LT3981B - Therapeutically active substituted benzimidazole and process for its preparation - Google Patents
Therapeutically active substituted benzimidazole and process for its preparation Download PDFInfo
- Publication number
- LT3981B LT3981B LTIP1722A LTIP1722A LT3981B LT 3981 B LT3981 B LT 3981B LT IP1722 A LTIP1722 A LT IP1722A LT IP1722 A LTIP1722 A LT IP1722A LT 3981 B LT3981 B LT 3981B
- Authority
- LT
- Lithuania
- Prior art keywords
- compound
- compound according
- benzimidazole
- dimethoxy
- methyl
- Prior art date
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- 238000000034 method Methods 0.000 title claims description 7
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- HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 claims description 3
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- 150000004679 hydroxides Chemical class 0.000 description 1
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- 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 description 1
- 235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 description 1
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- 208000027866 inflammatory disease Diseases 0.000 description 1
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- 239000004615 ingredient Substances 0.000 description 1
- 239000003112 inhibitor Substances 0.000 description 1
- 230000000968 intestinal effect Effects 0.000 description 1
- SNHMUERNLJLMHN-UHFFFAOYSA-N iodobenzene Chemical compound IC1=CC=CC=C1 SNHMUERNLJLMHN-UHFFFAOYSA-N 0.000 description 1
- 150000002576 ketones Chemical class 0.000 description 1
- 239000000314 lubricant Substances 0.000 description 1
- ZLNQQNXFFQJAID-UHFFFAOYSA-L magnesium carbonate Chemical class [Mg+2].[O-]C([O-])=O ZLNQQNXFFQJAID-UHFFFAOYSA-L 0.000 description 1
- 239000001095 magnesium carbonate Substances 0.000 description 1
- 235000011160 magnesium carbonates Nutrition 0.000 description 1
- 235000012254 magnesium hydroxide Nutrition 0.000 description 1
- 235000012245 magnesium oxide Nutrition 0.000 description 1
- 208000030159 metabolic disease Diseases 0.000 description 1
- 230000002503 metabolic effect Effects 0.000 description 1
- 244000005700 microbiome Species 0.000 description 1
- 229940016286 microcrystalline cellulose Drugs 0.000 description 1
- 235000019813 microcrystalline cellulose Nutrition 0.000 description 1
- 239000008108 microcrystalline cellulose Substances 0.000 description 1
- 206010063344 microscopic polyangiitis Diseases 0.000 description 1
- 229910017604 nitric acid Inorganic materials 0.000 description 1
- 239000007800 oxidant agent Substances 0.000 description 1
- 239000008188 pellet Substances 0.000 description 1
- ANRIQLNBZQLTFV-DZUOILHNSA-N pentagastrin Chemical compound C([C@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CC=1[C]2C=CC=CC2=NC=1)NC(=O)CCNC(=O)OC(C)(C)C)CCSC)C(N)=O)C1=CC=CC=C1 ANRIQLNBZQLTFV-DZUOILHNSA-N 0.000 description 1
- 229960000444 pentagastrin Drugs 0.000 description 1
- 208000011906 peptic ulcer disease Diseases 0.000 description 1
- 150000002976 peresters Chemical class 0.000 description 1
- 239000004014 plasticizer Substances 0.000 description 1
- 239000011591 potassium Substances 0.000 description 1
- 229910052700 potassium Inorganic materials 0.000 description 1
- 235000007686 potassium Nutrition 0.000 description 1
- 229920001592 potato starch Chemical class 0.000 description 1
- 230000003389 potentiating effect Effects 0.000 description 1
- 239000002244 precipitate Substances 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
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- 238000010992 reflux Methods 0.000 description 1
- 206010039073 rheumatoid arthritis Diseases 0.000 description 1
- 238000002390 rotary evaporation Methods 0.000 description 1
- 238000005070 sampling Methods 0.000 description 1
- 229920006395 saturated elastomer Polymers 0.000 description 1
