LU90855I2 - Proteine 1 osteogenique recombinante humaine: bmp-7 et ses d-riv-s pharmaceutiquement acceptables - Google Patents
Proteine 1 osteogenique recombinante humaine: bmp-7 et ses d-riv-s pharmaceutiquement acceptablesInfo
- Publication number
- LU90855I2 LU90855I2 LU90855C LU90855C LU90855I2 LU 90855 I2 LU90855 I2 LU 90855I2 LU 90855 C LU90855 C LU 90855C LU 90855 C LU90855 C LU 90855C LU 90855 I2 LU90855 I2 LU 90855I2
- Authority
- LU
- Luxembourg
- Prior art keywords
- osteogenic
- osteogenique
- recombinante
- humaine
- proteine
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
- C07K14/51—Bone morphogenetic factor; Osteogenins; Osteogenic factor; Bone-inducing factor
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/14—Macromolecular materials
- A61L27/22—Polypeptides or derivatives thereof, e.g. degradation products
- A61L27/227—Other specific proteins or polypeptides not covered by A61L27/222, A61L27/225 or A61L27/24
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/14—Macromolecular materials
- A61L27/22—Polypeptides or derivatives thereof, e.g. degradation products
- A61L27/24—Collagen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/28—Materials for coating prostheses
- A61L27/34—Macromolecular materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
- A61L27/3604—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix characterised by the human or animal origin of the biological material, e.g. hair, fascia, fish scales, silk, shellac, pericardium, pleura, renal tissue, amniotic membrane, parenchymal tissue, fetal tissue, muscle tissue, fat tissue, enamel
- A61L27/3608—Bone, e.g. demineralised bone matrix [DBM], bone powder
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61C—DENTISTRY; APPARATUS OR METHODS FOR ORAL OR DENTAL HYGIENE
- A61C8/00—Means to be fixed to the jaw-bone for consolidating natural teeth or for fixing dental prostheses thereon; Dental implants; Implanting tools
- A61C8/0003—Not used, see subgroups
- A61C8/0004—Consolidating natural teeth
- A61C8/0006—Periodontal tissue or bone regeneration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2310/00—Prostheses classified in A61F2/28 or A61F2/30 - A61F2/44 being constructed from or coated with a particular material
- A61F2310/00005—The prosthesis being constructed from a particular material
- A61F2310/00365—Proteins; Polypeptides; Degradation products thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2430/00—Materials or treatment for tissue regeneration
- A61L2430/02—Materials or treatment for tissue regeneration for reconstruction of bones; weight-bearing implants
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Transplantation (AREA)
- Dermatology (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Zoology (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biophysics (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Botany (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Physical Education & Sports Medicine (AREA)
- Toxicology (AREA)
- Gastroenterology & Hepatology (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Urology & Nephrology (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Materials For Medical Uses (AREA)
- Separation By Low-Temperature Treatments (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Prostheses (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US42269989A | 1989-10-17 | 1989-10-17 | |
| US07/483,913 US5171574A (en) | 1989-02-23 | 1990-02-22 | Bone collagen matrix for implants |
| US56992090A | 1990-08-20 | 1990-08-20 | |
| PCT/US1990/005903 WO1991005802A1 (en) | 1989-10-17 | 1990-10-15 | Osteogenic devices |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| LU90855I2 true LU90855I2 (en) | 2002-01-24 |
