LU81816A1 - Nouveau sel de l'acide acetylsalicylique,son procede de preparation et ses applications therapeutiques - Google Patents
Nouveau sel de l'acide acetylsalicylique,son procede de preparation et ses applications therapeutiques Download PDFInfo
- Publication number
- LU81816A1 LU81816A1 LU81816A LU81816A LU81816A1 LU 81816 A1 LU81816 A1 LU 81816A1 LU 81816 A LU81816 A LU 81816A LU 81816 A LU81816 A LU 81816A LU 81816 A1 LU81816 A1 LU 81816A1
- Authority
- LU
- Luxembourg
- Prior art keywords
- acetylsalicylic acid
- preparation
- therapeutic applications
- novel salt
- salt
- Prior art date
Links
- 150000003839 salts Chemical class 0.000 title description 9
- BSYNRYMUTXBXSQ-FOQJRBATSA-N 59096-14-9 Chemical compound CC(=O)OC1=CC=CC=C1[14C](O)=O BSYNRYMUTXBXSQ-FOQJRBATSA-N 0.000 title description 3
- 238000002360 preparation method Methods 0.000 title description 2
- 230000001225 therapeutic effect Effects 0.000 title description 2
- BSYNRYMUTXBXSQ-UHFFFAOYSA-N Aspirin Chemical compound CC(=O)OC1=CC=CC=C1C(O)=O BSYNRYMUTXBXSQ-UHFFFAOYSA-N 0.000 claims description 12
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 claims description 10
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 10
- 239000000243 solution Substances 0.000 claims description 6
- 239000007924 injection Substances 0.000 claims description 5
- 238000002347 injection Methods 0.000 claims description 5
- 230000003110 anti-inflammatory effect Effects 0.000 claims description 4
- 229940068372 acetyl salicylate Drugs 0.000 claims description 3
- 239000004480 active ingredient Substances 0.000 claims description 3
- 239000003814 drug Substances 0.000 claims description 3
- 238000000034 method Methods 0.000 claims description 3
- 239000003153 chemical reaction reagent Substances 0.000 claims description 2
- 238000001990 intravenous administration Methods 0.000 claims description 2
- 239000003960 organic solvent Substances 0.000 claims description 2
- 239000000843 powder Substances 0.000 claims description 2
- 239000002904 solvent Substances 0.000 claims description 2
- 239000003907 antipyretic analgesic agent Substances 0.000 claims 1
- 229940126601 medicinal product Drugs 0.000 claims 1
- 229960001138 acetylsalicylic acid Drugs 0.000 description 9
- 241000700159 Rattus Species 0.000 description 4
- 150000001875 compounds Chemical class 0.000 description 4
- 240000004808 Saccharomyces cerevisiae Species 0.000 description 3
- 235000014680 Saccharomyces cerevisiae Nutrition 0.000 description 3
- 230000000202 analgesic effect Effects 0.000 description 3
- 230000001754 anti-pyretic effect Effects 0.000 description 3
- UYDSGXAKLVZWIJ-UHFFFAOYSA-N ethyl 2-acetyloxybenzoate Chemical compound CCOC(=O)C1=CC=CC=C1OC(C)=O UYDSGXAKLVZWIJ-UHFFFAOYSA-N 0.000 description 3
- 238000002560 therapeutic procedure Methods 0.000 description 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 3
- RLQZIECDMISZHS-UHFFFAOYSA-N 2-phenylcyclohexa-2,5-diene-1,4-dione Chemical compound O=C1C=CC(=O)C(C=2C=CC=CC=2)=C1 RLQZIECDMISZHS-UHFFFAOYSA-N 0.000 description 2
- 241001465754 Metazoa Species 0.000 description 2
- 241000699670 Mus sp. Species 0.000 description 2
- 206010030113 Oedema Diseases 0.000 description 2
- 239000002253 acid Substances 0.000 description 2
- 239000002221 antipyretic Substances 0.000 description 2
- 235000010418 carrageenan Nutrition 0.000 description 2
- 229920001525 carrageenan Polymers 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 238000002844 melting Methods 0.000 description 2
- 230000008018 melting Effects 0.000 description 2
