur preparation, compositions pharmaceutiques les contenant et leur utilisation | |
FR2707641B1 (fr) | Composés de l'imidazol-5-carboxamide, leur procédé de préparation leurs intermédiaires et leur utilisation en thérapeutique. | |
MA26526A1 (fr) | Derives d'indole inhibiteurs de cyclo-oxygenase, procede pour leur preparation et compositions pharmaceutiques les contenant. | |
MA24158A1 (fr) | Derives d'imidazole substitues, procede pour leur preparation et compositions les contenant | |
FR2611366B1 (fr) | Nouvelles cetones tricycliques utiles comme medicaments, procede et intermediaires pour leur preparation | |
MA26433A1 (fr) | Derives de pyridylpyrrole, procede pour leur preparation et compositions pharmaceutiques les contenant | |
MA23942A1 (fr) | Formulation nouvelle contenant de la paroxetine, et procede pour sa preparation | |
ZA952086B (en) | Heterocyclic compounds their preparation and use | |
MA26519A1 (fr) | Derives d'azetidinylpropylpiperidine, procede pour leur preparation et compositions pharmaceutiques les contenant. |