LU84514A1 - Composition stable pour corticotherapie locale contenant a l'etat solubilise de l'hydrocortisone - Google Patents
Composition stable pour corticotherapie locale contenant a l'etat solubilise de l'hydrocortisone Download PDFInfo
- Publication number
- LU84514A1 LU84514A1 LU84514A LU84514A LU84514A1 LU 84514 A1 LU84514 A1 LU 84514A1 LU 84514 A LU84514 A LU 84514A LU 84514 A LU84514 A LU 84514A LU 84514 A1 LU84514 A1 LU 84514A1
- Authority
- LU
- Luxembourg
- Prior art keywords
- weight
- hydrocortisone
- solution
- composition according
- composition
- Prior art date
Links
- JYGXADMDTFJGBT-VWUMJDOOSA-N hydrocortisone Chemical compound O=C1CC[C@]2(C)[C@H]3[C@@H](O)C[C@](C)([C@@](CC4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 JYGXADMDTFJGBT-VWUMJDOOSA-N 0.000 title claims description 53
- 239000000203 mixture Substances 0.000 title claims description 31
- 229960000890 hydrocortisone Drugs 0.000 title claims description 28
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 20
- JBKVHLHDHHXQEQ-UHFFFAOYSA-N epsilon-caprolactam Chemical compound O=C1CCCCCN1 JBKVHLHDHHXQEQ-UHFFFAOYSA-N 0.000 claims description 20
- 239000000243 solution Substances 0.000 claims description 16
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 15
- 239000003246 corticosteroid Substances 0.000 claims description 9
- LQZZUXJYWNFBMV-UHFFFAOYSA-N dodecan-1-ol Chemical compound CCCCCCCCCCCCO LQZZUXJYWNFBMV-UHFFFAOYSA-N 0.000 claims description 8
- 238000002560 therapeutic procedure Methods 0.000 claims description 8
- 239000002904 solvent Substances 0.000 claims description 7
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 7
- 239000006210 lotion Substances 0.000 claims description 6
- 239000002674 ointment Substances 0.000 claims description 6
- MEJYDZQQVZJMPP-ULAWRXDQSA-N (3s,3ar,6r,6ar)-3,6-dimethoxy-2,3,3a,5,6,6a-hexahydrofuro[3,2-b]furan Chemical compound CO[C@H]1CO[C@@H]2[C@H](OC)CO[C@@H]21 MEJYDZQQVZJMPP-ULAWRXDQSA-N 0.000 claims description 4
- BBMCTIGTTCKYKF-UHFFFAOYSA-N 1-heptanol Chemical compound CCCCCCCO BBMCTIGTTCKYKF-UHFFFAOYSA-N 0.000 claims description 4
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 claims description 4
- LRHPLDYGYMQRHN-UHFFFAOYSA-N N-Butanol Chemical compound CCCCO LRHPLDYGYMQRHN-UHFFFAOYSA-N 0.000 claims description 4
- FYUHFVHZYOANMN-UHFFFAOYSA-M [Cl-].C(CCCCCCCCCCCCCCC(C)C)CC(O)[N+]1(C=NCC1)CC1=CC=CC=C1 Chemical compound [Cl-].C(CCCCCCCCCCCCCCC(C)C)CC(O)[N+]1(C=NCC1)CC1=CC=CC=C1 FYUHFVHZYOANMN-UHFFFAOYSA-M 0.000 claims description 4
- -1 nonylphenyl radical Chemical class 0.000 claims description 4
- 239000007864 aqueous solution Substances 0.000 claims description 3
- 125000004432 carbon atom Chemical group C* 0.000 claims description 3
- 229920000223 polyglycerol Polymers 0.000 claims description 3
- DNIAPMSPPWPWGF-GSVOUGTGSA-N (R)-(-)-Propylene glycol Chemical compound C[C@@H](O)CO DNIAPMSPPWPWGF-GSVOUGTGSA-N 0.000 claims description 2
- CBOIHMRHGLHBPB-UHFFFAOYSA-N hydroxymethyl Chemical compound O[CH2] CBOIHMRHGLHBPB-UHFFFAOYSA-N 0.000 claims description 2
- GSGDTSDELPUTKU-UHFFFAOYSA-N nonoxybenzene Chemical compound CCCCCCCCCOC1=CC=CC=C1 GSGDTSDELPUTKU-UHFFFAOYSA-N 0.000 claims description 2
- ZPIRTVJRHUMMOI-UHFFFAOYSA-N octoxybenzene Chemical compound CCCCCCCCOC1=CC=CC=C1 ZPIRTVJRHUMMOI-UHFFFAOYSA-N 0.000 claims description 2
- 230000015556 catabolic process Effects 0.000 description 6
- 238000006731 degradation reaction Methods 0.000 description 6
- 238000004128 high performance liquid chromatography Methods 0.000 description 4
- 239000007788 liquid Substances 0.000 description 4
- 230000000694 effects Effects 0.000 description 3
- 239000000499 gel Substances 0.000 description 3
- 235000011187 glycerol Nutrition 0.000 description 3
- 238000004321 preservation Methods 0.000 description 3
- 206010003694 Atrophy Diseases 0.000 description 2
- LCGLNKUTAGEVQW-UHFFFAOYSA-N Dimethyl ether Chemical compound COC LCGLNKUTAGEVQW-UHFFFAOYSA-N 0.000 description 2
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 2
- 229920002125 Sokalan® Polymers 0.000 description 2