Family
ID=27411374
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| LU90855C LU90855I2 (en) | 1989-10-17 | 2001-11-15 | Proteine 1 osteogenique recombinante humaine: bmp-7 et ses d-riv-s pharmaceutiquement acceptables |
Country Status (11)
| Country | Link |
|---|---|
| EP (1) | EP0448704B1 (enExample) |
| JP (6) | JP2845346B2 (enExample) |
| AT (1) | ATE167486T1 (enExample) |
| CA (1) | CA2042577A1 (enExample) |
| DE (1) | DE69032424T2 (enExample) |
| DK (1) | DK0448704T3 (enExample) |
| ES (1) | ES2118723T3 (enExample) |
| GR (1) | GR3027722T3 (enExample) |
| LU (1) | LU90855I2 (enExample) |
| NL (1) | NL300062I2 (enExample) |
| WO (1) | WO1991005802A1 (enExample) |
Families Citing this family (64)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6150328A (en) | 1986-07-01 | 2000-11-21 | Genetics Institute, Inc. | BMP products |
| US5939388A (en) * | 1986-07-01 | 1999-08-17 | Rosen; Vicki A. | Methods of administering BMP-5 compositions |
| US6432919B1 (en) | 1986-07-01 | 2002-08-13 | Genetics Institute, Inc. | Bone morphogenetic protein-3 and compositions |
| US5366875A (en) * | 1986-07-01 | 1994-11-22 | Genetics Institute, Inc. | Methods for producing BMP-7 proteins |
| US5187076A (en) * | 1986-07-01 | 1993-02-16 | Genetics Institute, Inc. | DNA sequences encoding BMP-6 proteins |
| US5543394A (en) * | 1986-07-01 | 1996-08-06 | Genetics Institute, Inc. | Bone morphogenetic protein 5(BMP-5) compositions |
| US5459047A (en) | 1986-07-01 | 1995-10-17 | Genetics Institute, Inc. | BMP-6 proteins |
| US5013649A (en) * | 1986-07-01 | 1991-05-07 | Genetics Institute, Inc. | DNA sequences encoding osteoinductive products |
| US5344654A (en) * | 1988-04-08 | 1994-09-06 | Stryker Corporation | Prosthetic devices having enhanced osteogenic properties |
| US5284756A (en) * | 1988-10-11 | 1994-02-08 | Lynn Grinna | Heterodimeric osteogenic factor |
| DK0429570T3 (da) * | 1989-03-28 | 1998-04-27 | Genetics Inst | Osteoinducerende præparater |
| US7378392B1 (en) | 1990-05-16 | 2008-05-27 | Genetics Institute, Llc | Bone and cartilage inductive proteins |
| US5688678A (en) * | 1990-05-16 | 1997-11-18 | Genetics Institute, Inc. | DNA encoding and methods for producing BMP-8 proteins |
| US6077823A (en) * | 1991-03-11 | 2000-06-20 | Creative Biomolecules, Inc. | Method for reducing tissue damage associated with ischemia-reperfusion or hypoxia injury |
| US6090776A (en) * | 1991-03-11 | 2000-07-18 | Creative Bio Molecules, Inc. | Morphogen treatment of organ implants |
| US6395883B1 (en) | 1991-03-11 | 2002-05-28 | Curis, Inc. | Soluble morphogenic protein complex compositions of matter |
| CA2104678C (en) | 1991-03-11 | 2002-05-14 | Charles M. Cohen | Protein-induced morphogenesis |
| US5739107A (en) * | 1991-03-11 | 1998-04-14 | Creative Biomolecules, Inc. | Morphogen treatment of gastrointestinal ulcers |
| DE69231946T2 (de) * | 1991-03-11 | 2002-04-04 | Curis, Inc. | Protein-induzierende morphogenese |
| US6194376B1 (en) | 1991-03-11 | 2001-02-27 | Creative Biomolecules, Inc. | Method for modulating inflammatory response comprising administering morphogen |
| US7056882B2 (en) | 1991-03-11 | 2006-06-06 | Curis, Inc. | Treatment to prevent loss of and/or increase bone mass in metabolic bone diseases |
| US5674844A (en) * | 1991-03-11 | 1997-10-07 | Creative Biomolecules, Inc. | Treatment to prevent loss of and/or increase bone mass in metabolic bone diseases |
| US5661007A (en) * | 1991-06-25 | 1997-08-26 | Genetics Institute, Inc. | Bone morphogenetic protein-9 compositions |
| US6287816B1 (en) * | 1991-06-25 | 2001-09-11 | Genetics Institute, Inc. | BMP-9 compositions |
