LT3494125T - Kompozicijos, apimančios 5-cholesteną-3, 25-diolį, 3-sulfatą (25hc3s) arba farmaciniu požiūriu priimtiną jo druską ir bent vieną ciklinį oligosacharidą - Google Patents

Kompozicijos, apimančios 5-cholesteną-3, 25-diolį, 3-sulfatą (25hc3s) arba farmaciniu požiūriu priimtiną jo druską ir bent vieną ciklinį oligosacharidą

Info

Publication number
LT3494125T
LT3494125T LTEPPCT/US2017/044840T LTUS2017044840T LT3494125T LT 3494125 T LT3494125 T LT 3494125T LT US2017044840 T LTUS2017044840 T LT US2017044840T LT 3494125 T LT3494125 T LT 3494125T
Authority
LT
Lithuania
Prior art keywords
25hc3s
cholesten
diol
sulfate
compositions
Prior art date
Application number
LTEPPCT/US2017/044840T
Other languages
English (en)
Lithuanian (lt)
Inventor
Shunlin Ren
Leyuan XU
Yanxia NING
Jin Kim
Weiqi Lin
Meej KIM
Andrew Miksztal
Hongwei WU
Min Lee
Wilma Tamraz
Original Assignee
Virginia Commonwealth University
The United States Government As Represented By The Department Of Veterans Affairs
Durect Corporation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Virginia Commonwealth University, The United States Government As Represented By The Department Of Veterans Affairs, Durect Corporation filed Critical Virginia Commonwealth University
Publication of LT3494125T publication Critical patent/LT3494125T/lt

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K9/10—Dispersions; Emulsions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/575—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of three or more carbon atoms, e.g. cholane, cholestane, ergosterol, sitosterol
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    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/716—Glucans
    • A61K31/724—Cyclodextrins
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K47/02—Inorganic compounds
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    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
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    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
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    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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  • Heart & Thoracic Surgery (AREA)
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  • Dispersion Chemistry (AREA)
  • Vascular Medicine (AREA)
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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Steroid Compounds (AREA)
LTEPPCT/US2017/044840T 2016-08-02 2017-08-01 Kompozicijos, apimančios 5-cholesteną-3, 25-diolį, 3-sulfatą (25hc3s) arba farmaciniu požiūriu priimtiną jo druską ir bent vieną ciklinį oligosacharidą LT3494125T (lt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201662370024P 2016-08-02 2016-08-02
US201762470578P 2017-03-13 2017-03-13
PCT/US2017/044840 WO2018026781A1 (en) 2016-08-02 2017-08-01 Compositions comprising 5-cholesten-3, 25-diol, 3-sulfate (25hc3s) or pharmaceutically acceptable salt thereof and at least one cyclic oligosaccharide

Publications (1)

Publication Number Publication Date
LT3494125T true LT3494125T (lt) 2022-11-10

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LTEPPCT/US2017/044840T LT3494125T (lt) 2016-08-02 2017-08-01 Kompozicijos, apimančios 5-cholesteną-3, 25-diolį, 3-sulfatą (25hc3s) arba farmaciniu požiūriu priimtiną jo druską ir bent vieną ciklinį oligosacharidą

Country Status (22)

Country Link
US (4) US20190269695A1 (cg-RX-API-DMAC7.html)
EP (2) EP4101861A1 (cg-RX-API-DMAC7.html)
JP (3) JP2019524772A (cg-RX-API-DMAC7.html)
KR (3) KR102593667B1 (cg-RX-API-DMAC7.html)
CN (2) CN116747233A (cg-RX-API-DMAC7.html)
AU (2) AU2017305239C1 (cg-RX-API-DMAC7.html)
CA (1) CA3031224A1 (cg-RX-API-DMAC7.html)
DK (1) DK3494125T3 (cg-RX-API-DMAC7.html)
EA (1) EA201990438A1 (cg-RX-API-DMAC7.html)
ES (1) ES2922933T3 (cg-RX-API-DMAC7.html)
HR (1) HRP20220932T1 (cg-RX-API-DMAC7.html)
HU (1) HUE059768T2 (cg-RX-API-DMAC7.html)
IL (2) IL298681A (cg-RX-API-DMAC7.html)
LT (1) LT3494125T (cg-RX-API-DMAC7.html)
MX (2) MX2019001323A (cg-RX-API-DMAC7.html)
PL (1) PL3494125T3 (cg-RX-API-DMAC7.html)
PT (1) PT3494125T (cg-RX-API-DMAC7.html)
RS (1) RS63529B1 (cg-RX-API-DMAC7.html)
SI (1) SI3494125T1 (cg-RX-API-DMAC7.html)
SM (1) SMT202200330T1 (cg-RX-API-DMAC7.html)
TW (2) TW202426000A (cg-RX-API-DMAC7.html)
WO (1) WO2018026781A1 (cg-RX-API-DMAC7.html)

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CA3031224A1 (en) * 2016-08-02 2018-02-08 Shunlin Ren Compositions comprising 5-cholesten-3, 25-diol, 3-sulfate (25hc3s) or pharmaceutically acceptable salt thereof and at least one cyclic oligosaccharide
WO2021067297A1 (en) * 2019-09-30 2021-04-08 Durect Corporation Treatment of alcoholic hepatitis
EP4103195A4 (en) * 2020-02-11 2024-04-17 Durect Corporation TREATMENT OF INFECTIOUS DISEASES
WO2021202608A1 (en) * 2020-03-31 2021-10-07 The Regents Of The University Of Michigan Serum metabolites as biomarkers for carnitine treatment of sepsis
CA3195103A1 (en) * 2020-05-22 2021-11-25 Durect Corporation Treatment of non-alcoholic steatohepatitis (nash)
CA3187310A1 (en) * 2020-06-26 2021-12-30 Durect Corporation Use of oxygenated cholesterol sulfates for treating autoimmune conditions
CN112967234B (zh) * 2021-02-09 2022-12-09 复旦大学附属中山医院 冠状动脉功能生理学病变模式定量评价方法
EP4359420A4 (en) * 2021-06-25 2025-07-16 Durect Corp 25-HYDROXY-CHOLEST-5-EN-3-SULFATE CHOLINE, PROCESSES FOR THEIR PREPARATION, AND THEIR USES
CN113750039B (zh) * 2021-10-26 2023-08-18 浙江中医药大学 一种黄芩苷-海藻酸钙温敏纳米凝胶、制备方法及其应用
WO2023196412A1 (en) * 2022-04-06 2023-10-12 Nobias Therapeutics, Inc. Liquid formulations comprising mitogen-activated protein kinase kinase (mek) inhibitors and methods using same
CN119896674A (zh) * 2023-10-27 2025-04-29 上海交通大学医学院附属新华医院 胆固醇硫酸酯在制备治疗特应性皮炎的药物中的应用

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