- 230000037444 atrophy Effects 0.000 description 2
- 230000002427 irreversible effect Effects 0.000 description 2
- 230000035515 penetration Effects 0.000 description 2
- 235000019271 petrolatum Nutrition 0.000 description 2
- 230000002035 prolonged effect Effects 0.000 description 2
- 230000003381 solubilizing effect Effects 0.000 description 2
- BXHHMSHUJKGQLJ-UHFFFAOYSA-N 1-(1-benzyl-4,5-dihydroimidazol-1-ium-1-yl)ethanol Chemical compound OC(C)[N+]1(C=NCC1)CC1=CC=CC=C1 BXHHMSHUJKGQLJ-UHFFFAOYSA-N 0.000 description 1
- FUFLCEKSBBHCMO-UHFFFAOYSA-N 11-dehydrocorticosterone Natural products O=C1CCC2(C)C3C(=O)CC(C)(C(CC4)C(=O)CO)C4C3CCC2=C1 FUFLCEKSBBHCMO-UHFFFAOYSA-N 0.000 description 1
- QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 description 1
- MFYSYFVPBJMHGN-ZPOLXVRWSA-N Cortisone Chemical compound O=C1CC[C@]2(C)[C@H]3C(=O)C[C@](C)([C@@](CC4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 MFYSYFVPBJMHGN-ZPOLXVRWSA-N 0.000 description 1
- MFYSYFVPBJMHGN-UHFFFAOYSA-N Cortisone Natural products O=C1CCC2(C)C3C(=O)CC(C)(C(CC4)(O)C(=O)CO)C4C3CCC2=C1 MFYSYFVPBJMHGN-UHFFFAOYSA-N 0.000 description 1
- 229920002153 Hydroxypropyl cellulose Polymers 0.000 description 1
- KLDXJTOLSGUMSJ-JGWLITMVSA-N Isosorbide Chemical compound O[C@@H]1CO[C@@H]2[C@@H](O)CO[C@@H]21 KLDXJTOLSGUMSJ-JGWLITMVSA-N 0.000 description 1
- 125000002066 L-histidyl group Chemical group [H]N1C([H])=NC(C([H])([H])[C@](C(=O)[*])([H])N([H])[H])=C1[H] 0.000 description 1
- 239000005662 Paraffin oil Substances 0.000 description 1
- 239000004480 active ingredient Substances 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- 150000001298 alcohols Chemical class 0.000 description 1
- YDLSUFFXJYEVHW-UHFFFAOYSA-N azonan-2-one Chemical compound O=C1CCCCCCCN1 YDLSUFFXJYEVHW-UHFFFAOYSA-N 0.000 description 1
- 235000013871 bee wax Nutrition 0.000 description 1
- 239000012166 beeswax Substances 0.000 description 1
- 238000009835 boiling Methods 0.000 description 1
- 239000001913 cellulose Substances 0.000 description 1
- 229920002678 cellulose Polymers 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 229960004544 cortisone Drugs 0.000 description 1
- 239000006071 cream Substances 0.000 description 1
- 230000007423 decrease Effects 0.000 description 1
- 230000000593 degrading effect Effects 0.000 description 1
- 239000006185 dispersion Substances 0.000 description 1
- 239000003349 gelling agent Substances 0.000 description 1
- 239000001863 hydroxypropyl cellulose Substances 0.000 description 1
- 235000010977 hydroxypropyl cellulose Nutrition 0.000 description 1
- 229960002479 isosorbide Drugs 0.000 description 1
- 150000003951 lactams Chemical class 0.000 description 1
- 238000012544 monitoring process Methods 0.000 description 1
- 239000012188 paraffin wax Substances 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 239000000377 silicon dioxide Substances 0.000 description 1
- 238000005063 solubilization Methods 0.000 description 1
- 230000007928 solubilization Effects 0.000 description 1
- 230000029305 taxis Effects 0.000 description 1
- 239000003871 white petrolatum Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
- A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
- A61K47/186—Quaternary ammonium compounds, e.g. benzalkonium chloride or cetrimide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/22—Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Dermatology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Cosmetics (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Priority Applications (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| LU84514A LU84514A1 (fr) | 1982-12-09 | 1982-12-09 | Composition stable pour corticotherapie locale contenant a l'etat solubilise de l'hydrocortisone |
| JP58230726A JPS59112921A (ja) | 1982-12-09 | 1983-12-08 | 局所皮膚治療用組成物 |
| BE0/212016A BE898417A (fr) | 1982-12-09 | 1983-12-08 | Composition stable pour corticotherapie locale contenant a l'etat solubilise de l'hydrocortisone. |
