LT3658547T - N-(5-(4-(4-formil-3-fenil-1h-pirazol-1-il)pirimidin-2-ilamino)-4-metoksi-2- morfolinofenil)akrilamido gamybos būdas - Google Patents
N-(5-(4-(4-formil-3-fenil-1h-pirazol-1-il)pirimidin-2-ilamino)-4-metoksi-2- morfolinofenil)akrilamido gamybos būdasInfo
- Publication number
- LT3658547T LT3658547T LTEPPCT/KR2018/008383T LT18838718T LT3658547T LT 3658547 T LT3658547 T LT 3658547T LT 18838718 T LT18838718 T LT 18838718T LT 3658547 T LT3658547 T LT 3658547T
- Authority
- LT
- Lithuania
- Prior art keywords
- morpholinophenyl
- ylamino
- pyrazol
- pyrimidin
- formyl
- Prior art date
Links
- HRPVXLWXLXDGHG-UHFFFAOYSA-N Acrylamide Chemical compound NC(=O)C=C HRPVXLWXLXDGHG-UHFFFAOYSA-N 0.000 title 1
- 238000004519 manufacturing process Methods 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D295/155—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
- C07D295/135—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Enzymes And Modification Thereof (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Peptides Or Proteins (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| KR20170096226 | 2017-07-28 | ||
| PCT/KR2018/008383 WO2019022487A1 (en) | 2017-07-28 | 2018-07-25 | INTERMEDIATES USEFUL FOR THE SYNTHESIS OF A SELECTIVE INHIBITOR TO PROTEIN KINASE AND METHODS FOR THEIR PREPARATION |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| LT3658547T true LT3658547T (lt) | 2023-10-10 |
Family
ID=65040643
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| LTEPPCT/KR2018/008383T LT3658547T (lt) | 2017-07-28 | 2018-07-25 | N-(5-(4-(4-formil-3-fenil-1h-pirazol-1-il)pirimidin-2-ilamino)-4-metoksi-2- morfolinofenil)akrilamido gamybos būdas |
Country Status (28)
| Country | Link |
|---|---|
| US (1) | US11198684B2 (lt) |
| EP (1) | EP3658547B1 (lt) |
| JP (1) | JP7189932B2 (lt) |
| KR (1) | KR20230137282A (lt) |
| CN (1) | CN111295381A (lt) |
| AU (1) | AU2018308164B2 (lt) |
| BR (1) | BR112020001457A2 (lt) |
| CA (1) | CA3070070A1 (lt) |
| CO (1) | CO2020000371A2 (lt) |
| DK (1) | DK3658547T3 (lt) |
| EA (1) | EA038078B1 (lt) |
| ES (1) | ES2959967T3 (lt) |
| FI (1) | FI3658547T3 (lt) |
| HR (1) | HRP20231020T1 (lt) |
| HU (1) | HUE063043T2 (lt) |
| IL (1) | IL271975B (lt) |
| LT (1) | LT3658547T (lt) |
| MA (1) | MA49705A (lt) |
| NZ (1) | NZ761158A (lt) |
| PH (1) | PH12020500093A1 (lt) |
| PL (1) | PL3658547T3 (lt) |
| PT (1) | PT3658547T (lt) |
| RS (1) | RS64545B1 (lt) |
| SA (1) | SA520411115B1 (lt) |
| SG (1) | SG11201913556SA (lt) |
| SI (1) | SI3658547T1 (lt) |
| UA (1) | UA125595C2 (lt) |
| WO (1) | WO2019022487A1 (lt) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111032650A (zh) * | 2017-07-28 | 2020-04-17 | 株式会社柳韩洋行 | 可用于合成氨基嘧啶衍生物的新型中间体、其制备方法以及使用其制备氨基嘧啶衍生物的方法 |
| LT3658552T (lt) | 2017-07-28 | 2023-11-27 | Yuhan Corporation | N-(5-((4-(4-((dimetilamino)metil)-3-fenil-1h-pirazol-1-il)pirimidin-2-il) amino)-4-metoksi-2-morfolinofenil)akrilamido gamybos būdas, vykdant reakciją tarp atitinkamo amino ir 3-halogen-propionilo chlorido |
| US11850248B2 (en) | 2019-05-14 | 2023-12-26 | Yuhan Corporation | Therapies with 3rd generation EGFR tyrosine kinase inhibitors |
| JOP20210304A1 (ar) | 2019-05-14 | 2023-01-30 | Janssen Biotech Inc | علاجات مركبة باستخدام الأجسام المضادة ثنائية النوعية المضادة لمستقبل عامل نمو البشرة (EGFR)/ مستقبل عامل نمو خلايا الكبد (c-Met) ومثبطات كيناز التيروسين الخاصة بمستقبل عامل نمو البشرة (EGFR) من الجيل الثالث |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2711249T3 (es) | 2008-06-27 | 2019-04-30 | Celgene Car Llc | Compuestos de heteroarilo y usos de los mismos |
