SMT202200330T1 - Composizioni comprendenti 5-colesten-3, 25-diolo, 3-solfato (25hc3s) o suo sale farmaceuticamente accettabile e almeno un oligosaccaride ciclico - Google Patents

Composizioni comprendenti 5-colesten-3, 25-diolo, 3-solfato (25hc3s) o suo sale farmaceuticamente accettabile e almeno un oligosaccaride ciclico

Info

Publication number
SMT202200330T1
SMT202200330T1 SM20220330T SMT202200330T SMT202200330T1 SM T202200330 T1 SMT202200330 T1 SM T202200330T1 SM 20220330 T SM20220330 T SM 20220330T SM T202200330 T SMT202200330 T SM T202200330T SM T202200330 T1 SMT202200330 T1 SM T202200330T1
Authority
SM
San Marino
Prior art keywords
25hc3s
cholesten
diol
sulfate
compositions
Prior art date
Application number
SM20220330T
Other languages
English (en)
Italian (it)
Inventor
Shunlin Ren
Leyuan Xu
Yanxia Ning
Jin Koung Kim
Weiqi Lin
Meej Kim
Andrew R Miksztal
Hongwei Wu
Min L Lee
Wilma Tamraz
Original Assignee
Univ Virginia Commonwealth
Us Gov Veterans Affairs
Durect Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Virginia Commonwealth, Us Gov Veterans Affairs, Durect Corp filed Critical Univ Virginia Commonwealth
Publication of SMT202200330T1 publication Critical patent/SMT202200330T1/it

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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/575—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of three or more carbon atoms, e.g. cholane, cholestane, ergosterol, sitosterol
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/716—Glucans
    • A61K31/724—Cyclodextrins
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    • A61K47/02—Inorganic compounds
    • A—HUMAN NECESSITIES
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    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
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    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
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    • A—HUMAN NECESSITIES
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    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
    • A61K47/6949—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit inclusion complexes, e.g. clathrates, cavitates or fullerenes
    • A61K47/6951—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit inclusion complexes, e.g. clathrates, cavitates or fullerenes using cyclodextrin
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
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    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
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    • A—HUMAN NECESSITIES
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    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
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    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
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    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
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    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J31/00—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring
    • C07J31/006—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring not covered by C07J31/003

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  • Chemical Kinetics & Catalysis (AREA)
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  • Epidemiology (AREA)
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  • Gastroenterology & Hepatology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
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  • Oncology (AREA)
  • Dispersion Chemistry (AREA)
  • Vascular Medicine (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Steroid Compounds (AREA)
SM20220330T 2016-08-02 2017-08-01 Composizioni comprendenti 5-colesten-3, 25-diolo, 3-solfato (25hc3s) o suo sale farmaceuticamente accettabile e almeno un oligosaccaride ciclico SMT202200330T1 (it)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201662370024P 2016-08-02 2016-08-02
US201762470578P 2017-03-13 2017-03-13
PCT/US2017/044840 WO2018026781A1 (en) 2016-08-02 2017-08-01 Compositions comprising 5-cholesten-3, 25-diol, 3-sulfate (25hc3s) or pharmaceutically acceptable salt thereof and at least one cyclic oligosaccharide
EP17837516.8A EP3494125B1 (en) 2016-08-02 2017-08-01 Compositions comprising 5-cholesten-3, 25-diol, 3-sulfate (25hc3s) or pharmaceutically acceptable salt thereof and at least one cyclic oligosaccharide

Publications (1)

Publication Number Publication Date
SMT202200330T1 true SMT202200330T1 (it) 2022-11-18

Family

ID=61073854

Family Applications (1)

Application Number Title Priority Date Filing Date
SM20220330T SMT202200330T1 (it) 2016-08-02 2017-08-01 Composizioni comprendenti 5-colesten-3, 25-diolo, 3-solfato (25hc3s) o suo sale farmaceuticamente accettabile e almeno un oligosaccaride ciclico