| FR8319664A FR2537438B1 (fr) | 1982-12-09 | 1983-12-08 | Composition stable pour corticotherapie locale contenant a l'etat solubilise de l'hydrocortisone |
| CH6582/83A CH658191A5 (fr) | 1982-12-09 | 1983-12-08 | Composition stable pour corticotherapie locale contenant a l'etat solubilise de l'hydrocortisone. |
| DE19833344437 DE3344437A1 (de) | 1982-12-09 | 1983-12-08 | Stabiles, solubilisiertes hydrocortison enthaltendes mittel zur lokalen kortiko-therapie |
| GB08332805A GB2131693B (en) | 1982-12-09 | 1983-12-08 | Composition for local corticotherapy containing hydrocortisone |
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| LU84514 | 1982-12-09 | ||
| LU84514A LU84514A1 (fr) | 1982-12-09 | 1982-12-09 | Composition stable pour corticotherapie locale contenant a l'etat solubilise de l'hydrocortisone |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| LU84514A1 true LU84514A1 (fr) | 1984-10-22 |
Family
ID=19729991
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| LU84514A LU84514A1 (fr) | 1982-12-09 | 1982-12-09 | Composition stable pour corticotherapie locale contenant a l'etat solubilise de l'hydrocortisone |
Country Status (7)
| Country | Link |
|---|---|
| JP (1) | JPS59112921A (enrdf_load_stackoverflow) |
| BE (1) | BE898417A (enrdf_load_stackoverflow) |
| CH (1) | CH658191A5 (enrdf_load_stackoverflow) |
| DE (1) | DE3344437A1 (enrdf_load_stackoverflow) |
| FR (1) | FR2537438B1 (enrdf_load_stackoverflow) |
| GB (1) | GB2131693B (enrdf_load_stackoverflow) |
| LU (1) | LU84514A1 (enrdf_load_stackoverflow) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1989004179A1 (en) * | 1987-11-03 | 1989-05-18 | Also Laboratori S.A.S. | Pharmaceutical formulations for transdermal administration |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0978574A1 (en) * | 1998-08-04 | 2000-02-09 | Nalco Chemical Company | Compositions of cationic surfactants and their use as antifouling agents for induced draft fans (IDF) |
| US20060018852A1 (en) | 2003-08-22 | 2006-01-26 | L'oreal | Compositions containing topical active agents and pentylene glycol |
| US10851507B2 (en) | 2017-12-11 | 2020-12-01 | Pro-Tech Manufacturing And Distribution, Inc. | Material pusher with floating coupler |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE673500C (de) * | 1933-01-15 | 1939-03-23 | Hoffmann La Roche & Co Akt Ges | Verfahren zur Herstellung von haltbaren Loesungen schwer loeslicher Arzneimittel |
| NL6610468A (enrdf_load_stackoverflow) * | 1965-08-03 | 1967-02-06 | ||
| FR2314731A1 (fr) * | 1975-06-19 | 1977-01-14 | Nelson Res & Dev | Azacycloalcan-2-ones 1-substituees et compositions pharmaceutiques contenant ces composes a titre d'excipients |
| US4082881A (en) * | 1976-12-23 | 1978-04-04 | E. R. Squibb & Sons, Inc. | Topical and other type pharmaceutical formulations containing isosorbide carrier |
| SE8004580L (sv) * | 1980-06-19 | 1981-12-20 | Draco Ab | Farmaceutisk beredning |
-
1982
- 1982-12-09 LU LU84514A patent/LU84514A1/fr unknown
-
1983
- 1983-12-08 GB GB08332805A patent/GB2131693B/en not_active Expired
- 1983-12-08 CH CH6582/83A patent/CH658191A5/fr not_active IP Right Cessation
- 1983-12-08 FR FR8319664A patent/FR2537438B1/fr not_active Expired
- 1983-12-08 DE DE19833344437 patent/DE3344437A1/de active Granted
- 1983-12-08 JP JP58230726A patent/JPS59112921A/ja active Granted
- 1983-12-08 BE BE0/212016A patent/BE898417A/fr not_active IP Right Cessation
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1989004179A1 (en) * | 1987-11-03 | 1989-05-18 | Also Laboratori S.A.S. | Pharmaceutical formulations for transdermal administration |
Also Published As
| Publication number | Publication date |
|---|---|
| FR2537438A1 (fr) | 1984-06-15 |
| DE3344437C2 (enrdf_load_stackoverflow) | 1991-04-04 |
| GB2131693B (en) | 1986-07-02 |
| GB2131693A (en) | 1984-06-27 |
| BE898417A (fr) | 1984-06-08 |
| DE3344437A1 (de) | 1984-06-14 |
| JPH034044B2 (enrdf_load_stackoverflow) | 1991-01-22 |
| FR2537438B1 (fr) | 1985-11-22 |
| CH658191A5 (fr) | 1986-10-31 |
| GB8332805D0 (en) | 1984-01-18 |
| JPS59112921A (ja) | 1984-06-29 |
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