LT3768846T - Virusiniai ir nevirusiniai nanoplazmidiniai vektoriai su patobulinta gamyba - Google Patents
Virusiniai ir nevirusiniai nanoplazmidiniai vektoriai su patobulinta gamybaInfo
- Publication number
- LT3768846T LT3768846T LTEPPCT/US2019/023209T LTUS2019023209T LT3768846T LT 3768846 T LT3768846 T LT 3768846T LT US2019023209 T LTUS2019023209 T LT US2019023209T LT 3768846 T LT3768846 T LT 3768846T
- Authority
- LT
- Lithuania
- Prior art keywords
- viral
- improved production
- nanoplasmid vectors
- nanoplasmid
- vectors
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/70—Vectors or expression systems specially adapted for E. coli
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/86—Viral vectors
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2740/00—Reverse transcribing RNA viruses
- C12N2740/00011—Details
- C12N2740/10011—Retroviridae
- C12N2740/15011—Lentivirus, not HIV, e.g. FIV, SIV
- C12N2740/15041—Use of virus, viral particle or viral elements as a vector
- C12N2740/15043—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2740/00—Reverse transcribing RNA viruses
- C12N2740/00011—Details
- C12N2740/10011—Retroviridae
- C12N2740/15011—Lentivirus, not HIV, e.g. FIV, SIV
- C12N2740/15051—Methods of production or purification of viral material
- C12N2740/15052—Methods of production or purification of viral material relating to complementing cells and packaging systems for producing virus or viral particles
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2750/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssDNA viruses
- C12N2750/00011—Details
- C12N2750/14011—Parvoviridae
- C12N2750/14111—Dependovirus, e.g. adenoassociated viruses
- C12N2750/14141—Use of virus, viral particle or viral elements as a vector
- C12N2750/14143—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2750/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssDNA viruses
- C12N2750/00011—Details
- C12N2750/14011—Parvoviridae
- C12N2750/14111—Dependovirus, e.g. adenoassociated viruses
- C12N2750/14151—Methods of production or purification of viral material
- C12N2750/14152—Methods of production or purification of viral material relating to complementing cells and packaging systems for producing virus or viral particles
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2800/00—Nucleic acids vectors
- C12N2800/10—Plasmid DNA
- C12N2800/101—Plasmid DNA for bacteria
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2800/00—Nucleic acids vectors
- C12N2800/24—Vectors characterised by the absence of particular element, e.g. selectable marker, viral origin of replication
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2800/00—Nucleic acids vectors
- C12N2800/90—Vectors containing a transposable element
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2820/00—Vectors comprising a special origin of replication system
- C12N2820/55—Vectors comprising a special origin of replication system from bacteria
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
- C12R2001/00—Microorganisms ; Processes using microorganisms
- C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
- C12R2001/185—Escherichia
- C12R2001/19—Escherichia coli
Landscapes