| ES2253736T3 (es) * | 1991-08-30 | 2006-06-01 | Curis, Inc. | Tratamiento para prevenir la perdida y/o aumentar la masa osea en transtornos metabolicos del hueso. |
| JP3693338B2 (ja) * | 1991-08-30 | 2005-09-07 | キュリス インコーポレイテッド | 組織形成因子誘導による炎症反応の調節 |
| US5171579A (en) * | 1991-10-11 | 1992-12-15 | Genetics Institute, Inc. | Formulations of blood clot-polymer matrix for delivery of osteogenic proteins |
| KR100259827B1 (ko) * | 1991-11-04 | 2000-06-15 | 브루스 엠. 에이센, 토마스 제이 데스로저 | 재조합 골형태 형성 단백질 헤테로다이머, 그 조성물 및 사용방법 |
| IT1259042B (it) * | 1992-01-27 | 1996-03-11 | Mini Ricerca Scient Tecnolog | Preparazione di vettori di espressione per la sintesi del polipeptide chiamato fattore osteogenetico op-1 in cellule eucariotiche di spodoptera frugiperda via infezione con baculovirus ricombinante |
| PT625989E (pt) * | 1992-02-12 | 2000-06-30 | Bioph Biotech Entw Pharm Gmbh | Sequencias de adn que codificam novos factores de crescimento/diferenciacao |
| IL110589A0 (en) * | 1993-08-10 | 1994-11-11 | Bioph Biotech Entw Pharm Gmbh | Growth/differentiation factor of the TGF- beta family |
| US6764994B1 (en) | 1993-08-10 | 2004-07-20 | Biopharm Gesellschaft Zur Biotechnologischen Entwicklung Von Pharmaka Mbh | Growth/differential factor of the TGF-B family |
| US6291206B1 (en) | 1993-09-17 | 2001-09-18 | Genetics Institute, Inc. | BMP receptor proteins |
| US5631159A (en) * | 1993-09-22 | 1997-05-20 | Creative Biomolecules, Inc. | Lipid-modified serum free media |
| DK0733109T3 (da) | 1993-12-07 | 2006-07-03 | Genetics Inst Llc | BMP-12, BMP-13 og seneinducerende præparater dermed |
| ATE378407T1 (de) * | 1994-04-29 | 2007-11-15 | Curis Inc | Morphogene protein-spezifische zelloberflächenrezeptoren und ihre verwendungen |
| US5906827A (en) * | 1994-06-03 | 1999-05-25 | Creative Biomolecules, Inc. | Matrix for the manufacture of autogenous replacement body parts |
| US6040431A (en) * | 1995-06-07 | 2000-03-21 | Stryker Corporation | Single chain analogs of the TGF-β superfamily (morphons) |
| US6214796B1 (en) | 1996-03-22 | 2001-04-10 | The General Hospital Corporation | Administration of polypeptide growth factors following central nervous system ischemia or trauma |
| US6492508B1 (en) | 1996-06-03 | 2002-12-10 | United States Surgical Corp. A Division Of Tyco Healthcare Group | Nucleic acids encoding extracellular matrix proteins |
| DE19647853A1 (de) | 1996-11-19 | 1998-05-20 | Bioph Biotech Entw Pharm Gmbh | Verbindungen mit verbesserter knorpel- und/oder knocheninduzierender Aktivität |
| US6034062A (en) * | 1997-03-13 | 2000-03-07 | Genetics Institute, Inc. | Bone morphogenetic protein (BMP)-9 compositions and their uses |
| EP0985149A1 (en) * | 1997-05-30 | 2000-03-15 | Creative Biomolecules, Inc. | Methods for evaluating tissue morphogenesis and activity |
| AU1706499A (en) * | 1997-12-04 | 1999-06-16 | Curis, Inc. | Maintenance of smooth muscle integrity by morphogenic proteins |
| US6677432B1 (en) | 1998-10-07 | 2004-01-13 | Stryker Corporation | Mutations of the C-terminal portion of TGF-β superfamily proteins |
| AU1103900A (en) | 1998-10-07 | 2000-04-26 | Stryker Corporation | Modified tgf-beta superfamily proteins |
| US6846906B1 (en) | 1998-10-07 | 2005-01-25 | Stryker Corporation | Modified proteins of the TGF-β superfamily, including morphogenic proteins |
| US6663870B2 (en) | 1998-12-07 | 2003-12-16 | Zymogenetics, Inc. | Methods for promoting growth of bone using zvegf3 |
| US6727224B1 (en) | 1999-02-01 | 2004-04-27 | Genetics Institute, Llc. | Methods and compositions for healing and repair of articular cartilage |
| DE19906096A1 (de) | 1999-02-13 | 2000-08-17 | Walter Sebald | Protein mit einem Heparin-bindenden Epitop |