- 230000000144 pharmacologic effect Effects 0.000 description 2
- DLYUQMMRRRQYAE-UHFFFAOYSA-N tetraphosphorus decaoxide Chemical compound O1P(O2)(=O)OP3(=O)OP1(=O)OP2(=O)O3 DLYUQMMRRRQYAE-UHFFFAOYSA-N 0.000 description 2
- 238000011282 treatment Methods 0.000 description 2
- 208000019695 Migraine disease Diseases 0.000 description 1
- 241000699666 Mus <mouse, genus> Species 0.000 description 1
- 208000002193 Pain Diseases 0.000 description 1
- 206010037660 Pyrexia Diseases 0.000 description 1
- 239000003929 acidic solution Substances 0.000 description 1
- -1 amino acid salts Chemical class 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- 125000006309 butyl amino group Chemical group 0.000 description 1
- 229940113118 carrageenan Drugs 0.000 description 1
- 239000000679 carrageenan Substances 0.000 description 1
- 239000012153 distilled water Substances 0.000 description 1
- 210000000548 hind-foot Anatomy 0.000 description 1
- 230000002977 hyperthermial effect Effects 0.000 description 1
- 230000002757 inflammatory effect Effects 0.000 description 1
- 230000005764 inhibitory process Effects 0.000 description 1
- 238000004452 microanalysis Methods 0.000 description 1
- 230000007935 neutral effect Effects 0.000 description 1
- 239000000546 pharmaceutical excipient Substances 0.000 description 1
- 239000002504 physiological saline solution Substances 0.000 description 1
- 239000002244 precipitate Substances 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 238000010254 subcutaneous injection Methods 0.000 description 1
- 239000007929 subcutaneous injection Substances 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 230000002110 toxicologic effect Effects 0.000 description 1
- 231100000027 toxicology Toxicity 0.000 description 1
- UHVMMEOXYDMDKI-JKYCWFKZSA-L zinc;1-(5-cyanopyridin-2-yl)-3-[(1s,2s)-2-(6-fluoro-2-hydroxy-3-propanoylphenyl)cyclopropyl]urea;diacetate Chemical compound [Zn+2].CC([O-])=O.CC([O-])=O.CCC(=O)C1=CC=C(F)C([C@H]2[C@H](C2)NC(=O)NC=2N=CC(=CC=2)C#N)=C1O UHVMMEOXYDMDKI-JKYCWFKZSA-L 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/60—Salicylic acid; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/235—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C1/00—Preparation of hydrocarbons from one or more compounds, none of them being a hydrocarbon
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
- C07C215/02—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C215/04—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being saturated
- C07C215/06—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being saturated and acyclic
- C07C215/08—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being saturated and acyclic with only one hydroxy group and one amino group bound to the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C65/00—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C65/01—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing hydroxy or O-metal groups
- C07C65/03—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing hydroxy or O-metal groups monocyclic and having all hydroxy or O-metal groups bound to the ring
- C07C65/05—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing hydroxy or O-metal groups monocyclic and having all hydroxy or O-metal groups bound to the ring o-Hydroxy carboxylic acids
- C07C65/10—Salicylic acid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C67/00—Preparation of carboxylic acid esters
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/02—Esters of acyclic saturated monocarboxylic acids having the carboxyl group bound to an acyclic carbon atom or to hydrogen