- Genetics & Genomics (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Organic Chemistry (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biophysics (AREA)
- Microbiology (AREA)
- Plant Pathology (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Physics & Mathematics (AREA)
- Virology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Carbon And Carbon Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862645892P | 2018-03-21 | 2018-03-21 | |
| PCT/US2019/023209 WO2019183248A1 (en) | 2018-03-21 | 2019-03-20 | Viral and non-viral nanoplasmid vectors with improved production |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| LT3768846T true LT3768846T (lt) | 2023-08-10 |
Family
ID=66001381
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| LTEPPCT/US2019/023209T LT3768846T (lt) | 2018-03-21 | 2019-03-20 | Virusiniai ir nevirusiniai nanoplazmidiniai vektoriai su patobulinta gamyba |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US12600984B2 (enExample) |
| EP (2) | EP4151735A1 (enExample) |
| JP (3) | JP7520719B2 (enExample) |
| KR (1) | KR20210016330A (enExample) |
| CN (2) | CN112154208B (enExample) |
| AU (2) | AU2019240068B2 (enExample) |
| CA (1) | CA3093346A1 (enExample) |
| DK (1) | DK3768846T5 (enExample) |
| ES (1) | ES2950736T3 (enExample) |
| FI (1) | FI3768846T3 (enExample) |
| LT (1) | LT3768846T (enExample) |
| SG (1) | SG11202009009UA (enExample) |
| WO (1) | WO2019183248A1 (enExample) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2019240068B2 (en) * | 2018-03-21 | 2025-03-13 | Aldevron, L.L.C. | Viral and non-viral nanoplasmid vectors with improved production |
| EP3898993A1 (en) * | 2018-12-20 | 2021-10-27 | Poseida Therapeutics, Inc. | Nanotransposon compositions and methods of use |
| WO2021055760A1 (en) | 2019-09-18 | 2021-03-25 | Intergalactic Therapeutics, Inc. | Synthetic dna vectors and methods of use |
| KR20220153606A (ko) * | 2020-03-11 | 2022-11-18 | 네이쳐 테크놀로지 코포레이션 | 박테리아 숙주 균주 |
| CA3201499A1 (en) | 2020-11-13 | 2022-05-19 | Catamaran Bio, Inc. | Genetically modified natural killer cells and methods of use thereof |
| US20230055381A1 (en) | 2021-06-25 | 2023-02-23 | Oxford Biomedica Solutions Llc | Adeno-associated virus packaging systems |
| JP2024531910A (ja) | 2021-08-04 | 2024-09-03 | ザ リージェンツ オブ ザ ユニバーシティ オブ コロラド，ア ボディー コーポレイト | Ｌａｔ活性化キメラ抗原受容体ｔ細胞及びその使用方法 |
| CN114045305B (zh) * | 2021-10-15 | 2023-03-24 | 深圳市深研生物科技有限公司 | 多转座子系统 |
| US20230323395A1 (en) | 2021-12-15 | 2023-10-12 | Homology Medicines, Inc. | Methods and compositions for the production of adeno-associated virus |
| WO2023172514A1 (en) | 2022-03-07 | 2023-09-14 | Catamaran Bio, Inc. | Engineered immune cell therapeutics targeted to her2 and methods of use thereof |
| CN118742645B (zh) * | 2022-06-13 | 2025-07-15 | 南京金斯瑞生物科技有限公司 | 一种可提高无筛选标签质粒制备效率的野生型-突变体π蛋白切换表达系统 |
| JP2025525583A (ja) | 2022-07-19 | 2025-08-05 | ランパート バイオサイエンス インコーポレイテッド | 非免疫原性環状非ウイルス性ｄｎａベクター |
| CN117305339B (zh) * | 2023-11-30 | 2024-02-06 | 苏州左旋星生物科技有限公司 | 优化大肠杆菌基因编辑的载体及其应用 |
| CN122497758A (zh) | 2024-01-25 | 2026-07-31 | 阿尔德夫隆有限责任公司 | 具有改进的生产性能的病毒和非病毒纳米质粒载体 |
| WO2025231315A2 (en) | 2024-05-03 | 2025-11-06 | Aldevron, L.L.C. | Bacterial host strains |