Country Status (22)

Country Link
US (4) US20190269695A1 (cg-RX-API-DMAC7.html)
EP (2) EP4101861A1 (cg-RX-API-DMAC7.html)
JP (3) JP2019524772A (cg-RX-API-DMAC7.html)
KR (3) KR102593667B1 (cg-RX-API-DMAC7.html)
CN (2) CN109983025B (cg-RX-API-DMAC7.html)
AU (2) AU2017305239C1 (cg-RX-API-DMAC7.html)
CA (1) CA3031224A1 (cg-RX-API-DMAC7.html)
DK (1) DK3494125T3 (cg-RX-API-DMAC7.html)
EA (1) EA201990438A1 (cg-RX-API-DMAC7.html)
ES (1) ES2922933T3 (cg-RX-API-DMAC7.html)
HR (1) HRP20220932T1 (cg-RX-API-DMAC7.html)
HU (1) HUE059768T2 (cg-RX-API-DMAC7.html)
IL (2) IL298681A (cg-RX-API-DMAC7.html)
LT (1) LT3494125T (cg-RX-API-DMAC7.html)
MX (2) MX2019001323A (cg-RX-API-DMAC7.html)
PL (1) PL3494125T3 (cg-RX-API-DMAC7.html)
PT (1) PT3494125T (cg-RX-API-DMAC7.html)
RS (1) RS63529B1 (cg-RX-API-DMAC7.html)
SI (1) SI3494125T1 (cg-RX-API-DMAC7.html)
SM (1) SMT202200330T1 (cg-RX-API-DMAC7.html)
TW (2) TW202426000A (cg-RX-API-DMAC7.html)
WO (1) WO2018026781A1 (cg-RX-API-DMAC7.html)

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KR102593667B1 (ko) 2016-08-02 2023-10-24 버지니아 커먼웰스 유니버시티 5-콜레스텐-3, 25-디올, 3-술페이트 (25hc3s) 또는 이의 약학적으로 허용 가능한 염, 및 적어도 하나의 시클릭 올리고당을 포함하는 조성물
EP4037650A4 (en) * 2019-09-30 2023-10-18 Durect Corporation TREATMENT OF ALCOHOLIC HEPATITIS
AU2021221109A1 (en) * 2020-02-11 2022-08-25 Durect Corporation Treatment of infectious diseases
WO2021202608A1 (en) * 2020-03-31 2021-10-07 The Regents Of The University Of Michigan Serum metabolites as biomarkers for carnitine treatment of sepsis
EP4153164A4 (en) * 2020-05-22 2024-06-26 Durect Corporation Treatment of non-alcoholic steatohepatitis (nash)
JP2023531735A (ja) * 2020-06-26 2023-07-25 デュレクト コーポレーション インスリン抵抗性、糖尿病、及び前糖尿病の少なくとも１つを処置するための酸素化コレステロールスルフェート類の使用
CN112967234B (zh) * 2021-02-09 2022-12-09 复旦大学附属中山医院 冠状动脉功能生理学病变模式定量评价方法
US20240425545A1 (en) * 2021-06-25 2024-12-26 Durect Corporation 25-Hydroxy-Cholest-5-En-3-Sulfate Choline and Methods for Preparing, and Uses of, Same
CN113750039B (zh) * 2021-10-26 2023-08-18 浙江中医药大学 一种黄芩苷-海藻酸钙温敏纳米凝胶、制备方法及其应用
WO2023196412A1 (en) * 2022-04-06 2023-10-12 Nobias Therapeutics, Inc. Liquid formulations comprising mitogen-activated protein kinase kinase (mek) inhibitors and methods using same
CN119896674A (zh) * 2023-10-27 2025-04-29 上海交通大学医学院附属新华医院 胆固醇硫酸酯在制备治疗特应性皮炎的药物中的应用

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