- 230000003248 secreting effect Effects 0.000 description 1
- 239000004208 shellac Substances 0.000 description 1
- ZLGIYFNHBLSMPS-ATJNOEHPSA-N shellac Chemical compound OCCCCCC(O)C(O)CCCCCCCC(O)=O.C1C23[C@H](C(O)=O)CCC2[C@](C)(CO)[C@@H]1C(C(O)=O)=C[C@@H]3O ZLGIYFNHBLSMPS-ATJNOEHPSA-N 0.000 description 1
- 229940113147 shellac Drugs 0.000 description 1
- 235000013874 shellac Nutrition 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 235000015424 sodium Nutrition 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 229940045902 sodium stearyl fumarate Drugs 0.000 description 1
- 239000008107 starch Chemical class 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- 239000008223 sterile water Substances 0.000 description 1
- 230000000638 stimulation Effects 0.000 description 1
- 238000007920 subcutaneous administration Methods 0.000 description 1
- 150000005846 sugar alcohols Chemical class 0.000 description 1
- 150000008163 sugars Chemical class 0.000 description 1
- 229910052717 sulfur Inorganic materials 0.000 description 1
- 125000004434 sulfur atom Chemical group 0.000 description 1
- YBBRCQOCSYXUOC-UHFFFAOYSA-N sulfuryl dichloride Chemical compound ClS(Cl)(=O)=O YBBRCQOCSYXUOC-UHFFFAOYSA-N 0.000 description 1
- 208000011580 syndromic disease Diseases 0.000 description 1
- IXZDIALLLMRYOU-UHFFFAOYSA-N tert-butyl hypochlorite Chemical compound CC(C)(C)OCl IXZDIALLLMRYOU-UHFFFAOYSA-N 0.000 description 1
- YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 description 1
- 239000002562 thickening agent Substances 0.000 description 1
- 210000001685 thyroid gland Anatomy 0.000 description 1
- 238000004448 titration Methods 0.000 description 1
- 150000003682 vanadium compounds Chemical class 0.000 description 1
- 235000019871 vegetable fat Nutrition 0.000 description 1
- 239000003981 vehicle Substances 0.000 description 1
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pyridine Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE19888804628A SE8804628D0 (sv) | 1988-12-22 | 1988-12-22 | New compounds |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| LTIP1722A LTIP1722A (en) | 1995-07-25 |
| LT3981B true LT3981B (en) | 1996-06-25 |
Family
ID=20374309
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| LTIP1722A LT3981B (en) | 1988-12-22 | 1993-12-30 | Therapeutically active substituted benzimidazole and process for its preparation |
Country Status (26)
| Country | Link |
|---|---|
| US (1) | US5019584A (de) |
| EP (1) | EP0451188B1 (de) |
| JP (1) | JP2793907B2 (de) |
| CN (1) | CN1028232C (de) |
| AT (1) | ATE110379T1 (de) |
| AU (1) | AU636866B2 (de) |
| CA (1) | CA2005987C (de) |
| DD (1) | DD296077A5 (de) |
| DE (1) | DE68917738T2 (de) |
| DK (1) | DK170801B1 (de) |
| FI (1) | FI913036A0 (de) |
| GR (1) | GR1000318B (de) |
| HU (1) | HUT57203A (de) |
| IE (1) | IE64850B1 (de) |
| IL (1) | IL92797A (de) |
| LT (1) | LT3981B (de) |
| LV (1) | LV10268B (de) |
| NO (1) | NO178338C (de) |
| PH (1) | PH27257A (de) |
| PT (1) | PT92647B (de) |
| RO (1) | RO110496B1 (de) |
| RU (1) | RU2070199C1 (de) |
| SE (1) | SE8804628D0 (de) |
| WO (1) | WO1990006926A1 (de) |
| YU (1) | YU242589A (de) |
| ZA (1) | ZA899796B (de) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PL166209B1 (pl) * | 1990-06-20 | 1995-04-28 | Astra Ab | Sposób wytwarzania nowych pochodnych benzimidazolu PL |
| NZ244301A (en) * | 1991-09-20 | 1994-08-26 | Merck & Co Inc | Preparation of 2-pyridylmethylsulphinylbenzimidazole and pyridoimidazole derivatives from the corresponding sulphenyl compounds |
| US6016044A (en) * | 1995-09-11 | 2000-01-18 | Alaris Medical Systems, Inc. | Open-loop step motor control system |
| US5840737A (en) | 1996-01-04 | 1998-11-24 | The Curators Of The University Of Missouri | Omeprazole solution and method for using same |
| US6699885B2 (en) | 1996-01-04 | 2004-03-02 | The Curators Of The University Of Missouri | Substituted benzimidazole dosage forms and methods of using same |
