LU84278A1 - Phenethylpiperidines antiarythmiques - Google Patents
Phenethylpiperidines antiarythmiques Download PDFInfo
- Publication number
- LU84278A1 LU84278A1 LU84278A LU84278A LU84278A1 LU 84278 A1 LU84278 A1 LU 84278A1 LU 84278 A LU84278 A LU 84278A LU 84278 A LU84278 A LU 84278A LU 84278 A1 LU84278 A1 LU 84278A1
- Authority
- LU
- Luxembourg
- Prior art keywords
- radical
- formula
- compound
- piperidinyl
- pharmaceutically acceptable
- Prior art date
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- 230000003288 anthiarrhythmic effect Effects 0.000 title description 12
- 239000003416 antiarrhythmic agent Substances 0.000 title description 8
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- -1 1-methyl-2-piperidinyl Chemical group 0.000 claims description 15
- 150000003839 salts Chemical class 0.000 claims description 11
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- 230000003000 nontoxic effect Effects 0.000 claims description 7
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- 239000001257 hydrogen Substances 0.000 claims description 4
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- 238000002156 mixing Methods 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- LNOPIUAQISRISI-UHFFFAOYSA-N n'-hydroxy-2-propan-2-ylsulfonylethanimidamide Chemical compound CC(C)S(=O)(=O)CC(N)=NO LNOPIUAQISRISI-UHFFFAOYSA-N 0.000 description 1
- 229910052757 nitrogen Inorganic materials 0.000 description 1
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 1
- OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 description 1
- 235000019198 oils Nutrition 0.000 description 1
- 230000003287 optical effect Effects 0.000 description 1
- 150000007524 organic acids Chemical class 0.000 description 1
- 235000005985 organic acids Nutrition 0.000 description 1
- 239000001301 oxygen Substances 0.000 description 1
- 229910052760 oxygen Inorganic materials 0.000 description 1
- 125000004430 oxygen atom Chemical group O* 0.000 description 1
- 210000003516 pericardium Anatomy 0.000 description 1
- 239000008194 pharmaceutical composition Substances 0.000 description 1
- 229940117803 phenethylamine Drugs 0.000 description 1
- 229940117953 phenylisothiocyanate Drugs 0.000 description 1
- 239000002244 precipitate Substances 0.000 description 1
- 239000002243 precursor Substances 0.000 description 1
- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 description 1
- 230000036279 refractory period Effects 0.000 description 1
- 210000005241 right ventricle Anatomy 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- 239000008117 stearic acid Substances 0.000 description 1
- 239000008174 sterile solution Substances 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 125000001424 substituent group Chemical group 0.000 description 1
- 239000013589 supplement Substances 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- 239000000454 talc Substances 0.000 description 1
- 235000012222 talc Nutrition 0.000 description 1
- 229910052623 talc Inorganic materials 0.000 description 1
- 239000011975 tartaric acid Substances 0.000 description 1
- 235000002906 tartaric acid Nutrition 0.000 description 1
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 description 1
- 235000015112 vegetable and seed oil Nutrition 0.000 description 1
- 235000019871 vegetable fat Nutrition 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
- 239000008096 xylene Substances 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D211/26—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by nitrogen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Hydrogenated Pyridines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US28371081 | 1981-07-16 | ||
| US06/283,710 US4399286A (en) | 1981-07-16 | 1981-07-16 | Antiarrhythmic phenethylpiperidine compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| LU84278A1 true LU84278A1 (fr) | 1983-04-13 |
Family
ID=23087221
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| LU84278A LU84278A1 (fr) | 1981-07-16 | 1982-07-16 | Phenethylpiperidines antiarythmiques |
Country Status (25)
| Country | Link |
|---|---|
| US (1) | US4399286A (ko) |
| JP (1) | JPS6059230B2 (ko) |
| KR (1) | KR860000516B1 (ko) |
| AR (1) | AR231720A1 (ko) |
| AU (1) | AU559967B2 (ko) |
| BE (1) | BE893862A (ko) |
| CA (1) | CA1192199A (ko) |
| CH (1) | CH654575A5 (ko) |
| CY (1) | CY1375A (ko) |
| DE (1) | DE3226540A1 (ko) |
| DK (1) | DK316882A (ko) |
| ES (1) | ES8307748A1 (ko) |
| FR (1) | FR2510568B1 (ko) |
| GB (1) | GB2104889B (ko) |
| GR (1) | GR76173B (ko) |
| HK (1) | HK4988A (ko) |
| IE (1) | IE53546B1 (ko) |
| IT (1) | IT1149020B (ko) |
| KE (1) | KE3719A (ko) |
| LU (1) | LU84278A1 (ko) |
| NL (1) | NL8202840A (ko) |
| PT (1) | PT75259B (ko) |
| SG (1) | SG29887G (ko) |