- C07C69/12—Acetic acid esters
- C07C69/14—Acetic acid esters of monohydroxylic compounds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/02—Esters of acyclic saturated monocarboxylic acids having the carboxyl group bound to an acyclic carbon atom or to hydrogen
- C07C69/12—Acetic acid esters
- C07C69/14—Acetic acid esters of monohydroxylic compounds
- C07C69/145—Acetic acid esters of monohydroxylic compounds of unsaturated alcohols
- C07C69/157—Acetic acid esters of monohydroxylic compounds of unsaturated alcohols containing six-membered aromatic rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Emergency Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR7831588A FR2440935A1 (fr) | 1978-11-08 | 1978-11-08 | Nouveau sel de l'acide acetylsalicylique, son procede de preparation et ses applications therapeutiques |
| FR7831588 | 1978-11-08 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| LU81816A1 true LU81816A1 (fr) | 1980-01-25 |
Family
ID=9214610
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| LU81816A LU81816A1 (fr) | 1978-11-08 | 1979-10-24 | Nouveau sel de l'acide acetylsalicylique,son procede de preparation et ses applications therapeutiques |
Country Status (16)
| Country | Link |
|---|---|
| JP (1) | JPS5566549A (nl) |
| AU (1) | AU527562B2 (nl) |
| BE (1) | BE879887A (nl) |
| DE (1) | DE2944485A1 (nl) |
| DK (1) | DK464479A (nl) |
| ES (1) | ES485596A1 (nl) |
| FI (1) | FI793423A (nl) |
| FR (1) | FR2440935A1 (nl) |
| GB (1) | GB2034711B (nl) |
| IT (1) | IT7950752A0 (nl) |
| LU (1) | LU81816A1 (nl) |
| NL (1) | NL7908079A (nl) |
| NO (1) | NO793581L (nl) |
| PL (1) | PL219468A1 (nl) |
| SE (1) | SE7908756L (nl) |
| ZA (1) | ZA795996B (nl) |
-
1978
- 1978-11-08 FR FR7831588A patent/FR2440935A1/fr active Granted
-
1979
- 1979-10-23 SE SE7908756A patent/SE7908756L/xx not_active Application Discontinuation
- 1979-10-24 LU LU81816A patent/LU81816A1/fr unknown
- 1979-10-30 GB GB7937546A patent/GB2034711B/en not_active Expired
- 1979-10-31 ES ES485596A patent/ES485596A1/es not_active Expired
- 1979-11-01 FI FI793423A patent/FI793423A/fi not_active Application Discontinuation
- 1979-11-02 DK DK464479A patent/DK464479A/da not_active Application Discontinuation
- 1979-11-03 DE DE19792944485 patent/DE2944485A1/de not_active Withdrawn
- 1979-11-05 NL NL7908079A patent/NL7908079A/nl not_active Application Discontinuation
- 1979-11-06 NO NO793581A patent/NO793581L/no unknown
- 1979-11-06 IT IT7950752A patent/IT7950752A0/it unknown
- 1979-11-07 ZA ZA00795996A patent/ZA795996B/xx unknown
- 1979-11-07 JP JP14427479A patent/JPS5566549A/ja active Pending
- 1979-11-07 PL PL21946879A patent/PL219468A1/xx unknown
- 1979-11-07 BE BE0/198017A patent/BE879887A/fr unknown
- 1979-11-08 AU AU52639/79A patent/AU527562B2/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| GB2034711A (en) | 1980-06-11 |
| JPS5566549A (en) | 1980-05-20 |
| AU5263979A (en) | 1980-05-15 |
| FR2440935B1 (nl) | 1981-04-17 |
| NO793581L (no) | 1980-05-09 |
| GB2034711B (en) | 1982-10-27 |
| IT7950752A0 (it) | 1979-11-06 |
| PL219468A1 (nl) | 1980-07-14 |
| FI793423A (fi) | 1980-05-09 |
| FR2440935A1 (fr) | 1980-06-06 |
| DE2944485A1 (de) | 1980-05-29 |
| ES485596A1 (es) | 1980-05-16 |
| AU527562B2 (en) | 1983-03-10 |
| SE7908756L (sv) | 1980-05-09 |
| NL7908079A (nl) | 1980-05-12 |
| BE879887A (fr) | 1980-05-07 |
| ZA795996B (en) | 1980-10-29 |
| DK464479A (da) | 1980-05-09 |
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