| EA024729B1 (ru) * | 2009-11-13 | 2016-10-31 | Джиноско | Киназные ингибиторы |
| EP4086246A1 (en) | 2011-07-27 | 2022-11-09 | AstraZeneca AB | 2-(2,4,5-substituted-anilino)pyrimidine compounds as egfr modulators |
| TW201332989A (zh) * | 2011-12-23 | 2013-08-16 | Millennium Pharm Inc | 雜芳基化合物及其用途 |
| EP2804861B1 (en) * | 2012-01-20 | 2018-02-28 | Genosco | Substituted pyrimidine compounds and their use as syk inhibitors |
| JP6321821B2 (ja) * | 2014-04-14 | 2018-05-09 | シャンハイ ハイヤン ファーマシューティカル テクノロジー カンパニー リミテッドＳｈａｎｇｈａｉ Ｈａｉｙａｎ Ｐｈａｒｍａｃｅｕｔｉｃａｌ Ｔｅｃｈｎｏｌｏｇｙ Ｃｏ．， Ｌｔｄ． | ２，３，４，６−４置換ベンゼン−１，５−ジアミン誘導体、その製造方法および医薬品における使用 |
| CN105461695B (zh) * | 2014-09-29 | 2018-03-27 | 齐鲁制药有限公司 | 嘧啶或三嗪衍生物及其制备方法和用途 |
| CN105524068B (zh) | 2014-09-30 | 2017-11-24 | 上海海雁医药科技有限公司 | 氮杂双环衍生物、其制法与医药上的用途 |
| CA2962914C (en) * | 2014-10-13 | 2018-10-23 | Yuhan Corporation | Compounds and compositions for modulating egfr mutant kinase activities |
| CN104788427B (zh) * | 2015-02-05 | 2017-05-31 | 上海泓博智源医药股份有限公司 | 3‑(2‑嘧啶氨基)苯基丙烯酰胺类化合物及其应用 |
| EP3399968B8 (en) * | 2016-01-07 | 2021-12-01 | Xuanzhu Biopharmaceutical Co., Ltd. | Selective inhibitors of clinically important mutants of the egfr tyrosine kinase |
| CN106083736A (zh) | 2016-06-21 | 2016-11-09 | 郑州泰基鸿诺医药股份有限公司 | 一种嘧啶类化合物、egfr抑制剂及其应用 |
-
2018
- 2018-07-25 JP JP2020504208A patent/JP7189932B2/ja active Active
- 2018-07-25 ES ES18838718T patent/ES2959967T3/es active Active
- 2018-07-25 AU AU2018308164A patent/AU2018308164B2/en active Active
- 2018-07-25 PT PT188387187T patent/PT3658547T/pt unknown
- 2018-07-25 CA CA3070070A patent/CA3070070A1/en active Pending
- 2018-07-25 EA EA202090384A patent/EA038078B1/ru unknown
- 2018-07-25 WO PCT/KR2018/008383 patent/WO2019022487A1/en active Application Filing
- 2018-07-25 SI SI201830982T patent/SI3658547T1/sl unknown
- 2018-07-25 IL IL271975A patent/IL271975B/en unknown
- 2018-07-25 EP EP18838718.7A patent/EP3658547B1/en active Active
- 2018-07-25 HU HUE18838718A patent/HUE063043T2/hu unknown
- 2018-07-25 MA MA049705A patent/MA49705A/fr unknown
- 2018-07-25 PL PL18838718.7T patent/PL3658547T3/pl unknown
- 2018-07-25 BR BR112020001457-5A patent/BR112020001457A2/pt unknown
- 2018-07-25 US US16/633,756 patent/US11198684B2/en active Active
- 2018-07-25 RS RS20230685A patent/RS64545B1/sr unknown
- 2018-07-25 FI FIEP18838718.7T patent/FI3658547T3/fi active
- 2018-07-25 NZ NZ761158A patent/NZ761158A/en not_active IP Right Cessation
- 2018-07-25 DK DK18838718.7T patent/DK3658547T3/da active
- 2018-07-25 SG SG11201913556SA patent/SG11201913556SA/en unknown
- 2018-07-25 CN CN201880048980.9A patent/CN111295381A/zh active Pending
- 2018-07-25 LT LTEPPCT/KR2018/008383T patent/LT3658547T/lt unknown
- 2018-07-25 HR HRP20231020TT patent/HRP20231020T1/hr unknown
- 2018-07-25 UA UAA202001302A patent/UA125595C2/uk unknown
-
2020
- 2020-01-14 PH PH12020500093A patent/PH12020500093A1/en unknown
- 2020-01-15 CO CONC2020/0000371A patent/CO2020000371A2/es unknown
- 2020-01-22 SA SA520411115A patent/SA520411115B1/ar unknown
-
2023
- 2023-09-21 KR KR1020230126377A patent/KR20230137282A/ko not_active Application Discontinuation
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