| US6468543B1 (en) | 1999-05-03 | 2002-10-22 | Zymogenetics, Inc. | Methods for promoting growth of bone using ZVEGF4 |
| US7189392B1 (en) | 1999-10-15 | 2007-03-13 | Genetics Institute, Llc | Injectable carrier formulations of hyaluronic acid derivatives for delivery of osteogenic proteins |
| AU2000251259A1 (en) * | 2000-02-04 | 2001-08-14 | Zymogenetics Inc. | Methods for promoting growth of bone, ligament, and cartilage using zvegf4 |
| CA2449008A1 (en) | 2001-06-01 | 2002-12-12 | Wyeth | Compositions and methods for systemic administration of sequences encoding bone morphogenetic proteins |
| TWI267378B (en) | 2001-06-08 | 2006-12-01 | Wyeth Corp | Calcium phosphate delivery vehicles for osteoinductive proteins |
| WO2003030925A1 (fr) * | 2001-10-02 | 2003-04-17 | Kiyoshi Nokihara | Medicaments d'angiogenese |
| US8546334B2 (en) | 2001-11-19 | 2013-10-01 | Scil Technology Gmbh | Device having osteoinductive and osteoconductive properties |
| CN100522241C (zh) | 2002-09-10 | 2009-08-05 | Scil技术股份有限公司 | 在低氧气浓度下用骨诱导蛋白包被的金属植入物 |
| US7163920B2 (en) | 2003-09-30 | 2007-01-16 | Ethicon, Inc. | Peptide with osteogenic activity |
| DK1737734T3 (da) | 2004-03-10 | 2010-11-08 | Scil Technology Gmbh | Overtrukne implantater, deres fremstilling og anvendelse deraf |
| US7575751B2 (en) | 2004-04-27 | 2009-08-18 | Research Development Foundation | Activin-A mutants |
| DE102008036576A1 (de) * | 2008-07-31 | 2010-02-04 | Gelita Ag | Partikel aus Kollagenmaterial und Verfahren zur Herstellung |
| US8952130B2 (en) | 2009-02-24 | 2015-02-10 | The Salk Institute For Biological Studies | Designer ligands of TGF-β superfamily |
| US20110002897A1 (en) | 2009-06-11 | 2011-01-06 | Burnham Institute For Medical Research | Directed differentiation of stem cells |
Family Cites Families (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4172128A (en) * | 1975-03-26 | 1979-10-23 | Erhard Thiele | Process of degrading and regenerating bone and tooth material and products |
| US4294753A (en) * | 1980-08-04 | 1981-10-13 | The Regents Of The University Of California | Bone morphogenetic protein process |
| US4394370A (en) * | 1981-09-21 | 1983-07-19 | Jefferies Steven R | Bone graft material for osseous defects and method of making same |
| US4434094A (en) * | 1983-04-12 | 1984-02-28 | Collagen Corporation | Partially purified osteogenic factor and process for preparing same from demineralized bone |
| CA1229789A (en) * | 1983-06-06 | 1987-12-01 | David Baylink | Polypeptides exhibiting skeletal growth factor activity |
| US4795804A (en) * | 1983-08-16 | 1989-01-03 | The Regents Of The University Of California | Bone morphogenetic agents |
| NZ210699A (en) * | 1984-01-04 | 1989-06-28 | Int Genetic Eng | Isolation of an osteogenic protein of the p3 immunologically related family |
| US4563489A (en) * | 1984-02-10 | 1986-01-07 | University Of California | Biodegradable organic polymer delivery system for bone morphogenetic protein |
| US4837285A (en) * | 1984-03-27 | 1989-06-06 | Medimatrix | Collagen matrix beads for soft tissue repair |
| CA1295796C (en) * | 1984-03-27 | 1992-02-18 | Conrad Whyne | Biodegradable matrix and methods for producing same |
| US4620327A (en) * | 1984-07-05 | 1986-11-04 | Caplan Arnold I | Process of adapting soluble bone protein for use in stimulating osteoinduction |
| US4789663A (en) * | 1984-07-06 | 1988-12-06 | Collagen Corporation | Methods of bone repair using collagen |
| EP0169016B2 (en) * | 1984-07-16 | 2004-04-28 | Celtrix Pharmaceuticals, Inc. | Polypeptide cartilage-inducing factors found in bone |
| EP0169001A3 (en) * | 1984-07-17 | 1987-11-25 | Collagen Corporation | Collagen coated bone implants |