| YU (1) | YU44095B (ko) |
| ZA (1) | ZA824487B (ko) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2531702A1 (fr) * | 1982-08-16 | 1984-02-17 | Synthelabo | Derives de phenethyl-1a-phenylperidine-3-propanenitrile, leur preparation et leur application en therapeutique |
| AU2978197A (en) * | 1996-06-04 | 1998-01-05 | Chugai Seiyaku Kabushiki Kaisha | Substituted benzenes having nos inhibitory effects |
| DE10132746A1 (de) * | 2001-07-05 | 2003-02-06 | Gruenenthal Gmbh | Substituierte 1-Phenethylpiperidinverbindungen |
| US7635548B2 (en) * | 2006-08-08 | 2009-12-22 | Xerox Corporation | Photoreceptor |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2626948A (en) * | 1950-07-24 | 1953-01-27 | Hoffmann La Roche | 1-alkyl-2 or 4-[(n-alkyl-n-beta-dialkyl-aminoalkyl) aminophenethyl]-piperidines and salts thereof |
| CA979009A (en) | 1968-09-16 | 1975-12-02 | Squibb (E. R.) And Sons | Substituted ureas and derivatives |
| US3852339A (en) * | 1970-06-15 | 1974-12-03 | Squibb & Sons Inc | Aminoalkoxyphenylurea derivatives |
| CA961038A (en) * | 1971-03-03 | 1975-01-14 | Joseph L. Minielli | Substituted piperidines |
| US4000143A (en) * | 1971-03-03 | 1976-12-28 | Mead Johnson & Company | Substituted piperidines |
| US4064254A (en) * | 1971-03-03 | 1977-12-20 | Mead Johnson & Company | Substituted piperidines therapeutic process and compositions |
| US3931195A (en) * | 1971-03-03 | 1976-01-06 | Mead Johnson & Company | Substituted piperidines |
| US4007181A (en) * | 1974-02-11 | 1977-02-08 | The Upjohn Company | Adamantyl containing guanidines |
| GB1459506A (en) * | 1974-02-18 | 1976-12-22 | Wyeth John & Brother Ltd | Piperidine derivatives |
| US4096276A (en) * | 1976-04-15 | 1978-06-20 | Hoffmann-La Roche Inc. | Thiourea derivatives for treating hypertension |
| US4071524A (en) * | 1976-11-08 | 1978-01-31 | Riker Laboratories, Inc. | Derivatives of urea |
-
1981
- 1981-07-16 US US06/283,710 patent/US4399286A/en not_active Expired - Fee Related
-
1982
- 1982-06-24 ZA ZA824487A patent/ZA824487B/xx unknown
- 1982-07-01 FR FR8211563A patent/FR2510568B1/fr not_active Expired
- 1982-07-02 GB GB08219237A patent/GB2104889B/en not_active Expired
- 1982-07-02 CY CY137582A patent/CY1375A/xx unknown
- 1982-07-05 CA CA000406583A patent/CA1192199A/en not_active Expired
- 1982-07-06 AU AU85660/82A patent/AU559967B2/en not_active Ceased
- 1982-07-08 AR AR289934A patent/AR231720A1/es active
- 1982-07-09 ES ES513832A patent/ES8307748A1/es not_active Expired
- 1982-07-12 IT IT48796/82A patent/IT1149020B/it active
- 1982-07-13 KR KR8203124A patent/KR860000516B1/ko active
- 1982-07-13 GR GR68742A patent/GR76173B/el unknown
- 1982-07-13 NL NL8202840A patent/NL8202840A/nl not_active Application Discontinuation
- 1982-07-14 DK DK316882A patent/DK316882A/da not_active Application Discontinuation
- 1982-07-15 CH CH4319/82A patent/CH654575A5/de not_active IP Right Cessation
- 1982-07-15 JP JP57123737A patent/JPS6059230B2/ja not_active Expired
- 1982-07-15 PT PT75259A patent/PT75259B/pt not_active IP Right Cessation
- 1982-07-15 IE IE1710/82A patent/IE53546B1/en unknown
- 1982-07-15 YU YU1543/82A patent/YU44095B/xx unknown
- 1982-07-15 DE DE19823226540 patent/DE3226540A1/de active Granted
- 1982-07-16 LU LU84278A patent/LU84278A1/fr unknown
- 1982-07-16 BE BE0/208612A patent/BE893862A/fr not_active IP Right Cessation
-
1987
- 1987-03-27 SG SG298/87A patent/SG29887G/en unknown
- 1987-03-31 KE KE3719A patent/KE3719A/xx unknown
-
1988
- 1988-01-21 HK HK49/88A patent/HK4988A/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CY1375A (en) | 1987-08-07 |
| GB2104889B (en) | 1985-05-22 |
| AR231720A1 (es) | 1985-02-28 |
| SG29887G (en) | 1987-07-17 |
| AU559967B2 (en) | 1987-03-26 |
| DE3226540C2 (ko) | 1990-04-12 |
| KR860000516B1 (ko) | 1986-05-02 |
| AU8566082A (en) | 1983-01-20 |
| HK4988A (en) | 1988-01-29 |
| GR76173B (ko) | 1984-08-03 |
| ES513832A0 (es) | 1983-08-01 |
| IT8248796A0 (it) | 1982-07-12 |
| KR840000492A (ko) | 1984-02-22 |
| FR2510568B1 (fr) | 1985-09-27 |
| CA1192199A (en) | 1985-08-20 |
| CH654575A5 (de) | 1986-02-28 |
| PT75259A (en) | 1982-08-01 |
| PT75259B (en) | 1985-10-04 |
| JPS5865276A (ja) | 1983-04-18 |
| YU154382A (en) | 1985-04-30 |
| IT1149020B (it) | 1986-12-03 |
| BE893862A (fr) | 1983-01-17 |
| US4399286A (en) | 1983-08-16 |
| GB2104889A (en) | 1983-03-16 |
| NL8202840A (nl) | 1983-02-16 |
| IE53546B1 (en) | 1988-12-07 |
| DK316882A (da) | 1983-01-17 |
| DE3226540A1 (de) | 1983-02-03 |
| ES8307748A1 (es) | 1983-08-01 |
| YU44095B (en) | 1990-02-28 |
| KE3719A (en) | 1987-04-16 |
| FR2510568A1 (fr) | 1983-02-04 |
| JPS6059230B2 (ja) | 1985-12-24 |
| ZA824487B (en) | 1983-04-27 |
| IE821710L (en) | 1983-01-16 |
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