| WO2026076187A1 (en) * | 2024-10-03 | 2026-04-09 | Aldevron, L.L.C. | Compositions and methods for microbial production of antibiotic-free closed-ended linear dna |
Family Cites Families (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH04197185A (ja) * | 1990-11-28 | 1992-07-16 | Mitsui Toatsu Chem Inc | 酵母発現ベクター及びこれを用いた誘導的発現 |
| GB9506051D0 (en) | 1995-03-24 | 1995-05-10 | Univ Singapore | Gene expression |
| US7279313B2 (en) | 1995-09-15 | 2007-10-09 | Centelion | Circular DNA molecule having a conditional origin of replication, process for their preparation and their use in gene therapy |
| FR2738842B1 (fr) | 1995-09-15 | 1997-10-31 | Rhone Poulenc Rorer Sa | Molecule d'adn circulaire a origine de replication conditionnelle, leur procede de preparation et leur utilisation en therapie genique |
| US5922583A (en) | 1995-10-17 | 1999-07-13 | Biostar Inc. | Methods for production of recombinant plasmids |
| US6709844B1 (en) * | 2000-11-16 | 2004-03-23 | Mannkind Corporation | Avoidance of undesirable replication intermediates in plasmid propagation |
| JP2004267001A (ja) | 2000-08-16 | 2004-09-30 | Kansai Tlo Kk | トランスジェニック哺乳動物及びその作製方法並びにこれを用いた遺伝子機能の解明方法 |
| UY26317A1 (es) | 2000-08-30 | 2000-10-31 | Alfonso Cayota Carlos Pritsch | Sistema de produccion de trombopoyetina humana por celulas de mamiferos en cultivo |
| FR2821855B1 (fr) | 2001-03-09 | 2004-04-02 | Cayla | Genes synthetiques et plasmides bacteriens depourvus de cpg |
| CA2794446C (en) * | 2001-04-04 | 2015-09-08 | Genencor International, Inc. | Uncoupled productive and catabolic host cell pathways |
| KR20050026384A (ko) * | 2002-04-26 | 2005-03-15 | 내셔날 인스티튜트 오브 어드밴스드 인더스트리얼 사이언스 앤드 테크놀로지 | ＲＮＡｉ효과를 가지는 스템 루프 형 ＲＮＡ 분자 발현 시스템 |
| WO2005003359A1 (ja) | 2003-07-08 | 2005-01-13 | Japan Science And Technology Corporation | トランスジェニック生物を作製する方法およびシステム |
| GB0327056D0 (en) | 2003-11-20 | 2003-12-24 | Cobra Biolog Ltd | Plasmid maintenance |
| EP1781800B1 (en) | 2004-08-19 | 2013-06-19 | Nature Technology Corp. | Process for plasmid dna fermentation |
| EP2169072A1 (en) * | 2004-08-23 | 2010-03-31 | Alnylam Pharmaceuticals, Inc | Multiple RNA polymerase III promoter expression constructs |
| TWI311152B (en) | 2004-09-17 | 2009-06-21 | Boehringer Ingelheim Rcv Gmbh & Co K | Host-vector system for antibiotic-free cole1 plasmid propagation |
| EP1844142B1 (en) | 2005-01-20 | 2015-08-12 | Nature Technology Corporation | Vectors and methods for genetic immunization |
| JP4927730B2 (ja) | 2005-07-05 | 2012-05-09 | 一般財団法人化学及血清療法研究所 | 改変トランスポゾンベクター及びその利用方法 |
| EP2160459A2 (en) | 2007-05-23 | 2010-03-10 | Nature Technology Corp. | Improved e. coli plasmid dna production |
| AU2008262478B9 (en) | 2007-05-29 | 2014-06-19 | Aldevron, L.L.C. | Vectors and methods for genetic immunization |
| US20110131668A1 (en) * | 2007-08-14 | 2011-06-02 | Commonwealth Scientific And Industrial Research Organisation | Improved gene silencing methods |
| US9045759B2 (en) | 2009-01-21 | 2015-06-02 | James Arthur Williams | DNA plasmids with improved copy number |
| US9012226B2 (en) | 2009-03-13 | 2015-04-21 | Nature Technology Corporation | Bacterial strains with improved plasmid stability |