| US6489346B1 (en) | 1996-01-04 | 2002-12-03 | The Curators Of The University Of Missouri | Substituted benzimidazole dosage forms and method of using same |
| US6645988B2 (en) * | 1996-01-04 | 2003-11-11 | Curators Of The University Of Missouri | Substituted benzimidazole dosage forms and method of using same |
| MXPA04007169A (es) * | 2002-01-25 | 2004-10-29 | Santarus Inc | Suministro transmucosal de inhibidores de bomba de protones. |
| US20050234103A1 (en) * | 2002-03-26 | 2005-10-20 | Reddy Manne S | Crystalline forms of rabeprazole sodium |
| CA2517005A1 (en) * | 2003-02-20 | 2004-09-02 | Santarus, Inc. | A novel formulation, omeprazole antacid complex-immediate release for rapid and sustained suppression of gastric acid |
| WO2005007115A2 (en) * | 2003-07-18 | 2005-01-27 | Santarus, Inc. | Pharmaceutical composition for inhibiting acid secretion |
| AR045061A1 (es) * | 2003-07-18 | 2005-10-12 | Santarus Inc | Formulacion farmaceutica y metodo para tratar trastornos gastrointestinales causados por acido |
| US8993599B2 (en) * | 2003-07-18 | 2015-03-31 | Santarus, Inc. | Pharmaceutical formulations useful for inhibiting acid secretion and methods for making and using them |
| US20070292498A1 (en) * | 2003-11-05 | 2007-12-20 | Warren Hall | Combinations of proton pump inhibitors, sleep aids, buffers and pain relievers |
| US8906940B2 (en) * | 2004-05-25 | 2014-12-09 | Santarus, Inc. | Pharmaceutical formulations useful for inhibiting acid secretion and methods for making and using them |
| US8815916B2 (en) * | 2004-05-25 | 2014-08-26 | Santarus, Inc. | Pharmaceutical formulations useful for inhibiting acid secretion and methods for making and using them |
| US20090092658A1 (en) * | 2007-10-05 | 2009-04-09 | Santarus, Inc. | Novel formulations of proton pump inhibitors and methods of using these formulations |
Citations (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1500043A (en) | 1974-02-18 | 1978-02-08 | Haessle Ab | Benzimidazole derivatives their preparation and their use in affecting gastric acid secretion |
| GB1525958A (en) | 1974-05-16 | 1978-09-27 | Haessle Ab | 2-(heterocyclic substituted alkylsulphinyl)-benzimidazoles and their pharmaceutical compositions |
| US4182766A (en) | 1977-09-19 | 1980-01-08 | Hoffmann-La Roche Inc. | Naphth[2,3-d]imidazoles |
| US4255431A (en) | 1978-04-14 | 1981-03-10 | Aktiebolaget Hassle | Gastric acid secretion inhibiting substituted 2-(2-benzimidazolyl)-pyridines, pharmaceutical preparations containing same, and method for inhibiting gastric acid secretion |
| US4359465A (en) | 1980-07-28 | 1982-11-16 | The Upjohn Company | Methods for treating gastrointestinal inflammation |
| US4555518A (en) | 1983-05-03 | 1985-11-26 | Byk Gulden Lomberg Chemische Fabrik Gmbh | Fluoroalkoxy substituted benzimidazoles useful as gastric acid secretion inhibitors |
| US4599347A (en) | 1980-08-21 | 1986-07-08 | Hoffmann-La Roche Inc. | Tetrahydro-naphth (2.3-d) imidazole derivatives |
| US4628098A (en) | 1984-08-16 | 1986-12-09 | Takeda Chemical Industries, Ltd. | 2-[2-pyridylmethylthio-(sulfinyl)]benzimidazoles |
| EP0208452A2 (de) | 1985-07-02 | 1987-01-14 | Takeda Chemical Industries, Ltd. | Pyridinderivate, deren Herstellung und Anwendung |
| US4727150A (en) | 1984-08-16 | 1988-02-23 | Takeda Chemical Industries, Ltd. | Pyridyl methylsulfinyl benzimidazole derivatives |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4331671A (en) * | 1981-01-09 | 1982-05-25 | Sterling Drug Inc. | 5-(Pyridinyl)-1H-benzimidazoles and 1-hydroxy-6-(pyridinyl)-1H-benzimidazoles and their cardiotonic use |
| SE8500996D0 (sv) * | 1985-03-01 | 1985-03-01 | Haessle Ab | Method of treatment |
| GB8610607D0 (en) * | 1986-04-30 | 1986-06-04 | Smith Kline French Lab | Chemical compounds |
| FR2593178B1 (fr) * | 1986-01-20 | 1988-04-29 | Esteve Labor Dr | Derives de 2-benzimidazolylalkylthio (ou sulfinyle ou sulfonyle) leur preparation et leur application en tant que medicaments. |