| US4657548A (en) * | 1984-09-11 | 1987-04-14 | Helitrex, Inc. | Delivery system for implantation of fine particles in surgical procedures |
| US4563350A (en) * | 1984-10-24 | 1986-01-07 | Collagen Corporation | Inductive collagen based bone repair preparations |
| US4888366A (en) * | 1984-10-24 | 1989-12-19 | Collagen Corporation | Inductive collagen-based bone repair preparations |
| US4600533A (en) * | 1984-12-24 | 1986-07-15 | Collagen Corporation | Collagen membranes for medical use |
| CA1277601C (en) * | 1985-12-27 | 1990-12-11 | Shigeji Sato | Method for producing sustained release formulation |
| IL83003A (en) * | 1986-07-01 | 1995-07-31 | Genetics Inst | Osteoinductive factors |
| US4824939A (en) * | 1986-10-09 | 1989-04-25 | Eastman Kodak Company | Process for leaching particulate solid materials |
| IT1214505B (it) * | 1987-03-12 | 1990-01-18 | Gentili Ist Spa | Procedimento per la preparazione di collageno e prodotti cosi'ottenuto. |
| JPS6434371A (en) * | 1987-07-31 | 1989-02-03 | Nitta Gelatin Kk | Periosteal bone forming material |
| US4812120A (en) * | 1987-11-02 | 1989-03-14 | Flanagan Dennis F | Implantable percutaneous device |
| WO1989009605A1 (en) * | 1988-04-06 | 1989-10-19 | Collagen Corporation | Bone-inducing protein |
| WO1989010409A1 (en) * | 1988-04-08 | 1989-11-02 | Genetics Institute, Inc. | Bone and cartilage inductive compositions |
| EP1225225A3 (en) * | 1988-04-08 | 2003-01-08 | Stryker Corporation | Osteogenic devices |
| DK0429570T3 (da) * | 1989-03-28 | 1998-04-27 | Genetics Inst | Osteoinducerende præparater |
-
1990
- 1990-10-15 CA CA002042577A patent/CA2042577A1/en not_active Abandoned
- 1990-10-15 EP EP90916655A patent/EP0448704B1/en not_active Expired - Lifetime
- 1990-10-15 ES ES90916655T patent/ES2118723T3/es not_active Expired - Lifetime
- 1990-10-15 DE DE69032424T patent/DE69032424T2/de not_active Expired - Lifetime
- 1990-10-15 DK DK90916655T patent/DK0448704T3/da active
- 1990-10-15 WO PCT/US1990/005903 patent/WO1991005802A1/en not_active Ceased
- 1990-10-15 JP JP2515578A patent/JP2845346B2/ja not_active Expired - Lifetime
- 1990-10-15 AT AT90916655T patent/ATE167486T1/de not_active IP Right Cessation
-
1997
- 1997-07-02 JP JP9177440A patent/JPH10114673A/ja not_active Withdrawn
-
1998
- 1998-08-26 GR GR980401900T patent/GR3027722T3/el unknown
-
2000
- 2000-08-24 JP JP2000254562A patent/JP3368260B2/ja not_active Expired - Lifetime
-
2001
- 2001-09-27 NL NL300062C patent/NL300062I2/nl unknown
- 2001-11-15 LU LU90855C patent/LU90855I2/en unknown
-
2002
- 2002-01-16 JP JP2002008070A patent/JP2002281976A/ja not_active Withdrawn
-
2003
- 2003-10-07 JP JP2003348890A patent/JP2004041236A/ja not_active Withdrawn
-
2005
- 2005-09-21 JP JP2005274803A patent/JP2006068018A/ja not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| DE69032424T2 (de) | 1999-02-04 |
| EP0448704A4 (en) | 1992-07-08 |
| ES2118723T3 (es) | 1998-10-01 |
| JP2004041236A (ja) | 2004-02-12 |
| AU6648190A (en) | 1991-05-16 |
| JP2845346B2 (ja) | 1999-01-13 |
| GR3027722T3 (en) | 1998-11-30 |
| JPH10114673A (ja) | 1998-05-06 |
| JP3368260B2 (ja) | 2003-01-20 |
| DK0448704T3 (da) | 1999-04-06 |
| EP0448704B1 (en) | 1998-06-17 |
| EP0448704A1 (en) | 1991-10-02 |
| JP2002281976A (ja) | 2002-10-02 |
| JP2006068018A (ja) | 2006-03-16 |
| DE69032424D1 (de) | 1998-07-23 |
| JP2001095591A (ja) | 2001-04-10 |
| NL300062I2 (nl) | 2002-02-01 |
| WO1991005802A1 (en) | 1991-05-02 |
| NL300062I1 (nl) | 2001-12-01 |
| JPH04502336A (ja) | 1992-04-23 |
| AU648997B2 (en) | 1994-05-12 |
| ATE167486T1 (de) | 1998-07-15 |
| CA2042577A1 (en) | 1991-04-18 |
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