| US9506082B2 (en) | 2010-04-12 | 2016-11-29 | Nature Technology Corporation | Eukaryotic expression vectors resistant to transgene silencing |
| HK1202578A1 (en) * | 2011-12-07 | 2015-10-02 | Ichnos Sciences SA | Expression cassette |
| US9550998B2 (en) * | 2012-08-29 | 2017-01-24 | Nature Technology Corporation | DNA plasmids with improved expression |
| US20150322439A1 (en) | 2012-11-19 | 2015-11-12 | Nature Technology Corporation | Replicative minicircle vectors with improved expression |
| CN105722976A (zh) | 2013-06-06 | 2016-06-29 | 诺华股份有限公司 | 流感病毒重配 |
| WO2017025447A1 (en) | 2015-08-10 | 2017-02-16 | Curevac Ag | Method of increasing the replication of a circular dna molecule |
| WO2017066579A1 (en) | 2015-10-14 | 2017-04-20 | Audentes Therapeutics, Inc. | Nucleic acid molecules containing spacers and methods of use thereof |
| AU2019240068B2 (en) | 2018-03-21 | 2025-03-13 | Aldevron, L.L.C. | Viral and non-viral nanoplasmid vectors with improved production |
| EP3898993A1 (en) * | 2018-12-20 | 2021-10-27 | Poseida Therapeutics, Inc. | Nanotransposon compositions and methods of use |
-
2019
- 2019-03-20 AU AU2019240068A patent/AU2019240068B2/en active Active
- 2019-03-20 WO PCT/US2019/023209 patent/WO2019183248A1/en not_active Ceased
- 2019-03-20 LT LTEPPCT/US2019/023209T patent/LT3768846T/lt unknown
- 2019-03-20 JP JP2020551263A patent/JP7520719B2/ja active Active
- 2019-03-20 DK DK19715345.5T patent/DK3768846T5/da active
- 2019-03-20 SG SG11202009009UA patent/SG11202009009UA/en unknown
- 2019-03-20 CN CN201980034026.9A patent/CN112154208B/zh active Active
- 2019-03-20 CA CA3093346A patent/CA3093346A1/en active Pending
- 2019-03-20 EP EP22194460.6A patent/EP4151735A1/en active Pending
- 2019-03-20 CN CN202510450562.4A patent/CN120249340A/zh active Pending
- 2019-03-20 EP EP19715345.5A patent/EP3768846B1/en active Active
- 2019-03-20 FI FIEP19715345.5T patent/FI3768846T3/fi active
- 2019-03-20 ES ES19715345T patent/ES2950736T3/es active Active
- 2019-03-20 KR KR1020207030139A patent/KR20210016330A/ko not_active Ceased
-
2020
- 2020-09-18 US US17/026,101 patent/US12600984B2/en active Active
-
2024
- 2024-07-10 JP JP2024110895A patent/JP7860174B2/ja active Active
-
2025
- 2025-05-08 AU AU2025203312A patent/AU2025203312A1/en active Pending
-
2026
- 2026-04-28 JP JP2026075524A patent/JP2026116424A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| US20210010021A1 (en) | 2021-01-14 |
| AU2019240068A1 (en) | 2020-10-01 |
| JP2021518150A (ja) | 2021-08-02 |
| JP7520719B2 (ja) | 2024-07-23 |
| CN120249340A (zh) | 2025-07-04 |
| DK3768846T3 (da) | 2023-07-24 |
| CA3093346A1 (en) | 2019-09-29 |
| EP3768846B1 (en) | 2023-06-21 |
| DK3768846T5 (da) | 2024-08-19 |
| EP4151735A1 (en) | 2023-03-22 |
| JP7860174B2 (ja) | 2026-05-15 |
| AU2025203312A1 (en) | 2025-05-29 |
| SG11202009009UA (en) | 2020-10-29 |
| KR20210016330A (ko) | 2021-02-15 |
| US12600984B2 (en) | 2026-04-14 |
| JP2024138410A (ja) | 2024-10-08 |
| ES2950736T3 (es) | 2023-10-13 |
| EP3768846A1 (en) | 2021-01-27 |
| AU2019240068B2 (en) | 2025-03-13 |
| FI3768846T3 (fi) | 2023-06-30 |
| WO2019183248A1 (en) | 2019-09-26 |
| JP2026116424A (ja) | 2026-07-09 |
| CN112154208A (zh) | 2020-12-29 |
| CN112154208B (zh) | 2025-04-15 |
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