| WO1989003830A1 (en) * | 1987-10-30 | 1989-05-05 | Aktiebolaget Hässle | 2-pyridinylmethyl (sulfinyl or thio)benzimidazoles for treatment of diseases related to bone loss |
-
1988
- 1988-12-22 SE SE19888804628A patent/SE8804628D0/xx unknown
-
1989
- 1989-12-18 IE IE404989A patent/IE64850B1/xx not_active IP Right Cessation
- 1989-12-19 PH PH39730A patent/PH27257A/en unknown
- 1989-12-19 IL IL9279789A patent/IL92797A/en not_active IP Right Cessation
- 1989-12-19 GR GR890100834A patent/GR1000318B/el unknown
- 1989-12-19 CA CA002005987A patent/CA2005987C/en not_active Expired - Lifetime
- 1989-12-20 EP EP90901080A patent/EP0451188B1/de not_active Expired - Lifetime
- 1989-12-20 ZA ZA899796A patent/ZA899796B/xx unknown
- 1989-12-20 AT AT90901080T patent/ATE110379T1/de not_active IP Right Cessation
- 1989-12-20 AU AU48176/90A patent/AU636866B2/en not_active Ceased
- 1989-12-20 HU HU901085A patent/HUT57203A/hu unknown
- 1989-12-20 JP JP2501538A patent/JP2793907B2/ja not_active Expired - Fee Related
- 1989-12-20 WO PCT/SE1989/000741 patent/WO1990006926A1/en active IP Right Grant
- 1989-12-20 DE DE68917738T patent/DE68917738T2/de not_active Expired - Fee Related
- 1989-12-20 RU SU894895822A patent/RU2070199C1/ru active
- 1989-12-20 US US07/454,046 patent/US5019584A/en not_active Expired - Lifetime
- 1989-12-20 DD DD89335979A patent/DD296077A5/de not_active IP Right Cessation
- 1989-12-20 RO RO147868A patent/RO110496B1/ro unknown
- 1989-12-21 CN CN89109588A patent/CN1028232C/zh not_active Expired - Fee Related
- 1989-12-21 YU YU02425/89A patent/YU242589A/xx unknown
- 1989-12-21 PT PT92647A patent/PT92647B/pt not_active IP Right Cessation
-
1991
- 1991-06-20 FI FI913036A patent/FI913036A0/fi not_active Application Discontinuation
- 1991-06-20 NO NO912416A patent/NO178338C/no unknown
- 1991-06-21 DK DK122391A patent/DK170801B1/da not_active IP Right Cessation
-
1993
- 1993-06-28 LV LVP-93-692A patent/LV10268B/lv unknown
- 1993-12-30 LT LTIP1722A patent/LT3981B/lt not_active IP Right Cessation
Patent Citations (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1500043A (en) | 1974-02-18 | 1978-02-08 | Haessle Ab | Benzimidazole derivatives their preparation and their use in affecting gastric acid secretion |
| GB1525958A (en) | 1974-05-16 | 1978-09-27 | Haessle Ab | 2-(heterocyclic substituted alkylsulphinyl)-benzimidazoles and their pharmaceutical compositions |
| US4182766A (en) | 1977-09-19 | 1980-01-08 | Hoffmann-La Roche Inc. | Naphth[2,3-d]imidazoles |
| US4255431A (en) | 1978-04-14 | 1981-03-10 | Aktiebolaget Hassle | Gastric acid secretion inhibiting substituted 2-(2-benzimidazolyl)-pyridines, pharmaceutical preparations containing same, and method for inhibiting gastric acid secretion |
| US4359465A (en) | 1980-07-28 | 1982-11-16 | The Upjohn Company | Methods for treating gastrointestinal inflammation |
| US4599347A (en) | 1980-08-21 | 1986-07-08 | Hoffmann-La Roche Inc. | Tetrahydro-naphth (2.3-d) imidazole derivatives |
| US4555518A (en) | 1983-05-03 | 1985-11-26 | Byk Gulden Lomberg Chemische Fabrik Gmbh | Fluoroalkoxy substituted benzimidazoles useful as gastric acid secretion inhibitors |
| US4628098A (en) | 1984-08-16 | 1986-12-09 | Takeda Chemical Industries, Ltd. | 2-[2-pyridylmethylthio-(sulfinyl)]benzimidazoles |
| US4727150A (en) | 1984-08-16 | 1988-02-23 | Takeda Chemical Industries, Ltd. | Pyridyl methylsulfinyl benzimidazole derivatives |
| EP0208452A2 (de) | 1985-07-02 | 1987-01-14 | Takeda Chemical Industries, Ltd. | Pyridinderivate, deren Herstellung und Anwendung |
Non-Patent Citations (2)
| Title |
|---|
| A. GOTH: "Medical Pharmacology, 7th ed.", pages: 19 |
| M. ROWLAND, T. N. TORER: "Clinical Pharmacokinetics, 2nd ed.", pages: 42 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MM9A | Lapsed patents |
Effective date: 19961230 |